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| 1 | Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences显示文摘 | Edward V Loftus | 2004 | Gastroenterology2004，，6： | 7 |
| 2 | Risk Factors for Opportunistic Infections in Patients With Inflammatory Bowel Disease显示文摘 | Murat Toruner Edward V. Loftus W. Scott Harmsen Alan R. Zinsmeister Robert Orenstein William J. Sandborn Jean–Frederic Colombel Laurence J. Egan | 2008 | Gastroenterology2008，，4： | 6 |
| 3 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 4 | Risk of Cerebrovascular Accidents and Ischemic Heart Disease in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis显示文摘 | Siddharth Singh Harkirat Singh Edward V. Loftus Darrell S. Pardi | 2014 | Clinical Gastroenterology and Hepatology2014，，3： | 3 |
| 5 | Risk of Intestinal Cancer in Inflammatory Bowel Disease: A Population-Based Study From Olmsted County, Minnesota显示文摘 | Tine Jess Edward V. Loftus Fernando S. Velayos W. Scott Harmsen Alan R. Zinsmeister Thomas C. Smyrk Cathy D. Schleck William J. Tremaine L. Joseph Melton Pia Munkholm William J. Sandborn | 2006 | Gastroenterology2006，，4： | 3 |
| 6 | Increased Matrix Metalloproteinase-9 Activity in Unstable Carotid Plaques: A Potential Role in Acute Plaque Disruption显示文摘 | Ian M. Loftus A. Ross Naylor Stephen Goodall Matthew Crowther Louise Jones Peter R. F. Bell Matthew M. Thompson | 2000 | Stroke: Journal of the American Heart Association2000，，1： | 2 |
| 7 | Risk of Lymphoma in Patients with Ulcerative Colitis Treated with Thiopurines—a Nationwide Retrospective Cohort Study显示文摘 | Nabeel Khan Ali M. Abbas Gary R. Lichtenstein Edward V. Loftus Lydia A. Bazzano | 2013 | Gastroenterology2013，，： | 2 |
| 8 | How Safe is Bilateral Internal Iliac Artery Embolization Prior to EVAR?显示文摘 | M. J. Bratby G. M. Munneke A.-M. Belli T. M. Loosemore I. Loftus M. M. Thompson R. A. Morgan | 2008 | CardioVascular and Interventional Radiology2008，，： | 2 |
| 9 | Infliximab for Crohn’s Disease: The First 500 Patients Followed Up Through 2009显示文摘 | Jennifer L. Seminerio Edward V. Loftus Jean-Frédéric Colombel Prabin Thapa William J. Sandborn | 2013 | Digestive Diseases and Sciences2013，，3： | 2 |
| 10 | A Phase 2/3, Multicenter, Randomized, Double-Masked, 2-Year Trial of Pegaptanib Sodium for the Treatment of Diabetic Macular Edema显示文摘 | Marla B. Sultan Duo Zhou Jane Loftus Theresa Dombi Kathleen S. Ice | 2011 | Ophthalmology2011，，6： | 2 |
| 11 | Peripheral neuropathy incidence in inflammatory bowel disease: A population-based study显示文摘 | Juan J. Figueroa Edward V. Loftus William S. Harmsen P. James B. Dyck Christopher J. Klein | 2013 | Neurology2013，，18： | 2 |
| 12 | 采用间接复位、钢板固定、不植骨的方法治疗稳定的股骨干髓内假体周围骨折显示文摘背景:间接复位技术相对于较早期的开放复位技术具有能够提高骨愈合率及减少植骨的优势,我们对以间接复位治疗股骨干假体周围骨折的结果进行了研究。
方法:连续对50例稳定的股骨干髓内假体周围骨折(Vancourvr B1型)进行治疗,根据病例记录包括切开复位、间接复位、外侧单钢板固定且不行同种异体或其他植骨。4例术后早期死亡,5例随访时间短,对其余41例(平均年龄72岁)进行了平均24个月的随访,并进行临床和影像学评估。
结果:所有骨折平均12周(7~23周)愈合,对位满意。1例有1根钢丝断裂,2例有1枚螺钉断裂,骨折最终愈合且无明显的内置物松动和对位不良。1例发生围手术期深部感染。41例中30例行走功能恢复到骨折前的状态。
结论:结果证实间接复位骨膜外侧单钢板固定且不进行植骨的方法对于稳定的股骨干髓内假体周围骨折的疗效是应该肯定的。
可信水平:治疗性研究,Ⅳ级,进一步可信度参见作者介绍。 | WILLIAM M. RICCI BRETT R. BOLHOFNER TIMOTHY LOFTUS CHRISTOPHER COX SCOTT MITCHELL JOSEPH BORRELLI JR 董强(译) 马宝通(译) | 2006 | 骨科动态2006，2，1： | 2 |
| 13 | Safety of Infliximab and Other Biologic Agents in the Inflammatory Bowel Diseases显示文摘 | Jagadeshwar G. Reddy Edward V. Loftus | 2006 | Gastroenterology Clinics of North America2006，，4： | 2 |
| 14 | Reduced food intake and body weight in mice treated with fatty-acid synthase inhibitors 显示文摘 | Loftus T M Jaworsky D E Frehywot G L | 2000 | Science2000，288，5475： | 2 |
| 15 | CT enterography and fistulizing Crohn’s disease: clinical benefit and radiographic findings显示文摘 | Fargol Booya Salma Akram Joel G. Fletcher J. E. Huprich C. D. Johnson J. L. Fidler J. M. Barlow C. A. Solem W. J. Sandborn Edward V. Loftus | 2009 | Abdominal Imaging2009，，4： | 2 |
| 16 | Designing an immersive virtual reality interface for layout planning 显示文摘 | Korves B Loftus M | 2000 | Journal of Materials Processing Technology2000，107，： | 2 |
| 17 | Effects of Adalimumab Therapy on Incidence of Hospitalization and Surgery in Crohn’s Disease: Results From the CHARM Study显示文摘 | Brian G. Feagan Remo Panaccione William J. Sandborn Geert R. D’Haens Stefan Schreiber Paul J. Rutgeerts Edward V. Loftus Kathleen G. Lomax Andrew P. Yu Eric Q. Wu Jingdong Chao Parvez Mulani | 2008 | Gastroenterology2008，，5： | 2 |
| 18 | Relationships Between Disease Activity and Serum and Fecal Biomarkers in Patients With Crohn’s Disease显示文摘 | Jennifer Jones Edward V. Loftus Remo Panaccione Li–Sheng Chen Sandra Peterson Joseph Mcconnell Linnea Baudhuin Karen Hanson Brian G. Feagan Scott W. Harmsen Alan R. Zinsmeister Emelie Helou William J. Sandborn | 2008 | Clinical Gastroenterology and Hepatology2008，，11： | 2 |
| 19 | Safety of selective cyclooxygenase-2 inhibitors in inflammatory bowel disease显示文摘 | Uma Mahadevan Edward V Loftus William J Tremaine William J Sandborn | 2002 | The American Journal of Gastroenterology2002，，4： | 2 |
| 20 | How Safe is Bilateral Internal Iliac Artery Embolization Prior to EVAR?显示文摘 | M. J. Bratby G. M. Munneke A.-M. Belli T. M. Loosemore I. Loftus M. M. Thompson R. A. Morgan | 2008 | CardioVascular and Interventional Radiology2008，，2： | 2 |
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