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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | 高通气综合征?还是惊恐障碍?显示文摘 | 韩江娜 R Schepers K Stegen O Van den Bergh KP Van de Woestijne | 2001 | 中华结核和呼吸杂志2001，24，9： | 9 |
| 3 | 运用《国际功能、残疾和健康分类》比较脑卒中康复功能性结局测量的内容显示文摘目的确定常用于脑卒中康复结局测量内容,主要是关于活动和参与的,并与《国际功能、残疾和健康分类》(ICF)对照。方法将以下量表的结构与ICF建立联系:Barthel指数(BI)、Berg平衡功能量表(BBS)、Chedoke Mc Master脑卒中评定量表(CMSA)、Euroqol-5D欧洲生活质量量表(EQ5D)、FI M功能独立性测量、Frenchay活动指数、Nottingham健康测验(NHP)、Rankin量表(RS)、Rivermead动作测量(RMA)、Rivermead移动指数(RMI)、中风影响测验-30(SASIP30)、医学结局研究简表(SF36),卒中影响量表(SIS)、脑卒中特定生存质量量表(SSQOL)和站立行走测验(TUG)。结果功能性结局测量中的绝大多数结构可与ICF分类建立联系。这些测量工具可以归入活动和参与的成份,活动是测量工具中最常见的类目内容。虽然测量工具的选择是基于它们主要关注的'活动'与'参与'内容,但有27%的结构属于身体功能类目,也有大约10%的结构与ICF不相关。结论在脑卒中的康复中,ICF是一种有效的工具来检测和比较脑卒中各测量工具的内容。这些内容上的比较使得临床医生和研究者们选择最符合他们兴趣和要求的测量。 | V. P. M. SCHEPERS M. KETELAAR I. G. L. VAN DE PORT J. M. A. VISSER-MEIL Y & E. LINDEMAN 王朴(译) 李沁燚(译) 邱卓英(审校) 吴弦光(审校) | 2008 | 中国康复理论与实践2008，14，12： | 6 |
| 4 | Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators显示文摘 | SCHEPERS G KOOPMAN P | 2000 | Dev Biol2000，227，2： | 1 |
| 5 | RNA interference:from an ancient mechanism to astate of the art therapeutic application显示文摘 | Arenz C Schepers U | 2003 | Naturwissenschaften2003，90，8： | 1 |
| 6 | Tumor necrosis factor-alpha plays an important role in restenosis development 显示文摘 | Monraats PS Pires NM Schepers A | 2005 | FASEB J2005，19，14： | 1 |
| 7 | New classes of lower bounds for bin-packing problem 显示文摘 | Fekete S P Schepers J | 1998 | IPCO 98 Springer Lecture Notes in Computer Science1998，1412，： | 1 |
| 8 | Calcaneal fracture classification: a comparative study显示文摘 | Schepers T Lieshout E Ginai A | 2009 | J Foot Ankle Surg2009，2，： | 1 |
| 9 | Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation显示文摘 | Schuringa J J Schepers H Vellenga E | 2001 | FEBS letters2001，495，1： | 1 |
| 10 | Appropriateness of management zones for characterzing spatial variability of soil properties and irrigated corn yields across years显示文摘 | SCHEPERS A R SHANAHAN J F LIEBIG M K | 2004 | Agron J2004，96，： | 1 |
| 11 | Comparison of corn leaf nitrogen concentration and chlorophyll meter readings 显示文摘 | Schepers J S Francis D D Vigil M Below F E | 1992 | Communications in Soil Science and Plant Analysis1992，23，17181920： | 1 |
| 12 | RNA interference: An ancient mechanism or a state of the art therapeutic application显示文摘 | Arenz C Schepers U | 2003 | Naturwis- senschaften2003，90，8： | 1 |
| 13 | Rapid generation of antigen-presenting cells from leukaemic blasts in acute myeloid leukemia显示文摘 | Westers TM Steam AG Scheper RJ | 2003 | Cancer Immunol Immunother2003，52，1： | 1 |
| 14 | Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators显示文摘 | Bowles J Schepers G Koopman P | 2000 | Dev Bio2000，227，： | 1 |
| 15 | Anti-MCP-1 genetherapy inhibits vascular smooth muscle cells proliferation and at-tenuates vein graft thickening both in vitro and in vivo显示文摘 | Schepers A Eefting D Bonta PI | 2006 | Arte-rioscler Thromb Vase Bio/2006，26，9： | 1 |
| 16 | The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac显示文摘 | Nikitakis NG Scheper MA Papanikolaou VS | 2009 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2009，107，6： | 1 |
| 17 | Clinical outcome scoringof intra ~articular caleaneal fractures显示文摘 | Schepers J Heetveld MJ Mulder PG et a1 | | 0，，： | 1 |
| 18 | Spouses'quality of life 1 year after stroke: prediction at the start of clinical reha bilitation显示文摘 | Visser-Meily A Post M Schepers V | 2005 | Cerebrovascular Diseases2005，20，6： | 1 |
| 19 | Whole-cell cancer vaccination: from autologous to allogeneic tumor- and dendritic cell-based vaccines显示文摘 | Tanja D. Gruijl Alfons J. M. den Eertwegh Herbert M. Pinedo Rik J. Scheper | 2008 | Cancer Immunology, Immunotherapy2008，，10： | 1 |
| 20 | Controlling nitrate leaching in irrigated agriculture显示文摘 | Spalding R F Watts D G Schepers J S | 2001 | Journal of Environmental Quality2001，30，： | 1 |
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