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| 1 | Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma显示文摘瞄准:学习的目的是与食道的癌(LASCOC ) 与权威的 chemoradiotherapy (CRT ) 对待的局部地先进的有鳞的房间在病人评估幸存的预兆的因素政体基于 5FU/CDDP 联合。方法:有用在 1994 和 2000 之间的 5FU/CDDP 联合与权威的 CRT 对待的 LASCOC 的所有病人回顾地被包括。对 CRT 的临床的完全的反应(CCR ) 被食道的内视镜检查法和 CT 扫描估计在 CRT 结束以后的 2 瞬间。幸存的预示的因素用 univariate 被估计,多,由艇长回归的变量分析当模特儿。结果:116 个病人的一个总数在学习被包括。到 CRT 的 CCR 在 86/116 (74.1%) 被观察。中部的幸存是 20 瞬间(范围 2-114 ) , 5 年的幸存是 9.4% 。到 CRT 的应答者病人的中部的幸存在非应答者病人作为与 9 瞬间(范围 2-81 ) 相比是 25 瞬间(范围 3-114 )(P <
0.001 ) 。在 univariate 分析,幸存与 CCR 被联系(P <
0.001 ) ,表演地位 <
2 (P = 0.01 ) ,瘤长度 <
6 厘米(P = 0.045 ) 并且 10% 在意义的限制的重量损失 <
(P = 0.053 ) 。在里面多变量分析,幸存对 CCR 依赖(P <
0.0001 ) ,重量损失 <
10%(P = 0.034 ) 并且表演 <
2 (P = 0.046 ) 。结论:我们的结果建议在有与权威的 CRT 对待的 LASCOC 的病人的那幸存被相关到 CCR,重量损失并且表演地位。 | Frédéric Di Fiore Stéphane Lecleire Olivier Rigal Marie-Pierre Galais Emmanuel Ben Soussan Isabelle David Bernard Paillot Jacques-Henri Jacob Pierre Michel | 2006 | World Journal of Gastroenterology2006，12，26： | 13 |
| 2 | Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis显示文摘AIM: To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis. METHODS: Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS: All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION: Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis. | David Philippe Laurent Favre Francis Foata Oskar Adolfsson Genevieve Perruisseau-Carrier Karine Vidal Gloria Reuteler Johanna Dayer-Schneider Christoph Mueller Stéphanie Blum | 2011 | World Journal of Gastroenterology2011，17，4： | 12 |
| 3 | Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS. | Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 4 | Molecular phylogeny of Trametes and related genera,and description of a new genus Leiotrametes显示文摘A phylogenetic analysis of Trametes and related taxa is proposed,based on a wide sampling of temperate and tropical species.Concatenate sequences of ribosomal DNA(ITS1-5.8S-ITS2)and RPB2 gene from mycelia cultures were analyzed by Maximum Likelihood and Bayesian methods,whilst morphological features were documented from the corresponding herbarium vouchers.Congruent results were obtained from analyses of ribosomal LSU sequences downloaded from Genbank.The Bayesian analysis of ITS+RPB2 sequences gave the best resolution for the phylogenetic reconstructions and revealed the existence of three main lineages in the Trametes-clade:1)a monospecific lineage represented by Artolenzites elegans 2)a lineage including the genus Pycnoporus in its traditional sense and several species usually classified in the genus Trametes(T.cingulata,T.lactinea,T.ljubarskyi,T.menziesii)&3)a lineage corresponding to the core genus Trametes,including type species of Trametes,Coriolopsis and Lenzites.The presence of a pseudostipe,aspect and structure of the abhymenial surface,colour change with 5%aqueous solutions of potassium hydroxide and topography of pigments on skeletal hyphae gave relevant morphological support to these clades.When the structure of the hymenial surface,presence of a black line below the tomentum and color of context(except for genus Pycnoporus)usually used in traditional polypore-classifications did not reveal any phylogenetic significance.A partial systematic arrangement of the Trametes clade is proposed,with the introduction of a new genus:Leiotrametes Welti&Courtec.gen.nov..Two new combinations:Leiotrametes lactinea(Berk.)Welti&Courtec.comb.nov.and L.menziesii(Berk.)Welti&Courtec.comb.nov.are proposed. | Stéphane Welti Pierre-Arthur Moreau Anne Favel Régis Courtecuisse Mireille Haon David Navarro Sabine Taussac Laurence Lesage-Meessen | 2012 | Fungal Diversity2012，，4： | 3 |
| 5 | 胎儿期恰逢1959~1961年饥荒的中国成人精神分裂症的发病率显示文摘背景:精神分裂症是一种常见的中度精神障碍。子宫内营养缺乏可增大患精神分裂症的危险。其主要依据来自1944~1945年荷兰饥饿冬天(Dutch Hunger Winter)研究,当时食品摄入在短期内极剧下降。这项有关饥荒期间受孕人群的大型队列研究显示,发生精神分裂症的危险增大两倍。
目的:确定经受1959~1961年大饥荒的中国人是否有相似的结果。
设计、地点及参试者:发生精神分裂症危险的调查于安徽省芜湖地区进行,这是当初受灾最重的地区之一。对饥荒之前、饥荒期间和饥荒以后出生的人群发病率进行比较。芜湖及其周围6个县是由一所精神病院负责的。对1971~2001年所有的精神病病历记录均进行检查。精神分裂症患者的临床和社会人口学资料由对自然灾害暴露情况不知情的研究者摘录。有关饥荒年出生人数和死亡人数的数据是有效可用的,累积死亡率根据以后的人口学调查进行估计。
主要观测指标:饥荒的证据已经核实,计算未校正的以及对死亡率进行校正后的发生精神分裂症的相对危险度。
结果:安徽省的出生率(每1000人)在饥荒期问降低了约80%,从1958年的28.28降至1959年的20.97、1960年的8.61和1961年的11.06。在饥荒期间出生的人,晚年发生精神分裂症的校正后危险明显增高,从1959年的0.84%增至1960年的2.15%和1961年的1.81%。死亡率校正相对危险在1960年出生者为2.30(95%可信区间,1.99~2.05),1961年出生者为1.93(95%可信区间,1.68~2.23)。
结论:我们的调查重复了荷兰不同种族人群的数据,结果显示,出生前遭受饥荒可增高晚年患精神分裂症的危险。 | David St Clair Mingqing Xu Peng Wang Yaqin Yu Yourong Fang Feng Zhang Xiaoying Zheng Niufan Gu Guoyin Feng Pak Sham Lin He 张继志(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 3 |
| 6 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 7 | Proteomic and metabolomic profiling underlines the stage- and time-dependent effects of high temperature on grape berry metabolism显示文摘Climate change scenarios predict an increase in mean air temperatures and in the frequency,intensity,and length of extreme temperature events in many wine-growing regions worldwide.Because elevated temperature has detrimental effects on berry growth and composition,it threatens the economic and environmental sustainability of wine production.Using Cabernet Sauvignon fruit-bearing cuttings,we investigated the effects of high temperature(HT)on grapevine berries through a label-free shotgun proteomic analysis coupled to a complementary metabolomic study.Among the 2,279 proteins identified,592 differentially abundant proteins were found in berries exposed to HT.The gene ontology categories“stress,”“protein,”“secondary metabolism,”and“cell wall”were predominantly altered under HT.High temperatures strongly impaired carbohydrate and energy metabolism,and the effects depended on the stage of development and duration of treatment.Transcript amounts correlated poorly with protein expression levels in HT berries,highlighting the value of proteomic studies in the context of heat stress.Furthermore,this work reveals that HT alters key proteins driving berry development and ripening.Finally,we provide a list of differentially abundant proteins that can be considered as potential markers for developing or selecting grape varieties that are better adapted to warmer climates or extreme heat waves. | David Lecourieux Christian Kappel Stéphane Claverol Philippe Pieri Regina Feil John E.Lunn Marc Bonneu Lijun Wang Eric Gomès Serge Delrot Fatma Lecourieux | 2020 | Journal of Integrative Plant Biology2020，62，8： | 2 |
| 8 | Early Administration of Azathioprine vs Conventional Management of Crohn’s Disease: a Randomized Controlled Trial显示文摘 | Jacques Cosnes Anne Bourrier David Laharie Stéphane Nahon Yoram Bouhnik Franck Carbonnel Matthieu Allez Jean-Louis Dupas Jean-Marie Reimund Guillaume Savoye Pauline Jouet Jacques Moreau Jean-Yves Mary Jean-Frédéric Colombel | 2013 | Gastroenterology2013，，： | 2 |
| 9 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 10 | 在亚洲和欧洲人群中对一个AC二核苷酸重复的多态性位点与精神分裂症的关联研究显示文摘连锁研究表明,染色体15q13-q14区域可能是精神分裂症的易感区域。在此项研究中,使用来自中国和苏格兰的3套独立的样本,对位于D15S118的AC二核苷酸重复的多态性位点与精神分裂症进行了关联分析。在苏格兰病例-对照样本中,该多态性位点的等位基因在患者和正常人中的分布存在显著性差异(P=0.04),但是这一结果在中国的病例-对照组中没有得到重复。在中国三口之家的样本中,我们没有观察到有等位基因从正常的父母向患病子女的传递不平衡。总之,至少在中国人中,此结果不支持这个AC二核苷酸重复的多态性位点在精神分裂症的易感性中扮演重要的角色。后续的研究有必要进一步阐明在欧洲人中该多态性位点在精神分裂症的易感性中扮演的角色。 | 马捷 樊金波 吴胜男 张长顺 纪宝虎 王磊 李兴旺 顾牛范 冯国鄞 David St Clair 贺林 | 2007 | 遗传2007，29，10： | 2 |
| 11 | HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor显示文摘 | Jeffrey J. Kovacs Patrick J.M. Murphy Stéphanie Gaillard Xuan Zhao June-Tai Wu Christopher V. Nicchitta Minoru Yoshida David O. Toft William B. Pratt Tso-Pang Yao | 2005 | Molecular Cell2005，，： | 2 |
| 12 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 13 | Human illness from avian influenza H7N3, British Columbia显示文摘 | Tweed SA Skowronski DM David ST | 2004 | Emerg Infect Dis2004，10，12： | 1 |
| 14 | Activity of chitin deacetylase from Colletotrichum gloeosporioides on chitinous substrates显示文摘 | Neith Pacheco Stéphane Trombotto Laurent David Keiko Shirai | 2013 | Carbohydrate Polymers2013，，： | 1 |
| 15 | Lack of genotoxicity of bitumen fumes in transgenic mouse lung显示文摘 | Jean Claude Micillino Catherine Coulais Stéphane Binet Marie-Claire Bottin Gérard Keith David Moulin Bertrand Henri Rihn | 2002 | Toxicology2002，，1： | 1 |
| 16 | Inflammatory bowel disease in spouses and their offspring显示文摘 | David Laharie Stéphane Debeugny Marc Peeters André Van Gossum Corinne Gower-Rousseau Jacques Bélahe René Fiasse Jean-Louis Dupas Eric Lerebours Sandrine Piotte Antoine Cortot Séverine Vermeire Bruno Grandbastien Jean-Frédéric Colombel | 2001 | Gastroenterology2001，，： | 1 |
| 17 | Genetic and phenotypic differences between isolates of Murray Valley encephalitis virus in Western Australia, 1972–2003显示文摘 | Cheryl A. Johansen Veronica Susai Roy A. Hall John S. Mackenzie David C. Clark Fiona J. May Stéphane Hemmerter David W. Smith Annette K. Broom | 2007 | Virus Genes2007，，： | 1 |
| 18 | Merged satellite ocean color data products using a bio-optical model: Characteristics, benefits and issues显示文摘 | Stéphane Maritorena Odile Hembise Fanton d’Andon Antoine Mangin David A. Siegel | 2010 | Remote Sensing of Environment2010，，8： | 1 |
| 19 | Clair,Enhancement of dimensional stability in soluble fluorinated polyimides via the in situ formation of lanthanum(Ⅲ)-oxo-polyimide nanocomposites显示文摘 | Robin E Southward D Scott Thompson David W Thompson Anne K St | 1998 | Chem Mater1998，10，： | 1 |
| 20 | Nuclear Control of the Inflammatory Response in Mammals by Peroxisome Proliferator-Activated Receptors显示文摘 | Stéphane Mandard David Patsouris Massimo Bionaz | 2013 | PPAR Research2013，，： | 1 |
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