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| 1 | Type 2 diabetes mellitus affects eradication rate of Helicobacter pylori显示文摘AIM: To study the eradication rate of Helicobacter pylori (Hp) in a group of type 2 diabetes and compared it with an age and sex matched non-diabetic group.METHODS: 40 diabetic patients (21 females, 19 males;56±7 years) and 40 non-diabetic dyspeptic patients (20females, 20 males; 54±9 years) were evaluated. Diabetic patients with dyspeptic complaints were referred for upper gastrointestinal endoscopies; 2 corpus and 2 antral gastric biopsy specimens were performed on each patient. Patients with positive Hp results on histopathological examination comprised the study group. Non-diabetic dyspeptic patients seen at the Gastroenterology Outpatient Clinic and with the same biopsy and treatment protocol formed the control group.A triple therapy with amoxycillin (1 g b.i.d), clarithromycin (500 mg b.i.d) and omeprazole (20 mg b.i.d.) was given to both groups for 10 days. Cure was defined as the absence of Hp infection assessed by corpus and antrum biopsies in control upper gastrointestinal endoscopies performed 6weeks after completing the antimicrobial therapy.RESULTS: The eradication rate was 50 % in the diabetic group versus 85 % in the non-diabetic control group (P<0.001).CONCLUSION: Type 2 diabetic patients showed a significantly lower eradication rate than controls which may be due to changes in microvasculature of the stomach and to frequent antibiotic usage because of recurrent bacterial infections with the development of resistant strains. | Mehmet Sarg■n OyaUygur-Bayramili Haluk Sarg■n Ekrem Orbay Dilek Yavuzer Ali Yayla | 2003 | World Journal of Gastroenterology2003，9，5： | 25 |
| 2 | Early diagnosis and prediction of severity in acute pancreatitis using the urine trypsinogen-2 dipstick test:A prospective study显示文摘瞄准:评估量杆(Actim 胰腺炎) 在尖锐胰腺炎(AP ) 为严厉的早诊断和预言测试的 trypsinogen-2 的使用。方法:有 AP 的 92 个病人在这研究被包括。控制组是从非胰腺的原因有剧烈腹的疼痛的 25 个病人。尿 trypsinogen-2 量杆测试(UTDT ) 和常规诊断测试在所有病人被执行。病人们被亚特兰大分类作为有温和或严重的胰腺炎划分成二个组。结果:UTDT 是积极的在里面(94.6%)(8%) 87 AP 病人并且在二控制(P <
0.05 ) 。积极 UTDT 在 61 被发现(92.4%) 66 (71.7%) 有温和胰腺炎并且在所有(100%) 的病人 26 (28.3%) 与严重胰腺炎(P >
0.05 ) 。UTDT 确实在温和胰腺炎与那相比在严重胰腺炎更长持续了(6.2 +/- 2.5 d 对 2.0 +/- 1.43 d, P <
0.05 ) 。敏感,特性,积极预兆的价值,否定预兆的价值(NPV ) ,积极可能性比率(PLR ) 和 UTDT 的否定可能性比率(NLR ) 分别地是 91% , 72% , 96.6% , 70.4% , 3.4 和 0.1。结论:UTDT 是为承认上的使用的一个简单、快速、可靠的方法。它在 AP 为严厉的早诊断和预言有高特性和低 NLR。然而,它的相对低的 NPV 不允许 trypsinogen-2 量杆测试是为尖锐胰腺炎的诊断的一个独立工具;另外的常规诊断工具的使用仍然是一个要求。 | Erdinc Kamer Haluk Recai Unalp Hayrullah Derici Tugrul Tansug Mehmet Ali Onal | 2007 | World Journal of Gastroenterology2007，13，46： | 14 |
| 3 | Role of triamcinolone in radiation enteritis management显示文摘AIM:To investigate the role of triamcinolone in the management of acute and chronic enteritis caused by pelvic radiotherapy.METHODS:Twenty-eight patients with rectum adenocarcinoma or endometrium adenocarcinoma were studied.We compared the results of 14 patients treated with injected triamcinolone acetonide(TA)with those of 14 patients who were not treated with TA.For the TA group,40 mg of TA was injected intramuscularly on the 1st,11th and 21st d of radiotherapy;the control group received no injections.All of the study participants had a median age of 65 years,had undergone postoperative radiotherapy and were evaluated weekly using Radiation Therapy Oncology Group and the European Organization for Research and Treatment of Cancer Acute Morbidity Score Criteria,and complete blood counts for every 10 d.RESULTS:Triamcinolone was found to effectively prevent and treat radiation-induced acute gastrointestinal(enteritis)and genitourinary(cystitis)side effects(P=0.022 and P=0.023).For the lower GI side effect follow up,11 patients in the control group had Grade 2toxicity and 3 patients had Grade 1 toxicity.In the TA group,5 patients had Grade 2 toxicity and 9 patients had Grade 1 toxicity.For the genitourinary system side effect follow up,4 patients had Grade 2 toxicity and 6patients had Grade 1 toxicity.Additionally,2 patients had Grade 2 toxicity and 2 patients had Grade 1 toxicity.The neutrophil counts did not differ between the TA group and the control group.There was no meaningful difference between age groups and primary cancers.At the 12th mo of follow up,there were no differences between groups for chronic side effects.CONCLUSION:Triamcinolone is a moderately potent steroid,that is inexpensive and has a good safety profile.It would be beneficial for reducing medical expenses related to treatment of radiation induced enteritis. | Eren Cetin Aysen Sevgi Ozturk Haluk Orhun Sukran Ulger | 2014 | World Journal of Gastroenterology2014，20，15： | 12 |
| 4 | 系统评价:证据为本社会工作的方法基础显示文摘随着政府购买服务决策的科学化,越来越多的决策需要基于证据,然而当前从业人员并不经常使用最佳依据指导决策和实践,这种情况也越来越受到重视,迫切需要加强证据为本的社会工作理念。社会工作教育者和研究者需要掌握更加专业的证据生产方法——系统评价,从而为证据为本的社会工作提供当前最佳的决策证据。本文将从问题的提出、检索和筛选文献、质量评价、数据分析合成、研究结果讨论等部分介绍系统评价的撰写方法,期待被国内更多的社会工作研究者和教育者应用。 | 拜争刚 吴淑婷 齐铱 何雪松 隋玉杰 沈晖 冉茂盛 Haluk Soydan 沈瓊桃 高翔 | 2017 | 华东理工大学学报(社会科学版)2017，32，4： | 7 |
| 5 | 中国儿童与老年健康证据转化平台的构建与应用显示文摘目的介绍并推广中国儿童与老年健康证据转化平台(Chinese Clearinghouse for Evidence Translation in Child&Aging Health,CCET)。方法分别成立儿童、老年健康顾问委员会,利用科学的评价量表评价筛选国内外相关的儿童、老年健康促进项目并由研究团队翻译转化。与兰州博阳软件工程有限公司合作,根据网站需呈现的内容与目标功能,共同规划设计网站框架与界面,初步建立站点。将转化的健康证据及其他信息资源(疾病基本情况、项目评价量表、研究报告标准等)上传使之在网站相应栏目中呈现,建立CCET网站,并通过微信和微博媒介定期传播儿童及老年健康最新进展、循证研究最新方法。结果 CCET主要由儿童健康、老年健康、评价量表、报告标准、推广应用和老年抑郁症循证防治数据库6个版块组成。CCET儿童与老年健康促进项目由国内外专家采用科学的评价量表筛选和评价,转化的证据科学性强,目前已有相关研究机构和社区有意向参与CCET研究和应用转化项目。结论CCET致力于循证方法培训,建立国内健康干预项目的科学性和适用性评价系统,对国外证据转换后的后续干预项目培训,提升服务机构能力,以及综合干预课程研发。CCET信息全面、界面简单、用户友好,为促进我国儿童与老年健康提供证据支持。 | 拜争刚 刘少堃 常健博 赵坤 李惠菊 Iris CHI Haluk SOYDAN 杨克虎 | 2015 | 转化医学杂志2015，4，3： | 6 |
| 6 | In-situ oxygen profiling and lignin modification in guts of wood-feeding termites显示文摘 | Jing Ke Jian-Zhong Sun Hung D. Nguyen Deepak Singh Karmen C. Lee Haluk Beyenal Shu-Lin Chen | 2010 | Insect Science2010，17，3： | 5 |
| 7 | 吸烟,血清抗氧化维生素水平和老年性黄斑变性之间的关系(英文)显示文摘目的:研究老年性黄斑变性(AMD)等级、血清抗氧化维生素水平(维生素A、C和E)和吸烟的关系。方法:对84例患者行黄斑彩色眼底成像,根据AMD损伤率和损伤程度将其分为五组(等级I^V)。应用高效液相色谱法(HPLC)测量血清抗氧化维生素水平。根据吸烟状况分不吸烟者、已戒烟者和吸烟者三组,并统计吸烟者每年的吸烟总量。结果:对照组中,维生素A、E、C水平分别为0.874±0.326mg/L,10.739±4.874mg/L和1.737±0.447mg/L,AMD组中分别为0.880±0.305mg/L,9.487±6.060mg/L和1.870±2.191mg/L,无显著差异(P>0.05)。AMD不同等级分组间维生素A(P=0.881)和E(P=0.293)水平差异无统计学意义,维生素C水平(P=0.044)随AMD程度的加深而增加。根据吸烟状况,AMD组与对照组之间无显著差异。根据每年的吸烟总量,两组之间有显著差异(P=0.02)。AMD越严重,年吸烟总量越高(P=0.007)。结论:研究结果显示AMD与维生素A、E血清水平无关,但和维生素C的血清水平相关,并与吸烟量有关。 | Sezen Akkaya Cakir Ozlem Sahin Haluk Kazokoglu Feyza Tekeli Goncagul Haklar Yelda Ozkurt | 2014 | 国际眼科杂志2014，14，5： | 5 |
| 8 | 1型糖尿病视网膜病变患者血清唾液酸浓度的增加(英文)显示文摘目的:探讨血清唾液酸和糖尿病性视网膜病变几个阶段之间潜在的关联。方法:1型糖尿病视网膜不同程度病变组40例。对照组30例,对其血清唾液酸水平进行研究。结果:结果显示,研究组与对照组相比有较高的血清唾液酸浓度(95.95±9.5 vs 45.05±19.91mmoL/L,P=0.0001)。我们也观察到糖尿病性视网膜病变的水平逐步上升,其浓度升高(P<0.05),但相关性较弱。血清唾液酸浓度与血糖浓度呈正相关(r=0.67,P=0.0001)。结论:血清唾液酸浓度的增加与视网膜病变阶段有关。这对确定1型糖尿病患者视网膜病变的程度有帮助。但是,仍然需要更详细的研究,以得到更精确的结论。 | Muhsin Eraslan 0zlem Yenice Haluk Kazokoglu Dilek Goga Yavuz Eren Cerman Hande Celiker | 2013 | 国际眼科杂志2013，13，10： | 5 |
| 9 | Discontinuous rock slope stability analysis by limit equilibrium approaches–a review显示文摘Slope stability is one of the most important topics of engineering geology with a background of more than 300 years.So far,various stability assessment techniques have been developed which include a range of simple evaluations,planar failure,limit state criteria,limit equilibrium analysis,numerical methods,hybrid and high-order approaches which are implemented in two-dimensional(2D)and three-dimensional(3D)space.In the meantime,limit equilibrium methods due to their simplicity,short analysis time,coupled with probabilistic and statistics functions to estimate the safety factor(F.S),probable slip surface,application on different failure mechanisms,and varied geological conditions has been received special attention from researchers.The presented paper provides a review to limit equilibrium methods used for discontinuous rock slope stability analyses with different failure mechanisms of natural and cut slopes.The article attempted to provide a systematic review for rock slope stability analysis outlook based on limit equilibrium approaches. | Mohammad Azarafza Haluk Akgün Akbar Ghazifard Ebrahim Asghari-Kaljahi Jafar Rahnamarad Reza Derakhshani | 2021 | International Journal of Digital Earth2021，14，12： | 5 |
| 10 | 老年男性勃起功能及迟发性性腺功能减退症状与下尿路症状严重性的关系显示文摘本文旨在研究土耳其爱琴海地区的老年男性下尿路症状(LUTSs)、勃起功能障碍(ED)和有症状的迟发性性腺功能减退症(SLOH)三者间的关系。符合以下标准的500名男性患者被纳入该研究:40周岁以上;过去6个月内有稳定的性关系;在六个泌尿外科诊所之一进行过就诊登记。每位患者均行血清PSA、睾酮水平及尿流率的检测,并填写国际前列腺症状评分和生活质量评分(IPSS-QoL)量表、国际勃起功能指数(IIEF)问卷和老年男性症状(AMS)量表。在所有的研究对象中,23.9%的患者有轻度LUTSs,53.3%有中度LUTSS,22.8%有重度LUTSS。每组间总睾酮水平无明显差异。除此之外,69.6%的病人患有ED,且ED的发生率与LUTS严重性呈正相关。71.2%的患者出现SLOH(AMS〉27),且IPSS评分越高,严重的性腺功能减退症状的发生率也越高。相关性分析显示以上三种问卷分数之间有显著关联。总之,LUTS严重性是ED和SLOH的非年龄依赖性危险因素,LUTS严重性和SLOH症状之间似乎有显著的相关性,但还需要从病因学和生物学角度进行深入阐明。 | Ozan Bozkurt Deniz Bolat Omer Demir Oktay Ucer Ali Sahin Burak Ozcift Abdulkadir Pekta Tahir Turan Bilal H Gümü Ertan Cans Ahmet Bolukbasi Haluk Erol Adil Esenx | 2013 | Asian Journal of Andrology2013，15，6： | 4 |
| 11 | Late clinical characteristics of infants with retinopathy of prematurity and treated with cryotherapy显示文摘AIM: To describe the clinical characteristics and late results of patients with retinopathy of prematurity(ROP)treated with '6h cryotherapy'.·METHODS: Out of 1252 infants screened for ROP, 52 patients were treated with temporal 6h cryotherapy from1997 to 2005 were recalled to our clinic. Among these 23 patients were available and 46 eyes of 23 infants were included to evaluate for visual acuity, refractive error,ocular alignment, nystagmus, retinal examination(abnormal branching of retinal vessels, retinal thinning,latis degenerations, tortuosity of vessels, straightening of temporal vessels, narrowing of the angle of vessel in the juxtapapillary entrance, pigment changes, macular heterotopia), optic atrophy and optic disc cupping, axial length at birth and axial length at 1y.·RESULTS: The median age at examination was 7(5-18)y.In 32.6% of patients, the visual acuity was ≤20/200 and the mean best corrected visual acuity was 20/35 as measured with a Snellen chart. Mean spherical refractive error was-1.76±2.69 D. The degree of myopia at the last examination was found to be correlated with the elongation of the eye in the first year of life. Exotropia was present in 17.4%(n =8) of infants and esotropia in13%(n =6). The most common retinal abnormality was abnormal branching of retinal vessels(82.6%) followed by retinal thinning(52.2%).·CONCLUSION: The late clinical outcomes of infants with ROP treated in our clinic with cryotherapy seems to comparable with results of laser treatment. | Eren Cerman Deniz Ozarslan Ozcan Hande Celiker Muhsin Eraslan Ozlem Sahin Haluk Kazokoglu | 2016 | International Journal of Ophthalmology(English edition)2016，9，4： | 4 |
| 12 | Imatinib response of gastrointestinal stromal tumor patients with germline mutation on KIT exon 13:A family report显示文摘Familial gastrointestinal stromal tumor(GIST) is a rare autosomal dominant disorder associated with mutations in the KIT gene in the majority of cases. Although, exon 11 appears to be the hot spot region for approximately 95% of germline mutations, pathogenic variations have also been identified in exon 8, 13 and 17. Exon 13 germline mutations are extremely rare amongst familial GISTs and seven families with a germline mutation have been reported to date. Moreover, the role of imatinib mesylate in this rare familiar settings is not completely known so far. We describe here clinical, imaging, pathological and genetic findings of a family with four affected members; grandmother, his son and two grand-sons having a germline gain-of-function mutation of KIT in exon 13 and discuss the imatinib mesylate treatment surveillance outcomes towards disease management. | Gulgun Engin Serpil Eraslan Hülya Kayserili Yersu Kapran Haluk Akman Ali Akyuz Nuri Faruk Aykan | 2017 | World Journal of Radiology2017，9，9： | 3 |
| 13 | Is adiponectin level a predictor of nonalcoholic fatty liver disease in nondiabetic male patients?显示文摘AIM: To study the levels of adiponectin in nondiabetic patients with nonalcoholic fatty liver disease (NAFLD) in comparison with control group.METHODS: Thirty-five patients who had elevated serum aminotransferase levels with bright liver and 34 healthy volunteers without liver disease were evaluated. Age,gender and body mass index (BMI) were recorded. Fasting plasma glucose, insulin, adiponectin, proinsulin and lipid profile were measured. A standard oral glucose tolerance test (OGTT) with insulin response was performed and the index of insulin resistance was calculated according to the homeostasis model assessment (HOMA) method.RESULTS: According to the OGTT results, none of the participants had diabetes. Serum adiponectin levels were statistically significantly lower in patients with NAFLD than in control group (8.14±3.4 μg/mL vs12.4±9.4 μg/mL,respectively, P<0.01). A statistically significant correlation was found between adiponectin and BMI (r: -0.33, P<0.01),HOMA (r: -0.26, P<0.05), proinsulin (r: -0.32, P<0.01),AST (r: -0.25, P<0.05), ALT (r: -0.26, P<0.05) or GGT (r: -0.22, P<0.05). In multiple regression analysis models,adiponectin levels were the only predictor of NAFLD in males, whereas in female group it was the BMI.CONCLUSION: Low adiponectin level might be a predictor of NAFLD especially in male nondiabetics. | Haluk Sargin Mehmet Sargin Hülya Gozu Asuman Orcun Gülcan Baloglu Murat Ozisik Mesut Seker Oya Uygur-Bayramicli | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 14 | Midkine secretion protects Hep3B cells from cadmium induced cellular damage显示文摘AIM: To evaluate role of midkine secretion during Cadmium (Cd) exposure in the human hepatocyte cell line Hep3B cells. METHODS: Different dosages of Cd (0.5-1-5-10 μg/mL) were applied to Hep3B cells and their effects to apoptosis, lactate dehydrogenase (LDH) leakage and midkine secretion were evaluated as time dependent manner. Same experiments were repeated with exogenously applied midkine (250-5000 pg/mL) and/or 5 μg/mL Cd.RESULTS: Cd exposure induced prominent apoptosis and LDH leakage beginning from lower dosages at the 48th h. Cd induced midkine secretion with higher dosages (P < 0.001), (control, Cd 0.5-1-5-10 μg/mL respectively: 1123 ± 73, 1157 ± 63, 1242 ± 90, 1886 ± 175, 1712 ± 166 pg/mL). Exogenous 500-5000 pg/mL midkine application during 5 μg/mL Cd toxicity prevented caspase-3 activation (control, Cd toxicity, 250, 500, 1000, 2500, 5000 pg/mL midkine+ Cd toxicity, respectively: 374 ± 64, 1786 ± 156, 1545 ± 179, 1203 ± 113, 974 ± 116, 646 ± 56, 556 ± 63 cfu) LDH leakage and cell death in Hep3B cells (P < 0.001). CONCLUSION: Our results showed that midkine secretion from Hep3B cells during Cd exposure protects liver cells from Cd induced cellular damage. Midkine has anti-apoptotic and cytoprotective role during Cd toxicity. Further studies are needed to explain the mechanism of midkine secretion and cytoprotective role of midkine during Cd exposure. Midkine may be a promising theurapatic agent in different toxic hepatic diseases. | Nuray Yazihan Haluk Ataoglu Ethem Akcil Burcu Yener Bulent Salman Cengiz Aydin | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 15 | Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients显示文摘 | Bertrand Baujat Hélène Audry Jean Bourhis Anthony T.C. Chan Haluk Onat Daniel T.T. Chua Dora L.W. Kwong Muhyi al-Sarraf Kwan-Hwa Chi Masato Hareyama Sing F. Leung Kullathorn Thephamongkhol Jean-Pierre Pignon | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，1： | 2 |
| 16 | Effects of long term hydrophilic bile acid therapy on in vitro contraction of gallbladder muscle strips in patients with cholesterol gallstones显示文摘AIM:To evaluate ursodeoxycholic acid (UDCA) therapy on the in vitro contraction of gallbladder smooth muscle strips from cholesterol gallstone patients. METHODS:The contraction forces of gallbladder smooth muscle strips from 28 patients with cholesterol gallstones treated with UDCA were compared with contraction forces from 14 untreated patients. The strips were stimulated with increasing concentrations of cholecystokinin-8 (CCK-8). RESULTS:Although the contraction forces that developed in response to CCK-8 were higher in strips from specimens of UDCA treated patients compared to untreated patients,longer treatment periods (6-wk) caused more contraction responses than the short treatment period of 3-wk (F = 19.297,1.85 ± 0.22 g vs 1.70 ± 0.10 g,P < 0.01). Contraction forces developed with maximal stimulation with KCl in the 6-wk treatment group were also higher than contraction forces in the untreated group (F = 4.274,3.77 ± 0.45 g vs 3.30 ± 0.30 g,P < 0.05). CONCLUSION:Six-week UDCA treatment caused an increase in contractions of muscle strips from patients with cholesterol gallstones when compared to shorter treatment administration or controls. We suggest that extending UDCA treatment periods may cause more effective contractions in the gallbladder,and thereby increase the rate of response to treatment. | Mehmet Refik Mas Bilgin Comert Nuket Mas Levent Yamanel Haluk Ozotuk Ilker Tasci Riadh P Jazrawi | 2007 | World Journal of Gastroenterology2007，13，32： | 2 |
| 17 | Effectiveness and safety of ureteroscopy in pregnant women: a comparative study显示文摘 | Yasar Bozkurt Haluk Soylemez Murat Atar Ahmet Ali Sancaktutar Necmettin Penbegul Nam?k Kemal Hatipoglu Mehmet Nuri Bodakc? Mehmet S?dd?k Evsen | 2013 | Urolithiasis2013，，1： | 2 |
| 18 | Dentoalveolar distraction osteogenesis for rapid orthodontic canine retration 显示文摘 | Reba S Haluk Iseri Hakan H | 2002 | J Oral Maxillofac Surg2002，60，： | 1 |
| 19 | Intra-Industry trade and labour Market Adjustment in Turkey 显示文摘 | GUZIN E HALUK E | 2003 | Electronic Journal2003，，5： | 1 |
| 20 | Anthocyanin degrationin oxidizing grape musts显示文摘 | KADER F HALUK J P NICOLAS J P | 1994 | Journal of the Scicence of Food andAgriculture1994，46，： | 1 |
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