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| 1 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 2 | Role of soluble triggering receptor expressed on myeloid cells in inflammatory bowel disease显示文摘瞄准:为了调查可溶的被触发的可能的角色,受体在煽动性的肠疾病(IBD ) 的致病在骨髓的上表示了 cells-1 (sTREM-1 ) 。方法:58 个病人被注册;十九个健康志愿者用作控制;8 个病人与 Crohn 的疾病被诊断,并且 31 与 ulcerative。有 Crohn 的疾病和 ulcerative 的病人的临床、内视镜的活动索引分别地被估计。在承认之上,血被取样;sTREM-1 和 TNFalpha 被 thiobarbitourate 试金被免疫分析和 malondialdehyde (MDA ) 测量,在通过一个 HPLC 系统的经过以后。结果:控制,有 Crohn 的疾病的病人和有 ulcerative 的病人的 TNFalpha 的中部的 +/- SE 是 6.02 +/- 3.94, 7.98 +/- 5.08 (P = NS 对控制) ,并且 8.45 +/- 4.15 ng/L (P = 0.018 对控制) 分别地。sTREM-1 的各自的价值是 53.31 +/- 32.93, 735.10 +/- 197.17 (P = 0.008 对控制) 并且 435.82 +/- 279.71 ng/L (P = 0.049 对控制) 。sTREM-1 断然与 Crohn 的疾病活动索引和 ulcerative 的临床、内视镜的活动索引被相关(P = 0.002, 0.001 和 0.009,分别地) 。有 ulcerative 的病人的 sTREM-1 断然与 TNFalpha 被相关(P = 0.001 ) 。结论:sTREM-1 似乎在与肠粘膜的炎性反应的度的关联在 IBD 作为一个新奇调停人表现。 | Michalis Tzivras Vassilios Koussoulas Evangelos J Giamarellos-Bourboulis Dimitrios Tzivras Thomas Tsaganos Pantelis Koutoukas Helen Giamarellou Athanasios Archimandritis | 2006 | World Journal of Gastroenterology2006，12，21： | 17 |
| 3 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 4 | Interferon-a plus lamivudine vslamivudine reduces breakthroughs, but does not affect sustained response in HBeAg negative chronic hepatitis B显示文摘AIM: To investigate the efficacy of combination treatment of IFN-α and lamivudine compared to lamivudine monotherapy, after 24 mo of administration in HBeAg-negative hepatitis B patients.METHODS: Fifty consecutive patients were randomly assigned to receive IFN-α-2b (5 MU thrice per week, n = 24) plus lamivudine (100 mg daily) or lamivudine only (n = 26) for 24 mo. Patients were followed up for further 6 mo. The primary outcome was the proportion with sustained virological response (undetectable serum HBV DNA concentrations) and or sustained biochemical response (transaminase levels within normal range) at 30 mo (6 mo after the end of therapy). Secondary end-points were timed from initial virological (biochemical) response to VBR (BBR, respectively) and the emergence of YMDD mutants across the two arms.RESULTS: Five of twenty-four (21%) patients in the combination arm vs 3/26 (12%) in the lamivudine arm had sustained response (i.e., normal serum transaminase levels and undetectable HBV DNA by PCR assay) 6 mo after treatment discontinuation. A reduction in the emergence of YMDD mutants and in the development of virological breakthroughs was observed in patients receiving combination treatment (10% vs46%, P= 0.01 and 14% vs46%, P= 0.03,respectively).Time from initial virologic response to virologic breakthrough (VBR) was greater among initial responders receiving combination treatment compared to those receiving lamivudine (22.9 mo vs 15.9 mo, respectively; P = 0.005).CONCLUSION: Our results demonstrate that IFN-α plus lamivudine combination therapy does not increase the sustained response, compared to lamivudine. However,combination therapy reduces the likelihood of VBR due to YMDD mutants and prolongs the time period until the breakthrough development. | Michalis Economou Spilios Manolakopoulos Thomas A Trikalinos Spyros Filis Sotiris Bethanis Dimitrios Tzourmakliotis Alec Avgerinos Sotiris Raptis Epameinondas V Tsianos | 2005 | World Journal of Gastroenterology2005，11，37： | 6 |
| 5 | A mobile robot employing insect strategies for navigation显示文摘 | Dimitrios Lambrinos Ralf M?ller Thomas Labhart Rolf Pfeifer Rüdiger Wehner | 2000 | Robotics and Autonomous Systems2000，，1： | 1 |
| 6 | Diagnostic and clinical utility of antibodies against the nuclear body promyelocytic leukaemia and Sp100 antigens in patients with primary biliary cirrhosis显示文摘 | Maria G. Mytilinaiou Wolfgang Meyer Thomas Scheper Eirini I. Rigopoulou Christian Probst Andreas L. Koutsoumpas Daniel Abeles Andrew K. Burroughs Lars Komorowski Diego Vergani Dimitrios P. Bogdanos | 2012 | Clinica Chimica Acta (-)2012，，15： | 1 |
| 7 | Carotid geometry effects on blood flow and on risk for vascular disease显示文摘 | Kien T. Nguyen Christopher D. Clark Thomas J. Chancellor Dimitrios V. Papavassiliou | 2007 | Journal of Biomechanics2007，，： | 1 |
| 8 | The role of technetium Tc99m-tetrofosmin as head and neck tumor-seeking agent:a preliminary report显示文摘Aim:To evaluate the diagnostic value of technetium Tc99m-tetrofosmin(^(99m)Tc-TF)in primary cancers of the head and neck.Methods:Single photon emission computer tomography with planar imaging of the neck for primary site evaluation and whole body scanning for assessment of metastases in 12 patients with newly diagnosed head and neck cancer.Tumor-to-background index(T/Bg)was derived in patients with positive findings(tumor or lymph nodes).Results:The tomographic images showed increased tracer uptake in pathological sites(primary tumor or lymph node)in 9 patients(overall sensitivity 75%).Primary tumor was visualised in 7 patients(sensitivity 58%)and infiltrated lymph nodes in 4 out 7 patients(sensitivity 57%).Mean values for T/Bg index were 5.44±1.28 for primary tumor and 4.25±1.67 for lymph nodes.Mean values for T/Bg index were 4.5±0.71 for patients with in situ and grade I carcinoma and 6.68±0.36 for patients with tumor grade II and III(P=0.034,Mann-Whitney U test).Conclusion:The present study demonstrates that ^(99m)Tc-TF is a valuable radiotracer for head and neck cancer imaging.To determine the potential role of this imaging protocol in clinical practice will require a larger sample size. | Chrissa Sioka Thomas Exarchopoulos Vlasis Skloupiotis Vaios Papathanassiou Vasileios Ragos Maria Argyropoulou Anna Gousia Periklis Tsekeris Georgios Exarchakos Dimitrios Assimakopoulos Andreas Fotopoulos | 2016 | Journal of Cancer Metastasis and Treatment2016，2，1： | 1 |
| 9 | Improved Outcome of High-Risk Early HER2 Positive Breast Cancer With High CXCL13-CXCR5 Messenger RNA Expression显示文摘 | Evangelia Razis Konstantine T. Kalogeras Vassiliki Kotoula Anastasia G. Eleftheraki Nikitas Nikitas Ralf Kronenwett Eleni Timotheadou Christos Christodoulou Dimitrios Pectasides Helen Gogas Ralph M. Wirtz Thomas Makatsoris Dimitrios Bafaloukos Gerasimos A | 2012 | Clinical Breast Cancer2012，，3： | 1 |
| 10 | Emergency Liver Resection for Combined Biliary and Vascular Injury Following Laparoscopic Cholecystectomy: Case Report and Review of the Literature显示文摘 | Evangelos Felekouras Thomas Megas Othon P. Michail Ioannis Papaconstantinou Nikolaos Nikiteas Dimitrios Dimitroulis John Griniatsos Anastasios Tsechpenakis Gregorios Kouraklis | 2007 | Southern Medical Journal2007，，3： | 1 |
| 11 | Abnormal glyceraldehyde-3-phosphate dehydrogenase binding and glycolytic flux in autosomal dominant polycystic kidney disease after a mild oxidative stress 显示文摘 | Dioudis C Dimitrios G Thomas TH | 2008 | Hippokratia2008，12，3： | 1 |
| 12 | Effect of IGF-I on Healing of Colonic Anastomoses in Rats Under 5-FU Treatment显示文摘 | Emmanouil Zacharakis Haralampos Demetriades Manousos-Georgios Pramateftakis Ioannis Lambrou Evangelos Zacharakis Thomas Zaraboukas Georgios Koliakos Ioannis Kanellos Dimitrios Betsis | 2008 | Journal of Surgical Research2008，，1： | 1 |
| 13 | Contribution of Insulin-Like Growth Factor I to the Healing of Colonic Anastomoses in Rats显示文摘 | Emmanouil Zacharakis Haralampos Demetriades Dimitrios Kanellos Nikolaos Sapidis Evangelos Zacharakis Ioannis Mantzoros Ioannis Kanellos Georgios Koliakos Thomas Zaraboukas Konstantina Topouridou Dimitrios Betsis | 2007 | Investigative Surgery2007，，1： | 1 |
| 14 | Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: a subanalysis of the FAIR-HF trial显示文摘 | Gerasimos Filippatos Dimitrios Farmakis Josep Comin Colet Kenneth Dickstein Thomas F. Lüscher Ronnie Willenheimer John Parissis Giedrius Gaudesius Claudio Mori Barbara von Eisenhart Rothe Nicola Greenlaw Ian Ford Piotr Ponikowski Stefan D. Anker | 2013 | European Journal of Heart Failure2013，，11： | 1 |
| 15 | Current concepts in the diagnosis and management of type 1 gastric neuroendocrine neoplasms显示文摘 | Gregory Kaltsas Simona Grozinsky‐Glasberg Krystallenia I. Alexandraki Dimitrios Thomas Apostolos V. Tsolakis David Gross Ashley B. Grossman | 2014 | Clin Endocrinol2014，，2： | 1 |
| 16 | DDDR pacing results in left ventricular asynchrony with preservation of ejection fraction and NT-proBNP: A prospective study in sick sinus syndrome and normal ventricular function显示文摘 | Stavroula N. Psychari Thomas S. Apostolou Efstathios K. Iliodromitis Athanasios Charalampopoulos Dimitrios T. Kremastinos | 2009 | International Journal of Cardiology2009，，2： | 1 |
| 17 | Ordinary colorectal adenocarcinomavs. primary colorectal signet-ring cell carcinoma显示文摘 | Dimitrios Psathakis M.D. Thomas H. K. Schiedeck M.D. Florian Krug M.D. Elisabeth Oevermann M.D. Peter Kujath M.D. Hans-Peter Bruch M.D | 1999 | Diseases of the Colon & Rectum1999，，12： | 1 |
| 18 | Sonosurgery for atraumatic tooth extraction: A clinical report显示文摘 | Dimitrios E.V. Papadimitriou Alessandro Geminiani Thomas Zahavi Carlo Ercoli | 2012 | The Journal of Prosthetic Dentistry2012，，6： | 1 |
| 19 | Obstructive ileus due to a giant fibroepithelial polyp of the anus显示文摘Fibroepithelial polyps or hypertrophied anal papillae are essentially skin tags that project up from the dentate line and the junction between the skin and the epithelial lining of the anus. They are usually small in size, but sometimes they become enlarged, causing unexpected medical conditions. An extremely rare case of a giant hypertrophied anal papilla complicated by obstructive ileus is reported. Fibroepithelial anal polyp, despite its size, should be included in the differential diagnosis of a smooth mass located near the anal verge, especially in a patient with a history of chronic anal irritation or infection. | Ioannis Galanis Dimitrios Dragoumis Michail Tsolakis Konstantinos Zarampoukas Thomas Zarampoukas Konstantinos Atmatzidis | 2009 | World Journal of Gastroenterology2009，15，29： | 1 |
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