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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Treatment of Chronic Delta Hepatitis显示文摘 | Cihan Yurdaydin | 2012 | Semin Liver Dis2012，，03： | 2 |
| 3 | Sustained Response of Hepatitis B e Antigen-Negative Patients 3 Years After Treatment with Peginterferon Alfa-2a显示文摘 | Patrick Marcellin Ferruccio Bonino George K.K. Lau Patrizia Farci Cihan Yurdaydin Teerha Piratvisuth Rui Jin Selim Gurel Zhi-Meng Lu Jian Wu Matei Popescu Stephanos Hadziyannis | 2009 | Gastroenterology2009，，7： | 2 |
| 4 | Sustained Response of Hepatitis B e Antigen-Negative Patients 3 Years After Treatment with Peginterferon Alfa-2a显示文摘 | Patrick Marcellin Ferruccio Bonino George K.K. Lau Patrizia Farci Cihan Yurdaydin Teerha Piratvisuth Rui Jin Selim Gurel Zhi-Meng Lu Jian Wu Matei Popescu Stephanos Hadziyannis | 2009 | Gastroenterology2009，，7： | 1 |
| 5 | Incidence and predictors of hepatocellular carcinoma in Caucasian chronic hepatitis B patients receiving entecavir or tenofovir显示文摘 | George V. Papatheodoridis George N. Dalekos Cihan Yurdaydin Maria Buti John Goulis Pauline Arends Vana Sypsa Spilios Manolakopoulos Giampaolo Mangia Nikolaos Gatselis Onur Kesk?n Savvoula Savvidou Bettina E. Hansen Christos Papaioannou Kostantinos Galanis | 2014 | Journal of Hepatology2014，，： | 1 |
| 6 | Hepatitis B surface antigen levels: association with 5-year response to peginterferon alfa-2a in hepatitis B e-antigen-negative patients显示文摘 | Patrick Marcellin Ferruccio Bonino Cihan Yurdaydin Stephanos Hadziyannis Rami Moucari Hans-Peter Kapprell Vivien Rothe Matei Popescu Maurizia R. Brunetto | 2013 | Hepatology International2013，，： | 1 |
| 7 | Thrombophilic gene mutations in cirrhotic patients with portal vein thrombosis显示文摘 | Ozlem Erkan Abdurrahman M. Bozdayi Selcuk Disibeyaz Dilek Oguz Muhit Ozcan Kadir Bahar Selim Karayalcin Ali Ozden Hakan Bozkaya Cihan Yurdaydin Ozden Uzunalimoglu | 2005 | European Journal of Gastroenterology & Hepatology2005，，3： | 1 |
| 8 | Entecavir for Treatment of Lamivudine-Refractory, HBeAg-Positive Chronic Hepatitis B显示文摘 | Morris Sherman Cihan Yurdaydin Jose Sollano Marcelo Silva Yun–Fan Liaw Janusz Cianciara Anna Boron–Kaczmarska Paul Martin Zachary Goodman Richard Colonno Anne Cross Gail Denisky Bruce Kreter Robert Hindes | 2006 | Gastroenterology2006，，7： | 1 |
| 9 | CASE REPORT: Remission of Severe Aplastic Anemia Associated with Hepatitis B Virus Infection After Viral Clearance: Potential Role of Lamivudine显示文摘 | Hakan Bozkaya Cihan Yurdaydin Murat T?rüner Mutlu Arat A. Mithat Bozdayi Selim Erekul Kubilay ?inar Haluk Ko? ?zden Uzunalimo?lu | 2002 | Digestive Diseases and Sciences2002，，8： | 1 |
| 10 | Endoscopic Management of Biliary Parasitic Diseases显示文摘 | Mehmet Bekta? Abdulkadir D?kmeci Kubilay Cinar Imge Halici Erkin Oztas Selim Karayalcin Ramazan Idilman Mustafa Sarioglu Yusuf Ustun Yasar Nazligul Necati Ormeci Hasan Ozkan Hakan Bozkaya Cihan Yurdaydin | 2010 | Digestive Diseases and Sciences2010，，5： | 1 |
| 11 | Hepatitis B surface antigen levels: association with 5-year response to peginterferon alfa-2a in hepatitis B e-antigen-negative patients显示文摘 | Patrick Marcellin Ferruccio Bonino Cihan Yurdaydin Stephanos Hadziyannis Rami Moucari Hans-Peter Kapprell Vivien Rothe Matei Popescu Maurizia R. Brunetto | 2013 | Hepatology International2013，，1： | 1 |
| 12 | Hepatitis B virus surface antigen levels: A guide to sustained response to peginterferon alfa‐2a in HBeAg‐negative chronic hepatitis B显示文摘 | Maurizia Rossana Brunetto Francesco Moriconi Ferruccio Bonino George K. K. Lau Patrizia Farci Cihan Yurdaydin Teerha Piratvisuth Kangxian Luo Yuming Wang Stephanos Hadziyannis Eva Wolf Philip McCloud Richard Batrla Patrick Marcellin | 2009 | Hepatology2009，，4： | 1 |
| 13 | Risk Factors for Hepatocellular Carcinoma in Turkey显示文摘 | ?zden Uzunalimo?lu Cihan Yurdaydin Hülya ?etinkaya Hakan Bozkaya Tülin ?ahin Salih ?olako?lu Ethem Tankurt Mustafa Sario?lu Seren ?zenirler Hikmet Akkiz Nurdan T?zün Halil De?ertekin Atilla ?kten | 2001 | Digestive Diseases and Sciences2001，，5： | 1 |
| 14 | Molecular characterization of a novel entecavir mutation pattern isolated from a multi-drug refractory patient with chronic hepatitis B infection显示文摘 | Ersin Karatayli Senem C. Karatayli Kubilay Cinar Selma Gokahmetoglu Kadri Güven Ramazan Idilman Cihan Yurdaydin A. Mithat Bozdayi | 2011 | Journal of Clinical Virology2011，，2： | 1 |
| 15 | Thrombophilic gene mutations in cirrhotic patients with portal vein thrombosis显示文摘 | Ozlem Erkan Abdurrahman M. Bozdayi Selcuk Disibeyaz Dilek Oguz Muhit Ozcan Kadir Bahar Selim Karayalcin Ali Ozden Hakan Bozkaya Cihan Yurdaydin Ozden Uzunalimoglu | 2005 | European Journal of Gastroenterology & Hepatology2005，，3： | 1 |
| 16 | Nuclear Localization of Hepatitis B Core Antigen and Its Relations to Liver Injury, Hepatocyte Proliferation, and Viral Load显示文摘 | Ebru Serinoz Murat Varli Esra Erden Kubilay Cinar Aydan Kansu Ozden Uzunalimoglu Cihan Yurdaydin Hakan Bozkaya | 2003 | Journal of Clinical Gastroenterology2003，，3： | 1 |
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