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| 1 | Serum IL-6, TNFα and CRP levels in Greek colorectal cancer patients: Prognostic implications显示文摘AIM: The significance of preoperative serum IL-6, TNFαand CRP levels in the progression of colorectal cancer (CRC) has not been fully elucidated. Our intention was to investigate their role and identify their prognostic significance.METHODS: The IL-6, TNFα and CRP levels were measured in 74 CRC patients and the relationships between their elevation s and both the clinicopathological factors and prognosis of patients were investigated. Serum concentrations of human IL-6 and TNFα were determined by enzyme-linked immunosorbent assay (ELISA). CRP was measured by an immunoturbinometric method.RESULTS: Median IL-6, TNFα and CRP levels weresignificantly higher in CRC patients than in normal controls.High levels of serum IL-6, TNFα and CRP were correlated with larger tumor size. Furthermore, high IL-6 and high CRP levels were associated with reduced overall survival.CONCLUSION: Serum IL-6, TNFα and CRP levels definitely increase in CRC patients. Pre-operative serum elevation of IL-6 and CRP was thus found to be predictor of the prognosis of CRC patients. The clinical value of TNFα in CRC needs to be further investigated. | Nikolaos I. Nikiteas Nikolaos Tzanakis Maria Gazouli George Rallis Kessaris Daniilidis George Theodoropoulos Alkiviadis Kostakis George Peros | 2005 | World Journal of Gastroenterology2005，11，11： | 23 |
| 2 | Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer显示文摘瞄准:在象 interleukin ( IL )那样的煽动性的反应相关的基因调查在普通单个核苷酸多型性( SNP )之间的协会-6, IL-8 ,肿瘤坏死因素高山哈( TNFalpha ), peroxisome 激活proliferators 的受体鲸鱼群妈( PPARgamma ),细胞间的粘附 molecule-1 ( ICAM-1 )和颜色的风险在一组希腊病人的表面的癌症( CRC )。方法:学习组由 222 个 CRC 病人和 200 健康控制组成了。Genotyping 用 PRC-RFLP 的等位基因特定的 PCR 被执行,结果被定序证实。我们在 IL-6 学习了 SNP 的协会(-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G 和 K469E ) ,和 PPARgamma (Pro12Ala ) 基因和 CRC 的风险。结果:ICAM-1 的 IL-6 -174G, R241 和 K469 等位基因与 CRC 的增加的风险被联系(或 = 1.77, 95% CI:1.34-2.34;或 = 1.83, 95% CI:1.23-2.72;并且或 = 1.35, 95% CI:1.03-1.77 分别地) 。IL-8 和 TNFalpha 多型性没有效果。而 PPARgamma Pro12 遗传型与疾病的增加的风险被联系(或 = 1.78, 95% CI:1.25-2.49 ) 。结论:在在免疫逻辑的普通 SNP 之间的协会反应相关的基因和 CRC 在现在的学习被报导。除了使恶意开始和前进的机制清楚些, SNP 可以改进在风险的为亚人口的适当屏蔽。 | George Theodoropoulos Ioannis Papaconstantinou Evangelos Felekouras Nikolaos Nikiteas Petros Karakitsos Dimitris Panoussopoulos Andreas Ch Lazaris Efstratios Patsouris John Bramis Maria Gazouli | 2006 | World Journal of Gastroenterology2006，12，31： | 16 |
| 3 | Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?显示文摘Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denotethat quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies. | Theodore D Tsirlis George Papastratis Kyriaki Masselou Christos Tsigris Antonis Papachristodoulou Alkiviadis Kostakis Nikolaos I Nikiteas | 2008 | World Journal of Gastroenterology2008，14，17： | 12 |
| 4 | Development of a quantum-dot-labelled magnetic immunoassay method for circulating colorectal cancer cell detection显示文摘AIM:To detect of colorectal cancer(CRC) circulating tumour cells(CTCs) surface antigens,we present an assay incorporating cadmium selenide quantum dots(QDs) in these paper.METHODS:The principle of the assay is the immunomagnetic separation of CTCs from body fluids in conjunction with QDs,using specific antibody biomarkers:epithelial cell adhesion molecule antibody,and monoclonal cytokeratin 19 antibody.The detection signal was acquired from the fluorescence signal of QDs.For the evaluation of the performance,the method under study was used to isolate the human colon adenocarcinoma cell line(DLD-1) and CTCs from CRC patients' peripheral blood.RESULTS:The minimum detection limit of the assay was defined to 10 DLD-1 CRC cells/mL as fluorescence was measured with a spectrofluorometer.Fluorescenceactivated cell sorting analysis and Real Time RT-PCR,they both have also been used to evaluate the performance of the described method.In conclusion,we developed a simple,sensitive,efficient and of lower cost(than the existing ones) method for the detection of CRC CTCs in human samples.We have accomplished these results by using magnetic bead isolation and subsequent QD fluorescence detection.CONCLUSION:The method described here can be easily adjusted for any other protein target of either the CTC or the host. | Maria Gazouli Anna Lyberopoulou Pericles Pericleous Spyros Rizos Gerassimos Aravantinos Nikolaos Nikiteas Nicholas P Anagnou Efstathios P Efstathopoulos | 2012 | World Journal of Gastroenterology2012，18，32： | 6 |
| 5 | Role of surgery in colorectal liver metastases:Too early or too late?显示文摘As colorectal cancer and colorectal liver metastases become a serious public health problem,new treatment modalities are needed in order to achieve better results. In the last decade there has been very important progress in oncology,with new and more effective chemotherapeutic agents administered alone or in combination improving the resectability rate in up to 40%of patients with colorectal liver metastases.Advances in interventional radiology,in particular,with the use of portal vein embolization and radiofrequency thermal ablation are new strategies allowing major liver resections and treatment of small liver metastases or early recurrences.Surgery,however,remains the gold standard strategy with intention to treat.In this review article we will describe the advanced role of surgery in the multidisciplinary approach to colorectal liver metastases,and the clinical problems the liver surgeon has to deal with,such as theresectability of the metastases,the presence of bilobar liver lesions and extrahepatic disease,the impact of chemotherapy in already resectable liver metastases,the problem of vanishing metastases after chemotherapy and the dilemma of staged or combined liver and colon operations and which organ first in the clinical scenario of synchronous colorectal liver metastases. | Dimitrios Dimitroulis Nikolaos Nikiteas Theodore Troupis Dimitrios Patsouras Panayiotis Skandalakis Gregory Kouraklis | 2010 | World Journal of Gastroenterology2010，16，28： | 5 |
| 6 | Barrett's esophagus with high-grade dysplasia:Focus on current treatment options显示文摘High-grade dysplasia(HGD) in Barrett's esophagus(BE) is the critical step before invasive esophageal adenocarcinoma.Although its natural history remains unclear,an aggressive therapeutic approach is usually indicated.Esophagectomy represents the only treatment able to reliably eradicate the neoplastic epithelium.In healthy patients with reasonable life expectancy,vagal-sparing esophagectomy,with associated low mortality and low early and late postoperative morbidity,is considered the treatment of choice for BE with HGD.Patients unfit for surgery should be managed in a less aggressive manner,using endoscopic ablation or endoscopic mucosal resection of the entire BE segment,followed by lifelong surveillance.Patients eligible for surgery who present with a long BE segment,multifocal dysplastic lesions,severe reflux symptoms,a large fixed hiatal hernia or dysphagia comprise a challenging group with regard to the appropriate treatment,either surgical or endoscopic. | Leonidas Lekakos Nikolaos P Karidis Dimitrios Dimitroulis Christos Tsigris Gregory Kouraklis Nikolaos Nikiteas | 2011 | World Journal of Gastroenterology2011，17，37： | 2 |
| 7 | Circulating MicroRNA in inflammatory bowel disease显示文摘 | Archanioti Paraskevi George Theodoropoulos Ioannis Papaconstantinou Gerassimos Mantzaris Nikolaos Nikiteas Maria Gazouli | 2012 | Journal of Crohn’s and Colitis2012，，9： | 2 |
| 8 | Vascular endo?thelial growth factor and endoglin (CDI05) in gastric cancer显示文摘 | Nikiteas NI Tzanakis N Theodoropoulos G | 2007 | Gastric Cancer2007，10，1： | 1 |
| 9 | No association with risk for colorectal cancer of the inser- tion/deletion polymorphism which affects levels of an- giotensin-converting enzyme显示文摘 | Nikiteas N Tsigris C Chatzitheofylaktou A | 2007 | In vivo2007，21，6： | 1 |
| 10 | No associ ation with risk for colorectal cancer of the insertion/deletion polymorphism which affects levels of angiotensin converting enzyme显示文摘 | Nikiteas N Tsigris C Chatzitheofylaktou A | 2007 | In Vivo2007，21，6： | 1 |
| 11 | Virtual reality simulators and training in laparoseopic surgery 显示文摘 | Yiannakopoulou E Nikiteas N Perrea D | 2015 | Int J Surg2015，13，： | 1 |
| 12 | Effect of laparoscopic surgery on oxidative stress response:systematic review显示文摘 | Yiannakopoulou ECh Nikiteas N Perrea D | 2013 | Surg Laparosc Endosc Percutan Tech2013，23，2： | 1 |
| 13 | Deconstructing laparoscopic competence in a virtual reality simulation environment显示文摘 | Loukas C Nikiteas N Kanakis M | | 0，，06： | 1 |
| 14 | Deconstructing laparoscopic competence in a virtual reality simulation environment显示文摘 | Loukas C Nikiteas N Kanakis M | 2011 | Surgery2011，149，6： | 1 |
| 15 | Vascular endothelial growth factor and endoglin (CD-105) in gastric cancer显示文摘 | Nikiteas NI Tzanakis N Theodoropoubs G | 2007 | Garstric Cancer2007，10，1： | 1 |
| 16 | Vascular endothelial growth factor and endoglin (CD-105) in gastric cancer显示文摘 | Nikiteas NI Tzanakis N Theodoropoulos G | 2007 | Gastric Cancer2007，10，1： | 1 |
| 17 | Emergency Liver Resection for Combined Biliary and Vascular Injury Following Laparoscopic Cholecystectomy: Case Report and Review of the Literature显示文摘 | Evangelos Felekouras Thomas Megas Othon P. Michail Ioannis Papaconstantinou Nikolaos Nikiteas Dimitrios Dimitroulis John Griniatsos Anastasios Tsechpenakis Gregorios Kouraklis | 2007 | Southern Medical Journal2007，，3： | 1 |
| 18 | Expression of nuclear factor κB in human gastric carcinoma: relationship with IκBa and prognostic significance显示文摘 | Georgia Levidou Penelope Korkolopoulou Nikolaos Nikiteas Nikolaos Tzanakis Irene Thymara Angelica A. Saetta Christos Tsigris George Rallis Konstantin Vlasis Efstratios Patsouris | 2007 | Virchows Archiv2007，，5： | 1 |
| 19 | Liver Resection in Cases of Isolated Hepatic Actinomycosis: Case Report and Review of the Literature显示文摘 | E. Felekouras C. Menenakos J. Griniatsos I. Deladetsima N. Kalaxanis N. Nikiteas E. Papalambros T. Kordossis E. Bastounis | 2004 | Scandinavian Journal of Infectious Diseases (-)2004，，6： | 1 |
| 20 | Deconstructing laparoscopic competence in a virtual reality simulation environment显示文摘 | Loukas C Nikiteas N Kanakis M | | 0，，06： | 1 |
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