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| 1 | Modified porous tantalum rod technique for the treatment of femoral head osteonecrosis显示文摘AIM: To study a modified porous tantalum technique for the treatment of osteonecrosis of the femoral head.METHODS: The porous tantalum rod was combined with endoscopy,curettage,autologous bone grafting and use of bone marrow aspirates from iliac crest aspiration in 49 patients(58 hips) with a mean age of 38 years.The majority of the patients had idiopathic osteonecrosis,followed by corticosteroid-induced osteonecrosis.Thirtyeight hips were of Steinberg stage Ⅱ disease and 20 hips were of stage Ⅲ disease.Patients were followed for 5 years and were evaluated clinically with the Merle D'Aubigne and Postel score and radiologically.The primary outcome of the study was survival based on the conversion to total hip arthroplasty(THA).Secondary outcomes included deterioration of the osteonecrosis to a higher disease stage at 5 years compared to the preoperative period and identification of factors that were associated with survival.The Kaplan-Meier survival analysis was performed to evaluate the survivorship ofthe prosthesis,and the Fisher exact test was performed to test associations between various parameters with survival.RESULTS: No patient developed any serious intraoperative or postoperative complication including implant loosening or migration and donor site morbidity.During the 5-year follow up,1 patient died,7 patients had disease progression and 4 hips were converted to THA.The 5-year survival based on conversion to THA was 93.1% and the respective rate based on disease progression was 87.9%.Stage Ⅱ disease was associated with statistically significant better survival rates compared to stage Ⅲ disease(P = 0.04).The comparison between idiopathic and non-idiopathic osteonecrosis and between steroid-induced and non-steroid-induced osteonecrosis did not showed any statistically significant difference in survival rates.The clinical evaluation revealed statistically significantly improved Merle d'Aubigne scores at 12 mo postoperatively compared to the preoperative period(P < 0.001).The mean preoperative Merle d'Aubigne score was 13.0(SD: 1.8).The respective score at 12 mo improved to 17.0(SD: 2.0).The 12-mo mean score was retained at 5 years.CONCLUSION: The modified porous tantalum rod technique presented here showed encouraging outcomes.The survival rates based on conversion to THA are the lowest reported in the published literature. | Emilios E Pakos Panayiotis Megas Nikolaos K Paschos Spyridon A Syggelos Antonios Kouzelis Georgios Georgiadis Theodoros A Xenakis | 2015 | World Journal of Orthopedics2015，6，10： | 20 |
| 2 | Is osteoporosis a peculiar association with primary biliary cirrhosis?显示文摘AIM: (1) To compare the prevalence of osteoporosis (t-score ≤-2.5 SD) between stage Ⅳ PBC patients, and two groups of age- and sex-matched controls: one with hepatitis C virus (HCV)-related cirrhosis, and the other one consisting of a group of healthy subjects from the general population; (2) to identify the main risk factors for the development of bone loss.METHODS: Thirty-five stage Ⅳ PBC patients (mean age 52.5±10 years), 49 females with HCV-related cirrhosis (mean age 52.9±5.8 years) and 33 healthy females (mean age 51.8+2.22 years) were enrolled in the study. Bone metabolism was evaluated by measuring serum calcium corrected for serum albumin (Ca corr.), 25-hydroxy vitamin D (25-OH vit D), parathyroid hormone, osteocalcin.Bone mineral density (BMD) was assessed at the lumbar spine by dual-photon X-ray absorptiometry.RESULTS: Osteoporosis was present in 5/35 PBC patients (14.2%) and in 7/49 HCV-related cirrhotic patients (14.3%),without any statistical difference between the two groups.Among healthy control subjects, none had osteoporosis.No difference was found between the three groups in serum parameters of bone metabolism. Univariate analysis showed that menopausal state and low BMI were significantly correlated with osteoporosis. Multivariate regression analysis showed that menopausal status, BMI <23, and old age were independent variables significantly correlated with osteoporosis.CONCLUSION: PBC in itself has no negative influence on BMD. End-stage liver disease patients carry a disease-specific risk for osteoporosis, but have an effective risk of bone loss in relation to individual potential risk for each patient. A practical message should be taken into account, that is, every effort should be made to prevent osteoporosis when a patient has simple osteopenia, or if it is a woman in or near menopausal age. | Annarosa Floreani Andrea Mega Valentina Camozzi Vincenzo Baldo Mario Plebani Patrizia Burra Giovanni Luisetto | 2005 | World Journal of Gastroenterology2005，11，34： | 7 |
| 3 | 希腊城市患者人群研究显示雌激素受体(α和β受体)而非雄激素受体的表达水平与局限性晚期前列腺癌(T3NOMO)术后复发、进展和生存具有相关性显示文摘本文旨在研究一希腊城区局限性晚期前列腺癌(T3NOMO)根治术后患者人群,评估雌激素受体(α和β受体)和雄激素受体在术后生化复发、进展和死亡中的预后价值。本研究回顾性分析了100名行根治性前列腺切除术后病理分期为T3NOM0的前列腺癌患者。患者平均年龄和随访期限分别为62岁和6年。使用组织化学评分方法对受体的免疫反应性进行半定量分析。依据患者术后的复发、进展和生存率指标评估α、β雌激素受体和雄激素受体的预后价值。结果显示雄激素受体和以上指标均无关联,而α、β雌激素受体和预后均有相关性。单变量Cox回归分析显示预测因素中α雌激素受体表达增高与预后风险增高有显著相关性,β雌激素受体增高与预后风险降低有显著相关性,当联合α、β雌激素受体表达情况进行评估,α雌激素受体高表达或β雌激素受体低表达的患者与α雌激素受体阴性表达合并β受体组织化学评分1.7以上的患者相比,前列腺癌生化复发、进展或死亡的风险分别增加了6.03,10.93和10.53倍。多因素CoxLt例风险模型分析显示年龄、术前PSA水平、Gleason评分和雌激素受体是所有预后指标的独立预测因子。雌激素受体的表达水平是病理分期T3NOMO前列腺癌术后患者预后的重要预测因子。相比之下,雄激素受体的预测价值有限。 | Georgios Megas Michael Chrisofos Ioannis Anastasiou Aida Tsitlidou Theodosia Choreftaki Charalampos Deliveliotis | 2015 | Asian Journal of Andrology2015，17，1： | 4 |
| 4 | Paternal physical exercise modulates global DNA methylation status in the hippocampus of male rat offspring显示文摘It is widely known that maternal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of paternal exercise have not been explored in detail. The present study was designed to evaluate the impact of paternal physical exercise on memory and learning, neuroplasticity and DNA methylation levels in the hippocampus of male offspring. Adult male Wistar rats were divided into two groups: sedentary or exercised fathers. The paternal preconception exercise protocol consisted of treadmill running, 20 minutes daily, 5 consecutive days per week for 22 days, while the mothers were not trained. After mating, paternal sperm was collected for global DNA methylation analysis. At postnatal day 53, the offspring were euthanized, and the hippocampus was dissected to measure cell survival by 5-bromo-2′-deoxiuridine and to determine the expression of synaptophysin, reelin, brain-derived neurotrophic factor and global DNA methylation levels. To measure spatial memory and learning changes in offspring, the Morris water maze paradigm was used. There was an improvement in spatial learning, as well as a significant decrease in hippocampal global DNA methylation levels in the offspring from exercised fathers compared with those from sedentary ones; however, no changes were observed in neuroplasticity biomarkers brain-derived neurotrophic factor, reelin and 5-bromo-2′-deoxiuridine. Finally, the global DNA methylation of paternal sperm was not significantly changed by physical exercise. These results suggest a link between paternal preconception physical activity and cognitive benefit, which may be associated with hippocampal epigenetic programming in male offspring. However, the biological mechanisms of this modulation remain unclear. | Christiano Spindler Ethiane Segabinazi Andre Luis Ferreira de Meireles Francele Valente Piazza Filipe Mega Gabriela dos Santos Salvalaggio Matilde Achaval Viviane Rostirola Elsner Simone Marcuzzo | 2019 | Neural Regeneration Research2019，14，3： | 3 |
| 5 | 三菱重工地面燃气轮机热障涂层研究进展显示文摘燃气轮机联合循环热效率的提高,要求涡轮进口温度不断增加。目前,三菱重工(MHI)已经积极参与日本国家项目,通过发展1700℃级燃气轮机,以使联合循环热效率实现达到62%指标。在此国家项目中开发的部分组件技术适用于1600℃级燃气轮机M501J,它具有世界上最高的涡轮进口温度。而热障涂层(TBC)是实现此目标的最关键技术之一。在发展先进的热障涂层中,在MHI工厂中建立名为T点的试验电厂是有必要的。在真实热部件中制备的先进TBC可以在工厂中进行验证,并且运行后的效果可以得到反馈。本文讨论了TBC的开发以及在三菱重工实际电厂中的验证。 | Yoshifumi Okajima Daisuke Kudo Naotoshi Okaya Taiji Torigoe Hideaki Kaneko Masahiko Mega Eisaku Ito Junichiro Masada Keizo Tsukagoshi 吴琼 | 2014 | 热喷涂技术2014，，3： | 2 |
| 6 | Candidates for liver transplantation with alcoholic liver disease: Psychosocial aspects显示文摘In Europe, 30% to 50% of liver transplantations are currently due to alcoholic liver disease(ALD). In the United States, this percentage is 17.2%. Post-transplantsurvival and other predictors of clinical course do not differ significantly from those in other types of transplanted patients, as long as there is no relapse of drinking. However, 20%-25% of these patients lapse or relapse to heavy drinking post-operatively, which has been associated with an increased risk of liver damage and mortality. It is therefore crucial to design specific selection and follow-up strategies aimed at this particular type of patient. Several good and poor prognosis factors that could help to predict a relapse have been suggested, among them the duration of abstinence, social support, a family history of alcoholism, abuse diagnosis versus alcohol dependence, non-acceptance of diagnosis related to alcohol use, presence of severe mental illness, nonadherence in a broad sense, number of years of alcoholism, and daily quantity of alcohol consumption. In this article, we discuss these and other, more controversial factors in selecting ALD patients for liver transplantation. Abstinence should be the main goal after transplantation in an ALD patient. In this article, we review the several definitions of post-transplant relapse, its monitoring and the psychopharmacological and psychotherapeutic treatment. | Diogo Telles-Correia Inês Mega | 2015 | World Journal of Gastroenterology2015，21，39： | 2 |
| 7 | Ionic liquid/tetraglyme hybrid Mg[TFSI]_2 electrolytes for rechargeable Mg batteries显示文摘The electrochemical reversibility of Mg in hybrid electrolytes based on mixtures of ionic liquid and glyme based organic solvents was investigated for applications in rechargeable magnesium batteries(RMBs). The electrolytes demonstrate reversible reduction and oxidation of Mg only after being pre-treated with the dehydrating agent, magnesium borohydride, Mg[BH_4]_2, highlighting the importance of removing water in Mg based electrolytes. The addition magnesium di[bis(trifluoromethanesulfonyl)imide](Mg[TFSI]_2)(0.3 M) to N-butyl-n-methyl-pyrrolidinium bis(trifluoromethanesulfonyl)imide [C4 mpyr][TFSI]/tetraglyme at a mole ratio of 1:2 showed stable CV cycling over almost 300 cycles while scanning electron microscopy(SEM) and X-ray diffraction(XRD) confirmed Mg deposition, showing non-dendritic morphology and a well-aligned growth. Further thermogravimetric analysis(TGA) demonstrated a mass retention of 79% at 250℃ for this electrolyte suggesting that the presence of the ionic liquid increases thermal stability substantially making these hybrid electrolytes compatible for RMBs. | Zheng Ma Maria Forsyth Douglas R.MacFarlane Mega Kar | 2019 | Green Energy & Environment2019，4，2： | 2 |
| 8 | The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia显示文摘 | J. L. Cummings M. Mega K. Gray S. Rosenberg-Thompson D. A. Carusi J. Gornbein | 1994 | Neurology1994，，12： | 2 |
| 9 | B-type brain natriuretic peptide and prognosis in patients with ST-segment elevation myocardial infarction:an ENTIRE-TIMI-23 substudy显示文摘 | Morrow DA Lemos JA | 2004 | J Am Coll cardiol2004，44，： | 1 |
| 10 | Dementia with lewy bodies,reliability and validity of clinical and pathologic criteria显示文摘 | Masterman DL Bension DF | 1996 | Neurol1996，47，14： | 1 |
| 11 | Neuropsychiatric inventory:comprehensive assessment of psychopathology in dementia显示文摘 | Cummings JL Mega M Gray K | 1994 | Neurology1994，44，11： | 1 |
| 12 | Cytoehrome P450 genetic polymorphism and the respcmse to prasugrel :relationship to pharmacokinetic, phannacodynamle , and clinical outcome显示文摘 | Mega JL Close SL Wiviott SD | 2009 | Ciruulation2009，119，19： | 1 |
| 13 | Prevention of complications after percu- taneous coronary interventions with statins 显示文摘 | Mega S Nusca A Patti G | 2012 | Recenti Prog Med2012，103，1： | 1 |
| 14 | Minimal in- ternal fixation augmented by small wire transfixion frames for high-energy tibial plateau fractures显示文摘 | KATSENIS D ATHANASIOU V MEGAS P | 2005 | J Orthop Trauma2005，19，4： | 1 |
| 15 | Interlocking intramedullary nailing in distal tibial fractures显示文摘 | TYLLIANAKIS M MEGAS P GIANNIKAS D | 2000 | Orthopedics2000，23，8： | 1 |
| 16 | Cytochrome p-450 polymorphisms and response to clopidogrel显示文摘 | Mega JL Close SL Wiviott SD | 2009 | N Engl J Med2009，360，4： | 1 |
| 17 | B-Type natriuretic peptide at presentation and prognosis in patients with ST-segment elevation myocardial infarction:an ENTIRE-TIMI-23 substudy显示文摘 | Mega JL Morrow DA De Lemos JA | 2004 | J Am Coll Cardiol2004，44，2： | 1 |
| 18 | Rivaroxaban in patients with a recent acute coronary syndrome显示文摘 | Mega JL Braunwald E Wiviott SD | 2012 | N Engl J Med2012，366，1： | 1 |
| 19 | Cytochrome P-450 polymorphisms and response to clopidogrel 显示文摘 | Mega JL Close SL Wiviott SD | 2009 | N Engl J Med2009，360，： | 1 |
| 20 | Cytochrome p450 polymorphisms and response to clopidogrel显示文摘 | Mega J L Close S L Wiviott S D | 2009 | N Engl J Med2009，360，21： | 1 |
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