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509篇 您的检索式:作者名="Bruch"
    题名 作者 年代 出处 被引量
1早期矽肺患者支气管肺泡灌洗液中生物标志物的研究显示文摘目的 探讨早期矽肺患者支气管肺泡灌洗液 (BALF)中生物标志物。方法 矽尘作业工人 18人 ,按X线诊断矽肺期别分为 0 +组和Ⅰ期组 ;以健康吸烟农民 7人为对照组。经纤支镜支气管肺泡灌洗收集BALF ,进行细胞学检验 ,用细胞毒性试验测定肿瘤坏死因子 (TNF α)含量 ,酶联免疫吸附法测定其他细胞因子含量。结果 矽肺 0 +组及Ⅰ期组BALF中TNF α含量分别为 (7.2 0±1.87)、(9.2 0± 1.10 )U/ml,明显高于对照组的 (5 .71± 0 .89)U/ml,差异有显著性 (P <0 .0 1) ;矽肺Ⅰ期组TNF α含量明显高于 0 +组 ,差异有显著性 (P <0 .0 5 )。TNF α含量与矽尘接触年限存在剂量 -效应关系 (rs=0 .46 98,P <0 .0 5 )。纤维连接蛋白、肺表面活性蛋白A和前胶原Ⅲ肽与对照比较 ,差异无显著性 (P >0 .0 5 )。结论 BALF中TNF冯国贤 南培宏 于建军 陈力 范连生 邢景才 周福同 宋鸿鹏 傅娟玲 Rehn B Rehn S Bruch J 周宗灿 2000中华劳动卫生职业病杂志2000,18,4:11
2早期煤工尘肺支气管肺泡灌洗液中SP-A及TNF-α含量的变化显示文摘目的 探讨煤尘职业接触者和早期煤工尘肺患者支气管肺泡灌洗液 (BALF)中细胞因子含量改变的特点及意义。方法 采煤工 2 3人 ,按X线胸片诊断为煤尘接触组 (接尘组 )、煤工尘肺 0 +和Ⅰ期组 ;健康农民 7人为对照组。经纤支镜做支气管肺泡灌洗 ,收集BALF ,用酶联免疫吸附法 (ELISA)测定肺泡表面活性蛋白 A(SP A)及肿瘤坏死因子 (TNF α)含量。结果 接尘组BALF中SP A含量为 (6 5 2 8.2±1872 .0 )ng/ml,TNF α含量为 (8.2 3± 1.6 1)U/ml,均明显高于对照组 [(10 5 0 .1± 912 .2 )ng/ml及 (5 .17±0 .89)U/ml],差异有显著性 (P <0 .0 1) ;且随煤工尘肺期别进展 ,SP A及TNF α含量降低 ,SP A及TNF α含量变化与煤工尘肺病变严重性之间呈负相关 (前者r =- 0 .6 4,P <0 .0 1;后者r=- 0 .45 ,P <0 .0 5 )。结论 BALF中SP A和TNF邢景才 范连生 冯国贤 宋鸿鹏 傅娟玲 周宗灿 Bruch J 2001中华劳动卫生职业病杂志2001,19,1:8
3Changes of Tumor Necrosis Factor, Surfactant Protein A, and Phospholipids in Bronchoalveolar Lavage Fluid in the Development and Progression of Coal Workers’ Pneumoconiosis显示文摘Objective To evaluate the alterations of biomarkers in the development and progression of coal workers’ pneumoconiosis (CWP). Methods The type and number of cells, and the levels of tumor necrosis factor-alpha (TNF-α), pulmonary surfactant protein, phospholipids and fibronectin in bronchoalveolar lavage fluid were assayed in 14 health active coal miners, 21 coal miners without CWP and 13 miners with CWP of 0/1 to 1/1. Results Compared to active coal miners without CWP (8.23 μg/mL), TNF-α concentration was gradually decreased when dust exposure was stopped (5.90 μg/mL). Elevated surfactant protein A (SP-A) level and phosphatidylglycerol (PG) to phosphatidylinositol (PI) ratio were found in miners actively exposed to coal dust (6528 ng/mL for SP-A and 10. for PG/PI), and both parameters decreased when CWP progressed from CWP (0/1) (3419 μg/mL for SP-A and 5.9 for PG/PI) to CWP (1/1) (1654 μg/mL for SP-A and 5.5 for PG/PI). Conclusion Biomarkers in bronchoalveolar lavage fluid can be used to screen coal miners at high risk of developing coal workers’ pneumoconiosis.JING-CAI XING WEI-HONG CHEN WEN-HUI HAN MEI-FENG GUO STEFFENI REHN JOACHIM BRUCH 2006Biomedical and Environmental Sciences2006,19,2:7
4胰腺癌的Ki-67抗原表达显示文摘应用Raine Ki-67等效抗体(MIB-1)测定40例胰腺癌和10例慢性胰腺炎中Ki-67核抗原的表达,结果发现:这种新型Ki-67等效抗体在石蜡切片中显示了较好的敏感性和特异性;胰腺癌癌巢细胞中Ki-67抗原的表达明显高于非癌巢细胞和慢性胰腺炎,而且Ki-67指数与胰腺癌组织学分级高度相关,提示Ki-67核抗原的测定有助于肿瘤临床病理分级诊断。吴育连 范敏明 顾才校 彭淑牖 MichaelDuchrow德国吕贝克医科大学外科实验室 MonikaEingler RainerBroll Hans-Peter Bruch 1996中华实验外科杂志1996,13,5:4
5煤尘职业接触者和早期煤工尘肺BAL液中表面活性物质研究显示文摘目的 探讨煤尘职业接触者和早期煤工尘肺患者BAL液中表面活性物质含量改变特点及其意义。方法 采煤工人 2 3人 ,按X线诊断煤工尘肺期别分为 0期 (煤尘接触者 )组 7人、0 +组 8人和Ⅰ期组 8人 ,并取健康农民 7人为对照组。经纤支镜支气管肺泡灌洗 (BAL)收集BAL液 ,测定表面活性蛋白A(SP A)和磷脂 (PL)及其组分含量。结果 0期组BAL液中SP A含量、SP A/PL和PG/PI明显高于对照组 (P <0 0 1) ,且随煤工尘肺期别的增加而有降低趋势。结论 BAL液中SP A含量、SP宋鸿鹏 傅娟玲 邢景才 范连生 南培宏 于建军 Bruch J 周宗灿 2001中国职业医学2001,28,2:3
6改良一步法从甲醛固定石蜡包埋组织中提取RNA显示文摘曹利平 Michael Duchrow Rainer Broll Hans Peter Bruch 2000中华医学杂志2000,80,5:3
7Transcatheter closure of interatrial communications for secondary prevention of paradoxical embolism: single-center experience显示文摘Bruch L Parsi A Grad MO 2002Circulation2002,105,24:2
8Tei-index in patients with mild-to-moderate congestive heart failure显示文摘Bruch C Schmermund A Marin D 0,,:2
9妊娠皮肤病显示文摘妊娠妇女可发生多种生理性的和病理性的皮肤改变,可发生于所有妊娠妇女的,多由内分泌改变所引起的生理性皮肤改变有:黄褐斑、棕黑线、妊娠纹、牙龈增生、静脉曲张等。病理性改变主要是导致一些已经存在的皮肤病加重。M.MegahED Daniela Bruch G.Goerz 陈兴平 徐祖森 1996德国医学1996,13,1:2
10Severe aortic valve stenosis with ventricular function: diagnostic usefulness of the Tei index 显示文摘Bruch C Schmernaund A Dagres N 2002J Am Soc Echocardiogr2002,15,:1
11Delineation of the 6p22 amplification unit in urinary bladder carcinoma cell lines显示文摘Bruch J Schulz WA Haussler J 2000Cancer Res2000,60,16:1
12Advantages of Sirius red staining for quantitative morphometric collagen measurements in lungs 显示文摘Malkusch W Rehn B Bruch J 1995Exp Lung Res1995,21,1:1
13Tei-index in patients with mild-to-moderate congestive heart failure显示文摘Bruch C Schmermund A Marin D 2000Eur Heart J2000,21,22:1
14Toward a unified model of the action of CLP/HSP100 chaperones in chloroplasts 显示文摘Rosano GL Bruch EM Colombo CV 2012Plant sighaling Behavior2012,7,6:1
15Laparoscopic ultrasound navigation in liver surgery: technical aspects and accuracy显示文摘M. Kleemann P. Hildebrand M. Birth H. P. Bruch 2006Surgical Endoscopy2006,,5:1
16Motor unit of mammalian muscle显示文摘Buchthal F Schmal bruch H 1980Physiol Rev1980,60,:1
17Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1显示文摘Dawson JC Bruche S Spence HJ 2012PLo S One2012,7,31:1
18Experimental and numerical study of annular PCM storage inthe presence of natural convection显示文摘Longeon M Soupart A Fourmigué J Bruch A MartyP 2013Applied Energy2013,,112:1
19Tei-index in patients with mild- to-moderate congestive heart failure 显示文摘Bruch C Schmermund A Marin D 2000Eur Heart J2000,21,22:1
20Tei-Index in patients with mild-to-moderate congestive heart failure显示文摘Bruch C Schmermund A Marin D 2000Eur Heart J2000,21,22:1
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