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| 1 | Factors influencing teamwork and collaboration within a tertiary medical center显示文摘AIM: To understand how work climate and related factors influence teamwork and collaboration in a large medical center. METHODS: A survey of 3462 employees was conducted to generate responses to Sexton's Safety Attitudes Questionnaire(SAQ) to assess perceptions of work environment via a series of five-point, Likert-scaled questions. Path analysis was performed, using teamwork(TW) and collaboration(CO) as endogenous variables. The exogenous variables are effective communication(EC), safety culture(SC), job satisfaction(JS), work pressure(PR), and work climate(WC). The measure-ment instruments for the variables or summated subscales are presented. Reliability of each sub-scale are calculated. Alpha Cronbach coefficients are relatively strong: TW(0.81), CO(0.76), EC(0.70), SC(0.83), JS(0.91), WP(0.85), and WC(0.78). Confirmatory factor analysis was performed for each of these constructs. RESULTS: Path analysis enables to identify statistically significant predictors of two endogenous variables, teamwork and intra-organizational collaboration. Significant amounts of variance in perceived teamwork(R2 = 0.59) and in collaboration(R2 = 0.75) are accounted for by the predictor variables. In the initial model, safety culture is the most important predictor of perceived teamwork, with a β weight of 0.51, and work climate is the most significant predictor of collaboration, with a β weight of 0.84. After eliminating statistically insignificant causal paths and allowing correlated predictors1, the revised model shows that work climate is the only predictor positively influencing both teamwork(β = 0.26) and collaboration(β = 0.88). A relatively weak positive(β = 0.14) but statistically significant relationship exists between teamwork and collaboration when the effects of other predictors are simultaneously controlled.CONCLUSION: Hospital executives who are interested in improving collaboration should assess the work climate to ensure that employees are operating in a setting conducive to intra-organizational collaboration. | Shu Feng Chien Thomas TH Wan Yu-Chih Chen | 2012 | World Journal of Methodology2012，2，2： | 4 |
| 2 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 3 | The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke显示文摘 | Christa Th?ne-Reineke Christian Neumann Pawel Namsolleck Kristin Schmerbach Maxim Krikov Jan H Schefe Kristin Lucht Heide H?rtnagl Michael Godes Susanne Müller Kay Rumschüssel Heiko Funke-Kaiser Arno Villringer U Muscha Steckelings Thomas Unger | 2008 | Journal of Hypertension2008，，12： | 2 |
| 4 | Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer’s disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology显示文摘 | Hans-Joachim Lüth Max Holzer Ulrich G?rtner Matthias Staufenbiel Thomas Arendt | 2001 | Brain Research2001，，1： | 1 |
| 5 | Hypertension and hyperkalaemia responding to bendrofluazide显示文摘 | Lee MR Ball SG Thomas TH | | 0，，： | 1 |
| 6 | An analytically predictive model for moderately rarefied gas flow显示文摘 | Veltzke Thomas Th?ming Jorg | 2012 | Journal of Fluid Mechanics2012，，： | 1 |
| 7 | Effect of solution treatment temperatures on microstructure, tensile and fracture properties of Co-free 18Ni maraging steel显示文摘 | Thomas Th arin | 1994 | Steel Research1994，65，11： | 1 |
| 8 | The world of tent-making bats 显示文摘 | Kunz TH Thomas H | 1994 | Sping1994，12，1： | 1 |
| 9 | Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Prehypertension: Relation to Endothelial Dysfunction显示文摘 | Giovanna Giannotti Carola Doerries Pavani S. Mocharla Maja F. Mueller Ferdinand H. Bahlmann Tibor Horvàth Hong Jiang Sajoscha A. Sorrentino Nora Steenken Costantina Manes Mario Marzilli K. Lenhard Rudolph Thomas F. Lüscher Helmut Drexler Ulf Landmesser | 2010 | Hypertension2010，，6： | 1 |
| 10 | Cohort profile:the Guangzhou Biobank Cohort Study,a Guangzhou-Hong Kong-Birmingham collaboration显示文摘 | Jiang C Thomas GN Lam TH | | 0，，： | 1 |
| 11 | Aldosterone antagonism in chronic kidney disease 显示文摘 | PONDA MP HOSTETTER TH THOMAS H | 2006 | Clin J Am Soc Nephrol2006，1，4： | 1 |
| 12 | BMI1 , The polycomb‐group gene, is recurrently targeted by genomic rearrangements in progressive B‐cell leukemia/lymphoma显示文摘 | Leila Rouhigharabaei Julio Finalet Ferreiro Natalie Put Lucienne Michaux Thomas Tousseyn Christine Lefebvre Anne Gardiner Wim Kelver Hilde Demuynck Johan Verschuere Ivan Théate Carmen Vicente Peter Vandenberghe Jan Cools Iwona Wlodarska | 2013 | Genes Chromosomes Cancer2013，，10： | 1 |
| 13 | Notch signaling regulates smooth muscle differentiation of epicardium-derived cells显示文摘 | Thomas G Carsten R Lüdtke TH | 2011 | Circ Res2011，108，7： | 1 |
| 14 | Lipids lowering therapy leads to a reducation in sodium-lithium countertransport activity显示文摘 | Carr SJ Thomas TH Laker MF | 1991 | Atherosclerosis1991，，87： | 1 |
| 15 | Impaired neutrophil store- mediated calcium entry in Type 2 diabetes 显示文摘 | Advani A Marshall SM Thomas TH | 2004 | Eur J Clin Invest2004，34，1： | 1 |
| 16 | Anti-inflammatory effect and modulation of cytochrome P450 activities by Artemisia annua tea infusions in human intestinal Caco-2 cells显示文摘 | Pedro Melillo de Magalh?es Isabelle Dupont Aurélie Hendrickx Aurélie Joly Thomas Raas Stéphanie Dessy Thérèse Sergent Yves-Jacques Schneider | 2012 | Food Chemistry2012，，2： | 1 |
| 17 | Functional outcome of the foot and ankle after free fibular graft显示文摘 | Daniels TR Thomas R Bell TH | 2005 | Foot Ankle Int2005，26，8： | 1 |
| 18 | Cohort profile: The Guangzhou Biobank Cohort Study, a Guangzhou-Hong Kong-Birmingham collab- oration显示文摘 | Jiang C Thomas GN Lam TH | 2006 | Int J Epidemiol2006，35，4： | 1 |
| 19 | Angiotensin Type 2 Receptor Stimulation Ameliorates Left Ventricular Fibrosis and Dysfunction via Regulation of Tissue Inhibitor of Matrix Metalloproteinase 1/Matrix Metalloproteinase 9 Axis and Transforming Growth Factor β1 in the Rat Heart显示文摘 | Dilyara Lauer Svetlana Slavic Manuela Sommerfeld Christa Th?ne-Reineke Yuliya Sharkovska Anders Hallberg Bjorn Dahl?f Ulrich Kintscher Thomas Unger Ulrike Muscha Steckelings Elena Kaschina | 2014 | Hypertension2014，，3： | 1 |
| 20 | Impaired neutrophil store-mediated calcium entry in Type 2 diabetes显示文摘 | Advani A Marshall SM Thomas TH | 2004 | Eur J Clin Invest2004，34，1： | 1 |
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