|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fibrosis显示文摘AIM: To examine the ultrastructural changes after ursodeoxycholic acid (UDCA) treatment in hepatocytes from experimentally induced fibrotic livers.METHODS: Liver fibrosis was induced in male Sprague-Dawley rats with CCl4 for 12 wk, and the rats were divided into two groups. Group I was treated with saline and group Ⅱ with UDCA (25 mg/kg per day) for 4 wk. All the rats were killed at wk 16. Mitochondria, nuclei, rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER) of hepatocytes were evaluated according to a scoring system.RESULTS: Mitochondria, nuclei, RER and SER injury scores in group Ⅱ were significantly lower than those in groupⅠ(P < 0.001). CONCLUSION: UDCA alleviates hepatocyte organelle injury in CCl4-induced liver fibrosis. | Nuket Mas Ilker Tasci Bilgin Comert Ramazan Ocal Mehmet Refik Mas | 2008 | World Journal of Gastroenterology2008，14，7： | 9 |
| 2 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 3 | Combination of allopurinol and hyperbaric oxygen therapy:A new treatment in experimental acute necrotizing pancreatitis?显示文摘瞄准:在试验性的老鼠在生物化学、组织病理学说的变化,氧化压力,和细菌的易位(BT ) 上调查 allopurinol 和高比重的氧(HBO ) 治疗的单个、联合的效果尖锐胰腺炎(AP ) 。方法:85 只 Sprague-Dawley 老鼠在学习被包括。85 只老鼠中的十五个被用作控制(假冒,组我) 。AP 在留下经由管内牛磺胆酸盐注入被导致七十只老鼠。幸存到尖锐引起坏死胰腺炎的正式就职的老鼠被使随机化进四个组。组 II 独自收到了 saline,组 III allopurinol,加 HBO 的组 IV allopurinol 和组 V HBO。浆液淀粉酶层次,氧化压力参数, BT 和组织病理学说的分数是坚定的。结果:浆液淀粉酶层次在与组 II 相比的组 III, IV 和 V 是更低的(974 +/- 110, 384 +/- 40, 851 +/- 56,和 1664 +/- 234 U/L,分别地 P <
0.05,为所有) 。联合揭示的二种处理选择显著地降低 median [25-75 百分位数] 组织病理学说的分数什么时候与单个政府相比(13 [12.5-15 ] 在 allopurinol 组, 9.5 [7-11.75 ] 在 HBO 组,并且 6 [4.5-7.5 ] 在联合的组, P <
0.01 ) 。氧化压力标记在与控制相比的所有处理组显著地更好。进胰和 mes 伤寒淋巴结的细菌的易位在与组 II 相比的组 III , IV 和 V 是更低的(54%,23%,50%对为到胰的易位的100%,并且62%,46%,58%对为到 mes 伤寒淋巴节点的易位的100%,分别地 P <
0.05 为所有)。结论:当在试验性的老鼠 AP 独立管理了时,现在的学习证实 HBO 和 allopurinol 处理的利益。这些处理选择的联合看起来更有效地阻止胰腺的损害参数的前进。 | Bilgin Comert Ahmet Turan Isik Sezai Aydin Ergun Bozoglu Bulent Unal Salih Deveci Nuket Mas Esref Cinar Mehmet Refik Mas | 2007 | World Journal of Gastroenterology2007，13，46： | 4 |
| 4 | Ultrastructural changes in hepatocytes after taurinetreatment in CCl_4 induced liver injury显示文摘AIM: To search the organelle based changes in hepatocytes after taurine treatment in experimental liver fi brosis induced by CCl_4 administration. METHODS: Thirty rats were divided into two groups. Group 1 (n = 15) was injected with CCl_4 plus taurine and Group 2 (n = 15) with CCl_4 plus saline for 12 wk. At the end of 12th wk, mitochondria, rough and smooth endoplasmic reticulum, and nuclei of hepatocytes were evaluated using a scoring system. The results were compared with histopathological f indings, as well. RESULTS: Taurine treatment reduced fi brosis scores signifi cantly as compared to placebo. Organelle injury scores decreased signifi cantly with taurine treatment. Ultrastructural and histopathological scores in both groups were in strong correlation (r = 0.931 for CCl_4 plus taurine and r = 0.899 for CCl_4 plus saline group). CONCLUSION: Organelle based transmission electron microscopy fi ndings can reflect successfully histological results as well as tissue healing in hepatocytes from hepatotoxin-induced liver fi brosis. | Ilker Tasci Nuket Mas Mehmet Refik Mas Murvet Tuncer Bilgin Comert | 2008 | World Journal of Gastroenterology2008，14，31： | 3 |
| 5 | Effects of long term hydrophilic bile acid therapy on in vitro contraction of gallbladder muscle strips in patients with cholesterol gallstones显示文摘AIM:To evaluate ursodeoxycholic acid (UDCA) therapy on the in vitro contraction of gallbladder smooth muscle strips from cholesterol gallstone patients. METHODS:The contraction forces of gallbladder smooth muscle strips from 28 patients with cholesterol gallstones treated with UDCA were compared with contraction forces from 14 untreated patients. The strips were stimulated with increasing concentrations of cholecystokinin-8 (CCK-8). RESULTS:Although the contraction forces that developed in response to CCK-8 were higher in strips from specimens of UDCA treated patients compared to untreated patients,longer treatment periods (6-wk) caused more contraction responses than the short treatment period of 3-wk (F = 19.297,1.85 ± 0.22 g vs 1.70 ± 0.10 g,P < 0.01). Contraction forces developed with maximal stimulation with KCl in the 6-wk treatment group were also higher than contraction forces in the untreated group (F = 4.274,3.77 ± 0.45 g vs 3.30 ± 0.30 g,P < 0.05). CONCLUSION:Six-week UDCA treatment caused an increase in contractions of muscle strips from patients with cholesterol gallstones when compared to shorter treatment administration or controls. We suggest that extending UDCA treatment periods may cause more effective contractions in the gallbladder,and thereby increase the rate of response to treatment. | Mehmet Refik Mas Bilgin Comert Nuket Mas Levent Yamanel Haluk Ozotuk Ilker Tasci Riadh P Jazrawi | 2007 | World Journal of Gastroenterology2007，13，32： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员