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| 1 | Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients显示文摘AIM: To develop a multiplex reverse transcription polymerase chain reaction (RT-PCR) method detecting cir-culating tumor cells in the peripheral blood of colorectal cancer (CRC) patients. METHODS: Peripheral blood samples were collected from 88 CRC patients and 40 healthy individuals from the blood donors' clinic and subsequently analyzed by multiplex RT-RCR for the expression of carcinoembryonic antigen (CEA), cytokeratin 20 (CK20) and epidermal growth factor receptor (EGFR) mRNA. The analysis involved determining the detection rates of CEA, CK20 and EGFR transcripts vs disease stage and overall survival. Median follow-up period was 19 mo (range 8-28 mo). RESULTS: Rates of CEA, CK20 and EGFR detection in CRC patients were 95.5%, 78.4% and 19.3%, respectively. CEA transcripts were detected in 3 healthy volunteer samples (7.5%), whereas all control samples were tested negative for CK20 and EGFR transcripts. The increasing number of positive detections for CEA, CK20 and EGFR transcripts in each blood sample was positively correlated with Astler-Coller disease stage (P< 0.001) and preoperative serum levels of CEA (P=0.029) in CRC patients. Data analysis using Kaplan-Meier estimator documented signif icant differences in the overall survival of the different CRC patient groups as formed according to the increasing number of positivity for CEA, CK20 and EGFR transcripts. CONCLUSION: These data suggest that multiplex RTPCR assay can provide useful information concerning disease stage and overall survival of CRC patients. | Aikaterini Tsouma Chrysanthi Aggeli Panagiotis Lembessis George N Zografos Dimitris P Korkolis Dimitrios Pectasides Maria Skondra Nikolaos Pissimissis Anastasia Tzonou Michael Koutsilieris | 2010 | World Journal of Gastroenterology2010，16，47： | 19 |
| 2 | Brain metastases from epithelial ovarian cancer: a review of the literature 显示文摘 | Pectasides D Pectasides M Eeonomopoulous T | 2006 | Oncologist2006，11，： | 1 |
| 3 | Developments in the systemic treatment of endometrial cancer显示文摘 | mountzios g Pectasides d Bournakis E | 2011 | Crit Rev Oncol Hematol2011，79，3： | 1 |
| 4 | Maintenance or consolidation therapy in advanced ovarian cancer显示文摘 | Pectasides D Pectasides E | 2006 | Oncology2006，70，5： | 1 |
| 5 | Germ cell tumors of the ovary显示文摘 | Pectasides D Pectasides E Kassanos D | 2008 | Cancer Treatment Reviews2008，34，5： | 1 |
| 6 | Anitbody guided irradiation of malignant pleural and pericardial effusions 显示文摘 | Pectasides D Steuart Courenay | 1986 | Br J Cancer1986，53，6： | 1 |
| 7 | Brain metastases from epithelial ovarian cancer:a review of the literature显示文摘 | Pectasides D Pectasides M Economopoulos T | 2006 | Oncologist2006，11，： | 1 |
| 8 | The role of neoadjuvant chemotherapy in the treatment of advanced ovarian cancer 显示文摘 | Pectasides D Farmakis D Koumarianou A | 2005 | Oncology2005，68，1： | 1 |
| 9 | Adjuvant and neo- adjuvant chemotherapy in muscle invasive bladder cancer: lit- erature review显示文摘 | Pectasides D Pectasides M Nikolaou M | 2005 | Eur Urol2005，48，1： | 1 |
| 10 | The role of tenofovir in preventing and treating hepatitis B virus (HBV) reactivation in immunosuppressed patients. A real life experience from a tertiary center显示文摘 | J.S. Koskinas M. Deutsch S. Adamidi M. Skondra M. Tampaki A. Alexopoulou S. Manolakopoulos D. Pectasides | 2014 | European Journal of Internal Medicine2014，，8： | 1 |
| 11 | Ad-vanced stage mucinous epithelial ovarian cancer:theHellenic Cooperative Oncology Group experience显示文摘 | Pectasides D Fountzilas G Aravantinos G | 2005 | Gynecol Oncol2005，97，2： | 1 |
| 12 | Paclitaxel and carboplatin as first-line chemotherapy combined with gefitinib (IRESSA) in patients with advanced breast cancer:a phase Ⅰ/Ⅱ study conducted by the Hellenic Cooperative Oncology Group显示文摘 | Fountzilas G Pectasides D Kalogera-Fountzila A | 2005 | Breast Cancer Res Treat2005，92，1： | 1 |
| 13 | Determination and biological relevance of serum cross-linked type Ⅰ collagen N-telopeptide and bone-specific alkaline phosphatase in breast metastatic cancer显示文摘 | KANAKIS I NIKOLAOU M PECTASIDES D | 2004 | Journal of Pharmaceutical and Biomedical Analysis2004，34，4： | 1 |
| 14 | Fallopian tube car- cinoma: a review显示文摘 | Pectasides D Pectasides E Economopoulos T | 2006 | Oncologist2006，11，8： | 1 |
| 15 | Activation of Wnt signaling pathway by human papillomavirus E6 and E7 oncogenes in HPV16-positive oropharyngeal squamous carcinoma ceils 显示文摘 | Rampias T Boutati E Pectasides E | 2010 | Mol Cancer Res2010，8，3： | 1 |
| 16 | Chemotherapy for recurrent cervical cancer 显示文摘 | Pectasides D Kamposioras K Papaxoinis G Pectasides E | 2008 | Cancer Treat Rev2008，34，7： | 1 |
| 17 | CEA, CA19- 9,and CA- 50 in monitoring gastric carcinoma显示文摘 | Pectasides D Mylonalakis A Kostopoulou M | 1997 | Am J Clin Onco1997，20，4： | 1 |
| 18 | Adjuvant dosedense sequential chemotherapy with epirubicin, CMF, and weekly docetaxel is feasible and safe in patients with operable breast cancer 显示文摘 | Fowntzilas G Pectasides D Christodoulou C | 2006 | MedOncol2006，23，4： | 1 |
| 19 | The role of neoadjuvant chemotherapy in the treatment of advanced ovarian cancer 显示文摘 | Pectasides D Farmakis Dv Koumarianou Av et a1 | 2005 | Oncology2005，68，1： | 1 |
| 20 | The role of neoadjuvant chemotherapy in the treatment of advanced ovarian cancer显示文摘 | Pectasides D Farmakis D Koumarianou A | | 0，，： | 1 |
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