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| 1 | Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis显示文摘AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology. | Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz Murat Keskin Murat Kiyici Sibel Aker Arzu Yilmaztepe Selim Gurel Macit Gulten Selim Giray Nak | 2007 | World Journal of Gastroenterology2007，13，6： | 19 |
| 2 | Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients显示文摘AIM: To investigate the diagnostic eff icacy of leukocyte esterase and nitrite reagent strips for bedside diagnosis of spontaneous bacterial peritonitis (SBP). METHODS: A total of 63 consecutive patients with cirrhotic ascites (38 male, 25 female) tested between April 2005 and July 2006 were included in the study. Bedside reagent strip testing was performed on ascitic ? uid and the results compared to manual cell counting and ascitic fluid culture. SBP was defined as having a polymorphonuclear ascites count of ≥ 250/mm3. RESULTS: Fifteen samples showed SBP. The sensitivity, specificity, positive and negative predictive values of the leukocyte esterase reagent strips were; 93%, 100%, 100%, and 98%, respectively. The sensitivity, specifi city, positive and negative predictive value of the nitrite reagent strips were 13%, 93%, 40%, and 77%, respectively. The combination of leukocyte esterase and nitrite reagents strips did not yield statistically signif icant effects on diagnostic accuracy. CONCLUSION: Leukocyte esterase reagent strips may provide a rapid, bedside diagnostic test for SBP. | Serkan Torun Enver Dolar Yusuf Yilmaz Murat Keskin Murat Kiyici Melda Sinirtas Emre Sarandol Selim Gurel Selim Giray Nak Macit Gulten | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 3 | Cytomegalovirus colitis in a patient with Behcet’s disease receiving tumor necrosis factor alpha inhibitory treatment显示文摘Anti-tumor necrosis factor alpha (TNF-α) inhibitors are effective in the treatment of various inflammatory rheumatic conditions. Increased risks of serious infections are the major issues concerning the long-term safety of these agents. We present a case of a young male Behcet’s patient whose disease was complicated by cytomegalovirus (CMV) colitis. Colitis started 10 d after the third Infliximab dose and responded to the cessation of TNF blocking treatment and administration of ganciclovir. Tumor necrosis factor alpha and interferon gamma act at several levels in combating viral infections.CMV infections should be kept in mind and included in the differential diagnosis of severe gastrointestinal symptoms in patients receiving anti-TNF agents. | Ismail Sari Merih Birlik Can Gonen Servet Akar Duygu Gurel Fatos Onen Nurullah Akkoc | 2008 | World Journal of Gastroenterology2008，14，18： | 5 |
| 4 | Sustained Response of Hepatitis B e Antigen-Negative Patients 3 Years After Treatment with Peginterferon Alfa-2a显示文摘 | Patrick Marcellin Ferruccio Bonino George K.K. Lau Patrizia Farci Cihan Yurdaydin Teerha Piratvisuth Rui Jin Selim Gurel Zhi-Meng Lu Jian Wu Matei Popescu Stephanos Hadziyannis | 2009 | Gastroenterology2009，，7： | 2 |
| 5 | Expression of IGR-IR and VEGF and trophoblastic proliferative activity in placentas from pregnancies complicated by IUGR显示文摘 | Gurel D Ozer E Altunyurt S | 2003 | Pathol Res Pract2003，199，12： | 1 |
| 6 | U2504 determines the species specificity of the A- site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome显示文摘 | Gurel G Blaha G Moore PB | 2009 | J Mol Bioi2009，7，： | 1 |
| 7 | Adenosine deaminase activities in sera,lymphocytes and granulocytes in patients with cutaneous leishmaniasis显示文摘 | Erel O Kocyigit A Gurel MS | 1998 | Mem Inst Oswaldo Cruz1998，93，4： | 1 |
| 8 | Randomized Comparison of Tenofovir Disoproxil Fumarate vs Emtricitabine and Tenofovir Disoproxil Fumarate in Patients with Lamivudine-resistant Chronic Hepatitis B显示文摘 | Scott Fung Peter Kwan Milotka Fabri Andrzej Horban Mijomir Pelemis Hie-Won Hann Selim Gurel Florin A. Caruntu John F. Flaherty Benedetta Massetto Phillip Dinh Amoreena Corsa G. Mani Subramanian John G. McHutchison Petr Husa Edward Gane | 2013 | Gastroenterology2013，，： | 1 |
| 9 | Vascular injuries and amputation following limb fractures 显示文摘 | EREN N OZGEN G GUREL A | 1990 | Thorac Cardiovasc Surg1990，38，： | 1 |
| 10 | Detection and differential diagnosis of hepatic masses using pulse inversion harmonic imaging during the liver specific late phase of contrast enhancement with Levovist 显示文摘 | YUCEL C OZDEMIR H GUREL S | 2002 | J Clin Ultrasound2002，30，： | 1 |
| 11 | Structure-function relationships of epoxide hydrolases and their potential use in biocatalysis显示文摘 | Widersten M Gurell A Lindberg D | | 0，，03： | 1 |
| 12 | Sustained Response of Hepatitis B e Antigen-Negative Patients 3 Years After Treatment with Peginterferon Alfa-2a显示文摘 | Patrick Marcellin Ferruccio Bonino George K.K. Lau Patrizia Farci Cihan Yurdaydin Teerha Piratvisuth Rui Jin Selim Gurel Zhi-Meng Lu Jian Wu Matei Popescu Stephanos Hadziyannis | 2009 | Gastroenterology2009，，7： | 1 |
| 13 | The efficiency of CAPE on retardation of hepatic fibrosis in biliary ob?structed rats显示文摘 | Tomur A Kanter M Gurel A et a1 | 2011 | J Mol Histol2011，42，5： | 1 |
| 14 | Expression of hsp 90 in the human kidney and in proximal tubule cells exposed to heat, sodium arsenite and cadmium chloride 显示文摘 | Somji S Ann Sens M Garrett SH Gurel V Todd JH Sens DA | 2002 | Toxicol Lett2002，133，23： | 1 |
| 15 | Enhancing the accuracy of the interpo lations and anterpolations in MLFMA显示文摘 | Ergul O Gurel L | 2006 | IEEE Transactions on Antennas Propagation2006，54，12： | 1 |
| 16 | Ethical ideologies of tourism marketers 显示文摘 | Yaman H R Gurel E | 2006 | Annals of Tourism Research2006，33，2： | 1 |
| 17 | Parallel machine match-up scheduling with manufacturing cost considerations显示文摘 | Akturk M S Atamturk A Gurel S | 2010 | Journal of Scheduling2010，13，1： | 1 |
| 18 | Vitamin E protects against oxida- tive damage caused by formaldehyde in the liver and ptasma of rats 显示文摘 | Gulec M Gurel A Armutcu F | 2006 | Mol Cell Biochem2006，290，3： | 1 |
| 19 | Clothing importance and self-perception of female adolescents with and without scoliosis显示文摘 | Liskey-Fitzwater N More CL Gurel LM | 1993 | Cloth Text Res J1993，1，1： | 1 |
| 20 | Investigation of optical band gap and device parameters of rubrene thin film prepared using spin coating technique 显示文摘 | Nihat Tug luog lu Behzad Boris Hatice Gurel | 2014 | Journal of Alloys and Compounds2014，582，： | 1 |
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