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| 1 | Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Gert van Assche Walter Reinisch Jean–Frederic Colombel Geert D’Haens Douglas C. Wolf Martina Kron Mary Beth Tighe Andreas Lazar Roopal B. Thakkar | 2012 | Gastroenterology2012，，2： | 9 |
| 2 | Clinical impact of immunomonitoring in the treatment of inflammatory bowel disease显示文摘Despite improvement in outcomes, loss of response(LOR) to tumor necrosis factor-alpha (TNFα) therapies is a big concern in the management of inflammatory bowel disease. LOR is associated with flares of disease, increased hospitalisation rates, need for surgical interventions, and decline in quality of life. LOR may be multifactorial, but immunogenicity makes a significant contribution. Traditionally doses of anti-TNFα have been adjusted based on clinical response, using a standard approach. Immunomonitoring involves the measurement of anti-TNFα trough and antibody levels. It takes into account the underlying pharmacokinetics of anti-TNFα therapies. Expanding on this a treat to target approach may be used, where doses are intensified, or tailored to the individual based on the measurement of anti-TNFα trough and antibody levels. This review looks at the history, evolution, and clinical impact that immunomonitoring is having in the treatment of inflammatory bowel disease. It will focus on the role of immunomonitoring in helping to achieve long lasting deep remission and mucosal healing. It will explore the different options in terms of best measuring trough and antibody levels, explore possible advantages of immunomonitoring, and discuss its role in best optimising response, at induction, during the maintenance phase of treatment, as well as a role in withdrawing or switching therapy. | Donal Tighe Deirdre Mc Namara | 2017 | World Journal of Gastroenterology2017，23，3： | 6 |
| 3 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 4 | “白改黑”路面不同结构组合抗裂性能分析显示文摘为更加直观地了解'白改黑'路面不同结构组合的抗裂性能,采用多功能道路检测车对在役不同加铺结构'白改黑'路面进行检测,对比分析不同结构组合路面的横向裂缝间距、纵向裂缝贯穿率、龟裂分布律,并评价其对路面平整度和抗车辙性能的影响,验证不同加铺结构的抗裂性能。研究结果表明:增加结构层厚度、增设聚酯玻纤布或高弹性应力吸收层均可起到一定的抗裂缝反射性能;不同加铺结构不会对路面的平整度、抗车辙性能产生较大影响。 | 刘志胜 刘鹏飞 Susan Tighe 孙晓龙 | 2017 | 筑路机械与施工机械化2017，34，10： | 4 |
| 5 | Crystal growth of large-area single-crystal CdTe and CdZnTe by the computer-controlled vertical modified - Bridgman process 显示文摘 | SEN S KONKEL W H TIGHE S J | 1988 | J Cryst Growth1988，86，： | 2 |
| 6 | Extramedullary plas-macytoma of the eyelid显示文摘 | Ahamed E Samuel LM Tighe JE | 2003 | Ophthal2003，87，： | 1 |
| 7 | A review of biodegradable polymers: Uses,current developments in the synthesis and characterization of biodegradable polyesters,blends of biodegradable polymers and recent advances in biodegradation studies 显示文摘 | Amass W Amass A Tighe B | 1998 | Polym Int1998，25，： | 1 |
| 8 | Urine dry reagent strip 'error' rates using different reading methods 显示文摘 | TIGHE P | 2000 | Accred Qual Assur2000，5，12： | 1 |
| 9 | Differences in ventilatory inefficiency between pulmonary arterial hypertension and chronicthromboembolic pulmonary hypertension显示文摘 | Zhai Z Murphy K Tighe H | 2011 | Chest2011，140，5： | 1 |
| 10 | Quantitative analysis of IL-10 and IFN-gamma mRNA levels in normal cervix and human papillomavirus type 16 associated cervical precancer显示文摘 | El-Sherif AM Seth R Tighe PJ | 2001 | J Pathol2001，195，2： | 1 |
| 11 | Vacuum-assisted stereotactic breast biopsy:histologic underestimation of malignant lesions 显示文摘 | Burak W E Jr Owens K E Tighe M B | 2000 | Arch Surg2000，135，6： | 1 |
| 12 | Quantitative analysis of IL- l0 and IFN-',/mRNA levels in normal cervix and human papilloma- virus type 16 assoeiated cervical preeancer 显示文摘 | EI-Sherif A M Seth R Tighe P J | 2001 | J Pathol2001，195，2： | 1 |
| 13 | Hyperbaric oxygen therapy 显示文摘 | Tighe S Q Nelson R A | 2000 | Br J Anaesth2000，85，4： | 1 |
| 14 | Transcriptional regulation of scar gene expression in primary astrocytes显示文摘 | GRIS P TIGHE A LEVIN D | 2007 | Glia2007，55，11： | 1 |
| 15 | Neurons containing hypocretin (orexin) project to multiple neuronal systems显示文摘 | Peyron C Tighe D K van den Pol A N | 1998 | J Neurosci1998，18，10： | 1 |
| 16 | Group B streptococcal disease in infants:a case control study显示文摘 | Health PT Balfour GF Tighe H | 2009 | Arch Dis Child2009，94，： | 1 |
| 17 | The effect of recycled concrete aggregate properties on the bond strength between RCA concrete and steel reinforcement显示文摘 | L. Butler J.S. West S.L. Tighe | 2011 | Cement and Concrete Research2011，，10： | 1 |
| 18 | Screen - detected colorec- tal cancers show improved cancer - specific survival when com- pared with cancers diagnosed via the 2 - week suspected colorectal cancer referral guidelines 显示文摘 | Courtney ED ChongD Tighe R | 2013 | Colorectal disease2013，15，2： | 1 |
| 19 | Crystal growth of largearea single -crystal CdTe and CdZnTe by the computercontrolled vertical modified- Bridgman process显示文摘 | Sen S Konkel W H Tighe S J | 1988 | J Cryst Growth1988，86，： | 1 |
| 20 | Gene vaccination: plasmid DNA is more than just a blueprint显示文摘 | Tighe H Corr M Roman M | 1998 | Immunol Today1998，19，： | 1 |
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