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| 1 | 主要人参皂甙的分布和比例及人参产品的质量控制显示文摘采用反相高效液相色谱法,对150多种西洋参、人参及三七的根、叶及其产品进行了分析。以8种主要的人参皂甙Rg,Re,Rf,Rb1,Rc,Rb2,Rg2和Rd作为对照品,来评价人参及其产品的质量,这8种人参皂甙的分布及其比例在对人参及其商品的定性、定量分析方面具有显著的意义。本文首次提出了单体皂甙的含量比率这一有价值的数据在人参品种及不同用药部位鉴定方面的有效性。 | Ma Yuanchun Luo Mai Lynn Malley Monique Doucet(Celex Laboratories Inc., Atholville Industrial Park, 77 Comeau St.,P. O. Box 428,Atholville,New Brunswick CANADA EOK 1A0) | 1996 | 中国药物化学杂志1996，6，1： | 12 |
| 2 | The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients. | Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens | 2016 | Bone Research2016，4，2： | 6 |
| 3 | Cloning, expression and localization of a trypsin-like serine protease in the spruce budworm, Choristoneura fumiferana显示文摘像胰岛素的脱毛相关的丝氨酸朊酶 cDNA (CfMRSP ) 从云杉芽虫被克隆, Choristoneura fumiferana。全身的 CfMRSP 互补 DNA (cDNA ) 编码了包含了像胰岛素的丝氨酸朊酶的 43 kDa 蛋白质催化领域,而是没有片断领域。C 终端延期包含了五 cystein 残余,它可以允许蛋白质形成通过更暗淡的一个人内部锁住二硫化物契约并且调整 CfMRSP 的活动。种系发生的树分析证明 CfMRSP 与象丝氨酸朊酶 1 Lonomia obliqua 那样的鳞翅类的相当或相同事物聚类,血淋巴朊酶 20 (HP20 ) ,模式识别丝氨酸朊酶先锋(ProHP14 ) 和 Manduca 祷告的像胰岛素的蛋白质一。CfMRSP 的发展表示的北污点分析显示它的抄本首先在外皮被发现并且测试视距在所有期间被生产,从第 4 中间形态幼虫到蛹,但是增加了抄本总是在每根脱毛以后被发现的 CfMRSP 的层次。蛋白质的高水平被免疫组织化学分析在外皮发现。总的来说这些数据建议 CfMRSP 在 molting 和变形期间在外皮起一个作用。 | Wen-Ying He Yi-Ping Zheng Lin Tang Si-Chun Zheng Catherine Beliveau Daniel Doucet Michel Cusson Qi-Li Feng | 2009 | Insect Science2009，16，6： | 3 |
| 4 | Calcium intake,body composition,and lipoprotein- lipid concentrations in adults显示文摘 | JACQMAIN M DOUCET E DESPRES J P BOUCHARD C | 2003 | American Journal of Clinical Nutrition2003，77，： | 2 |
| 5 | Characterization of a spruce budworm chitin deacetylase gene: Stage- and tissue-specific expression, and inhibition using RNA interference显示文摘 | Guoxing Quan Tim Ladd Jun Duan Fayuan Wen Daniel Doucet Michel Cusson Peter J. Krell | 2013 | Insect Biochemistry and Molecular Biology2013，，8： | 2 |
| 6 | Construction of an oilseed rape (Brassica napus L.) genetic map with SSR markers显示文摘 | J. Piquemal E. Cinquin F. Couton C. Rondeau E. Seignoret I. doucet D. Perret M.-J. Villeger P. Vincourt P. Blanchard | 2005 | Theoretical and Applied Genetics2005，，8： | 2 |
| 7 | 基于分子对接的苯丙素甙(PPGs)类化合物的虚拟筛选和合理设计显示文摘采用虚拟化合物生成法对抗肿瘤的苯丙素甙 (PPGs)类化合物进行了配体受体对接研究 .以三种不同的骨架结构为基础分别生成了五十个虚拟苯丙素甙 (PPGs)类化合物 ,并将它们与端粒DNA受体进行分子对接 ,分析已知结构的对接结果 ,通过虚拟筛选的方法得到了一批与受体相互作用能较高并且复合物能量较低的新的有潜力的活性化合物 .该方法可以弥补分子对接研究中 ,只能计算药物与受体的相互作用 ,无法有效设计新化合物的不足 . | 陈海峰 高坤 范波涛 袁身刚 贾忠建 郑荣梁 PANAYE A DOUCET J.P | 2002 | 化学学报2002，60，10： | 2 |
| 8 | On sequential Monte Carlo sampling methods for Bayesian filtering显示文摘 | Arnaud Doucet Simon Godsill Christophe Andrieu | 2000 | Statistics and Computing2000，，3： | 2 |
| 9 | Grading system modification and management of blunt aortic injury显示文摘 | Kaavya N Reddy Tim Matatov Linda D Doucet Maureen Heldmann Cynthia X Zhao Wayne W Zhang | 2013 | Chinese Medical Journal2013，，3： | 2 |
| 10 | An Introduction to MCMC for Machine Learning显示文摘 | Christophe Andrieu Nando de Freitas Arnaud Doucet Michael I. Jordan | 2003 | Machine Learning (-)2003，，1： | 2 |
| 11 | Sequential Monte Carlo Methods for Multi-target Filtering with Random Finite Sets显示文摘 | Vo B Singh S Doucet A | 2005 | IEEE Trans on Aerospace and Electronic Systems2005，41，4： | 1 |
| 12 | On sequential Monte Carlo methods for Bayesiam filtering显示文摘 | DOUCET A GODSIL SL ANDRIEU C | 2000 | Statistics and Computing2000，10，： | 1 |
| 13 | Sequential monte carlo methods for multi-target filtering with random finite sets显示文摘 | Ba-ngu vo Singh S and Doucet A | 2005 | IEEE Transactions on Aerospace and Electronic Systems2005，41，4： | 1 |
| 14 | A note on auxiliary panicle filters 显示文摘 | JOHANSEN A M DOUCET A | 2008 | Statistics and Probability Letters2008，78，12： | 1 |
| 15 | Pesticide residues in the Canadian market basket survey- 1992 to 1996显示文摘 | Newsome WH Doucet J Davies D | 2000 | Food Addit Cantam2000，17，10： | 1 |
| 16 | On sequential Monte Carlo sampling methods for Bayesian filtering 显示文摘 | DOUCET A GODSILL S ANDRIEU C | 2000 | Statist Computer2000，，10： | 1 |
| 17 | Bayesian Blind and Semi-Blind Equalization of Channels with Markov Inputs显示文摘 | DOUCET A ANDRIEU C URIEN R | 2001 | IEE Proceedings - Vi- sion Image and Signal Processing2001，148，4： | 1 |
| 18 | Hypoglycaemia and dementia in diabetic patients显示文摘 | Bauduceau B Doucet J Bordier L | 2010 | Diabetes Metab2010，36，13： | 1 |
| 19 | The influence of storage conditions on flavour changes in human milk显示文摘 | SPITZER J DOUCET S BUETTNER A | | 0，，： | 1 |
| 20 | Performance of D-bolts under dynamic loading 显示文摘 | Charlic C Li Chantale Doucet | 2012 | Rock Mechanics and Rock Engineering2012，45，2： | 1 |
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