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| 1 | Risk for hepatocellular carcinoma in the course of chronic hepatitis B virus infection and the protective effect of therapy with nucleos(t)ide analogues显示文摘Hepatocellular carcinoma(HCC) is a major health problem worldwide, representing one of the leading causes of death. Chronic hepatitis B virus(HBV) infection(CHB) is the most important etiologic factor of this tumor, accounting for the development of more than50% of the cases in the world. Primary prevention ofHCC is possible by hepatitis B vaccination conferring protection from HBV infection. However, according to the World Health Organization Hepatitis B Fact sheet N° 204(update of July 2014) globally there exists a large pool of > 240 million people chronically infected with HBV who are at risk for development of HCC. These individuals represent a target population for secondary prevention both of cirrhosis and of HCC. Since ongoing HBV replication in CHB is linked with the progression of the underlying liver disease to cirrhosis as well as with the development of HCC, effective antiviral treatment in CHB has also been evaluated in terms of secondary prevention of HCC. Currently, most patients with active CHB are subjected to long term treatment with the first line nucleos(t)ide analogues entecavir and tenofovir. These compounds are of high antiviral potency and have a high barrier to HBV resistance compared to lamivudine, adefovir dipivoxil and even telbivudine. Many studies have shown that patients under antiviral treatment, especially those in virological remission, develop less frequently HCC compared to the untreated ones. However, the risk for development of HCC cannot be eliminated. Therefore, surveillance for the development of HCC of patients with chronic hepatitis B must be lifelong or until a time in the future when new treatments will be able to completely eradicate HBV from the liver particularly in the early stages of CHB infection. In this context, the aim of this review is to outline the magnitude of the risk for development of HCC among patients with CHB, in the various phases of the infection and in relation to virus, host and environmental factors as evaluated in the world literature. Moreover, the benefits of antiviral treatment of CHB with nucleos/tide analogs, which have changed the natural history of the disease and have reduced but not eliminated the risk of HCC are also reviewed. | Irene Rapti Stephanos Hadziyannis | 2015 | World Journal of Hepatology2015，7，8： | 20 |
| 2 | Wireless capsule endoscopy in the investigation of patients with chronic renal failure and obscure gastrointestinal bleeding (preliminary data)显示文摘瞄准:在小肠(SB ) 的察觉调查无线的囊内视镜检查法(WCE ) 的角色在有长期的肾衰竭(CRF ) 并且阴暗流血的病人的病理。方法:有阴暗流血的连续 CRF 病人有希望地被学习。有正常肾的功能并且阴暗流血的病人,与 WCE 在一样的时期期间调查了,被用于结果的解释。结果:十七个 CRF 病人(11 公开, 6 玄术流血) 并且 51 个病人(33 公开, 18 玄术流血) 与正常,肾的功能在这研究被注册。积极 SB 调查结果在 70.6% CRF 病人被检测(P <
0.05 ) 。SB angiodysplasia 在 47% CRF 病人被识别。Univariate 逻辑回归为 angiodysplasia 作为一个重要预兆的因素揭示了 CRF (P <
0.05 ) 。治疗学的措施与积极调查结果在 66% 病人被承担。结论:根据我们的初步的结果, SB angiodysplasia 与阴暗流血在 CRF 病人之中在增加的流行被发现。WCE 在胃肠的病理的诊断并且在计划适当治疗学的干预是有用的并且因此,应该在这组病人的病情的检查被包括。 | Stephanos Karagiannis Spyros Goulas Georgios Kosmadakis Petros Galanis Dimitrios Arvanitis John Boletis Evangelos Georgiou Christos Mavrogiannis | 2006 | World Journal of Gastroenterology2006，12，32： | 8 |
| 3 | 考虑转向操纵机构万向节间隙的车辆摆振系统动力学行为分析显示文摘基于Hertz定理,用二状态模型描述十字轴与主动轴叉之间的接触状态,结合转向系结构特点,建立了考虑万向节传动间隙的3自由度车辆摆振动力学模型,通过数值分析,对计入万向节传动间隙的车辆摆振系统动力学响应进行了讨论,分析了考虑万向节间隙后车辆摆振系统动力学行为的变迁规律。相关方法和结论有助于进一步改善车辆摆振系统动力学响应,为更好地抑制车辆摆振提供理论支持。 | 卢剑伟 辛加运 张士路 Theodossiades Stephanos | 2014 | 汽车工程2014，36，7： | 7 |
| 4 | 秸秆还田下施镁对土壤交换镁及春玉米镁素积累和产量的影响显示文摘于2017—2019年在吉林省农安县设置大田试验,采用双因素裂区设计,主区为秸秆还田J(12000 kg/hm^2)、秸秆不还田W,副区为施镁M3(施纯镁10 kg/hm^2)、不施镁M0,包含JM3(秸秆+镁肥)、JM0(秸秆+无镁肥)、WM3(无秸秆+镁肥)、WM0(常规)4个处理。结果表明:玉米生育期,土壤交换镁含量逐渐降低,至成熟期,JM3处理土壤交换镁含量比WM3、JM0、WM0分别提高6.59%,8.47%,14.09%。施用镁肥促进玉米植株对镁素养分的吸收,秸秆还田配施镁肥进一步增加了玉米植株对镁素养分的吸收,WM3处理玉米镁素积累量比WM0平均提高12.30%;JM3处理的镁素积累量比WM3、JM0、WM0处理分别提高9.79%,15.99%,23.28%。春玉米干物质积累量随着生育期的进行逐渐增加,施镁肥能提高干物质积累量与春玉米产量,在成熟期WM3(无秸秆+镁肥)的干物质积累量与产量分别比WM0(常规)提高5.30%与4.38%,JM3(秸秆+镁肥)的干物质积累量与产量比WM0(常规)分别提高11.50%与5.52%。综上可以得出,施用镁肥可以显著提高土壤交换镁含量,促进春玉米植株对镁素养分的吸收,增加干物质积累量及提高春玉米产量。秸秆还田配施镁肥不但可以提高土壤交换镁含量,保持土壤镁素在整个玉米生育期的持续有效供应,还进一步促进春玉米植株对镁素的吸收,提高了干物质积累量及春玉米产量。 | 张美玲 耿玉辉 曹国军 Stephano Mabagala Frank 黄琦嘉 周丽娟 | 2020 | 水土保持学报2020，34，3： | 5 |
| 5 | Natural history of chronic hepatitis B in Euro-Mediterranean and African Countries显示文摘 | Stephanos J. Hadziyannis | 2011 | Journal of Hepatology2011，，1： | 4 |
| 6 | Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years显示文摘 | Stephanos J. Hadziyannis Nicolaos C. Tassopoulos E. Jenny Heathcote Ting–Tsung Chang George Kitis Mario Rizzetto Patrick Marcellin Seng Gee Lim Zachary Goodman Jia Ma Carol L. Brosgart Katyna Borroto–Esoda Sarah Arterburn Steven L. Chuck | 2006 | Gastroenterology2006，，6： | 3 |
| 7 | 秸秆还田下施锌对春玉米产量及锌素吸收分配的影响显示文摘【目的】研究秸秆还田条件下施锌对春玉米产量及锌素吸收分配的影响,为锌肥的合理利用及肥料配施提供理论依据。【方法】采用双因素裂区设计,主区为秸秆不还田(S0)和秸秆还田量12000 kg/hm 2(S1)2个水平,副区为不施锌(Z0)和施纯Zn 40 kg/hm 2(Z4)2个水平,形成CK(不施肥)、S0Z0(无秸秆+无锌肥)、S0Z4(无秸秆+锌肥)、S1Z0(秸秆+无锌肥)、S1Z4(秸秆+锌肥)5个处理,通过田间试验的方式,研究秸秆还田条件下施锌对春玉米产量、干物质积累及锌素累积和分配的影响。【结果】无秸秆还田条件下,施锌S0Z4处理春玉米产量比不施锌S0Z0处理提高14.06%;秸秆还田条件下,施锌处理S1Z4较不施锌处理S1Z0增产17.3%,秸秆配合施锌处理S1Z4的产量达到最高(11809 kg/hm 2)。无秸秆还田情况下,施锌S0Z4处理春玉米的干物质积累量比不施锌S0Z0处理提高11.51%;秸秆还田条件下,施锌S1Z4处理干物质积累量较不施锌处理S1Z0提高14.06%,秸秆配合施锌处理S1Z4的干物质积累量最高(22077 kg/hm 2);各处理中籽粒质量占总干物质积累量的52.41%~57.56%。无秸秆还田情况下,施锌处理S0Z4春玉米的锌素累积量比不施锌处理S0Z0提高18.32%;秸秆还田条件下,施锌处理S1Z4锌素累积量较不施锌处理S1Z0提高23.4%;秸秆配合施锌处理S1Z4的锌素累积量最高(519.43 g/hm 2),各处理中籽粒含锌量占总锌素累积量的68.5%~72.8%。无秸秆还田情况下,施锌处理S0Z4锌素转运量比不施锌处理S0Z0增加了11.82%;秸秆还田条件下,施锌处理S1Z4锌素转运量较不施锌处理S1Z0提高21.91%;秸秆配合施锌处理S1Z4的锌素转运量最高(232.17 g/hm 2)。【结论】施用锌肥显著提高了春玉米的产量和干物质积累量,并促进了植株对锌素的吸收和向籽粒的分配;秸秆还田配合施锌进一步提高了锌肥的增产效果,及植株对锌素的吸收和向籽粒的分配。 | 孟祥齐 王一丁 曹国军 王淑华 张美玲 Mabagala Stephano Frank 耿玉辉 | 2020 | 西北农林科技大学学报(自然科学版)2020，48，3： | 3 |
| 8 | Sustained Responses and Loss of HBsAg in HBeAg-Negative Patients With Chronic Hepatitis B Who Stop Long-Term Treatment With Adefovir显示文摘 | Stephanos J. Hadziyannis Vassilios Sevastianos Irene Rapti Dimitrios Vassilopoulos Emilia Hadziyannis | 2012 | Gastroenterology2012，，3： | 2 |
| 9 | Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years显示文摘 | Stephanos J. Hadziyannis Nicolaos C. Tassopoulos E. Jenny Heathcote Ting–Tsung Chang George Kitis Mario Rizzetto Patrick Marcellin Seng Gee Lim Zachary Goodman Jia Ma Carol L. Brosgart Katyna Borroto–Esoda Sarah Arterburn Steven L. Chuck | 2006 | Gastroenterology2006，，6： | 2 |
| 10 | Role of diaphragm in pancreaticopleural fistula显示文摘A pancreatic pleural effusion may result from a pancreatopleural fistula. We herein discuss two interesting issues in a similar case report of a pleural effusion caused after splenectomy, which was recently published in the World Journal of Gastroenterology . Pancreatic exudate passes directly through a natural hiatus in the diaphragm or by direct penetration through the dome of the diaphragm from a neighboring subdiaphragmatic collection. The diaphragmatic lymphatic 'stomata' does not contribute to the formation of such a pleural effusion, as it is inaccurately mentioned in that report. A strictly conservative approach is recommended in that article as the management of choice. Although this may be an option in selected frail patients, there has been enough accumulative evidence that a pancreaticopleural fistula may be best managed by early endoscopy in order to avoid complications causing prolonged hospitalization. | Anestis P Ninos Stephanos K Pierrakakis | 2011 | World Journal of Gastroenterology2011，17，32： | 2 |
| 11 | Hepatitis B e antigen—negative chronic hepatitis B显示文摘 | Stephanos J. Hadziyannis Dimitrios Vassilopoulos | 2001 | Hepatology2001，，4： | 2 |
| 12 | Sustained Response of Hepatitis B e Antigen-Negative Patients 3 Years After Treatment with Peginterferon Alfa-2a显示文摘 | Patrick Marcellin Ferruccio Bonino George K.K. Lau Patrizia Farci Cihan Yurdaydin Teerha Piratvisuth Rui Jin Selim Gurel Zhi-Meng Lu Jian Wu Matei Popescu Stephanos Hadziyannis | 2009 | Gastroenterology2009，，7： | 2 |
| 13 | Comparing imagery and verbal instructions for the experimental modification of interpretation and judgmental bias in children显示文摘 | Stephanos P Vassilopoulos Simon E Blackwell Nicholas J Moberly Eleni Karahaliou | | 0，，01： | 1 |
| 14 | A survey of peer-to-peer content distribution technologies显示文摘 | Stephanos Routsellis Theotokis Diomidis Spinellis | 2004 | ACM Computing Surveys2004，36，4： | 1 |
| 15 | Sustained Response of Hepatitis B e Antigen-Negative Patients 3 Years After Treatment with Peginterferon Alfa-2a显示文摘 | Patrick Marcellin Ferruccio Bonino George K.K. Lau Patrizia Farci Cihan Yurdaydin Teerha Piratvisuth Rui Jin Selim Gurel Zhi-Meng Lu Jian Wu Matei Popescu Stephanos Hadziyannis | 2009 | Gastroenterology2009，，7： | 1 |
| 16 | Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years显示文摘 | Stephanos J Hadziyannis Nicolaos C | 2006 | Gastroenterology2006，13，6： | 1 |
| 17 | Coordination compounds of hydrazine derivatives with transition metals. Part 27. Coordination chemistry of 4-amino-3-alkyl-5-thio-1,2,4-triazolines and 4-amino-5-oxo-3-thioxo-6-alkyl-2,3,4,5-tetrahydro-1,2,4-triazines显示文摘 | Magdi F. Iskander Josefe Stephanos Nagwa El Kady Mohyi El Essawi Ahmed El Toukhy Laila El Sayed | 1989 | Transition Metal Chemistry1989，，1： | 1 |
| 18 | Risk of hepatocellular carcinoma and extrahepatic malignancies in primary biliary cirrhosis显示文摘 | Melanie Deutsch George V. Papatheodoridis Anastasia Tzakou Stephanos J. Hadziyannis | 2008 | European Journal of Gastroenterology & Hepatology2008，，1： | 1 |
| 19 | Drug-protein interactions:Two-site binding ofheterocyclic ligands to a monomeric hemoglobin显示文摘 | Stephanos J J | 1996 | J InorgBiochem1996，62，3： | 1 |
| 20 | Concrete jacket construction detail effectiveness when strengthening RC columns显示文摘 | Konstantinos G. Vandoros Stephanos E. Dritsos | 2006 | Construction and Building Materials2006，，3： | 1 |
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