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| 1 | Impact of disease severity on gastric residual volume in critical patients显示文摘AIM: To investigate whether illness severity has an impact on gastric residual volume (GRV) in medical critically ill patients. METHODS: Medical intensive care unit (ICU) patients requiring nasogastric feeding were enrolled. Sequential Organ Failure Assessment (SOFA) score was assessed immediately preceding the start of the study. Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores were recorded on the first, fourth, seventh, and fourteenth day of the study period. GRV was measured every 4 h during enteral feeding. The relationship be-tween mean daily GRV and SOFA scores and the correlation between mean daily GRV and mean APACHE Ⅱ score of all patients were evaluated and compared. RESULTS: Of the 61 patients, 43 patients were survivors and 18 patients were non-survivors. The mean daily GRV increased as SOFA scores increased (P < 0.001, analysis of variance). Mean APACHE Ⅱ scores of all patients correlated with mean daily GRV (P = 0.011, Pearson correlation) during the study period. Patients with decreasing GRV in the first 2 d had better survival than patients without decreasing GRV (P = 0.017, log rank test). CONCLUSION: GRV is higher in more severely ill medical ICU patients. Patients with decreasing GRV had lower ICU mortality than patients without decreasing GRV. | Chien-Wei Hsu Shu-Fen Sun David Lin Lee Shoa-Lin Lin Kam-Fai Wong Hsiu-Hua Huang Hung-Ju Li | 2011 | World Journal of Gastroenterology2011，17，15： | 8 |
| 2 | Muscular Dystrophy Therapy by Nonautologous Mesenchymal Stem Cells: Muscle Regeneration Without Immunosuppression and Inflammation显示文摘 | Arsalan Shabbir David Zisa Merced Leiker Curtis Johnston Huey Lin Techung Lee | 2009 | Transplantation2009，，9： | 1 |
| 3 | A Web-based Bookmark Tool with Ontological Approach for Knowledge Sharing of Special Interest Groups显示文摘 | Wu Lin Lee Tsa Chun-Yen | 2005 | Advanced Information Networking and Applications2005，2，3： | 1 |
| 4 | Early Course of Inflammatory Bowel Disease in a Population-Based Inception Cohort Study From 8 Countries in Asia and Australia显示文摘 | Siew C. Ng Zhirong Zeng Ola Niewiadomski Whitney Tang Sally Bell Michael A. Kamm Pinjin Hu H. Janaka de Silva Madunil A. Niriella W.S.A.A. Yasith Udara David Ong Khoon Lin Ling Choon Jin Ooi Ida Hilmi Khean Lee Goh Qin Ouyang Yu Fang Wang Kaichun Wu Xin W | 2015 | Gastroenterology2015，，： | 1 |
| 5 | Enhanced affect/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients显示文摘 | Hsing-Feng Lee Jen-Chuen Hsieh Ching-Liang Lu Tzu-Chen Yeh Cheng-Hao Tu Chou-Ming Cheng David M. Niddam Han-Chieh Lin Fa-Yauh Lee Full-Young Chang | 2012 | Pain2012，，： | 1 |
| 6 | Secreted Frizzled-related Protein 2 (SFRP2) is Highly Expressed in Canine Mammary Gland Tumors but not in Normal Mammary Glands显示文摘 | Jia-Lin Lee Ching-Jin Chang Szu-Ying Wu David R. Sargan Chung-Tien Lin | 2004 | Breast Cancer Research and Treatment2004，，2： | 1 |
| 7 | Synergistic Effects of Family History of Hepatocellular Carcinoma and Hepatitis B Virus Infection on Risk for Incident Hepatocellular Carcinoma显示文摘 | Rohit Loomba Jessica Liu Hwai–I. Yang Mei–Hsuan Lee Sheng–Nan Lu Li–Yu Wang Uchenna H. Iloeje San–Lin You David Brenner Chien–Jen Chen | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 8 | An open‐label, single‐arm, phase 2 trial of the polo‐like kinase inhibitor volasertib (BI 6727) in patients with locally advanced or metastatic urothelial cancer显示文摘 | Walter M. Stadler David J. Vaughn Guru Sonpavde Nicholas J. Vogelzang Scott T. Tagawa Daniel P. Petrylak Peter Rosen Chia‐Chi Lin John Mahoney Sanjiv Modi Peter Lee Marc S. Ernstoff Wu‐Chou Su Alexander Spira Korinna Pilz Richard Vinisko Charles Schloss H | 2014 | Cancer2014，，7： | 1 |
| 9 | Enhanced affect/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients显示文摘 | Hsing-Feng Lee Jen-Chuen Hsieh Ching-Liang Lu Tzu-Chen Yeh Cheng-Hao Tu Chou-Ming Cheng David M. Niddam Han-Chieh Lin Fa-Yauh Lee Full-Young Chang | 2012 | Pain2012，，6： | 1 |
| 10 | Marine geology in the arc-continent collision zone off southeastern Taiwan:Implications for late Neogene evolution of the Coastal Range显示文摘 | Huang Chi-Yue Shyu Chen-Tien Lin Szubin B Lee Teh-Quei and Sheu David D | | 0，，： | 1 |
| 11 | VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway显示文摘Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases. | Chunsik Lee Rongyuan Chen Guangli Sun Xialin Liu Xianchai Lin Chang He Liying Xing Lixian Liu Lasse DJensen Anil Kumar Harald FLanger Xiangrong Ren Jianing Zhang Lijuan Huang Xiangke Yin JongKyong Kim Juanhua Zhu Guanqun Huang Jiani Li Weiwei Lu Wei Chen Juanxi Liu Jiaxin Hu Qihang Sun Weisi Lu Lekun Fang Shasha Wang Haiqing Kuang Yihan Zhang Geng Tian Jia Mi Bi-Ang Kang Masashi Narazaki Aaron Prodeus Luc Schoonjans David MOrnitz Jean Gariepy Guy Eelen Mieke Dewerchin Yunlong Yang Jing-Song Ou Antonio Mora Jin Yao Chen Zhao Yizhi Liu Peter Carmeliet Yihai Cao Xuri Li | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 12 | 急性卒中影像学研究路径图Ⅱ显示文摘卒中影像学研究组(StrokeImagingResearchGroup,STIR)、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议,最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议(Stroke Treatment Academy Industry Roundtable,STAIR)期间举行。 | Max Wintermark Gregory W. Albers Joseph P. Broderick Andrew M. Demchuk Jochen B. Fiebach Jens Fiehler James C. Grotta Gary Houser Tudor G. Jovin Kennedy R. Lees Michael H. Lev David S. Liebeskind Marie Luby Keith W. Muir Mark W. Parsons Rudiger von Kummer Joanna M. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Richard I. Aviv Roland Bammer Jean-Claude Baron Fernando Calamante Bruce C.V. Campbell Trevor C. Carpenter Sφren Christensen William A. Copen Colin P. Derdeyn E. Clarke Haley Jr Pooja Khatri Kohsuke Kudo Maarten G. Lansberg Lawrence L. Latour Ting-Yim Lee Richard Leigh Weili Lin Patrick Lyden Grant Mair Bijoy IC Menon Patrik Michel Robert Mikulik Raul G. Nogueira Left φstergaard Salvador Pedraza Christian H. Riedel Howard A. Rowley Pina C. Sanelli Makoto Sasaki Jeffrey L. Saver Pamela W. Schaefer Peter D. Schellinger Georgios Tsivgoulis Lawrence R. Wechsler Philip M. White Greg Zaharchuk Osama O. Zaidat Stephen M. Davis Geoffrey A. Donnan Anthony J. Furlan Werner Hacke Dong-Wha Kang Chelsea Kidw ell Vincent N. Thijs Gotz Thomalla Steven J. Warach 严晓铭 刘牧 张晶晶 柯开富 | 2014 | 国际脑血管病杂志2014，22，2： | 0 |
| 13 | How profitable is switchgrass in Illinois, USA? An economic definition of marginal land显示文摘Background:Decisions regarding the conversion of land from an existing crop to bioenergy crops are critical for the sustainable production of both food and fuels.This study seeks to establish criteria for delineating land as“economically marginal”,and thus suited for growing switchgrass.Methods:In this case study of an Illinois agricultural field,the profitability of switchgrass,with farmgate prices of$44 Mg−1,$66 Mg−1,or$88 Mg−1,was compared to corn and soybean crop prices.Further,the study also evaluates the profitability of switchgrass when replacing corn‐based yield estimates from the Soil Productivity Index(SPI)of Illinois.Results:Based on a dry‐matter yield of 10.45 Mg ha−1,switchgrass can compete with soybeans only at the high price of$88 Mg−1,but depending on location,can compete with corn at$66 Mg−1.Across Illinois,at$88 ha−1,all Illinois land with SPI<100%and 95%of land under SPI class C(SPI 100–116)is profitable under switchgrass.Switchgrass may not be profitable relative to corn grown in the SPI class A(SPI>133)and only 7%of class B(SPI 117–132).Conclusions:Our results show that land with drainage and erosion limitations is economically marginal when corn and soybean yields are low,and the farmgate price for switchgrass is greater than$66 Mg−1.However,this may not be possible on land where switchgrass is replacing frequent soybean rotations(corn–soybean ratio≤1).Land used to produce only soybeans may only be marginal at the farmgate price of$88 Mg−1.Further studies need to be conducted to identify how much land can be converted to switchgrass without harming corn production. | Nictor Namoi David Archer Todd S.Rosenstock Chunhwa Jang Cheng‐Hsien Lin Arvid Boe DoKyoung Lee | 2022 | Grassland Research2022，1，2： | 0 |
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