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| 1 | Liver stiffness in the hepatitis B virus carrier:A non-invasive marker of liver disease influenced by the pattern of transaminases显示文摘AIM: To investigate the usefulness of transient elastography by Fibroscan (FS),a rapid non-invasive technique to evaluate liver fibrosis,in the management of chronic hepatitis B virus (HBV) carriers.METHODS: In 297 consecutive HBV carriers,we studied the correlation between liver stiffness (LS),stage of liver disease and other factors potentially influencing FS measurements.In 87 chronic hepatitis B (CHB) patients,we monitored the FS variations according to the spontaneous or treatment-induced variations of biochemical activity during follow-up.RESULTS: FS values were 12.3 ± 3.3 kPa in acute hepatitis,10.3 ± 8.8 kPa in chronic hepatitis,4.3 ± 1.0 kPa in inactive carriers and 4.6 ± 1.2 kPa in blood donors.We identified the cut-offs of 7.5 and 11.8 kPa for the diagnosis of fibrosis ≥ S3 and cirrhosis respectively,showing 93.9% and 86.5% sensitivity,88.5% and 96.3% specificity,76.7% and 86.7% positive predictive value (PPV),97.3% and 96.3% negative predictive value (NPV) and 90.1% and 94.2% diagnostic accuracy.At multivariate analysis in 171 untreated carriers,fibrosis stage (t = 13.187,P < 0.001),active vs inactive HBV infection (t = 6.437,P < 0.001),alanine aminotransferase (ALT) (t = 4.740,P < 0.001) and HBV-DNA levels (t = -2.046,P = 0.042) were independently associated with FS.Necroinflammation score (t = 2.158,> 10/18 vs ≤ 10/18,P = 0.035) and ALT levels (t = 3.566,P = 0.001) were independently associated with LS in 83 untreated patients without cirrhosis and long-term biochemical remission (t = 4.662,P < 0.001) in 80 treated patients.During FS monitoring (mean follow-up 19.9 ± 7.1 mo) FS values paralleled those of ALT in patients with hepatitis exacerbation (with 1.2 to 4.4-fold increases in CHB patients) and showed a progressive decrease during antiviral therapy.CONCLUSION: FS is a non-invasive tool to monitor liver disease in chronic HBV carriers,provided that the pattern of biochemical activity is taken into account.In the inactive carrier,it identifies non-HBV-related causes of liver damage and transient reactivations.In CHB patients,it may warrant a more appropriate timing of control liver biopsies. | Filippo Oliveri Barbara Coco Pietro Ciccorossi Piero Colombatto Veronica Romagnoli Beatrice Cherubini Ferruccio Bonino Maurizia Rossana Brunetto | 2008 | World Journal of Gastroenterology2008，14，40： | 43 |
| 2 | Hepatocellular carcinoma treated with transarterial chemoembolization: Dynamic perfusion-CT in the assessment of residual tumor显示文摘AIM: To asses the value of computed tomography (CT)-perfusion in the detection of residual hepatocellular carcinoma (HCC) vascularization after transarterial chemoembolization (TACE). METHODS: Thirty-two consecutive patients were pro-spectively included in this study. All patients had liver cirrhosis and a conf irmed HCC lesion which was treated with TACE. One month after treatment, perfusion measurements of treated lesions were carried out. The CTperfusion (CT-p) protocol was performed with 16 slice multidetector computed tomography which included the following parameters: 8 dynamic slices/scan per 40 scans after iv injection of 50 mL of iodinated contrast (350 mg/mL) at a flow rate of 6 mL/s. Treated lesions were evaluated using dedicated perfusion software, which generated a quantitative colour map of perfusion. The following parameters were considered: hepatic perfusion (HP), arterial perfusion (AP), blood volume (BV), hepatic perfusion index (HPI), and time to peak (TTP). Perfusion parameters were described with quartile values of their distribution and statistically analyzed. RESULTS: Perfusion parameters of the treated lesions could be quantitatively assessed using CT-p analysis. The presence of residual tumor tissue was observed in 13 of the 32 patients. The values of the perfusion parameters measured within the relapse tissue were: HP (mL/100 g per minute): median = 44.4 (1stqt = 31.3, 3rdqt = 55.8); BV (mL/100 g): median = 18.7 (1stqt = 11.5, 3rdqt = 22.5); AP (mL/min): median = 39.0 (1stqt = 36.5, 3rdqt = 61.3); HPI (%): median = 34.0 (1stqt = 30.4, 3rdqt = 38.9); TTP (s): median = 17.3 (1stqt = 15.8, 3rdqt = 26.5). With the use of the univariate paired Wilcoxon signed rank test, HP, AP and HPI were shown to be significantly higher (P<0.001) in the relapse site than in the primary lesion. The BV and TTP parameters showed a tendency to be greater and lower, respectively, in the relapse site than in the primary lesion. CONCLUSION: In patients with HCC treated with TACE, CT-p provides measurement of flow parameters related to residual arterial structures in viable tumor, thus helping in the assessment of therapeutic response. | Davide Ippolito Pietro Andrea Bonaff ini Laura Ratti Laura Antolini Rocco Corso Ferruccio Fazio Sandro Sironi | 2010 | World Journal of Gastroenterology2010，16，47： | 15 |
| 3 | Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: An Italian position statement显示文摘Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis steatohepatitis,fibrosis,and cirrhosis to hepatocellular carcinoma.Forty-four per cent of all deaths from cirrhosis are attributed to alcohol.Alcoholic liver disease is the second most common diagnosis among patients undergoing liver transplantation(LT).The vast majority of transplant programmes(85%)require 6 mo of abstinence prior to transplantation;commonly referred to as the'6-mo rule'.Both in the case of progressive end-stage liver disease(ESLD)and in the case of severe acute alcoholic hepatitis(AAH),not responding to medical therapy,there is a lack of evidence to support a 6-mo sobriety period.It is necessary to identify other risk factors that could be associated with the resumption of alcohol drinking.The'Group of Italian Regions'suggests that:in a case of ESLD with model for end-stage liver disease<19 a 6-mo abstinence period is required;in a case of ESLD,a 3-mo sober period before LT may be more ideal than a 6-mo period,in selected patients;and in a case of severe AAH,not respond-ing to medical therapies(up to 70%of patients die within 6 mo),LT is mandatory,even without achieving abstinence.The multidisciplinary transplant team must include an addiction specialist/hepato-alcohologist.Patients have to participate in self-help groups. | Gianni Testino Patrizia Burra Ferruccio Bonino Francesco Piani Alessandro Sumberaz Roberto Peressutti Andrea Giannelli Castiglione Valentino Patussi Tiziana Fanucchi Ornella Ancarani Giovanna De Cerce Anna Teresa Iannini Giovanni Greco Antonio Mosti Marilena Durante Paola Babocci Mariano Quartini Davide Mioni Sarino Aricò Aniello Baselice Silvia Leone Fabiola Lozer Emanuele Scafato Paolo Borro | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 4 | 苏云金杆菌防治储烟害虫研究进展显示文摘在所有为害贮存烟草并能造成严重损失的昆虫种类中 ,烟草甲虫Lasiodermaserricorne(F .)和烟草粉螟Ephestiaelutella(H¨ubner)是原烟及加工后烟草的 2种主要害虫。收获后烟草害虫的防治主要通过消毒、害虫监测以及磷化氢熏蒸来实现 ,而储烟害虫已对磷化氢产生抗药性 ,并已有防治失败的实例报道 ,而熏蒸也越来越受到相关法规的制约。一些生物防治剂如苏云金杆菌Bacillusthuringiensis(Bt) ,因对环境无害而有可能替代化学防治。Bt是一种细菌 ,在芽孢形成阶段能够产生杀虫晶体蛋白。Bt用作植食性害虫的生防制剂已有 4 0多年的历史。Bt产生的杀虫晶体蛋白对几个目的昆虫具有特有的生物活性 ,可对昆虫的取食产生影响。我们实验室进行了广泛的研究并在世界范围内开展了调查 ,对仓储烟草中的Bt进行评价 ,现已证实了以前的研究结果 ,即Bt是自然发生的叶面微生物群落中的一部分。已从烟草上分离出几个Bt菌株并进行了特征描述 (DNA和蛋白质图谱 )。已通过胃毒的方法对所分离的菌株以及 2个商业产品对烟草甲幼虫的杀虫活性进行了测定。在长达 30个月的贮存期内 ,对已调制烟叶上的Bt孢子及其晶体蛋白的稳定性进行了分析。Bt处理过的烟叶制成卷烟样品评吸后 ,处理与对照卷烟无显著性差异。尽管在规定的时间及剂量情? | Michel Blanc Pascale Kaelin Ferruccio Gadani 王颖 | 2003 | 烟草科技2003，36，6： | 3 |
| 5 | Brain-gut-liver interactions across the spectrum of insulin resistance in metabolic fatty liver disease显示文摘Metabolic associated fatty liver disease(MAFLD),formerly named“nonalcoholic fatty liver disease”occurs in about one-third of the general population of developed countries worldwide and behaves as a major morbidity and mortality risk factor for major causes of death,such as cardio-vascular,digestive,metabolic,neoplastic and neuro-degenerative diseases.However,progression of MAFLD and its associated systemic complications occur almost invariably in patients who experience the additional burden of intrahepatic and/or systemic inflammation,which acts as disease accelerator.Our review is focused on the new knowledge about the brain-gut-liver axis in the context of metabolic dysregulations associated with fatty liver,where insulin resistance has been assumed to play an important role.Special emphasis has been given to digital imaging studies and in particular to positron emission tomography,as it represents a unique opportunity for the noninvasive in vivo study of tissue metabolism.An exhaustive revision of targeted animal models is also provided in order to clarify what the available preclinical evidence suggests for the causal interactions between fatty liver,dysregulated endogenous glucose production and insulin resistance. | Eleni Rebelos Patricia Iozzo Maria Angela Guzzardi Maurizia Rossana Brunetto Ferruccio Bonino | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 6 | Sustained Response of Hepatitis B e Antigen-Negative Patients 3 Years After Treatment with Peginterferon Alfa-2a显示文摘 | Patrick Marcellin Ferruccio Bonino George K.K. Lau Patrizia Farci Cihan Yurdaydin Teerha Piratvisuth Rui Jin Selim Gurel Zhi-Meng Lu Jian Wu Matei Popescu Stephanos Hadziyannis | 2009 | Gastroenterology2009，，7： | 2 |
| 7 | Clinical out come of submerged vs non-submerged implants placed infresh exactraction sockets 显示文摘 | Luca C Ferruccio T Mario R | 2009 | Clin Oral Implant Res2009，20，： | 1 |
| 8 | Sustained Response of Hepatitis B e Antigen-Negative Patients 3 Years After Treatment with Peginterferon Alfa-2a显示文摘 | Patrick Marcellin Ferruccio Bonino George K.K. Lau Patrizia Farci Cihan Yurdaydin Teerha Piratvisuth Rui Jin Selim Gurel Zhi-Meng Lu Jian Wu Matei Popescu Stephanos Hadziyannis | 2009 | Gastroenterology2009，，7： | 1 |
| 9 | Clinical out come of submerged vs non-submerged implants placed in fresh exactraction sockets 显示文摘 | Luca C Ferruccio T Mario R | 2009 | Clin Oral Implant Res2009，20，： | 1 |
| 10 | Intensity-Modulated Proton Therapy Versus Helical Tomotherapy in Nasopharynx Cancer: Planning Comparison and NTCP Evaluation显示文摘 | Lamberto Widesott Alessio Pierelli Claudio Fiorino Italo Dell’Oca Sara Broggi Giovanni Mauro Cattaneo Nadia Di Muzio Ferruccio Fazio Riccardo Calandrino Marco Schwarz | 2008 | International Journal of Radiation Oncology, Biology, Physics2008，，： | 1 |
| 11 | Identification, sequence and developmental expression of invertebrate flotillins from Drosophila melanogaster 1 The nucleotide sequences reported in this paper have been submitted to the GenBank/EMBL Data Bank with accession Nos AF044734 and AF044916. 1显示文摘 | Ferruccio Galbiati Daniela Volonté Jason S Goltz Zac Steele Jonaki Sen Jennifer Jurcsak David Stein Leslie Stevens Michael P Lisanti | 1998 | Gene1998，，2： | 1 |
| 12 | A new region and stereo selective intermolecular Friedel-Crafts alkylation of phenolic substrates with aryl epoxides显示文摘 | Ferruccio B Paolo C Franco M | 2006 | Tetrahedron Letters2006，47，： | 1 |
| 13 | Relationships of PAI-1 levels to central obesity and liver steatosis in a sample of adult male population in southern Italy显示文摘 | Antonio Barbato Roberto Iacone Giovanni Tarantino Ornella Russo Paolo Sorrentino Sonia Avallone Ferruccio Galletti Eduardo Farinaro Elisabetta Della Valle Pasquale Strazzullo | 2009 | Internal and Emergency Medicine2009，，4： | 1 |
| 14 | Can chronic gastritis cause an increase in fecal calprotectin concentrations?显示文摘AIM:To evaluate fecal calprotectin concentrations(FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score.METHODS:FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers.Histological grading of gastritis was performed according to the updated Sydney gastritis classification.Patients were subdivided into 2 groups according to the presence/absence of an active gastritis.Patients with chronic active gastritis were divided into 3 subgroups on the basis of the activity score(mild,moderate,marked).FFCs in relation to Helicobacter pylori(H.pylori) infection and proton pump inhibitor(PPI) use were also evaluated.RESULTS:FCCs in patients with chronic active gastritis were not significantly different to FCCs either in subjects with non active gastritis or in healthy controls.Among patients with chronic active gastritis(even marked),FCCs did not significantly differ according to activity score.No significant differences in FCCs were found when considering H.pylori,as well as when considering PPI chronic use.CONCLUSION:FCCs were not significantly increased in subjects with chronic gastritis,even in those patients with a marked neutrophil infiltration. | Massimo Montalto Antonella Gallo Gianluca Ianiro Luca Santoro Ferruccio D Onofrio Riccardo Ricci Giovanni Cammarota Marcello Covino Monica Vastola Antonio Gasbarrini Giovanni Gasbarrini Ricca rdo Ricci | 2010 | World Journal of Gastroenterology2010，16，27： | 1 |
| 15 | Value of integrated PET/CT for lesion localisation in cancer patients: a comparative study显示文摘 | Ettore Pelosi Cristina Messa Sandro Sironi Maria Picchio Claudio Landoni Valentino Bettinardi Luigi Gianolli Alessandro Maschio Maria Carla Gilardi Ferruccio Fazio | 2004 | European Journal of Nuclear Medicine and Molecular Imaging2004，，7： | 1 |
| 16 | Establishing a reference system in clinical enzymology显示文摘 | Mauro P Ferruccio C Gerhard S | 2001 | Clin Chem Lab Med2001，39，9： | 1 |
| 17 | Hepatitis B surface antigen levels: association with 5-year response to peginterferon alfa-2a in hepatitis B e-antigen-negative patients显示文摘 | Patrick Marcellin Ferruccio Bonino Cihan Yurdaydin Stephanos Hadziyannis Rami Moucari Hans-Peter Kapprell Vivien Rothe Matei Popescu Maurizia R. Brunetto | 2013 | Hepatology International2013，，： | 1 |
| 18 | Clinical out come of submerged vs non-submerged implants placed infresh exactraction sockets显示文摘 | Luca C Ferruccio T Mario R | 2009 | Clin Oral Implant Res2009，20，： | 1 |
| 19 | The damp- ing in MEMS inertial sensors both athigh and low pressurelevels 显示文摘 | Braghin Francesco Leo Elisabetta Resta Ferruccio | 2008 | Nonlinear Dynamics2008，，10： | 1 |
| 20 | Optimization of the Tradenff Between Switching Speed of the Internal Diode and On-Resistance in Gnld-and Platinum-Implanted Power Metal-oxide-Semiconductor Devices显示文摘 | Catania Marisa Francesca Frisina Ferruccio Tavolo Nella | 1992 | IEEE Transaction on Electrnn Devices1992，39，12： | 1 |
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