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| 1 | Therapy-refractory gastrointestinal motility disorder in a child with c-kit mutations显示文摘Constipation and fecal impaction are frequent and distressing complaints in pediatric gastroenterology. Especially in neurologically handicapped children, treatment of severe forms of slow-transit constipation (STC) can be difficult. In the majority of cases, STC is of unknown etiology. However, in recent years, there is growing evidence that interstitial cells of Cajal (ICCs), which serve as electrical pacemakers and generate spontaneous electrical slow waves in the gastrointestinal tract, might play an important role in the pathophysiology of STC. It remains unclear whether morphological ICC alterations seen in affected patients are based on congenital developmental anomalies, or whether they are a consequence of long-term constipation with secondary damage of the gastrointestinal nervous system. To the best of our knowledge, we present the first case of a patient with histological alterations in ICC morphology who displayed multiple alterations of c-kit at the level of mRNA. The protein encoded by c-kit is the receptor tyrosine kinase Kit (CD117), which is crucial for development and function of ICCs. Therefore, these findings provide a new explanation for congenital alterations of ICC development that result in gastrointestinal motility disorders. | Christian Breuer Jun Oh Gerhard J Molderings Michael Schemann Birgit Kuch Ertan Mayatepek Rüdiger Adam | 2010 | World Journal of Gastroenterology2010，16，34： | 7 |
| 2 | Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation显示文摘 | Natalie Steck Micha Hoffmann Irina G. Sava Sandra C. Kim Hannes Hahne Susan L. Tonkonogy Katrin Mair Dagmar Krueger Mihaela Pruteanu Fergus Shanahan Roger Vogelmann Michael Schemann Bernhard Kuster R. Balfor Sartor Dirk Haller | 2011 | Gastroenterology2011，，3： | 2 |
| 3 | Enteric nervous system显示文摘 | Grundy D Schemann M | 2001 | Curr Opin Gastroenterol2001，21，2： | 1 |
| 4 | Cholinergic neurons ofthe pelvic autonomic ganglia and uterus of the female rat : distribution ofaxons and presence of muscarinic receptors 显示文摘 | Papka ER Traurig HH Schemann M | 1999 | Cell Tissue Res1999，296，2： | 1 |
| 5 | A tale of two brains, one little and one big 显示文摘 | Grundy D Schemann M Wood J | 2000 | Neurogastroenterol Motil2000，12，2： | 1 |
| 6 | Cholinergic neurons of the Pelvic autonomic ganglia and uterus of the female rat: distribution of axons and presence of muscarinic receptors 显示文摘 | Papka ER Traurig HH Schemann M | 1999 | Cell Tissue Res1999，296，2： | 1 |
| 7 | Multifunctional mechanosensitive neurons in the entedc nervous system显示文摘 | SCHEMANN M MAZZUOLI G | 2010 | Autott Neurosei2010，153，： | 1 |
| 8 | Cho linergic neurons of the pelvic autonomic ganglia and uterus of the female rat: distribution of axons and presence of muscarinic receptors显示文摘 | Papka R E Traurig H H Schemann M | 1999 | Cell Tissue Res1999，296，2： | 1 |
| 9 | In vitro motility disorders associated with displaced abomasum in dairy cows显示文摘 | Geishauser T Reiche D Schemann M | 1998 | Neurogastroenterology and Motility1998，10，： | 1 |
| 10 | In vitro motility disorders associated with displaced abomasum in dairy cows显示文摘 | Geishauser T Reiche D Schemann M | 1998 | Neurogastroenterology and Motility1998，10，： | 1 |
| 11 | Enteric nervous system显示文摘 | Grundy D Schemann M | 2005 | Curr Opin Gastroenterol2005，21，： | 1 |
| 12 | Role of hydrogen sulfide in visceral nociception显示文摘 | Schemann M Grundy D | 2009 | Gut2009，58，6： | 1 |
| 13 | Effect of hyoscine butylbromide (Buscopan<sup>?</sup>) on cholinergic pathways in the human intestine显示文摘 | D. Krueger K. Michel S. Allam T. Weiser I. E. Demir G. O. Ceyhan F. Zeller M. Schemann | 2013 | Neurogastroenterol Motil2013，，8： | 1 |
| 14 | A tale of two brains,one little and one big显示文摘 | Grundy D Schemann M Wood J | 2000 | Neurogastroenterol Mot2000，12，： | 1 |
| 15 | 5-HT receptors on intersti- tial cells of Cajal, smooth muscle and enteric nerves 显示文摘 | Wouters MM Farrugia G Schemann M | 2007 | Neurogas- troenterol Motil2007，192，： | 1 |
| 16 | In vitro motility disorders associated with displaced abomasums in dairy cows显示文摘 | Geishauser T Reiche D Schemann M | 1998 | Neurogastroenterology and Motility1998，10，： | 1 |
| 17 | Capsaicinsenstive extrinsic afferents are involved in acid-induce activation of distinct myenteric neurons in the rat stomach显示文摘 | SCHICHO R SCHEMANN M PABST M A | 2003 | Neurogastroenterol Motil2003，15，1： | 1 |
| 18 | Republished: bacterial proteases in IBD and IBS显示文摘 | Steck N Mueller K Schemann M | 2013 | Postgrad Med J2013，89，1047： | 1 |
| 19 | Neurochemical coding of enteric neurons in the guinea pig stomach显示文摘 | Schemann M Schaaf C Mader M | 1995 | J Comp Neurol1995，353，： | 1 |
| 20 | A General Synthetic Route to Anomeric-Azido and -Amino Acids and Formal Synthesis of ( + ) -Hidantocidin 显示文摘 | DONDONI A SCHEMANN M C MARRA A | 1994 | J Org Chem1994，59，： | 1 |
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