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| 1 | Gender influence on defecographic abnormalities in patients with posterior pelvic floor disorders显示文摘AIM:To compare defecographic abnormalities in symptomatic men and women and to analyze differences between men and age-and symptom-matched women.METHODS:Sixty-six men(mean age:55.4 years,range:20-81 years) who complained of constipation and/or fecal incontinence and/or pelvic pain underwent defecography after intake of a barium meal.Radiographs were analyzed for the diagnosis of rectocele,enterocele,intussusception and perineal descent.They were compared with age-and symptom-matched women(n = 198) who underwent defecography during the same period.RESULTS:Normal defecography was observed in 22.7% of men vs 5.5% of women(P < 0.001).Defecography in men compared with women showed 4.5%vs 44.4%(P < 0.001) rectocele,and 10.6% vs 29.8%(P < 0.001) enterocele,respectively.No difference was observed for the diagnosis of intussusception(57.6% vs 44.9%).Perineal descent at rest was more frequent in women(P < 0.005).CONCLUSION:For the same complaint,diagnosis of defecographic abnormalities was different in men than in women:rectocele,enterocele and perineal descent at rest were observed less frequently in men than in women. | Céline Savoye-Collet Guillaume Savoye Edith Koning Anne-Marie Leroi Jean-Nicolas Dacher | 2010 | World Journal of Gastroenterology2010，16，4： | 8 |
| 2 | Magnetic resonance imaging may predict deep remission in patients with perianal fistulizing Crohn's disease显示文摘AIM To evaluate the imaging course of Crohn's disease(CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor(TNF)-α therapy and identify predictors of deep remission.METHODS All patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging(MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. Clinical assessment(remission, response and non-response) was based on Present's criteria. Rectoscopic patterns, MRI Van Assche score, and MRI fistula activity signs(T2 signal and contrast enhancement) were collected for the two MR examinations. Fistula healing was defined as the absence of T2 hyperintensity and contrast enhancement on MRI. Deep remission was defined as the association of both clinical remission, absence of anal canal ulcers and healing on MRI. Characteristics and imaging patterns of patients with and without deep remission were compared by univariate and multivariate analyses.RESULTS Forty-nine consecutive patients(31 females and 18 males) were included. They ranged in age from 14-70 years(mean, 33 years). MRI and clinical assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. Clinical remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respectively. Deep remission was observed in 32.7% of patients. Among the 26 patients in clinical remission, 10 had persisting inflammation of fistulas on MRI(T2 hyperintensity, n = 7; contrast enhancement, n = 10). Univariate analysis showed that deep remission was associated with the absence of rectal involvement and the absence of switch of anti-TNF-α treatment or surgery requirement. Multivariate analysis demonstrated that only the absence of rectal involvement(OR = 4.6; 95%CI: 1.03-20.5) was associated with deep remission.CONCLUSION Deep remission is achieved in approximately one third of patients on maintenance anti-TNF-α therapy. Absence of rectal involvement is predictive of deep remission. | Lucie Thomassin Laura Armengol-Debeir Cloé Charpentier Valerie Bridoux Edith Koning Guillaume Savoye Céline Savoye-Collet | 2017 | World Journal of Gastroenterology2017，23，23： | 5 |
| 3 | Maintenance of Remission Among Patients With Crohn’s Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped显示文摘 | Edouard Louis Jean–Yves Mary Gwenola Vernier–Massouille Jean–Charles Grimaud Yoram Bouhnik David Laharie Jean–Louis Dupas Hélène Pillant Laurence Picon Michel Veyrac Mathurin Flamant Guillaume Savoye Raymond Jian Martine DeVos Rapha?l Porcher Gilles Paint | 2012 | Gastroenterology2012，，1： | 4 |
| 4 | 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling显示文摘AIM:To investigate whether targeting proteasome might reverse intestinal fibrosis in rats.METHODS:Chronic colitis was induced in rats by repeated administration of increasing dose of2,4,6-trinitrobenzene sulfonic acid(TNBS,15,30,45,60,60,60 mg)by rectal injection for 6 wk(from day0 to day 35),while control rats received the vehicle.TNBS+bortezomib(BTZ)rats received intraperitoneal injections of BTZ twice weekly(from day 37 to day44)at a dose of 25 mg/kg,whereas the control and TNBS groups received the same amount of the vehicle.Histologic scoring of inflammation and fibrosis was performed.Colonic production of transforming growth factor(TGF)-βwas measured by ELISA.Colon fibrosisrelated proteins such as phospho-p38,phosphoSMAD2/3,Akt and peroxisome proliferator activated receptorγ(PPARγ)were studied by western blot.Expression of the tight junction proteins,occludin and claudin-1,were assessed by Western blot.Colon proteasome activities(chymotrypsin-like and trypsinlike activities)were assessed.RESULTS:TNBS-treated rats had a higher colon weight/length ratio compared to control rats(P<0.01).Furthermore,fibrosis and inflammation scores were higher in TNBS-treated rats compared to control rats(P<0.01 for both).Colonic production of TGF-βproduction tended to be higher in TNBS-treated rats(P<0.06).Fibrosis-related proteins such as phospho-p38,phospho-SMAD2/3,and PPARγwere significantly higher in TNBS-treated rats compared to control rats(all P<0.05).TNBS rats had a higher expression of Akt compared to control rats(P<0.01).Tight junction proteins were modified by repeated TNBS challenge:colon occludin expression rose significantly(P<0.01),whereas claudin-1 expression fell(P<0.01).Bortezomib inhibition significantly decreased chymotrypsin-like activity(P<0.05),but had no significant effect on trypsin-like activity(P>0.05).In contrast,bortezomib had no effect on other studied parameters such as fibrosis score,TGF-βsignaling,or tight junction expression(P>0.05 for all).CONCLUSION:Rats with TNBS-induced chronic colitis exhibited colon fibrosis associated with higher TGF-βsignaling.Proteasome inhibition by bortezomib had no effect on fibrosis in our experimental conditions. | Emilien Loeuillard Julien Bertrand Anni Herranen Chloé Melchior Charlène Guérin Mo?se Co?ffier Moutaz Aziz Pierre Déchelotte Guillaume Savoye Rachel Marion-Letellier | 2014 | World Journal of Gastroenterology2014，20，48： | 4 |
| 5 | Epidemiology of inflammatory bowel diseases: New insights from a French population-based registry (EPIMAD)显示文摘 | Corinne Gower-Rousseau Francis Vasseur Mathurin Fumery Guillaume Savoye Julia Salleron Luc Dauchet Dominique Turck Antoine Cortot Laurent Peyrin-Biroulet Jean Frédéric Colombel | 2012 | Digestive and Liver Disease2012，，： | 3 |
| 6 | Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial显示文摘 | David Laharie Arnaud Bourreille Julien Branche Matthieu Allez Yoram Bouhnik Jerome Filippi Frank Zerbib Guillaume Savoye Maria Nachury Jacques Moreau Jean-Charles Delchier Jacques Cosnes Elena Ricart Olivier Dewit Antonio Lopez-Sanroman Jean-Louis Dupas F | 2012 | The Lancet2012，，9857： | 2 |
| 7 | Early Administration of Azathioprine vs Conventional Management of Crohn’s Disease: a Randomized Controlled Trial显示文摘 | Jacques Cosnes Anne Bourrier David Laharie Stéphane Nahon Yoram Bouhnik Franck Carbonnel Matthieu Allez Jean-Louis Dupas Jean-Marie Reimund Guillaume Savoye Pauline Jouet Jacques Moreau Jean-Yves Mary Jean-Frédéric Colombel | 2013 | Gastroenterology2013，，： | 2 |
| 8 | 显示文摘 | Goedhart J Von Stetten D Noirclere Savoye M | 2012 | Nature Communications2012，20，3： | 1 |
| 9 | Systemic Infection Related to Endocarditis on Pacemaker Leads: Clinical Presentation and Management显示文摘 | Didier Klug Dominique Lacroix Christine Savoye Luc Goullard Daniel Grandmougin Jean Luc Hennequin Salem Kacet Jean Lekieffre | 1997 | Circulation1997，，8： | 1 |
| 10 | Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study显示文摘 | Martina Goffredo Sonia Caprio Ariel E. Feldstein Ebe D’Adamo Melissa M. Shaw Bridget Pierpont Mary Savoye Hongyu Zhao Allen E. Bale Nicola Santoro | 2016 | Hepatology2016，，1： | 1 |
| 11 | Inadequate T follicular cell help impairs B cell immunity during HIV infection显示文摘 | Cubas RA Mudd JC Savoye AL | 2013 | Nat Med2013，19，4： | 1 |
| 12 | Morphology and architecture of the present canyonand channel system of the Zaire deep-sea fan显示文摘 | BABONNEAU N SAVOYE B CREMER M | 2001 | Ma-rine and Petroleum Geology2001，19，： | 1 |
| 13 | Wastewater disinfection by ozone: main parameters for process design显示文摘 | Pei Xu Marie-Laure Janex Philippe Savoye Arnaud Cockx Valentina Lazarova | 2002 | Water Research2002，，4： | 1 |
| 14 | Thiol WR-1065 and disulfide WR-33278, two metabolites of the drug Ethol(WR-2721), protect DNA against fast neutron induced strand breakage 显示文摘 | Savoye C Swenberg C Hugot S | 1997 | Int J Radiat Biol1997，71，： | 1 |
| 15 | Advanced Wastewater Disinfection Technologies: State of the Art and Perspectives 显示文摘 | Lazarova V Savoye P Janex M L | 1999 | Water Science and Technology1999，40，45： | 1 |
| 16 | Morphology and architecture of the present canyon and channel system of the Zaire deep-sea fan显示文摘 | Babonneau N Savoye B Cremer M | | 0，，4： | 1 |
| 17 | Effects of a weight manage- ment program on body composition and metabolic parameters in over- weight children : A randomized controlled trial 显示文摘 | SAVOYE M SHAW M DZIURA J | 2007 | JAMA2007，297，24： | 1 |
| 18 | Fatty acids, eico- sanoids and PPAR gamma 显示文摘 | Marion-Letellier R Savoye G Ghosh S | 2015 | European Journal of Pharmacology2015，，30： | 1 |
| 19 | Hemorrhagic shock resuscitation affects early and selectivemesenteric artery endothelial function through a free radical-dependent mechanism显示文摘 | SAVOYE G TAMION F RICHARD V | 2005 | Shock2005，23，5： | 1 |
| 20 | Low levels of glutathione in endoscopic biopsies in patients with Crohn's colitis: the role of malnutrition 显示文摘 | Miralles-Barrachina O Savoye G Belmonte-Zalar L | 1999 | Clin Nutr1999，18，5： | 1 |
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