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| 1 | 拉萨地体的起源和古生代构造演化显示文摘早期由于资料有限,对拉萨地体古生代时期的裂解、漂移、俯冲和碰撞历史的认知程度还很低。本文利用目前已有地质和地球化学资料,分析了拉萨地体的中生代岩石圈结构,探讨了拉萨地体的起源和古生代演化历史。大量长英质岩石的锆石Hf同位素和全岩Nd同位素表明,南部和北部拉萨地体以新生地壳为主,部分地区可能存在前寒武纪结晶基底,而中部拉萨地体是具有古元古代甚至太古代结晶基底的条带状微陆块。大量古生代沉积岩的碎屑锆石U-Pb年龄数据表明,拉萨地体约1170Ma的碎屑锆石年龄指标,明显不同于以约950Ma为碎屑锆石年龄指标的安多、羌塘和特提斯喜马拉雅。拉萨地体起源于澳大利亚大陆北缘是目前资料情况下的最合理解释。中部拉萨地体约492Ma的双峰式火山岩形成于活动大陆边缘背景,代表了古地理上位于澳大利亚大陆北缘的岩浆弧的一部分,可能与原特提斯洋岩石圈板片的断离有关。拉萨地体南缘和南羌塘的泥盆纪末期—石炭纪早期片麻状花岗岩类为存在明显幔源物质输入的S型花岗岩,可能形成于最终演化为松多特提斯洋的弧后盆地背景。中二叠世末期发生的拉萨地体与澳大利亚大陆北缘的碰撞造山事件可能触发了班公湖—怒江特提斯洋岩石圈的南向俯冲,并随后对拉萨地体的中生代构造岩浆演化发挥关键性作用。 | 朱弟成 赵志丹 牛耀龄 王青 Yildirim DILEK 董国臣 莫宣学 | 2012 | 高校地质学报2012，18，1： | 87 |
| 2 | Type 2 diabetes mellitus affects eradication rate of Helicobacter pylori显示文摘AIM: To study the eradication rate of Helicobacter pylori (Hp) in a group of type 2 diabetes and compared it with an age and sex matched non-diabetic group.METHODS: 40 diabetic patients (21 females, 19 males;56±7 years) and 40 non-diabetic dyspeptic patients (20females, 20 males; 54±9 years) were evaluated. Diabetic patients with dyspeptic complaints were referred for upper gastrointestinal endoscopies; 2 corpus and 2 antral gastric biopsy specimens were performed on each patient. Patients with positive Hp results on histopathological examination comprised the study group. Non-diabetic dyspeptic patients seen at the Gastroenterology Outpatient Clinic and with the same biopsy and treatment protocol formed the control group.A triple therapy with amoxycillin (1 g b.i.d), clarithromycin (500 mg b.i.d) and omeprazole (20 mg b.i.d.) was given to both groups for 10 days. Cure was defined as the absence of Hp infection assessed by corpus and antrum biopsies in control upper gastrointestinal endoscopies performed 6weeks after completing the antimicrobial therapy.RESULTS: The eradication rate was 50 % in the diabetic group versus 85 % in the non-diabetic control group (P<0.001).CONCLUSION: Type 2 diabetic patients showed a significantly lower eradication rate than controls which may be due to changes in microvasculature of the stomach and to frequent antibiotic usage because of recurrent bacterial infections with the development of resistant strains. | Mehmet Sarg■n OyaUygur-Bayramili Haluk Sarg■n Ekrem Orbay Dilek Yavuzer Ali Yayla | 2003 | World Journal of Gastroenterology2003，9，5： | 25 |
| 3 | 西藏雅鲁藏布蛇绿岩形成构造环境的地球化学鉴别显示文摘本文对西藏雅鲁藏布蛇绿岩带中部日喀则地区夏鲁蛇绿岩中的基性岩石进行了元素地球化学研究。岩石为低钾亚碱性玄武质岩石,具有低TiO2(0.64%~1.5%)、低K2O(<0.69%)、富Na2O(2.5%~6.0%)、烧失量普遍较高(2.0%~7.5%)的特征,表明样品普遍遭受蚀变。岩石具有与N-MORB类似的稀土元素和总体一致的微量元素特征,但是岩石明显富集大离子亲石元素和亏损高场强元素,显示了洋脊玄武岩向着岛弧岩浆作用的过渡趋势。日喀则蛇绿岩不是典型的洋中脊成因,应为SSZ型蛇绿岩,可能形成于与洋内俯冲有关的SSZ型的弧后或者弧前盆地中。对东西延伸超过1500km的雅鲁藏布蛇绿岩246套基性岩石形成的构造环境进行的地球化学判别,表明至少存在大陆岛弧型、地幔柱-洋内热点型、洋中脊-大洋岛弧型和典型大洋岛弧型等四种类型洋壳,揭示了特提斯洋存在多种构造环境的特征,有利于恢复和还原一个长期演化的、丰富的特提斯洋。 | 李文霞 赵志丹 朱弟成 董国臣 周肃 莫宣学 Don DePAOLO Yildirim DILEK | 2012 | 岩石学报2012，28，5： | 23 |
| 4 | Clinical probability and risk analysis of patients with suspected pulmonary embolism显示文摘BACKGROUND: Pulmonary embolism(PE) is one of the most frequent diseases that could be missed in overcrowded emergency departments as in Turkey. Early and accurate diagnosis could decrease the mortality rate and this standard algorithm should be defi ned. This study is to fi nd the accurate, fast, non-invasive, cost-effective, easy-to-access diagnostic tests, clinical scoring systems and the patients who should be tested for clinical diagnosis of PE in emergency department.METHODS: One hundred and forty patients admitted to the emergency department with the fi nal diagnosis of PE regarding to anamnesis, physical examination and risk factors, were included in this prospective, cross-sectional study. The patients with a diagnosis of pulmonary embolism, acute coronary syndrome or infection and chronic obstructive pulmonary disease(COPD) were excluded from the study. The demographics, risk factors, radiological fi ndings, vital signs, symptoms, physicallaboratory fi ndings, diagnostic tests and clinical scoring systems of patients(Wells and Geneva) were noted. The diagnostic criteria for pulmonary emboli were: fi lling defect in the pulmonary artery lumen on spiral computed tomographic angiography and perfusion defect on perfusion scintigraphy.RESULTS: Totally, 90(64%) of the patients had PE. Age, hypotension, having deep vein thrombosis were the risk factors, and oxygen saturation, shock index, BNP, troponin and fi brinogen levels as for the biochemical parameters were signifi cantly different between the PE(+) and PE(–) groups(P<0.05).The Wells scoring system was more successful than the other scoring systems.CONCLUSION: Biochemical parameters, clinical findings, and scoring systems, when used altogether, can contribute to the diagnosis of PE. | Gulden Ozeren Yetgin Sule Akkose Aydin Ozlem Koksal Fatma Ozdemir Dilek Kostak Mert Gokhan Torun | 2014 | World Journal of Emergency Medicine2014，5，4： | 20 |
| 5 | Prevalence of osteoporosis and vertebral fractures and related factors in patients with ankylosing spondylitis显示文摘 | Mehmet Ali Ulu ibrahim Batmaz Banu Dilek Remzi Cevik | 2014 | Chinese Medical Journal2014，，15： | 15 |
| 6 | Expression of bcI-2 gene family during resection induced liver regeneration:Comparison between hepatectomized and sham groups显示文摘AIM:During liver regeneration cellular proliferation and apoptosis result in tissue remodeling to restore normal hepatic mass and structure.Main regulators of the apoptotic machinery are the Bcl-2 family proteins but their roles are not well defined throughout the liver regeneration.We aimed to analyze the expression levels of bcl-2 gene family members during resection induced liver regeneration.METHODS:We performed semi-quantitative RT-PCR to examine the expression level of bak, bax, bcl-2 and bcl-XL in 70% hepatectomized rat livers during the whole regeneration process and compared to that of the sham and normal groups.RESULTS:The expression of bak and baxwas decreased whereas that of bcl-2 and bcl-XL was increased in hepatectomized animals compared to normal liver at most time points.We also reported for the first time that sham group of animals had statistically significant higher expression of bak and bax than hepatectomized animals.In addition, the area under the curve (AUC) values of these genes was larger in sham groups than the hepatectomized groups.CONCLUSION: The expression changes of bak, bax, bcl-2 and bcl-XL genes are altered not only due to regeneration,but also due to effects of surgical operations. | Kamil Can Akcali Aydin Dalgic Ahmet Ucar Khemaeis Ben Haj Dilek Guvenc | 2004 | World Journal of Gastroenterology2004，10，2： | 13 |
| 7 | Four billion years of ophiolites reveal secular trends in oceanic crust formation显示文摘We combine a geological,geochemical and tectonic dataset from 118 ophioiite complexes of the major global Phanerozoic orogenic belts with similar datasets of ophiolites from 111 Precambrian greenstone belts to construct an overview of oceanic crust generation over 4 billion years.Geochemical discrimination systematics built on immobile trace elements reveal that the basaltic units of the Phanerozoic ophiolites are dominantly subduction-related(75%),linked to backarc processes and characterized by a strong MORB component,similar to ophiolites in Precambrian greenstone sequences(85%).The remaining 25%Phanerozoic subduction-unrelated ophiolites are mainly(74%) of Mid-Ocean-Ridge type(MORB type),in contrast to the equal proportion of Rift/Continental Margin,Plume,and MORB type ophiolites in the Precambrian greenstone belts.Throughout the Phanerozoic there are large geochemical variations in major and trace elements,but for average element values calculated in 5 bins of 100 million year intervals there are no obvious secular trends.By contrast,basaltic units in the ophiolites of the Precambrian greenstones(calculated in 12 bins of 250 million years intervals),starting in late Paleo- to early Mesoproterozoic(ca.2.0-1.8 Ga),exhibit an apparent decrease in the average values of incompatible elements such as Ti,P,Zr,Y and Nb,and an increase in the compatible elements Ni and Cr with deeper time to the end of the Archean and into the Hadean.These changes can be attributed to decreasing degrees of partial melting of the upper mantle from Hadean/Archean to Present.The onset of geochemical changes coincide with the timing of detectible changes in the structural architecture of the ophiolites such as greater volumes of gabbro and more common sheeted dyke complexes,and lesser occurrences of ocelli(varioles) in the pillow lavas in ophiolites younger than 2 Ga.The global data from the Precambrian ophiolites,representative of nearly 50%of all known worldwide greenstone belts provide significant clues for the operation of plate tectonic processes in the Archean. | Harald Furnes Maarten de Wit Yildirim Dilek | 2014 | Geoscience Frontiers2014，5，4： | 13 |
| 8 | 西藏拉萨地块过铝质花岗岩中继承锆石的物源区示踪及其古地理意义显示文摘富含继承锆石的过铝质花岗岩一般来源于富铝质岩石(如变泥质岩)的部分熔融,因而分析这些继承锆石的U-Pb年龄可以像分析沉积岩碎屑锆石的U-Pb年龄一样,提供过铝质花岗岩源区物质中碎屑沉积物物源区的丰富信息。本文报道了中部拉萨地块早侏罗世过铝质花岗岩的全岩地球化学和锆石U-Pb年代学数据,结合拉萨地块已有二叠纪和晚三叠世过铝质花岗岩的继承锆石年代学数据,总结了目前已有的拉萨地块过铝质花岗岩的继承锆石U-Pb年龄特征(共199个谐和测点)。这些过铝质花岗岩属强过铝质S型花岗岩,其中的继承锆石定义了1250~1100Ma(峰值1181±14Ma)和550~450Ma(峰值494±7Ma)2个最突出的年龄群,分别可比于拉萨地块古生代沉积岩的碎屑锆石年龄峰值(约1170Ma)和寒武纪火山岩的侵位时代,明显不同于西羌塘、安多和特提斯喜马拉雅新元古代-古生代沉积岩中的碎屑锆石年龄频谱。拉萨地块过铝质花岗岩中约1181Ma的继承锆石,可能与拉萨地块古生代沉积岩中的同期碎屑锆石一样,都来自澳大利亚南西部Albany-Fraser造山带和东南极Wilkes等地,而约494的继承锆石,既可能来自澳大利亚西部,也可能来自拉萨地块本地。本文提供了拉萨地块与澳大利亚大陆北缘具有古地理联系的过铝质花岗岩继承锆石U-Pb年龄证据。拉萨地块的研究实践表明,采用过铝质花岗岩继承锆石和古生代沉积岩碎屑锆石相结合的锆石U-Pb年代学方法,可为重建冈瓦纳大陆北缘其它微陆块的古地理和构造岩浆演化提供重要约束。 | 朱弟成 赵志丹 牛耀龄 王青 DILEK Yildirim 管琪 刘勇胜 莫宣学 | 2011 | 岩石学报2011，27，7： | 12 |
| 9 | Crustal Structure of the Indus-Tsangpo Suture Zone and its Ophiolites, Southern Tibet显示文摘The>2000-km-long Indus-Tsangpo suture zone(ITSZ)in southern Tibet marks the boundary between the India and Eurasia plates and contains the remnants of the Neotethyan oceanic lithosphere,ophiolitic mélanges,flysch units and continental rocks.Field-based structural analyses and drill core observations from the | XU Zhiqin DILEK Yildrim YANG Jingsui LIANG Fenghua LIU Fei BA Dengzhu CAI Zhihui LI Guangweia DONG Hanwen | 2015 | Acta Geologica Sinica(English Edition)2015，89，A02： | 10 |
| 10 | Diamonds Discovered from High–Cr Podiform Chromitites of Bulqiza,Eastern Mirdita Ophiolite,Albania显示文摘Various combinations of diamond, moissanite, zircon, corundum, rutile and titanitehave been recovered from the Bulqiza chromitites. More than 10 grains of diamond have been recovered, most of which are pale yellow to reddish–orange to colorless. The grains are all 100–300 μm in size and mostly anhedral, but with a range of morphologies including elongated, octahedral and subhedral varieties. Their identification was confirmed by a characteristic shift in the Raman spectra between 1325 cm^(-1) and 1333 cm^(-1), mostly at 1331.51 cm^(-1) or 1326.96 cm^(-1). This investigation extends the occurrence of diamond and moissanite to the Bulqiza chromitites in the Eastern Mirdita Ophiolite. Integration of the mineralogical, petrological and geochemical data of the Bulqiza chromitites suggests their multi–stage formation. Magnesiochromite grains and perhaps small bodies of chromitite formed at various depths in the upper mantle, and encapsulated the ultra–high pressure, highly reduced and crustal minerals. Some oceanic crustal slabs containing the magnesiochromite and their inclusion were later trapped in suprasubduction zones, where they were modified by tholeiitic and boninitic arc magmas, thus changing the magnesiochromite compositions and depositing chromitite ores in melt channels. | XIONG Fahui YANG Jingsui ROBINSON Paul T. DILEK Yildirim MILUSHI Ibrahim XU Xiangzhen ZHOU Wenda ZHANG Zhongming RONG He | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 9 |
| 11 | Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations显示文摘AIM: To determine the mutation status of human telomerase reverse transcriptase gene(TERT) promoter region in hepatocellular carcinoma(HCC) from different geographical regions.METHODS: We analyzed the genomic DNA sequences of 59 HCC samples comprising 15 cell lines and 44 primary tumors,collected from patients living in Asia,Europe and Africa.We amplified a 474 bp DNA fragment of the promoter region of TERT gene including the 1295228 and 1295250 sequence of chromosome 5 by using PCR.Amplicons were then sequenced by Sanger technique and the sequence data were analyzed with by using DNADynamo software in comparison with wild type TERT gene sequence as a reference.RESULTS: The TERT mutations were found highly frequent in HCC.Eight of the fifteen tested cell lines displayed C228 T mutation,and one had C250 T mutation with a mutation frequency up to 60%.All of the mutations were heterozygous and mutually exclusive.Ten out of forty-four tumors displayed C228 T mutation,and additional five tumors had C250 T mutation providing evidence for mutation frequency of 34% in primary tumors.Considering the geographic origins of HCC tumors tested,TERT promoter mutation frequencies were higher in African(53%),when compared to non-African(24%) tumors(P = 0.056).There was also a weak inverse correlation between TERT promoter mutations and murine double minute 2 single nucleotide polymorphism 309 TG polymorphism(P = 0.058).Mutation frequency was nearly two times higher in established HCC celllines(60%) compared to the primary tumors(34%).CONCLUSION: TERT promoter is one of most frequent mutational targets in liver cancer,and hepatocellular carcinogenesis is highly associated with the loss of telomere-dependent cellular senescence control. | Dilek Cevik Gokhan Yildiz Mehmet Ozturk | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 12 | 1型糖尿病视网膜病变患者血清唾液酸浓度的增加(英文)显示文摘目的:探讨血清唾液酸和糖尿病性视网膜病变几个阶段之间潜在的关联。方法:1型糖尿病视网膜不同程度病变组40例。对照组30例,对其血清唾液酸水平进行研究。结果:结果显示,研究组与对照组相比有较高的血清唾液酸浓度(95.95±9.5 vs 45.05±19.91mmoL/L,P=0.0001)。我们也观察到糖尿病性视网膜病变的水平逐步上升,其浓度升高(P<0.05),但相关性较弱。血清唾液酸浓度与血糖浓度呈正相关(r=0.67,P=0.0001)。结论:血清唾液酸浓度的增加与视网膜病变阶段有关。这对确定1型糖尿病患者视网膜病变的程度有帮助。但是,仍然需要更详细的研究,以得到更精确的结论。 | Muhsin Eraslan 0zlem Yenice Haluk Kazokoglu Dilek Goga Yavuz Eren Cerman Hande Celiker | 2013 | 国际眼科杂志2013，13，10： | 5 |
| 13 | Clinical and hemodynamic profiles of elderly patients with pulmonary arterial hypertension: a single center, prospective study显示文摘sPulmonary 动脉的高血压(哼) 以前被认为主要影响幼仔的病,但是现在,它逐渐地也被认出在老。这研究的目的是比较诊断与的老对更年轻的病人的特征,并且定义影响他们的长期的 survival.MethodsIn 的预示的因素哼这未来的、单个中心研究,临床, echocardiographic ,血液动力学的特征,并且结果更年轻( 18-65 年)并且老( 65 年)有 precapillary 的权威的诊断的病人哼 119 个病人全部的 compared.ResultsA 在这研究被分析;43 是老的(吝啬的年龄:71.5 ? 灡牰灯楲瑡 ? 慣摮摩瑡 ? 景瀠汵潭慮祲愠瑲牥慩? 票数瑲湥楳湯 ? 灳 ' 虝娹娆 _ 敨慲祰椠 ? 汥敤汲 ? 慰楴湥獴眠瑩 ? 異浬湯牡 ? | Ebru Ozpelit Bahri Akdeniz Dilek Sezgin Can Sevinc Kemal Can Tertemiz Mehmet Emre Ozpelit Mustafa Baris Nezihi Baris | 2017 | Journal of Geriatric Cardiology2017，14，1： | 5 |
| 14 | Probing the Troodos Ophiolite:IGCP-649 Workshop and Field Excursion Held in Agros-Cyprus显示文摘The second IGCP-649 Workshop,held in Agros-Cyprus during 14-20 May 2016,brought together nearly fifty international scientists from around the world,and included a 5-day field excursion on the classic Troodos ophiolite.Organized by the IGCP-649 Project Leadership and the Geological Survey Department of Cyprus。 | YANG Jingsui Julian PEARCE Yildirim DILEK | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 4 |
| 15 | Flexible high energy density zinc-ion batteries enabled by binder-free MnO_(2)/reduced graphene oxide electrode显示文摘We demonstrate a rechargeable zinc-ion battery with high energy density and cyclability using MnO_(2)and reduced graphene oxide(MnO_(2)/rGO)electrode.The flexible and binder free electrode,with high MnO_(2)mass ratio(80 wt%of MnO_(2)),is fabricated using vacuum filtration without any additional additives other than rGO.Compared to batteries with conventional MnO_(2)electrodes,the Zn-MnO_(2)/rGO battery shows a significant enhanced capacity(332.2 mAh g^(-1)at 0.3 A g^(-1)),improved rate capability(172.3 mAh g^(-1)at 6 A g^(-1))and cyclability.The capacity retention remains 96%after 500 charge/discharge cycles at 6 A g^(-1).The high MnO_(2)mass ratio makes MnO_(2)/rGO electrode advantageous when the capacity is normalized to the whole electrode,particularly at high rates.The calculated gravimetric energy density of Zn-MnO_(2)/rGO battery is 33.17Wh kg^(-1),which is comparable to the existing commercial lead-acid batteries(30-40Wh kg^(-1)).Furthermore,the discharge profile and capacity of our Zn-MnO_(2)/rGO battery shows no deterioration during bending test,indicating good flexibility.As a result,zinc-ion battery is believed to be a promising technology for powering next generation flexible electronics. | Yuan Huang Jiuwei Liu Qiyao Huang Zijian Zheng Pritesh Hiralal Fulin Zheng Dilek Ozgit Sikai Su Shuming Chen Ping-Heng Tan Shengdong Zhang Hang Zhou | 2018 | npj Flexible Electronics2018，2，1： | 4 |
| 16 | Application of the modern ophiolite concept with special reference to Precambrian ophiolites显示文摘Much has been learned in the past 40 years about the great diversity of the internal structure and geochemical compositions of Phanerozoic ophiolites, indicating that these on-land fragments of ancient oceanic lithosphere formed in distinctly different tectonic settings during their igneous evolution. Recent studies in Archean and Proterozoic greenstone belts have shown that the Precambrian rock record may also include exposures of a diverse suite of ophiolite complexes as part of craton development in the early history of the Earth. We review the salient features of the Precambrian ophiolite record to highlight what has been learned about Precambrian oceanic spreading systems since the original Penrose definition of ophiolites in 1972. Some of the diagnostic, characteristic, typical, and rare aspects of ophiolites of all ages are presented in a table in order to help determine if tectonically deformed and metamophosed sequences in Precambrian shield areas may be considered as ophiolites. The results of this comparative study are important in that they enable researchers to more realistically characterize allochthonous mafic/ultramafic rock sequences as ophiolitic or non-ophiolitic. This approach is more deterministic in contrast to some other arbitrary classification schemes requiring three or four of the Penrose-style ophiolitic units to be present in the Precambrian record for a specific rock sequence to be considered ophiolitic. Once these tectonic fragments are recognized as remnants of ancient oceanic lithosphere, great progress shall be made in understanding early Earth history. We discuss the significance and implications of the Precambrian ophiolite record to constrain the mode and nature of the plate tectonics that operated in deep time. | Timothy M. KUSKY WANG Lu Yildirim DILEK Paul ROBINSON PENG SongBai HUANG XuYa | 2011 | Science China Earth Sciences2011，54，3： | 4 |
| 17 | Exploring the influence of the built environment on human experience through a neuroscience approach:A systematic review显示文摘The built environment provides a habitat for the most sophisticated mammal in our universe,the human being.Developments in science and technology are forcing us to reconsider the priority of human needs in current theories of architecture and the built environment.Newly developed theories and methodologies in neuroscience have allowed us to improve and deepen our knowledge of human experience in the built environment.The potential of the relationship between neuroscience and architecture for knowledge creation generates an increasing interest in theoretical and methodological approaches to explore this intersection.Thus,a common ground on which to conduct interdisciplinary studies investigating developing and emerging concepts at the intersection must be established.However,few reviews in the literature have systematically examined developing and emerging concepts at the intersection of neuroscience and architecture.The present review aims to examine the existing literature systematically to explain the influence of the built environment on human experience by using approaches from neuroscience by examining the conceptualizations in the field.The study is conducted as a systematic qualitative review that analyzes and synthesizes the developing and emerging concepts that have appeared in the ever-evolving literature.The study concludes with an overall discussion about these concepts as a means of deeply understanding the influence of the built environment on human experience,responses to the environment based on approaches from neuroscience,and their potential for providing further directions for future research. | Tulay Karakas Dilek Yiidiz | 2020 | Frontiers of Architectural Research2020，9，1： | 4 |
| 18 | 中英中小企业技术创新支持体系比较显示文摘比较中英两国中小企业技术创新的支持体系,可以看到中英两国都已经初步建立了财税和金融支持体系,但英国的体系更完善,支持的力度更大,覆盖面更宽,操作性更强,形式更丰富,效果更明显;在协同创新支持体系建设方面,英国的显著特点是以项目为载体,促进大学与企业的合作,中国主要通过行政机制来实现产学研的结合,缺乏自主合作、市场化推进的协作机制;在社会化服务体系建设方面,英国建立了从政府服务机构、社会中介服务机构到高校创新服务机构在内的联系紧密的服务体系,而中国相关的社会化服务体系尚未真正建立。 | 葛峙中 Dilek Demirbas | 2007 | 社会科学辑刊2007，，5： | 4 |
| 19 | Comparison of pre-treatment and post-treatment use of selenium in retinal ischemia reperfusion injury显示文摘AIM: To investigate the effects of selenium in rat retinal ischemia reperfusion(IR) model and compare pretreatment and post-treatment use.METHODS: Selenium pre-treatment group(n =8) was treated with intraperitoneal(i.p.) selenium 0.5 mg/kg for7 d and terminated 24 h after the IR injury. Selenium posttreatment group( n = 8) was treated with i. p. selenium0.5 mg/kg for 7d after the IR injury with termination at the end of the 7d period. Sham group(n =8) received i.p.saline injections identical to the selenium volume for 7d with termination 24 h after the IR injury. Control group(n =8) received no intervention. Main outcome measures were retina superoxide dismutase(SOD), glutathione(GSH),total antioxidant status(TAS), malondialdehyde(MDA),DNA fragmentation levels, and immunohistological apoptosis evaluation.RESULTS: Compared to the Sham group, selenium pre-treatment had a statistical difference in all parameters except SOD. Post-treatment selenium also resulted in statistical differences in all parameters except the MDA levels. When comparing selenium groups, the pre-treatment selenium group had a statistically higher success in reduction of markers of cell damage such as MDA and DNA fragmentation. In contrast, the post-selenium treatment group had resulted in statisticallyhigher levels of GSH. Histologically both selenium groups succeeded to limit retinal thickening and apoptosis. Pre-treatment use was statistically more successful in decreasing apoptosis in ganglion cell layer compared to post-treatment use.CONCLUSION: Selenium was successful in retinal protection in IR injuries. Pre-treatment efficacy was superior in terms of prevention of tissue damage and apoptosis. | Alper Yazici Hasan Aksit Esin Sogutlu Sari Arzu Yay Haydar Ali Erken Dilek Aksit Harun Cakmak Kamil Seyrek Sitki Samet Ermis | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 3 |
| 20 | Genetics and epigenetics of liver cancer显示文摘 | Cigdem Ozen Gokhan Yildiz Alper Tunga Dagcan Dilek Cevik Aysegul Ors Umur Keles Hande Topel Mehmet Ozturk | 2013 | New BIOTECHNOLOGY2013，，4： | 3 |
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