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| 1 | New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p H metry in extraesophageal gastroesophageal reflux disease显示文摘AIM:To determine the laryngeal H+K+-ATPase and pharyngeal p H in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI therapy.METHODS:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human H+K+-ATPase.Quantitative real-time RT-PCR for each of the H+K+-ATPase subunits was performed.The p H values were assessed in the aerosolized environment of the oropharynx(Dxp H Catheter) and compared to a subsequently applied combined p H/MII measurement.RESULTS:Twenty patients with LPR symptoms were included.In only one patient,the laryngeal H+K+-ATPase was verified by immunohistochemical staining.In another patient,real-time RT-PCR for each H+K+-ATPase subunit was positive.Fourteen out of twenty patients had pathological results in Dxp H,and 6/20 patients had pathological results in p H/MII.Four patients had pathological results in both functional tests.Nine out of twenty patients responded to PPIs.CONCLUSION:The laryngeal H+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR symptoms.Alternative hypotheses for the pathomechanism are needed.The role of pharyngeal p H-metry remains unclearand its use can only be recommended for patients in a research study setting. | Valentin Becker Romina Drabner Simone Graf Christoph Schlag Simon Nennstiel Anna Maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj | 2015 | World Journal of Gastroenterology2015，21，3： | 14 |
| 2 | Folate Biofortification of Potato by Tuber-Specific Expression of Four Folate Biosynthesis Genes显示文摘微量元素的不够的饮食的吸入,是隐藏饥饿知道,是破坏全球负担,影响 20 亿个人。folates (维生素 B9 ) 的缺乏,被知道在 C 1 新陈代谢起一个中央作用,每年在至少 1/4 百万个人引起出生缺点。在庄稼提高自然地发生的 folates 的水平的 Biofortification 种,证明是在战斗的一个有效、划算的工具叶酸的缺乏。以前,叶酸的生合成基因 GTPCHI 和模数转换器的介绍,证明是在米饭和西红柿的成功的 biofortification 策略,结果不够足够地在土豆 tubers 增加叶酸的层次。这里,我们提供概念的一个证明 HPPK/DHPS 或 FPGS 的那另外的介绍,在 mitochondrial 的下游的基因叶酸的生合成,启用 folates 的扩大到令人满意的层次(12 褶层) 并且在 tubers 的长期的存储之上保证叶酸的稳定性。在结论,这设计策略能在叶酸积累的土豆栽培变种的创造担任一个模型,在消费土豆的人口受不了容易地适用叶酸的缺乏。 | Jolien De Lepeleire Simon Strobbe Jana Verstraete Dieter Blancquaert Lars Ambach Richard G.F. Visser Christophe Stove Dominique Van Der Straeten | 2018 | Molecular Plant2018，11，1： | 12 |
| 3 | Genomic Analyses Yield Markers for Identifying Agronomically Important Genes in Potato显示文摘野土豆种类有实质的 phenotypic 和生理的差异。这里,我们基于茄属节 Petota 的 201 就职的 genomic 分析报导对野、栽培的土豆种类的一个全面评价。我们定序这 201 就职的染色体并且识别了 6 ? 487 ? 从在 clade 的 167 就职的 006 高质量的单个核苷酸多型性(SNP ) 4 茄属节 Petota,包括 146 野并且有宽广地理分布的 21 栽培双土豆就职。染色体宽的基因变化分析比栽培土豆,和在农学地重要的疾病抵抗的高得多的基因差异,基因在野土豆被观察的证明野土豆的差异高。由关于已知的量的特点 loci (QTL ) 利用信息,而且,我们在选择下面识别了 609 基因,包括那些在 tubers 与痛苦的损失相关,那些在 tuberization 包含了,土豆的二个主要驯养的特点。种系发生的分析在 clade 揭示了所有种类的一个纵贯的部门 4,不是就那些在 S.? brevicaule 建筑群,和进一步支持的 S。是的 candolleanum 栽培土豆和在南部的秘鲁的栽培土豆的 monophyletic 起源的祖先。另外,我们分析了 S. 的染色体 ? candolleanum 并且鉴别 529 基因在栽培土豆输了。一起,在这研究产生的分子的标记为为土豆繁殖有用的农学地重要的基因的鉴定提供一个珍贵资源。 | Yangping Li Christophe Colleoni Junjie Zhang Qiqi Liang Yufeng Hu Holly Ruess Reinhard Simon Yinghong Liu Hanmei Liu Guowu Yu Eric Schmitt Ghloe Ponitzki Guangjian Liu Huanhuan Huang Feilong Zhan Lin Chen Yubi Huang David Spooner Binquan Huang | 2018 | Molecular Plant2018，11，3： | 8 |
| 4 | The complexity of sediment recycling as revealed by common Pb isotopes in K-feldspar显示文摘Detrital zircon U-Pb geochronology has become the gold standard in evaluating source to sink relationships in sedimentary basins. However, the physical and chemical robustness of zircon, which make it such a useful mineral for provenance studies, is also a hindrance as zircon can be recycled through numerous sedimentary basins, thus obscuring the first cycle source to sink relationship. An elegant approach to addressing this potential issue is to compare the Pb isotope composition of detrital K-feldspar, a mineral which is unlikely to survive more than one erosion-transport-deposition cycle, with that of magmatic K-feldspar from potential basement source terranes. Here we present new in situ Pb isotope data on detrital K-feldspar from two Proterozoic arkosic sandstones from Western Australia, and magmatic K-feldspar grains from potential igneous source rocks, as inferred by the age and Hf isotope composition of detrital zircon grains. The data indicate that the detrital zircon and K-feldspar grains could not have been liberated from the same source rocks, and that the zircon has most likely been recycled through older sedimentary basins. These results provide a more complete understanding of apparently simple source to sink relationships in this part of Proterozoic Western Australia. | Simon P.Johnson Christopher L.Kirkland Noreen J.Evans Brad J.McDonald Huntly N.Cutten | 2018 | Geoscience Frontiers2018，9，5： | 5 |
| 5 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 6 | Nano-Morphology of a Polymer Electrolyte Fuel Cell Catalyst Layer Imaging, Reconstruction and Analysis显示文摘在聚合物电解质燃料房间(PEFC ) 的阴极催化剂层(CCL ) 的氧减小反应(ORR ) 在操作期间是表演损失的主要原因之一。另外, CCL 由于磅催化剂的使用是最昂贵的部件。除了 ORR 本身,种类运输到并且从反应地点决定 PEFC 的表演。在 CCL 的种类的有效运输性质取决于它的 nanostructure。因此, CCL 的三维的重建被要求。一系列二维的图象从集中的离子横梁扫描被获得为二维的图象的电子显微镜(FIB-SEM ) 成像和一个分割方法被开发了。毛孔尺寸分发(PSD ) 为三维的几何学被计算。PSD 上的排列和各向异性的象素尺寸的影响被调查了。毛孔在在 5 nm 和 205 nm 之间的范围被发现。Knudsen 数字的评估证明在 CCL 的那煤气的运输被转变流动政体管理。液体水运输能被包括在连续统水动力学以内描述合适滑动流动边界条件。 | Simon Thiele Roland Zengerle Christoph Ziegler | 2011 | Nano Research2011，4，9： | 5 |
| 7 | Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS)显示文摘 | Nuh N. Rahbari O. James Garden Robert Padbury Mark Brooke-Smith Michael Crawford Rene Adam Moritz Koch Masatoshi Makuuchi Ronald P. Dematteo Christopher Christophi Simon Banting Val Usatoff Masato Nagino Guy Maddern Thomas J. Hugh Jean-Nicolas Vauthey Pau | 2011 | Surgery2011，，5： | 4 |
| 8 | Superconducting single-photon detectors integrated with diamond nanophotonic circuits显示文摘Photonic quantum technologies hold promise to repeat the success of integrated nanophotonic circuits in non-classical applications.Using linear optical elements,quantum optical computations can be performed with integrated optical circuits and can therefore overcome the existing limitations in terms of scalability.In addition to passive optical devices for realizing photonic quantum gates,active elements,such as single-photon sources and single-photon detectors,are essential ingredients for future optical quantum circuits.Material systems that allow for the monolithic integration of all components are particularly attractive,including III-V semiconductors,silicon and diamond.Here,we demonstrate nanophotonic integrated circuits made from high-quality polycrystalline diamond thin films in combination with on-chip single-photon detectors.By using superconducting nanowires that are coupled evanescently to traveling waves,we achieve high detection efficiencies of up to 66%as well as low dark count rates and a timing resolution of 190 ps.Our devices are fully scalable and hold promise for functional diamond photonic quantum devices. | Patrik Rath Oliver Kahl Simone Ferrari Fabian Sproll Georgia Lewes-Malandrakis Dietmar Brink Konstantin Ilin Michael Siegel Christoph Nebel Wolfram Pernice | 2015 | Light(Science & Applications)2015，4，1： | 3 |
| 9 | The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease显示文摘 | Holm H. Uhlig Tobias Schwerd Sibylle Koletzko Neil Shah Jochen Kammermeier Abdul Elkadri Jodie Ouahed David C. Wilson Simon P. Travis Dan Turner Christoph Klein Scott B. Snapper Aleixo M. Muise | 2014 | Gastroenterology2014，，： | 3 |
| 10 | Clinical utility of the ARCHITECT HCV Ag assay for early treatment monitoring in patients with chronic hepatitis C genotype 1 infection显示文摘 | Johannes Vermehren Simone Susser Annemarie Berger Dany Perner Kai-Henrik Peiffer Regina Allwinn Stefan Zeuzem Christoph Sarrazin | 2012 | Journal of Clinical Virology2012，，1： | 3 |
| 11 | Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS)显示文摘 | Nuh N. Rahbari O. James Garden Robert Padbury Mark Brooke-Smith Michael Crawford Rene Adam Moritz Koch Masatoshi Makuuchi Ronald P. Dematteo Christopher Christophi Simon Banting Val Usatoff Masato Nagino Guy Maddern Thomas J. Hugh Jean-Nicolas Vauthey Pau | 2011 | Surgery2011，，5： | 2 |
| 12 | Bile leakage after hepatobiliary and pancreatic surgery: A definition and grading of severity by the International Study Group of Liver Surgery显示文摘 | Moritz Koch O. James Garden Robert Padbury Nuh N. Rahbari Rene Adam Lorenzo Capussotti Sheung Tat Fan Yukihiro Yokoyama Michael Crawford Masatoshi Makuuchi Christopher Christophi Simon Banting Mark Brooke-Smith Val Usatoff Masato Nagino Guy Maddern Thomas | 2011 | Surgery2011，，5： | 2 |
| 13 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet . 2005 (9454)2005，，： | 2 |
| 14 | Comparative Effectiveness for Survival and Renal Function of Partial and Radical Nephrectomy for Localized Renal Tumors: A Systematic Review and Meta-Analysis显示文摘 | Simon P. Kim R. Houston Thompson Stephen A. Boorjian Christopher J. Weight Leona C. Han M. Hassan Murad Nathan D. Shippee Patricia J. Erwin Brian A. Costello George K. Chow Bradley C. Leibovich | 2012 | The Journal of Urology2012，，： | 2 |
| 15 | Budesonide Is Effective in Adolescent and Adult Patients With Active Eosinophilic Esophagitis显示文摘 | Alex Straumann Sebastien Conus Lukas Degen Stephanie Felder Mirjam Kummer Hansjürg Engel Christian Bussmann Christoph Beglinger Alain Schoepfer Hans–Uwe Simon | 2010 | Gastroenterology2010，，： | 2 |
| 16 | Long-Term Budesonide Maintenance Treatment Is Partially Effective for Patients With Eosinophilic Esophagitis显示文摘 | Alex Straumann Sebastien Conus Lukas Degen Cornelia Frei Christian Bussmann Christoph Beglinger Alain Schoepfer Hans–Uwe Simon | 2011 | Clinical Gastroenterology and Hepatology2011，，： | 2 |
| 17 | Liver regeneration biology:Implications for liver tumour therapies显示文摘The liver has remarkable regenerative potential,with the capacity to regenerate after 75%hepatectomy in humans and up to 90%hepatectomy in some rodent models,enabling it to meet the challenge of diverse injury types,including physical trauma,infection,inflammatory processes,direct toxicity,and immunological insults.Current understanding of liver regeneration is based largely on animal research,historically in large animals,and more recently in rodents and zebrafish,which provide powerful genetic manipulation experimental tools.Whilst immensely valuable,these models have limitations in extrapolation to the human situation.In vitro models have evolved from 2-dimensional culture to complex 3 dimensional organoids,but also have shortcomings in replicating the complex hepatic micro-anatomical and physiological milieu.The process of liver regeneration is only partially understood and characterized by layers of complexity.Liver regeneration is triggered and controlled by a multitude of mitogens acting in autocrine,paracrine,and endocrine ways,with much redundancy and cross-talk between biochemical pathways.The regenerative response is variable,involving both hypertrophy and true proliferative hyperplasia,which is itself variable,including both cellular phenotypic fidelity and cellular trans-differentiation,according to the type of injury.Complex interactions occur between parenchymal and non-parenchymal cells,and regeneration is affected by the status of the liver parenchyma,with differences between healthy and diseased liver.Finally,the process of termination of liver regeneration is even less well understood than its triggers.The complexity of liver regeneration biology combined with limited understanding has restricted specific clinical interventions to enhance liver regeneration.Moreover,manipulating the fundamental biochemical pathways involved would require cautious assessment,for fear of unintended consequences.Nevertheless,current knowledge provides guiding principles for strategies to optimise liver regeneration potential. | Christopher Hadjittofi Michael Feretis Jack Martin Simon Harper Emmanuel Huguet | 2021 | World Journal of Clinical Oncology2021，12，12： | 2 |
| 18 | Imaging Electronic Structure of Carbon Nanotubes by Voltage-Contrast Scanning Electron Microscopy显示文摘We introduce voltage-contrast scanning electron microscopy(VC-SEM)for visual characterization of the electronic properties of single-walled carbon nanotubes.VC-SEM involves tuning the electronic band structure and imaging the potential profi le along the length of the nanotube.The resultant secondary electron contrast allows to distinguish between metallic and semiconducting carbon nanotubes and to follow the switching of semiconducting nanotube devices,as confi rmed by in situ electrical transport measurements.We demonstrate that high-density arrays of individual nanotube devices can be rapidly and simultaneously characterized.A leakage current model in combination with fi nite element simulations of the device electrostatics is presented in order to explain the observed contrast evolution of the nanotube and surface electrodes.This work serves to fi ll a void in electronic characterization of molecular device architectures. | Aravind Vijayaraghavan Sabine Blatt Christoph Marquardt Simone Dehm Raghav Wahi Frank Hennrich Ralph Krupke | 2008 | Nano Research2008，1，4： | 2 |
| 19 | Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma显示文摘 | Bonertz Andreas Weitz Jürgen Pietsch Dong-Ho Kim Rahbari Nuh N Schlude Christoph Ge Yingzi Juenger Simone Vlodavsky Israel Khazaie Khashayarsha Jaeger Dirk Reissfelder Christoph Antolovic Dalibor Aigner Maximilian Koch Moritz Beckhove Phili | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
| 20 | On sequential Monte Carlo sampling methods for Bayesian filtering显示文摘 | Arnaud Doucet Simon Godsill Christophe Andrieu | 2000 | Statistics and Computing2000，，3： | 2 |
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