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| 1 | Epidemiology and Natural History of Inflammatory Bowel Diseases显示文摘 | Jacques Cosnes Corinne Gower–Rousseau Philippe Seksik Antoine Cortot | 2011 | Gastroenterology2011，，6： | 11 |
| 2 | Disease activity and cancer risk in inflammatory bowel disease associated with primary sclerosing cholangitis显示文摘AIM: To investigate the phenotype of inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD). METHODS: Data from 75 PSC-IBD patients evaluated in our tertiary center between 1963 and 2006 were collected and compared to 150 IBD patients without PSC, matched for sex, birth date, IBD diagnosis date and initial disease location regarding ileal, different colonic segments, and rectum, respectively. RESULTS: While PSC-IBD patients received more 5-aminosalicylates (8.7 years/patient vs 2.9 years/ patient, P < 0.001), they required less immuno-suppressors (24% vs 46% at 10 years; P < 0.001) and less intestinal resection (10% vs 44% at 10 years, P < 0.001). The 25-year cumulative rate of colectomy was 25.1% in PSC-IBD and 37.3% in controls (P = 0.004). The 25-year cumulative rate of colorectal cancer was 23.4% in PSC-IBD vs 0% in controls (P = 0.002). PSC was the only independent risk factor for the development of colorectal cancer (OR = 10.8; 95% CI, 3.7-31.3). Overall survival rate without liver transplantation was reduced in PSC-IBD patients (67% vs 91% in controls at 25 years, P = 0.001).CONCLUSION: This study confirms that patients with PSC-IBD have a particular disease phenotype independent of the initial disease location. Although their disease is less active and they use more 5-aminosalicylates, they present a higher risk of colorectal cancer. | Harry Sokol Jacques Cosnes Olivier Chazouilleres Laurent Beaugerie Emmanuel Tiret Raoul Poupon Philippe Seksik | 2008 | World Journal of Gastroenterology2008，14，22： | 10 |
| 3 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat | 2009 | The Lancet . 2009 (9701)2009，，： | 4 |
| 4 | Gender differences in the response of colitis to smoking显示文摘 | Jacques Cosnes Isabelle Nion-larmurier Pauline Afchain Laurent Beaugerie Jean-pierre Gendre | 2004 | Clinical Gastroenterology and Hepatology2004，，： | 2 |
| 5 | Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial显示文摘 | David Laharie Arnaud Bourreille Julien Branche Matthieu Allez Yoram Bouhnik Jerome Filippi Frank Zerbib Guillaume Savoye Maria Nachury Jacques Moreau Jean-Charles Delchier Jacques Cosnes Elena Ricart Olivier Dewit Antonio Lopez-Sanroman Jean-Louis Dupas F | 2012 | The Lancet2012，，9857： | 2 |
| 6 | Early Administration of Azathioprine vs Conventional Management of Crohn’s Disease: a Randomized Controlled Trial显示文摘 | Jacques Cosnes Anne Bourrier David Laharie Stéphane Nahon Yoram Bouhnik Franck Carbonnel Matthieu Allez Jean-Louis Dupas Jean-Marie Reimund Guillaume Savoye Pauline Jouet Jacques Moreau Jean-Yves Mary Jean-Frédéric Colombel | 2013 | Gastroenterology2013，，： | 2 |
| 7 | Tobacco and IBD: relevance in the understanding of disease mechanisms and clinical practice显示文摘 | Jacques Cosnes | 2004 | Best Practice & Research Clinical Gastroenterology2004，，： | 2 |
| 8 | Impact of cessation of smoking on the course of ulcerative colitis显示文摘 | Laurent Beaugerie Nathalie Massot Franck Carbonnel Stéphane Cattan Jean-Pierre Gendre Jacques Cosnes | 2001 | The American Journal of Gastroenterology2001，，7： | 2 |
| 9 | Smoking cessation and the course of Crohn’s disease: An intervention study显示文摘 | Jacques Cosnes Laurent Beaugerie Franck Carbonnel Jean-Pierre Gendre | 2001 | Gastroenterology2001，，： | 2 |
| 10 | Adaptive hyperphagia in patients with post-surgical malabsorption 显示文摘 | Cosnes J Lamy P Beaugerie L | 1990 | Gastroenterology1990，99，6： | 1 |
| 11 | Smoking cessation and the cours of Crohn's disease:an intervention study显示文摘 | Cosnes J Beaugerie L Carbonnel F | 2001 | Gastroenter- ology2001，120，5： | 1 |
| 12 | Excess risk of urinary tract cancers in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | A. Bourrier F. Carrat J.‐F. Colombel A.‐M. Bouvier V. Abitbol P. Marteau J. Cosnes T. Simon L. Peyrin‐Biroulet L. Beaugerie | 2016 | Aliment Pharmacol Ther2016，，2： | 1 |
| 13 | Incidence of benign upper respiratory tract infections, HSV and HPV cutaneous infections in inflammatory bowel disease patients treated with azathioprine显示文摘 | Seksik P Cosnes J Sokol H | 2009 | Aliment Pharmacol Ther2009，29，10： | 1 |
| 14 | Impact of the diagnosis and treatment of cancer on the course of inflammatory bowel disease显示文摘 | S. Rajca P. Seksik A. Bourrier H. Sokol I. Nion-Larmurier L. Beaugerie J. Cosnes | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 15 | Prior appendectomy and the phenotype and course of Crohn's disease显示文摘瞄准:决定优先的阑尾切除术是否修改 Crohn 的疾病的显型和严厉。方法:阑尾切除术地位和吸烟习惯被直接会见在连续地在 1995 和 2004 之间看见的 2838 个病人指定。复杂并发症和治疗学的需要的出现回顾地被考察。另外,年度疾病活动在没有回盲肠切除术的病人并且一个匹配的控制组在 1995 和 2004 之间有希望地被估计。结果:比作 1770 个 non-appendectomized 病人,在 Crohn 的疾病诊断(n=716 ) 前的超过 5 年更经常是的 appendectomized 病人女性,吸烟者,与 i 一起忠实疾病。考克斯回归证明那优先的阑尾切除术是断然与肠的苛评的风险有关(调整危险比率, 1.24;95% 信心间隔, 1.13 ~ 1.36;P=0.02 ) 并且相反地与仙子的风险有关肛门成瘘 2. 造瘘术(调整危险比率, 0.75;95% 信心间隔, 0.68 ~ 0.83;P=0.002 ) 。没有差别关于治疗学的需要在二个组之间被观察,除了在 appendectomized 病人,的外科的增加的风险对 i 的增加的流行可归因忠实疾病。在 1995 和 2004 之间, Crohn 的疾病在在 appendectomized 病人的 50% 年期间是活跃的(1318 从 2637 耐心年) 并且 51% 在 non-appendectomized 病人(1454 从 2841 耐心年;NS ) 。结论:优先的阑尾切除术与更近似的疾病被联系并且有苛评的增加的风险和肛门成瘘 2. 造瘘术的更小的风险。然而,疾病的严厉是未受影响的。 | Jacques Cosnes Philippe Seksik Isabelle Nion-Larmurier Laurent Beaugerie Jean-Pierre Gendre | 2006 | World Journal of Gastroenterology2006，12，8： | 1 |
| 16 | Intravenous cyclosporine in attacks of ulcerative colitis显示文摘 | Dr. Franck Carbonnel MD Arnaud Boruchowicz MD Bernard Duclos MD Jean Claude Soulé MD Eric Lerebours MD Marc Lémann MD Jean Bela?che MD Jean Frédéric Colombel MD Jacques Cosnes MD Jean Pierre Gendre MD | 1996 | Digestive Diseases and Sciences1996，，12： | 1 |
| 17 | Long-term evolution of disease behavior of Crohn' s disease 显示文摘 | Cosnes J Cattan S Blain A | 2002 | Inflamm Bowel Dis2002，8，4： | 1 |
| 18 | Nodular regenerative hyperplasia in patients with inflammatory bowel disease treated with azathioprine 显示文摘 | Vernier - Massouille G Cosnes J Lemann M | 2007 | Gut2007，56，10： | 1 |
| 19 | Classification of the sequelae of bowel resection for Crohn' s disease 显示文摘 | Cosnes J de Parades V Carbonnel F | 1994 | Br J Surg1994，81，11： | 1 |
| 20 | Early azathioprine in Crohn' s disease 显示文摘 | Cosne~s J Seksik P | 2013 | Inflamm Bowel Dis2013，19，3： | 1 |
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