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| 1 | Different profiles of cytokine expression during mild and severe acute pancreatitis显示文摘AIM:To study secretion patterns of proand anti-in-flammatory cytokines, and activation of various cellular subsets of leukocytes in peripheral blood.METHODS: We have conducted a prospective obser-vational study. One hundred and eight patients with a diagnosis of acute pancreatitis and onset of the disease within last 72 h were included in this study. The mRNA expression of 25 different types of cytokines in white blood cells was determined by quantitative real time polymerase chain reaction. Levels of 8 different cytokines in blood serum were measured by enzymelinked immunosorbent assay. Clinical data and cytokine expression results were subjected to statistical analysis.RESULTS: Severe and necrotizing acute pancreatitis (AP) is characterized by the significant depletion of circulating lymphocytes. Severe acute pancreatitis is as-sociated with a typical systemic inflammatory response syndrome and over-expression of pro-inflammatory cy-tokines [interleukin (IL)-6, IL-8, macrophage migration inhibitory factor (MIF)]. Serum IL-6 and MIF concentra-tions are the best discriminators of severe and necrotiz-ing AP as well as possible fatal outcome during the early course of the disease. CONCLUSION: Deregulation of cellular immune sys-tem is a key event leading to severe and necrotizing AP. IL-6 and MIF could be used as early predictors of complications. | Zilvinas Dambrauskas Nathalia Giese Antanas Gulbinas Thomas Giese Pascal O Berberat Juozas Pundzius Giedrius Barauskas Helmut Friess | 2010 | World Journal of Gastroenterology2010，16，15： | 49 |
| 2 | Early recognition of abdominal compartment syndrome in patients with acute pancreatitis显示文摘AIM:To assess the value of widely used clinical scores in the early identification of acute pancreatitis(AP) patients who are likely to suffer from intra-abdominal hypertension(IAH)and abdominal compartment syndrome(ACS). METHODS:Patients(n=44)with AP recruited in this study were divided into two groups(ACS and non-ACS) according to intra-abdominal pressure(IAP)determined by indirect measurement using the transvesical route via Foley bladder catheter.On admission and at regular intervals,the severity of the AP and presence of organ dysfunction were assessed utilizing different multifactorial prognostic systems:Glasgow-Imrie score,Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE-Ⅱ)score,and Multiorgan Dysfunction Score(MODS).The diagnostic performance of scores predicting ACS development,cut-off values and specificity and sensitivity were established using receiver operating characteristic(ROC)curve analysis. RESULTS:The incidence of ACS in our study population was 19.35%.IAP at admission in the ACS group was 22.0(18.5-25.0)mmHg and 9.25(3.0-12.4)mmHg in the non-ACS group(P<0.01).Univariate statistical analysis revealed that patients in the ACS group had significantly higher multifactorial clinical scores(APACHE Ⅱ,Glasgow-Imrie and MODS)on admission and highermaximal scores during hospitalization(P<0.01).ROC curve analysis revealed that APACHEⅡ,Glasgow-Imrie, and MODS are valuable tools for early prediction of ACS with high sensitivity and specificity,and that cut- off values are similar to those used for stratification of patients with severe acute pancreatitis(SAP). CONCLUSION:IAH and ACS are rare findings in patients with mild AP.Based on the results of our study we recommend measuring the IAP in cases when patients present with SAP(APACHEⅡ>7;MODS>2 or Glasgow-Imrie score>3). | Zilvinas Dambrauskas Audrius Parseliunas Antanas Gulbinas Juozas Pundzius Giedrius Barauskas | 2009 | World Journal of Gastroenterology2009，15，6： | 32 |
| 3 | How severe is moderately severe acute pancreatitis? Clinical validation of revised 2012 Atlanta Classification显示文摘AIM To explore the outcomes and the appropriate treatment for patients with moderately severe acute pancreatitis(AP).METHODS Statistical analysis was performed on data from the prospectively collected database of 103 AP patients admitted to the Department of Surgery,Hospital of Lithuanian University of Health Sciences in 2008-2013. All patients were confirmed to have the diagnosis of AP during the first 24 h following admission. The severity of pancreatitis was assessed by MODS and APACHE Ⅱ scale. Clinical course was re-evaluated after 24,48 and 72 h. All patients were categorized into 3 groups based on Atlanta 2012 classification: Mild,moderately severe,and severe.Outcomes and management in moderately severe group were also compared to mild and severe cases according to Atlanta 1992 and 2012 classification.RESULTS Fifty-three-point four percent of patients had edematous while 46.6 % were diagnosed with necrotic AP. The most common cause of AP was alcohol(42.7%) followed by alimentary(26.2%),biliary(26.2%) and idiopathic(4.9%). Under Atlanta 1992 classification 56(54.4%) cases were classified as 'mild' and 47(45.6%) as 'severe'. Using the revised classification(Atlanta 2012),the patient stratification was different: 49(47.6%) mild,27(26.2%) moderately severe and 27(26.2%) severe AP cases. The two severe groups(Atlanta 1992 and Revised Atlanta 2012) did not show statistically significant differences in clinical parameters,including ICU stay,need for interventional treatment,infected pancreatic necrosis or mortality rates. The moderately severe group of 27 patients(according to Atlanta 2012) had significantly better outcomes when compared to those 47 patients classified as severe form of AP(according to Atlanta 1992) with lower incidence of necrosis and sepsis,lower APACHE Ⅱ(P = 0.002) and MODS(P = 0.001) scores,shorter ICU stay,decreased need for interventional and surgical treatment.CONCLUSION Study shows that Atlanta 2012 criteria are more accurate,reduce unnecessary treatments for patients with mild and moderate severe pancreatitis,potentially resulting in health costs savings. | Povilas Ignatavicius Aiste Gulla Karolis Cernauskis Giedrius Barauskas Zilvinas Dambrauskas | 2017 | World Journal of Gastroenterology2017，23，43： | 16 |
| 4 | Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells显示文摘AIM To investigate the response to hyperthermia and chemotherapy, analyzing apoptosis, cytotoxicity, and cisplatin concentration in different digestive system cancer cells.METHODS AGS(gastric cancer cell line), Caco-2(colon cancer cell line) and T3M4(pancreatic cancer cell line) were treated by cisplatin and different temperature setting(37 ℃ to 45 ℃) either in isolation, or in combination. Treatment lasted for one hour. 48 h after the treatment viability was evaluated by MTT, cell apoptosis by Annexin V-PE and 7 ADD flow cytometry. Intracellular cisplatin concentration was measured immediately after the treatment, using mass spectrometry. Isobologram analysis was performed to evaluate the mathematical combined effect of temperature and cisplatin.RESULTS AGS cells were the most sensitive to isolated application of hyperthermia. Hyperthermia, in addition to cisplatin treatment, did not provoke a synergistic effect at intervals from 37 ℃ to 41 ℃ in neither cancer cell line. However, a temperature of 43 ℃ enhanced cisplatin cytotoxicity for Caco-2 cells. Moreover, isobologram analysis revealed mathematical antagonistic effects of cisplatin and temperature combined treatment in AGS cells; variations between synergistic, additive, and antagonistic effects in Caco-2 cells; and additive and antagonistic effects in T3 M4 cells. Combined treatment enhanced initiation of cell apoptosis in AGS, Caco-2, and T3 M4 cells by 61%, 20%, and 19% respectively. The increase of intracellular cisplatin concentration was observed at 43 ℃ by 30%, 20%, and 18% in AGS, Caco-2, and T3 M4 cells, respectively.CONCLUSION In addition to cisplatin, hyperthermia up to 43 ℃ does not affect the viability of cancer cells in a synergistic manner. | Vaidotas Cesna Arturas Sukovas Aldona Jasukaitiene Rima Naginiene Giedrius Barauskas Zilvinas Dambrauskas Saulius Paskauskas Antanas Gulbinas | 2018 | World Journal of Gastroenterology2018，24，10： | 6 |
| 5 | Towards sustainable rural development in Central and Eastern Europe:Applying land consolidation显示文摘 | GIEDRIUS PASAKARNIS VIDA MALIENE | 2010 | Land Use Policy2010，，27： | 1 |
| 6 | Toward sustainable rural development in central land Eastern Europe: Applying land consolidation显示文摘 | Giedrius Pagakarnis Vida Maliene | 2010 | Land Use Policy2010，27，2： | 1 |
| 7 | The effects of anesthesia, mouse strain and age on intraocular pressure and an improved murine model of experimental glaucoma显示文摘 | Frances E. Cone Matthew R. Steinhart Ericka N. Oglesby Giedrius Kalesnykas Mary E. Pease Harry A. Quigley | 2012 | Experimental Eye Research2012，，： | 1 |
| 8 | Tumor-related factors and patient’s age influence survival after resection for ampullary adenocarcinoma显示文摘 | Giedrius Barauskas Antanas Gulbinas Darius Pranys Zilvinas Dambrauskas Juozas Pundzius | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，4： | 1 |
| 9 | Towards sustainable rural develop-ment in Central and Eastern Europe: Applying land con-solidation 显示文摘 | Giedrius P Vida M | 2010 | Land Use Policy2010，27，2： | 1 |
| 10 | Towards sustainable rural development in central and eastern europe:applying land con-solidation显示文摘 | Giedrius Paˇsakarnis Vida Maliene | | 0，，27： | 1 |
| 11 | Cas3 is a single-stranded DNA nuclease and ATP-de pendent helicase in the CRISPR/Cas immune system 显示文摘 | TOMAS S GIEDRIUS G CHRISTOPHE F | 2011 | The EMBO Journal2011，30，： | 1 |
| 12 | Towards sustainable rural development in Central and Eastern Europe: Applying land consolidation显示文摘 | Giedrius Pasakamis Vida Maliene | 2010 | Land Use Policy2010，，27： | 1 |
| 13 | Towards sustainable rural de- velopment in Central and Eastern Europen: Applying land con- solidation显示文摘 | Giedrius Pasakarnis Vida Maliene | 2010 | Land Use Policy2010，27，2： | 1 |
| 14 | Towards sustainable rural development in Central and Eastern Europe: applying land consolidation 显示文摘 | Giedrius Pasakarnis Vida Maliene | 2010 | Land Use Policy2010，27，： | 1 |
| 15 | Value of the different prognostic systems and biological markers for predicting severity and progression of acute pancreatitis显示文摘 | Zilvinas Dambrauskas Antanas Gulbinas Juozas Pundzius Giedrius Barauskas | 2010 | Scandinavian Journal of Gastroenterology (-)2010，，7： | 1 |
| 16 | Finite element model- ing of cooled - tip probe radiofrequency ablation processes in liver is- sue显示文摘 | Rimantas B Antanas G Tomas V Giedrius B | 2008 | Comput Biol Med2008，38，6： | 1 |
| 17 | Obtaining of high surface roughness copper deposits by electroless plating technique显示文摘 | EUGENIJUS N ALGIRDAS V JANE J IRENA S GIEDRIUS S | 2006 | Electrochemical Acta2006，51，： | 1 |
| 18 | Rural development and challenges establishing sustainable land use in Eastern European countries显示文摘 | Giedrius PaVsakarnis David Morley Vida Malien | 2013 | Land Use Policy2013，30，1： | 1 |
| 19 | Influence of formwork surface on the orientation of steel fibers within self-compacting concrete and on the mechanical properties of east structural element显示文摘 | Oldrich Svec Giedrius Zirgulis | 2014 | Cement Concrete Composite2014，50，： | 1 |
| 20 | Incidence and precipitating factors of delirium after coronary artery bypass grafting显示文摘 | Ieva Norkiene Donata Ringaitiene Irina Misiuriene Robertas Samalavicius Rimas Bubulis Alis Baublys Giedrius Uzdavinys | 2007 | Scandinavian Cardiovascular Journal2007，，3： | 1 |
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