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| 1 | Prolonged QT dispersion in inflammatory bowel disease显示文摘AIM:To investigate the frequency and factors of prolonged QT dispersion that may lead to severe ventricular arrhythmias in patients with inflammatory bowel disease(IBD).METHODS:This study included 63 ulcerative colitis(UC) and 41 Crohn's disease(CD) patients.Forty-seven healthy patients were included as the control group.Heart rate was calculated using electrocardiography,corrected QT dispersion(QTcd) and the Bazett's formula.Homeostasis model assessment(HOMA) was used to determine insulin resistance(IR).HOMA values < 1 were considered normal and values > 2.5 indicated a high probability of IR.RESULTS:Prolonged QTcd was found in 12.2% of UC patients,and in 14.5% of CD patients compared with the control group(P < 0.05).A significant difference was found between the insulin values(CD:10.95 ± 6.10 vs 6.44 ± 3.28,P < 0.05;UC:10.88 ± 7.19 vs 7.20 ± 4.54,P < 0.05) and HOMA(CD:2.56 ± 1.43 vs 1.42 ± 0.75,P < 0.05;UC:2.94 ± 1.88 vs 1.90 ± 1.09,P < 0.05) in UC and CD patients with and without prolonged QTcd.Disease behavior types were determined in CD patients with prolonged QTcd.Increased systolic arterial pressure(125 ± 13.81 vs 114.09 ± 8.73,P < 0.01) and age(48.67 ± 13.93 vs 39.57 ± 11.58,P < 0.05) in UC patients were significantly associated with prolonged QTcd.CONCLUSION:Our data show that IBD patients have prolonged QTcd in relation to controls.The routine followup of IBD patients should include determination of HOMA,insulin values and electrocardiogram examination. | Elif Yorulmaz Aslihan Sezgin Gupse Adali Hatice Yorulmaz Hilmi Ciftci | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 2 | Immune therapies in pancreatic ductal adenocarcinoma: Where are we now?显示文摘Pancreatic ductal adenocarcinoma(PDAC)is one of the deadliest cancers,mostly due to its resistance to treatment.Of these,checkpoint inhibitors(CPI)are inefficient when used as monotherapy,except in the case of a rare subset of tumors harboring microsatellite instability(<2%).This inefficacy mainly resides in the low immunogenicity and non-inflamed phenotype of PDAC.The abundant stroma generates a hypoxic microenvironment and drives the recruitment of immunosuppressive cells through cancerassociated-fibroblast activation and transforming growth factorβsecretion.Several strategies have recently been developed to overcome this immunosuppressive microenvironment.Combination therapies involving CPI aim at increasing tumor immunogenicity and promoting the recruitment and activation of effector T cells.Ongoing studies are therefore exploring the association of CPI with vaccines,oncolytic viruses,MEK inhibitors,cytokine inhibitors,and hypoxia-and stroma-targeting agents.Adoptive T-cell transfer is also under investigation.Moreover,translational studies on tumor tissue and blood,prior to and during treatment may lead to the identification of biomarkers with predictive value for both clinical outcome and response to immunotherapy. | Marc Hilmi Laurent Bartholin Cindy Neuzillet | 2018 | World Journal of Gastroenterology2018，24，20： | 6 |
| 3 | Carbon-coated manganese dioxide nanoparticles and their enhanced electrochemical properties for zinc-ion battery applications显示文摘In this study, we report the cost-effective and simple synthesis of carbon-coated α-MnO_2nanoparticles(α-MnO_2@C) for use as cathodes of aqueous zinc-ion batteries(ZIBs) for the first time. α-MnO_2@C was prepared via a gel formation, using maleic acid(C_4H_4O_4) as the carbon source, followed by annealing at low temperature of 270 °C. A uniform carbon network among the α-MnO_2 nanoparticles was observed by transmission electron microscopy. When tested in a zinc cell, the α-MnO_2@C exhibited a high initial discharge capacity of 272 m Ah/g under 66 m A/g current density compared to 213 m Ah/g, at the same current density, displayed by the pristine sample. Further, α-MnO_2@C demonstrated superior cycleability compared to the pristine samples. This study may pave the way for the utilizing carbon-coated MnO_2 electrodes for aqueous ZIB applications and thereby contribute to realizing high performance eco-friendly batteries. | Saiful Islam Muhammad Hilmy Alfaruqi Jinju Song Sungjin Kim Duong Tung Pham Jeonggeun Jo Seokhun Kim Vinod Mathew Joseph Paul Baboo Zhiliang Xiu Jaekook Kim | 2017 | Journal of Energy Chemistry2017，26，4： | 6 |
| 4 | Crohn's disease in adults: Observations in a multiracial Asian population显示文摘瞄准:决定人口统计学和 CD 并且第二的临床的表示在一张多种族的亚洲人口在在不同的种族组之间的流行决定任何差别。方法:在马来亚医学中心(UMMC ) 的大学里在 2001-2003 被看见的有 CD 的病人在这研究被注册。疾病的流行作为分母每种族组与医院录取总体上并且由种族为这个组被计算。结果:34 个病人被诊断有 CD。病人的基本人口统计的数据;male:female 17:17;意味着年龄 29.1 年(+/-13.5 年) ;种族组:马来语 5 (14.7%) ,汉语 12 (35.3%) 并且印第安人 17 (50%) 。(76.5%) 26 不到 40 和 8 岁被诊断(23.5%) 超过 40 岁被诊断。疾病的地点作为 follows:ileocolonic 13 (38.2%) ,终端回肠仅仅 9 (26.5%) ,结肠仅仅 8 (23.5%) ,并且上面胃肠 4 (11.8%) 。(47.1%) 十六让了渗透疾病,(26.5%) 9 有 stricturing 疾病,(26.5%) 9 有非渗透、苛评得非的疾病。CD 的医院承认流行总的来说是 26.0,印第安人 52.6,汉语 6.9,并且马来语 9.3 每 10 (5 ) 录取每种族组。印第安人和马来语之间的差别:[或 5.67 (1.97, 17.53 ) P<0.001 ] 是统计上重要的然而并非在印第安人和汉语之间[或 1.95 (0.89, 4.35 ) P=0.700 ] 汉语之间的 .The 差别和马来语也不是统计上重要的。[或 2.90 (0.95, 9.42 ) P=0.063 ] 。结论:CD 的临床的演讲类似于西方的经验。尽管全面流行是低的,看起来是在印第安人之中的清楚的种族优势。 | Ida Hilmi YM Tan KL Goh | 2006 | World Journal of Gastroenterology2006，12，9： | 4 |
| 5 | The effect of nanoparticles on reservoir wettability alteration:a critical review显示文摘A novel concept of treating oil reservoirs by nanofluids is being developed to improve oil recovery and reduce the trapped oil in hydrocarbon reservoirs.Nanoparticles show great potential in enhancing oil recovery under ambient conditions.In this paper,the approaches of wettability alteration by using nanofluid,stability of nanofluids,and the most reliable wettability alteration mechanisms associated with variant types of nanoparticles have been reviewed.Moreover,the parameters that have a significant influence on nanofluid flooding have been discussed.Finally,the recent studies of the effect of nanoparticles on wettability alteration have been summarised and analysed.Furthermore,this paper presents possible opportunities and challenges regarding wettability alteration using nanofluids. | Hilmy Eltoum Yu-Long Yang Ji-Rui Hou | 2021 | Petroleum Science2021，18，1： | 3 |
| 6 | Primary sclerosing cholangitis in Turkish patients:characteristic features and prognosis显示文摘BACKGROUND:Primary sclerosing cholangitis(PSC)is a chronic cholestatic liver disease characterized by destruction and fibrosis of the bile ducts.This study aimed to demonstrate the hepatic and extrahepatic characteristic findings and prognostic outcomes of Turkish patients with PSC. METHODS:The medical records of 35 consecutive patients with PSC from January 1988 to June 2007 were recorded prospectively.From the time of diagnosis,clinical features and laboratory data were collected. RESULTS:The mean age of the 35 patients was 41.69 years (range 15-80 years)at the time of diagnosis;14(40%)were female,and 21(60%)were male.The mean duration of follow-up was 58.86 months(1-180 months).Twenty(57.1%) of the patients with PSC were asymptomatic and 22(62.9%) had inflammatory bowel disease.At the time of diagnosis, 20(57.1%)of the patients had both intra-and extra-hepatic PSC.Twenty-one(60%)of the patients,who had undergone ERCP for stent placement,had dominant bile duct stenosis. Cholangiocarcinoma was found in 2(5.7%)of the patients and cirrhosis was detected in 7(20%);5(14.3%)underwent liver transplantation.The median follow-up time after liver transplantation was 23 months and all are still alive.Six (17.1%)patients died. CONCLUSIONS:PSC has a clinical course varied from advanced liver disease requiring liver transplantation within a short time to being asymptomatic for decades. The prognosis of Turkish patients with PSC is also disappointing as described in other studies. | Hilmi Ataseven Erkan Parlak lhami Yüksel mer Ba■ar brahim Ertu■rul Nurgül ■a■maz Burhan ■ahin | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，3： | 3 |
| 7 | Effect of Helicobacter pylori Eradication on Insulin Resistance, Serum Lipids and Low-Grade Inflammation显示文摘 | Ramazan Gen Mehmet Demir Hilmi Ataseven | 2010 | Southern Medical Journal2010，，3： | 3 |
| 8 | Vital roles of stem cells and biomaterials in skin tissue engineering显示文摘Tissue engineering essentially refers to technology for growing new human tissue and is distinct from regenerative medicine. Currently, pieces of skin are already being fabricated for clinical use and many other tissue types may be fabricated in the future.Tissue engineering was first defined in 1987 by the United States National Science Foundation which critically discussed the future targets of bioengineering research and its consequences. The principles of tissue engineering are to initiate cell cultures in vitro, grow them on scaffolds in situ and transplant the composite into a recipient in vivo. From the beginning, scaffolds have been necessary in tissue engineering applications. Regardless, the latest technology has redirected established approaches by omitting scaffolds. Currently, scientists from diverse research institutes are engineering skin without scaffolds. Due to their advantageous properties, stem cells have robustly transformed the tissue engineering field as part of an engineered bilayered skin substitute that will later be discussed in detail. Additionally, utilizing biomaterials or skin replacement products in skin tissue engineering as strategy to successfully direct cell proliferation and differentiation as well as to optimize the safety of handling during grafting is beneficial. This approach has also led to the cells' application in developing the novel skin substitute that will be briefly explained in this review. | Abu Bakar Mohd Hilmi Ahmad Sukari Halim | 2015 | World Journal of Stem Cells2015，7，2： | 2 |
| 9 | Alvarado, Eskelinen, Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis scores for diagnosis of acute appendicitis显示文摘AIM:To assess the reliability and practical applicability of the widely used Alvarado,Eskelinen,Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis(RIPASA)scoring systems in patients with suspected acute appendicitis.METHODS:Patients admitted to our tertiary center due to suspected acute appendicitis constituted the study group.Patients were divided into two groups.appendicitis group(Group A)consisted of patients who underwent appendectomy and were histopathologically diagnosed with acute appendicitis,and non-appendicitis group(Group N-A)consisted of patients who underwent negative appendectomy and were diagnosed with pathologies other than appendicitis and patients that were followed non-operatively.The operative findings for the patients,the additional analyses from follow up of the patients and the results of those analyses were recorded using the follow-up forms.RESULTS:One hundred and thirteen patients with suspected acute appendicitis were included in the study.Of the 113 patients(62 males,51 females),the mean age was 30.2±10.1(range 18-67)years.Of the 113patients,94 patients underwent surgery,while the rest were followed non-operatively.Of the 94 patients,77patients were histopathologically diagnosed with acute appendicitis.Our study showed a sensitivity level of81%for the Alvarado system when a cut-off value of 6.5was used,a sensitivity level of 83.1%for the Ohmann system when a cut-off value of 13.75 was used,a sensitivity level of 80.5%for the Eskelinen system when a cut-off value of 63.72 was used,and a sensitivity level of 83.1%for the RIPASA system when a cut-off value of 10.25 was used.CONCLUSION:The Ohmann and RIPASA scoring systems had the highest specificity for the diagnosis of acute appendicitis. | Hasan Erdem Süleyman etinkünar Koray Das Enver Reyhan Cumhur Deger Mehmet Aziret Hilmi Bozkurt Seluk Uzun Selim Szen Oktay rkrücü | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 10 | Colorectal neoplasm in asymptomatic Asians: a prospective multinational multicenter colonoscopy survey显示文摘 | Jeong-Sik Byeon Suk-Kyun Yang Tae Il Kim Won Ho Kim James Y.W. Lau Wai-Keung Leung Rikiya Fujita Govind K. Makharia Murdan Abdullah Ida Hilmi Jose Sollano Khay-Guan Yeoh Deng-Chyang Wu Min Hu Chen Pradermchai Kongkam Joseph J.Y. Sung | 2007 | Gastrointestinal Endoscopy2007，，： | 2 |
| 11 | Isolated small bowel transplantation outcomes and the impact of immunosuppressants: Experience of a single transplant center显示文摘AIM: To investigate patient and graft outcomes in isolated small bowel transplant(SBTx) recipients and immunosuppressant induction agent impact on outcomes.METHODS: A retrospective review of the perioperative data of patients who underwent SBTx transplant during an 8-year period was conducted. The intraoperative data were: patient demographics, etiology of short gut syndrome, hemodynamic parameters, coagulation profiles, intraoperative fluid and blood products transfused, and development of post-reperfusion. The postoperative data were: hospital/intensive care unit stays, duration of mechanical ventilation, postoperative incidence of acute kidney injury, and 1-year patient and graft outcomes. The effects of the three immunosuppressant induction agents(Zenapax, Thymoglobulin, Campath) on patient and graft outcomes were reviewed.RESULTS: During the 8-year period there were 77 patients; 1-year patient and graft survival were 95% and 86% respectively. Sixteen patients received Zenapax, 22 received Thymoglobulin, and 39 received Campath without effects on patient or graft survival(P = 0.90, P = 0.14, respectively). The use of different immune induction agents did not affect the incidence of rejection and infection during the first 90 postoperative days(P = 0.072, P = 0.29, respectively). The Zenapax group received more intraoperative fluid and blood products and were coagulopathic at the end of surgery. Zenapax and Thymoglobulin significantly increased serum creatinine at 48 h(P = 0.023) and 1 wk(P = 0.001) post-transplant, but none developed renal failure or required dialysis at the end of the first year.CONCLUSION: One-year patient and graft survival were 95% and 86%, respectively. The use of different immunosuppressant induction agents may affect the intraoperative course and short-term postoperative morbidities, but not 1-year patient and graft outcomes. | Ibtesam A Hilmi Raymond M Planinsic Ramona Nicolau-Raducu Daniela Damian Ali Al-Khafaji Tetsuro Sakai Kareem Abu-Elmagd | 2013 | World Journal of Transplantation2013，3，4： | 2 |
| 12 | Radiation and chemical pretreatment of cellulosic waste显示文摘 | Hilmy N Erizal Erlinda T B | 1993 | Radiat Phys Chem1993，42，： | 1 |
| 13 | Tuning software phase-locked loop for series-connectedconverters显示文摘 | Awad Hilmy Svensson Jan Bollen M J | 2005 | IEEE Transactions on Power Delivery2005，20，1： | 1 |
| 14 | FOrster resonance energy transfer en- hanced color-conversion using colloidal semiconductor quantum dots for solid state lighting 显示文摘 | Sedat N Hilmi V D | 2009 | Appl Phys Lett2009，95，15： | 1 |
| 15 | A note on the exact travelling wave solution to the KdV–Burgers equation显示文摘 | Hilmi Demiray | 2003 | Wave Motion2003，，4： | 1 |
| 16 | A risk based PML estimation method for single-story reinforced concrete industrial buildings and its im- pact on earthquake insurance rates 显示文摘 | Ceyhun Eren · Hilmi Lus | 2015 | Bull Earthquake Eng2015，，13： | 1 |
| 17 | Electrochemical detectors prepared by electroless deposition for microfabricated electrophoresis chips显示文摘 | Hilmi A Luong JH | 2000 | Anal Chem2000，72，19： | 1 |
| 18 | Neurologic complications of cancer: Part 1: Central nervous system metastasis显示文摘 | Erol T Ahmet Hilmi K Sirzat B | 2004 | Neurosurg Quart2004，14，2： | 1 |
| 19 | Endo- scopic sphenopalatine artery ligation-when, why and how to do it显示文摘 | LOUGHRAN S HILMI O MCGARRY G W | 2005 | Clinical Otolarvnzol2005，，30： | 1 |
| 20 | Analysis and Design of a Stabilized Fly Ash as Pavement Base Material显示文摘 | Hilmi Lav A Aysen Lav M Burak Goktepe A | 2006 | Fuel2006，85，16： | 1 |
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