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| 1 | 新发贫血对慢性心力衰竭发病率和死亡率的影响:来自COMET研究的结果显示文摘Aims: Anaemia is a common comorbidity in chronic heart failure(CHF). The predictors of new onset anaemia(NOA) and its long-term prognostic value, particularly in patients treated with beta-blockers, are not known. Methods and results: In COMET, 3029 patients with CHF in NYHA Ⅱ-IV and EF< 35%were randomized to carvedilol or metoprolol tartrate and were followed for an average of 58 months. Plasma haemoglobin(Hb) concentrations were measured at a central laboratory at randomization, at four monthly intervals for the first year and annually thereafter. According to WHO criteria, anaemia was defined when Hb measured< 13 g/dL for men and< 12 g/dL for women. We considered anaemia to be severe when Hb< 11.5 g/dL for men and< 10.5 g/dL for women. The baseline mean Hb was 14.2±1.5 g/dL(n=2996) and 15.9%of patients had anaemia(males, 16.0%; females, 15.2%). At baseline, severe anaemia was found in 3.3%of patients(males, 3.6%; females, 2.0%). During the study, all-cause mortality(RR 1.47) death or hospitalization(RR 1.28), and heart failure hospitalization(RR 1.43, all P< 0.0001) were higher in anaemic when compared with non-anaemic patients. In patients without anaemia at baseline, at the end of the study, the cumulative frequency of NOA was 28.1%in males and 27.0%in females. NOA increased over time from 14.2%at year 1 to 27.5%at year 5. Predictors of NOA were: higher age, diuretic dose, creatinine(all P< 0.0001), higher serum potassium, lower serum sodium, body mass index, and use of aldosterone antagonists, carvedilol, and digitalis(all P< 0.03). Treatment with carvedilol(vs. metoprolol tartrate) was associated with a 24%increased risk to develop NOA(P=0.0047),but not severe anaemia(P=0.18). Patients with a Hb decrease of >3 g/dL(RR 3.37, P< 0.0001) or of 2.0-3.0 g/dL(RR 1.47, P=0.011) from baseline had an increased subsequent mortality when compared with patients having Hb increases of 0-1.0 g/dL. Conclusion: In stable ambulatory CHF patients, development of NOA is frequent and can be predicted by a set of clinical variables. Decreases in Hb over time relate to future increased morbidity and mortality. | Komajda M. Anker S.D. Charlesworth A. 郭俊 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 14 |
| 2 | Definition and classification of cancer cachexia: an international consensus显示文摘 | Kenneth Fearon Florian Strasser Stefan D Anker Ingvar Bosaeus Eduardo Bruera Robin L Fainsinger Aminah Jatoi Charles Loprinzi Neil MacDonald Giovanni Mantovani Mellar Davis Maurizio Muscaritoli Faith Ottery Lukas Radbruch Paula Ravasco Declan Walsh Andrew | 2011 | Lancet Oncology2011，，5： | 8 |
| 3 | Darbepoetin α对有症状性慢性心力衰竭伴贫血患者运动耐量的影响:一项随机、双盲、安慰剂对照试验显示文摘目的:本研究旨在观察darbepoetin α(一种红细胞生成刺激蛋白,ESP)能否改善有症状性慢性心力衰竭(CHF)伴贫血患者的运动耐量。背景:贫血在CHF患者中较为常见。方法:在此项多中心、随机、双盲、安慰剂对照研究中,伴有贫血(血红蛋白90~120g/L)的CHF患者接受安慰剂(n=22)或darbepoetind(n=19)皮下注射,初始剂量为0.75μg/kg,每2周1次,持续26周。主要终点是从基线到27周时以峰值耗氧量[ml/(min·kg体重)】测量的运动耐量的变化。其他终点包括:绝对峰值耗氧量、运动持续时间以及健康相关生活质量的变化。 | Ponikowski P. Anker S.D. Szachniewicz J. K.McDonald 韩瑞娟 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，3，7： | 4 |
| 4 | Oxy-fuel combustion of solid fuels显示文摘 | Maja B. Toftegaard Jacob Brix Peter A. Jensen Peter Glarborg Anker D. Jensen | 2010 | Progress in Energy and Combustion Science2010，，5： | 3 |
| 5 | Neutal Carrier Based Ion-Selective Electrode for the Determination of Total Calcium in Blood Serum显示文摘 | Anker P Wieland E Ammann D | 1981 | J anal Chem1981，53，13： | 2 |
| 6 | The burden of chronic obstructive pulmonary disease in patients hospitalized with heart failure显示文摘 | Mitja Lainscak Lea Majc Hodoscek Hans-Dirk Düngen Mathias Rauchhaus Wolfram Doehner Stefan D. Anker Stephan von Haehling | 2009 | Wiener klinische Wochenschrift (-)2009，，9： | 2 |
| 7 | Neurohormonal activation and inflammation in chronic cardiopulmonary disease: a brief systematic review显示文摘 | Wolfram Doehner Stephan von Haehling Stefan D. Anker Mitja Lainscak | 2009 | Wiener klinische Wochenschrift (-)2009，，9： | 2 |
| 8 | The role of inflammatory mediators in chronic heart failure: Cytokines,nitric oxide,and endothelin-l 显示文摘 | Sharma R Coats AJ Anker SD | 2000 | Int J Cardiol2000，72，2： | 2 |
| 9 | Peripheral Chemoreceptor Hypersensitivity: An Ominous Sign in Patients With Chronic Heart Failure显示文摘 | Piotr Ponikowski Tuan Peng Chua Stefan D. Anker Darrel P. Francis Wolfram Doehner Waldemar Banasiak Phillip A. Poole-Wilson Massimo F. Piepoli Andrew J.S. Coats | 2001 | Circulation: Journal of the American Heart Association2001，，： | 2 |
| 10 | The role of inflammatory mediators in chronic heart failure:cytokines,nitric oxide,and endothelin-1显示文摘 | Sharma R Coats AJ Anker SD | | 0，，： | 2 |
| 11 | Engineered RNA-mediated resistance to tomato spotted wilt virus is sequence specific显示文摘 | DE OLIEEIRA RESENDE R ANKER C | 1996 | Mol Plant-Microbe Interact1996，9，： | 1 |
| 12 | Statins and the role of nitric oxide in chronic heart failure 显示文摘 | Haehhng S Anker SD Bassenge E | 2003 | Heart Fail Rev2003，8，： | 1 |
| 13 | Elevatedsoluble CD14 receptors and altered cytokines in chronic heartfailure 显示文摘 | ANKER S D EGERER K R VOLK H D | 1997 | Am J Cardiol1997，79，10： | 1 |
| 14 | Cardio-renal syndromes:report from the consensus conference of the acute dialysis quality initiative显示文摘 | Ronco C McCullough P Anker SD | | 0，，： | 1 |
| 15 | ESPEN Guidelines on P-arenteral Nutrition:on cardiology and pneumology显示文摘 | Anker SD Laviano A Filippatos G | | 0，，04： | 1 |
| 16 | Biosensing with plasmonic nanosensors显示文摘 | ANKER J N HALL W P LYANDRES O | 2008 | Nat Mater2008，7，6： | 1 |
| 17 | Consensus definition of sarcopenia, cachexia and pre - eachexia : joint document elaborated by special interest groups ( SIG ) ' caehexia - anorexia in chronic wasting diseases' and 'nutrition in geriatrics' 显示文摘 | Masearitofi M Anker S D Argiles J | 2010 | Clin Nutr2010，29，2： | 1 |
| 18 | Metabolic impairment in heart failure: the myocardial and systemic perspective 显示文摘 | D()EHNER W FRENNEAUX M ANKER S I) | 2014 | J Am Coll Cardiol2014，64，13： | 1 |
| 19 | High plasma concentration of factor Ⅷ:C is a major risk factor for venous显示文摘 | ANKER PS KOOPMAN MMW | 2000 | Thromb Haemost2000，83，： | 1 |
| 20 | Improved water vapor barrier of whey protein films by addition of an acetylated mono glyceride显示文摘 | Jonas Berntsen Anne-Marie Hermansson Mats Stading | 2002 | Innovative Food Science & Emerging Technologies2002，3，： | 1 |
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