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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Is portal hypertension due to liver cirrhosis a major factor in the development of portal hypertensive gastropathy显示文摘 | Bayraktar Y Balkanci F Uzunalimoglu B | 1996 | Am J Gastroenterol1996，91，6： | 1 |
| 3 | Intestinal Behcet's disease: surgical experience in seven cases显示文摘 | Aran O Uzunalimoglu B | 1991 | Hepatogastroenterology1991，38，： | 1 |
| 4 | Is Portal hy pertension due to liver cinhosis a maion factor in the develop ment of portal hypertensive gastropahty显示文摘 | Bayraktar Y Balkanci F Uzunalimoglu B | 1996 | Am J Gastroen terol1996，91，： | 1 |
| 5 | Importance of proliferation markers in gastrointestinal carcinoid tumors:a clinicopathologic study显示文摘 | Sokmensuer C Gedikoglu G Uzunalimoglu B | 2001 | Hepatogastroenterology2001，48，39： | 1 |
| 6 | Importance of proliferation markers in gastrointestinal carcinoid tumors : a clinico pathologic study 显示文摘 | Sokmensuer C Gedikoglu G Uzunalimoglu B | 2001 | Hepatogastroenterology2001，48，39： | 1 |
| 7 | Thrombophilic gene mutations in cirrhotic patients with portal vein thrombosis显示文摘 | Ozlem Erkan Abdurrahman M. Bozdayi Selcuk Disibeyaz Dilek Oguz Muhit Ozcan Kadir Bahar Selim Karayalcin Ali Ozden Hakan Bozkaya Cihan Yurdaydin Ozden Uzunalimoglu | 2005 | European Journal of Gastroenterology & Hepatology2005，，3： | 1 |
| 8 | Hepatic osteodystrophy: a review显示文摘 | Idilman R de Maria N Uzunalimoglu O | 1997 | Hepatogastroenterology1997，44，14： | 1 |
| 9 | Is portal hypertension due to liver cirrhosis a major factor in the development of portal hypertensive gastropathy?显示文摘 | Bayraktar Y Balkanci F Uzunalimoglu B | 1996 | Am J Gastroenterol1996，91，3： | 1 |
| 10 | YSDD:a novel mutation in HBV DNA polyrnerase confers clinical resistance to lamivudine显示文摘 | Bozdayi AM Uzunalimoglu O Turkyilmaz AR | | 0，，4： | 1 |
| 11 | Is portal hypertension due to liver cirrhosis a major factor in the development of portal hypertensive gastropathy显示文摘 | Bayraktar Y Balkanci F Uzunalimoglu B | | 0，，03： | 1 |
| 12 | Congenital hepatic fibrosis associated with cavernous transformation of the protal vein显示文摘 | Bayraktar Y Balkanci F Kayhan B Uzunalimoglu B Ozenc A Ozdemir A | 1997 | Hepatogastroenterology1997，44，18： | 1 |
| 13 | Cavernous transformation of the portal vein is associated with pancreatic duct atrophy显示文摘 | Bayraktar Y Balkanci F Bayraktar M Koseoglu T Serap Arslan Uzunalimoglu B | 1996 | Hepatogastroenterology1996，43，10： | 1 |
| 14 | Intestinal Behcet' s disease: surgical experience in seven cases 显示文摘 | Sayek I Aran O Uzunalimoglu B | 1991 | Hepatogastroenterology1991，38，： | 1 |
| 15 | Is portal hypertension due to liver cirrhosis a major factor in the development of portal hypertensive gastropathy? 显示文摘 | Bayraktar Y Balkanci F Uzunalimoglu B | 1996 | Am J Gastroenterol1996，91，3： | 1 |
| 16 | YSDD-a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine显示文摘 | Bozdayi AM Uzunalimoglu O | 2003 | J Viral Hepat2003，10，4： | 1 |
| 17 | Isportal hypertension due to liver cirrhosis a major factor in thedevelopment of portal hypertensive gastropathy? 显示文摘 | BAYRAKTAR Y BALKANCI F UZUNALIMOGLU B | 1996 | Am JGastroenterol1996，91，3： | 1 |
| 18 | Is portal hypertension due to liver cirrhosis a major factor in the development of portal hypertensive gastropathy?显示文摘 | Bayraktar Y Balkanci F Uzunalimoglu B | 1996 | Am J Gastroenterol1996，91，3： | 1 |
| 19 | Nuclear localization of hepatitis B core antigen and its relations to liver injury,hepatocyte proliferation,and viral load显示文摘 | Serinoz E Varli M Erden E Cinar K Kansu A Uzunalimoglu O | | Journal of Clinical Gastroenterology0，，： | 1 |
| 20 | YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine显示文摘 | Uzunalimoglu O Turkyilmaz AR | 2003 | Journal of Viral Hepatology2003，10，4： | 1 |
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