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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Benign liver tumors in pediatric patients-Review with emphasis on imaging features显示文摘Benign hepatic tumors are commonly observed in adults,but rarely reported in children.The reasons for this remain speculative and the exact data concerning the incidence of these lesions are lacking.Benign hepatic tumors represent a diverse group of epithelial and mesenchymal tumors.In pediatric patients,most benign focal liver lesions are inborn and may grow like the rest of the body.Knowledge of pediatric liver diseases and their imaging appearances is essential in order to make an appropriate differential diagnosis.Selection of the appropriate imaging test is challenging,since it depends on a number of age-related factors.This paper will discuss the most frequently encountered benign liver tumors in children(infantile hepatic hemangioendothelioma,mesenchymal hamartoma,focal nodular hyperplasia,nodular regenerative hyperplasia,and hepatocellular adenoma),as well as a comparison to the current knowledge regarding such tumors in adult patients.The current emphasis is on imaging features,which are helpful not only for the initial diagnosis,but also for pre- and posttreatment evaluation and follow-up.In addition,future perspectives of contrast-enhanced ultrasound(CEUS) in pediatric patients are highlighted,with descriptions of enhancement patterns for each lesion being discussed.The role of advanced imaging tests such as CEUS and magnetic resonance imaging,which allow for non-invasive assessment of liver tumors,is of utmost importance in pediatric patients,especially when repeated imaging tests are needed and radiation exposure should be avoided. | Liliana Chiorean Xin-Wu Cui Andrea Tannapfel Doris Franke Martin Stenzel Wojciech Kosiak Dagmar Schreiber-Dietrich J?rg Jüngert Jian-Min Chang Christoph F Dietrich | 2015 | World Journal of Gastroenterology2015，21，28： | 16 |
| 3 | 干辣椒风味物质气相色谱及质谱方法的研究显示文摘用嗅觉测量法-气相色谱联用(GC-O),火焰离子检测器-气相色谱联用(GC-FID),质谱-气相色谱联用(GC-MS)三种气相色谱检测方法和常压化学离子化飞行时间质谱(APCI-TOFMS),质子传递反应质谱(PTR-MS)两种直接质谱检测方法来比较测定干辣椒中的挥发性香味成分。干辣椒的挥发性香味成分的大体描述最后由感官评定来确定。三种较显著的风味分别是:辣椒味、煮熟蔬菜味和青草味。用气质联用顶空分析法共有63种挥发性香味成分被分离出来。而嗅觉测量法-气相色谱联用(GC-O)认为其中的11种成分决定了辣椒的香味活跃程度。在所有的方法中普遍认为:3-甲基正丁醛是最活跃的香味成份,其次是2-甲基正丁醛。确定挥发性香味成分的多少主要是受测定方法的影响。色谱方法之间有很强的相关性(ρ=0.946)。直接质谱法相关性不显著(ρ=0.613)。经过不同方法的分析,我们发现,用GC-MS,GC-FID和PTR-MS三种方法检测出的挥发性香味成分并没有显著的不同,显著性的差异主要存在于PCI-TOFMS法和其工艺的不同(P<0.01).(Int J Mass Spectrom223-224(2003)55-65) | Saskia van Ruth Elena Boscaini Dagmar Mayr Jonathan Pugh Maarten Posthumus 刘蓉 刘志敏 | 2007 | 辣椒杂志2007，，1： | 15 |
| 4 | Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization显示文摘临床的试用和动物实验的增加的数字显示出细菌为过敏症预防正在答应工具的那 probiotic。这里,我们在过敏促进感受性上分析了三选择乳杆菌紧张的 immunomodulatory 性质和他们的混合的影响赌 1 用一只 gnotobiotic 老鼠建模的 v。我们显示出那乳杆菌(L.) rhamnosus LOCK0900, L。rhamnosus LOCK0908 和 L。casei LOCK0919 经由像使用费的受体被认出 2 (TLR2 ) 并且核苷酸绑定 oligomerization 包含域的蛋白质 2 (NOD2 ) 受体并且刺激骨头在种类依赖者和紧张依赖者礼貌生产 cytokines 的导出髓的树枝状的房间。殖民无菌(GF ) 有所有三紧张(Lmix ) 的混合物的鼠标由加强 enterocytes 的顶端的 junctional 建筑群并且恢复延续到终端网的微细丝的结构改进了肠的障碍。与 Lmix 开拓殖民地于并且敏化 1 变应原到赌注 v 的老鼠显著地象一个增加的转变生长因素(TGF ) 一样在 sera 和肠的 lavages 显示出变应原特定的 IgE, IgG1 和 IgG2a 和提高的全部的 IgA 水平的底层 -β与敏化的 GF 老鼠相比铺平。从开拓殖民地于 Lmix 的老鼠的 Splenocytes 和 mesenteric 淋巴节点房间显示出 TGF-β 的重要 upregulation;在以后在有赌注 v 的 vitro 刺激 1。我们的结果证明 Lmix 殖民改进了内脏对赌注 v 的上皮的障碍和减少的过敏促进感受性 1。而且,这些调查结果被传播和能分泌的 IgA 和规章的 cytokine TGF-β 的增加的生产伴随;。因此,三乳杆菌紧张的这混合物在人在增加的内脏渗透和过敏症的发作的预防为使用显示出潜力。 | Hana Kozakova Martin Schwarzer Ludmila Tuckova Dagmar Srutkova Elzbieta Czarnowska Ilona Rosiak Tomas Hudcovic Irma Schabussova Petra Hermanova Zuzana Zakostelska Tamara Aleksandrzak-Piekarczyk Anna Koryszewska-Baginska Helena Tlaskalova-Hogenova Bozena Cukrowska | 2016 | Cellular & Molecular Immunology2016，13，2： | 10 |
| 5 | Ultrasonographic imaging of inflammatory bowel disease in pediatric patients显示文摘Inflammatory bowel disease(IBD) is one of the most common chronic gastrointestinal diseases in pediatric patients.Choosing the optimal imaging modality for the assessment of gastrointestinal disease in pediatric patients can be challenging.The invasiveness and patient acceptance,the radiation exposure and the quality performance of the diagnostic test need to be considered.By reviewing the literature regarding imaging in inflammatory bowel disease the value of ultrasound in the clinical management of pediatric patients is highlighted.Transabdominal ultrasound is a useful,noninvasive method for the initial diagnosis of IBD in children;it also provides guidance for therapeutic decisions and helps to characterize and predict the course of the disease in individual patients.Ultrasound techniques including color Doppler imaging and contrast-enhanced ultrasound are promising imaging tools to determine disease activity and complications.Comparative studies between different imaging methods are needed. | Liliana Chiorean Dagmar Schreiber-Dietrich Barbara Braden Xin-Wu Cui Reiner Buchhorn Jian-Min Chang Christoph F Dietrich | 2015 | World Journal of Gastroenterology2015，21，17： | 7 |
| 6 | Localized bursting of mesocarp cells triggers catastrophic fruit cracking显示文摘The so-called rain-cracking of sweet cherry fruit severely threatens commercial production.Simple observation tells us that cuticular microcracking(invisible)always precedes skin macrocracking(visible).The objective here was to investigate how a macrocrack develops.Incubating detached sweet cherry fruit in deionized water induces microcracking.Incubating fruit in D2O and concurrent magnetic resonance imaging demonstrates that water penetration occurs only(principally)through the microcracks,with nondetectable amounts penetrating the intact cuticle.Optical coherence tomography of detached,whole fruit incubated in deionized water,allowed generation of virtual cross-sections through the zone of a developing macrocrack.Outer mesocarp cell volume increased before macrocracks developed but increased at a markedly higher rate thereafter.Little change in mesocarp cell volume occurred in a control zone distant from the crack.As water incubation continued,the cell volume in the crack zone decreased,indicating leaking/bursting of individual mesocarp cells.As incubation continued still longer,the crack propagated between cells both to form a long,deep macrocrack.Outer mesocarp cell turgor did not differ significantly before and after incubation between fruit with or without macrocracks;nor between cells within the crack zone and those in a control zone distant from the macrocrack.The cumulative frequency distribution of the logtransformed turgor pressure of a population of outer mesocarp cells reveals all cell turgor data followed a normal distribution.The results demonstrate that microcracks develop into macrocracks following the volume increase of a few outer mesocarp cells and is soon accompanied by cell bursting. | Eckhard Grimm Jan Hahn Daniel Pflugfelder Moritz Jonathan Schmidt Dagmar van Dusschoten Moritz Knoche | 2019 | Horticulture Research2019，6，1： | 5 |
| 7 | How to perform gastrointestinal ultrasound: anatomy and normal findings显示文摘Gastrointestinal ultrasound is a practical, safe, cheap and reproducible diagnostic tool in inflammatorybowel disease gaining global prominence amongst clinicians. Understanding the embryological processes of the intestinal tract assists in the interpretation of abnormal sonographic findings. In general terms, the examination principally comprises interrogation of the colon, mesentery and small intestine using both lowfrequency and high-frequency probes. Interpretation of findings on GIUS includes assessment of bowel wall thickness, symmetry of this thickness, evidence of transmural changes, assessment of vascularity using Doppler imaging and assessment of other specific features including lymph nodes, mesentery and luminal motility. In addition to B-mode imaging, transperineal ultrasonography, elastography and contrast-enhanced ultrasonography are useful adjuncts. This supplement expands upon these features in more depth. | Nathan S S Atkinson Robert V Bryant Yi Dong Christian Maaser Torsten Kucharzik Giovanni Maconi Anil K Asthana Michael Blaivas Adrian Goudie Odd Helge Gilja Dieter Nuernberg Dagmar Schreiber-Dietrich Christoph F Dietrich | 2017 | World Journal of Gastroenterology2017，23，38： | 5 |
| 8 | Liver elastography, comments on EFSUMB elastography guidelines 2013显示文摘Recently the European Federation of Societies for Ultrasound in Medicine and Biology Guidelines and Recommendations have been published assessing the clinical use of ultrasound elastography.The document is intended to form a reference and to guide clinical users in a practical way.They give practical advice for the use and interpretation.Liver disease forms the largest section,reflecting published experience to date including evidence from meta-analyses with shear wave and strain elastography.In this review comments and illustrations on the guidelines are given. | Xin-Wu Cui Mireen Friedrich-Rust Chiara De Molo Andre Ignee Dagmar Schreiber-Dietrich Christoph F Dietrich | 2013 | World Journal of Gastroenterology2013，19，38： | 4 |
| 9 | Cis-hydroxyproline-induced inhibition of pancreatic cancer cell growth is mediated by endoplasmic reticulum stress显示文摘瞄准:在老鼠上调查 cis-hydroxyproline (CHP ) 的生物效果,并且检验内在的分子的机制胰腺的癌房间线 DSL6A。方法:DSL6A 房间增长上的 CHP 的效果被使用 BrdU 加入估计。焦点的粘附激酶(FAK ) 的表示被西方的弄污和免疫荧光描绘。endoplasmic 感应(嗯) 应力被使用 RT-PCR 并且为葡萄糖相关的 protein-78 (GRP78 ) 和生长拘捕和 DNA 的西方的弄污调查可诱导的基因(GADD153 ) 。房间生存能力通过基于 DSL6A 房间的减小潜力测量新陈代谢的活动被决定。Apoptosis 被 caspase-3 激活的察觉和多形核白细胞(自动数据处理核糖) 的劈开分析象 DNA laddering 一样的聚合酶(PARP ) 。结果:除了增长的抑制,有 CHP 的孵化从焦点的粘附导致了 FAK 的解朊的劈开和酶的 delocalisation,由房间坚持的损失列在后面。同时,我们能显示出 GRP78 和 GADD153 的增加的表情,显示在 DSL6A 房间线的 ER 压力串联的调停 CHP 的激活。有 CHP 的 DSL6A 房间的延长孵化最后导致了 apoptotic 细胞死亡。在 L 脯氨酸旁边,由一个广谱朊酶禁止者的增加的细胞内部的解朊作用的抑制能在细胞的功能和分子的过程上废除 CHP 的效果。相反,阻碍执行 apoptosis caspases 的活动没在调停 CHP 的房间损坏上有影响。结论:我们的数据建议开始嗯由 CHP 的压力机械导致细胞内部的解朊的进程的激活包括 caspase 独立的 FAK 降级,导致损坏胰腺的癌房间。 | Christoph Mueller Joerg Emmrich Robert Jaster Dagmar Braun Stefan Liebe Gisela Sparmann | 2006 | World Journal of Gastroenterology2006，12，10： | 3 |
| 10 | Multifunctional zinc ion doped sol-gel derived mesoporous bioactive glass nanoparticles for biomedical applications显示文摘Mesoporous bioactive glasses have been widely investigated for applications in bone tissue regeneration and,more recently,in soft tissue repair and wound healing.In this study we produced mesoporous bioactive glass nanoparticles(MBGNs)based on the SiO2-CaO system.With the intention of adding subsidiary biological function,MBGNs were doped with Zn2+ions.Zn-MBGNs with 8 mol%ZnO content were synthesized via microemulsion assisted sol-gel method.The synthesized particles were homogeneous in shape and size.They exhibited spherical shape,good dispersity,and a size of 130±10 nm.The addition of zinc precursors did not affect the morphology of particles,while their specific surface area increased in comparison to MBGNs.The presence of Zn2+ions inhibited the formation of hydroxycarbonate apatite(HCAp)on the particles after immersion in simulated body fluid(SBF).No formation of HCAp crystals on the surface of Zn-MBGNs could be observed after 14 days of immersion.Interestingly,powders containing relatively high amount of zinc released Zn2+ions in low concentration(0.6-1.2 mg L^−1)but in a sustained manner.This releasing feature enables Zn-MBGNs to avoid potentially toxic levels of Zn2+ions,indeed Zn-MBGNs were seen to improve the differentiation of osteoblast-like cells(MG-63).Additionally,Zn-MBGNs showed higher ability to adsorb proteins in comparison to MBGNs,which could indicate a favourable later attachment of cells.Due to their advantageous morphological and physiochemical properties,Zn-MBGNs show great potential as bioactive fillers or drug delivery systems in a variety of applications including bone regeneration and wound healing. | Zuzana Neščáková Kai Zheng Liliana Liverani Qaisar Nawaz Dagmar Galusková Hana Kaňková Martin Michálek Dušan Galusek Aldo R.Boccaccini | 2019 | Bioactive Materials2019，4，1： | 3 |
| 11 | Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice显示文摘 | Prakash G. Chandak Sascha Obrowsky Branislav Radovic Prakash Doddapattar Elma Aflaki Adelheid Kratzer Lalit S. Doshi Silvia Povoden Helmut Ahammer Gerald Hoefler Sanja Levak-Frank Dagmar Kratky | 2011 | BBA - Molecular and Cell Biology of Lipids2011，，12： | 3 |
| 12 | Effect of unburned carbon content in fly ash on the retention of 12 elements out of coal-combustion flue gas显示文摘The aim of this study was to evaluate whether unburned carbon particles present in fly ash can help in the retention of S,Cl,Br,As,Se,Cu,Ni,Zn,Ga,Ge,Rb,and Pb out of flue gas during the coal combustion at fluidised-bed power station where the coal was combusted along with limestone.The competitive influence of 10%-25% CaO in fly ashes on the distribution of studied elements was studied as well to be clear which factor governs behaviour of studied elements.Except of S(with significant association with CaO) and Rb and Pb(with major affinity to Al2O3) the statistically significant and positive correlation coefficients were calculated for the relations between unburned carbon content and Br(0.959),Cl(0.957),Cu(0.916),Se(0.898),Ni(0.866),As(0.861),Zn(0.742),Ge(0.717),and Ga(0.588) content.The results suggest that the unburned carbon is promising material in terms of flue gas cleaning even if contained in highly calcareous fly ashes. | Lucie Bartonov Bohumír ech Lucie Ruppenthalov Vendula Majvelderov Dagmar Juchelkov Zdeněk Klika | 2012 | Journal of Environmental Sciences2012，24，9： | 3 |
| 13 | Effects of urbanisation on the water balance – A long-term trajectory显示文摘 | Dagmar Haase | 2009 | Environmental Impact Assessment Review2009，，4： | 2 |
| 14 | Preclinical activity of a new platinum analogue, lobaplatin, in cisplatin-sensitive and -resistant human testicular, ovarian, and gastric carcinoma cell lines显示文摘 | Andreas Harstrick Carsten Bokemeyer Martin Scharnofkse Gunnar Hapke Dagmar Reile Hans-Joachim Schmoll | 1993 | Cancer Chemotherapy and Pharmacology1993，，1： | 2 |
| 15 | Metals, oxidative stress and neurodegenerative disorders显示文摘 | Klaudia Jomova Dagmar Vondrakova Michael Lawson Marian Valko | 2010 | Molecular and Cellular Biochemistry2010，，1： | 2 |
| 16 | Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation显示文摘 | Natalie Steck Micha Hoffmann Irina G. Sava Sandra C. Kim Hannes Hahne Susan L. Tonkonogy Katrin Mair Dagmar Krueger Mihaela Pruteanu Fergus Shanahan Roger Vogelmann Michael Schemann Bernhard Kuster R. Balfor Sartor Dirk Haller | 2011 | Gastroenterology2011，，3： | 2 |
| 17 | Xylanase, invertase and protease at the soil–litter interface of a loamy sand显示文摘 | Ellen Kandeler Jesper Luxh?i Dagmar Tscherko Jakob Magid | 1999 | Soil Biology and Biochemistry1999，，8： | 2 |
| 18 | A spatially explicit and quantitative vulnerability assessment of ecosystem service change in Europe显示文摘 | Marc J. Metzger Dagmar Schr?ter Rik Leemans Wolfgang Cramer | 2008 | Regional Environmental Change2008，，3： | 2 |
| 19 | Studies on the Chemical Identity and Biological Functions of Pangamic Acid显示文摘 | Schneider Dagmar Helwig Veronika Staniek Katrin Nohl Hans Elstner Erich | 1999 | Arzneimittelforschung1999，，04： | 2 |
| 20 | Details of crystalline growth in co-deposited electroplated nickel films with hard (nano) particles 显示文摘 | Thomas L Bernhard W Dagmar D | 2006 | Applied Surface Science2006，253，5： | 1 |
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