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| 1 | Low rectal cancer:Sphincter preserving techniques-selection of patients,techniques and outcomes显示文摘Low rectal cancer is traditionally treated by abdominoperineal resection. In recent years, several new techniques for the treatment of very low rectal cancer patients aiming to preserve the gastrointestinal continuity and to improve both the oncological as well as the functional outcomes, have been emerged. Literature suggest that when the intersphincteric resection is applied in T1-3 tumors located within 30-35 mm from the anal verge, is technically feasible, safe, with equal oncological outcomes compared to conventional surgery and acceptable quality of life. The Anterior Perineal Plan E for Ultra-low Anterior Resection technique, is not disrupting the sphincters, but carries a high complication rate, while the reports on the oncological and functional outcomes are limited. Transanal Endoscopic Micro Surgery(TEM) and Trans Anal Minimally Invasive Surgery(TAMIS) should represent the treatment of choice for T1 rectal tumors, with specific criteria according to the NCCN guidelines and favorable pathologic features. Alternatively to the standard conventional surgery, neoadjuvant chemo-radiotherapy followed by TEM or TAMIS seems promising for tumors of a local stage T1sm2-3 or T2. Transanal Total Mesorectal Excision should be performed only when a board approved protocol is available by colorectal surgeons with extensive experience in minimally invasive and transanal endoscopic surgery. | Nikoletta Dimitriou Othon Michail Dimitrios Moris John Griniatsos | 2015 | World Journal of Gastrointestinal Oncology2015，7，7： | 13 |
| 2 | Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients显示文摘AIM: To determine the frequency of occult hepatitis B infection(OHBI) in a group of human immunodeficiency virus(HIV)-1+/ hepatitis B surface antigen negative(HBsAg)- patients from Mexico. METHODS: We investigated the presence of OHBI in 49 HIV-1+/HBsAg- patients. Hepatitis B virus(HBV) DNA was analyzed using nested PCR to amplify the Core(C) region and by real-time PCR to amplify a region of the S and X genes. The possible associations between the variables and OHBI were investigated using Pearson's χ2 and/or Fisher's exact test.RESULTS: We found that the frequency of OHBI was 49% among the group of 49 HIV-1+/HBsAg- patients studied. The presence of OHBI was significantly associated with the HIV-1 RNA viral load [odds ratio(OR) = 8.75; P = 0.001; 95%CI: 2.26-33.79] and with HIVantiretroviral treatment with drugs that interfere with HBV replication(lamivudine, tenofovir or emtricitabine)(OR = 0.25; P = 0.05; 95%CI: 0.08-1.05). CONCLUSION: The OHBI frequency is high among 49 Mexican HIV-1+/HBsAg- patients and it was more frequent in patients with detectable HIV RNA, and less frequent in patients who are undergoing HIV-ARV treatment with drugs active against HBV. | Ma Teresa Alvarez-Muoz Angelica Maldonado-Rodriguez Othon Rojas-Montes Rocio Torres-Ibarra Fernanda Gutierrez-Escolano Guillermo Vazquez-Rosales Alejandro Gomez Onofre Muoz Javier Torres Rosalia Lira | 2014 | World Journal of Gastroenterology2014，20，37： | 3 |
| 3 | Complete mesocolic excision: Techniques and outcomes显示文摘Complete mesocolic excision(CME) for the treatment of colon cancer was first introduced in the West in 2008. The first aim of this procedure is to remove the afflicted colon and its accessory lymphovascular supply by resecting the colon and mesocolon in an intact envelope of visceral peritoneum, which holds potentiallyinvolved lymph nodes. The second component of CME is a central vascular tie to remove completely all lymph nodes in the central(vertical) direction. In its original iteration, CME was performed via laparotomy, although many centers preferentially perform laparoscopic surgery, with its associated benefits and similar oncolo-gical outcomes, as the standard treatment for colonic cancer. Here, we present the surgical techniques for CME in open and laparoscopic surgery, as well as the surgical, pathological and oncological outcomes of the procedure that are available to date. Because there are no randomized control trials comparing CME to 'standard' colon surgery, the principles underlying CME seem anatomical and logical, and the results published from the Far East, reporting an 80% 5-year survival rate for Stage III cancer, should guide us. | Nikoletta Dimitriou Othon Michail Dimitrios Moris John Griniatsos | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 2 |
| 4 | Occult hepatitis B virus co-infection in human immunodeficiency virus-positive patients: A review of prevalence, diagnosis and clinical significance显示文摘The prevalence of human immunodeficiency virus(HIV) and hepatitis B virus(HBV) co-infection is high as they share similar mechanisms of transmission. The development and widespread use of highly sensitive tests for HBV diagnosis has demonstrated that a significant proportion of apparently healthy individuals with evidence of exposure to HBV continue to carry fully functional HBV DNA in their hepatocytes, a situation that predisposes them to the development of progressive liver disease and hepatocellular carcinoma. The presence of co-infections frequently influences the natural evolution of each of the participating infections present by either facilitating their virulence or competing for resources. Furthermore, the drugs used to treat these infections may also contribute to changes in the natural course of these infections, making the analysis of the impact of co-infection more difficult. The majority of studies has examined the impact of HIV on overt chronic hepatitis B, finding that co-infection carries an increased risk of progressive liver disease and the development of hepatocellular carcinoma. Although the effect of HIV on the natural history of occult hepatitis B infection(OBI) has not been fully assessed, all available data suggest a persisting risk of repeated flares of hepatitis and progressive liver disease. We describe studies regarding the diagnosis, prevalence and clinical significance of OBI in HIVpositive patients in this short review. Discrepancies in worldwide prevalence show the urgent need for the standardization of diagnostic criteria, as established by the Taormina statements. Ideally, standardized protocols for testing should be employed to enable the comparison of data from different groups. Additional studies are needed to define the differences in risk for OBI without HIV and in HIV-HBV co-infected patients with or without overt disease. | Angelica Maldonado-Rodriguez Ana Maria Cevallos Othon Rojas-Montes Karina Enriquez-Navarro Ma Teresa Alvarez-Mu?oz Rosalia Lira | 2015 | World Journal of Hepatology2015，7，2： | 2 |
| 5 | Appendiceal neuroendocrine tumors: Recent insights and clinical implications显示文摘New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors(NETs),which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma.The clinical implication of that knowledge reflected to surgical strategies which also vary from simple appendicectomy to radical abdominal procedures based on specific clinical and histological characteristics.Since the diagnosis is usually established post-appendicectomy,current recommendations focus on the early detection of:(1)the subgroup of patients who require further therapy;(2)the recurrence based on the chromogranin a plasma levels;and(3)other malignancies which are commonly developed in patients with appendiceal NETs. | John Griniatsos Othon Michail | 2010 | World Journal of Gastrointestinal Oncology2010，2，4： | 2 |
| 6 | Lymph node,peritoneal and bone marrow micrometastases in gastric cancer:Their clinical significance显示文摘The 7th TNM classification clearly states that micro-metastases detected by morphological techniques(HE stain and immunohistochemistry) should always be reported and calculated in the staging of the disease(pN1mi or M1),while patients in whom micrometas-tases are detected by non-morphological techniques(e.g.,ow cytometry,reverse-transcriptase polymerase chain reaction) should still be classif ied as N0 or M0.In gastric cancer patients,micrometastases have been de-tected in lymph nodes,the peritoneal cavity and bone marrow.However,the clinical implications and/or their prognostic signif icance are still a matter of debate.Cur-rent literature suggests that lymph node micrometasta-ses should be encountered for the loco-regional staging of the disease,while skip lymph node micrometastases should also be encountered in the total number of infiltrated lymph nodes.Peritoneal fluid cytology ex-amination should be obligatorily performed in pT3 or pT4 tumors.A positive cytology classif ies gastric cancer patients as stage Ⅳ.Although a curative resection is not precluded,these patients face an overall dismal prognosis.Whether patients with a positive cytology should be treated similarly to patients with macroscopic peritoneal recurrence should be evaluated further.Gas-tric cancer cells are detected with high incidence in the bone marrow.However,the published results make comparison of data between groups almost impossible due to severe methodological problems.If these meth-odological problems are overcome in the future,specif ic target therapies may be designed for specif ic groups of patients. | John Griniatsos Othon Michail Nikoletta Dimitriou Ioannis Karavokyros | 2012 | World Journal of Gastrointestinal Oncology2012，4，2： | 1 |
| 7 | Tungsten-containing amorphous carbon films deposited by pulsed vacuum arc显示文摘 | MONTEIRO OTHON R DELPLANCKE-OGLETREE MARIE-PAULE BROWN G | 1999 | Thin Solid Films1999，342，： | 1 |
| 8 | Transfer of quinolone resistance gene qnrA1 to Escherichia coli through a 50 kb conjugative plasmid resulting from the splitting of a 300 kb plasmid显示文摘 | Ulises Garza-Ramos Humberto Barrios Maria Jose Hernandez-Vargas Teresa Rojas-Moreno Fernando Reyna-Flores Perla Tinoco Victor Othon Laurent Poirel Patrice Nordmann Vincent Cattoir Guillermo Ruiz-Palacios Jose Luis Fernandez Rosa Isela Santamaria Patricia | 2012 | Journal of Antimicrobial Chemotherapy2012，，7： | 1 |
| 9 | Single-cell printing to form three-dimensional lines of olfactory ensheathing ceils 显示文摘 | Othon CM Wu X Anders JJ | 2008 | Biomed Mater2008，3，03： | 1 |
| 10 | Ferroelectric polymer Langmuir-Blodgett films nonvolatile memory applications显示文摘 | Ducharme S Reece T J Othon C M | 2005 | IEEE Transaction on device and materials reliability2005，5，4： | 1 |
| 11 | Misorientation mapping for visualization of plastic deformation via electron back-scattered diffraction 显示文摘 | Brewer L N Othon M A Young L M Angeliu T M | 2006 | Microscopy and Microanalysis2006，12，1： | 1 |
| 12 | EBSD characterization of residual plastic strain across alloy 182 weld joints 显示文摘 | Othon M A Morra M M | 2005 | Microsc Microanal2005，11，2： | 1 |
| 13 | The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α显示文摘 | Lei Zhong Agustina D’Urso Debra Toiber Carlos Sebastian Ryan E. Henry Douangsone D. Vadysirisack Alexander Guimaraes Brett Marinelli Jakob D. Wikstrom Tomer Nir Clary B. Clish Bhavapriya Vaitheesvaran Othon Iliopoulos Irwin Kurland Yuval Dor Ralph Weissle | 2010 | Cell2010，，2： | 1 |
| 14 | Emergency Liver Resection for Combined Biliary and Vascular Injury Following Laparoscopic Cholecystectomy: Case Report and Review of the Literature显示文摘 | Evangelos Felekouras Thomas Megas Othon P. Michail Ioannis Papaconstantinou Nikolaos Nikiteas Dimitrios Dimitroulis John Griniatsos Anastasios Tsechpenakis Gregorios Kouraklis | 2007 | Southern Medical Journal2007，，3： | 1 |
| 15 | Autologous Transplantation of Adipose-Derived Stem Cells Enhances Skin Graft Survival and Wound Healing in Diabetic Rats显示文摘 | Aggeliki Zografou Othon Papadopoulos Christos Tsigris Nikolaos Kavantzas Efstathios Michalopoulos Theofanis Chatzistamatiou Andreas Papassavas Catherine Stavropoulou-Gioka Ismini Dontas Despoina Perrea | 2013 | Annals of Plastic Surgery2013，，2： | 1 |
| 16 | Investigation of non-hydrogena-ed DLC:Si prepared by cathodic arc显示文摘 | MONTEIRO OTHON R DELPLANCKE-OGLETREE MARIE-PAULE | 2003 | Surf Coat Technol2003，，： | 1 |
| 17 | Investigation of nonhydrogenated DLC:Si Prepared by cathodic arc显示文摘 | Othon R.Monteriro Marie Paule | | 0，，： | 1 |
| 18 | The Compressible Calibration of Miniature Multi-Hole Probes显示文摘 | Espen S J Othon K R Greg J | 2001 | Journal of Fluids Engineering2001，123，： | 1 |
| 19 | activated ADF/cofilin sequesters phosphorylated microtubule-associated-protein during the assembly fo Alzheimer-like neuritic cytoskeletal striations显示文摘 | Ineka TW Othon LG Karen MC | 2009 | J Neurosci2009，29，12： | 1 |
| 20 | Tungsten-containing amorphous carbon films deposited by pulsed vacuum arc 显示文摘 | MONTEIO OTHON R DELPLANCKE-OGLETREE MARIE-PAULE BROWN IAN G | 1999 | Thin Solid Films1999，342，： | 1 |
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