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| 1 | Transcriptional Regulation of the Ambient Temperature Response by H2A.Z Nucleosomes and HSF1 Transcription Factors in Arabidopsis显示文摘 | Sandra Cortijo Varodom Charoensawan Anna Brestovitsky Ruth Buning Charles Ravarani Daniela Rhodes John van Noort Katja E. Jaeger Philip A. Wigge | 2017 | Molecular Plant2017，10，10： | 15 |
| 2 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 3 | 自动化显微镜检测和数字化胸片诊断系统在肺结核筛查中的应用显示文摘中国有世界上第二大的结核病疫情(仅次于印度),具有较高的结核病感染、发病、耐药以及病死率。因此,快速、准确的诊断,以及时采取治疗,是控制这种疾病的关键问题。涂片荧光显微镜与金胺-O染色是在病理实验室检测肺结核抗酸杆菌(acid fast bacilli,AFB)最常用的诊断方法。但是以眼睛观察显微镜来筛查检测抗酸杆菌是一项烦琐、劳动密集型任务。低质量、不一致的痰涂片染色技术,标本碎屑,人眼视觉的变异和疲劳等因素会导致灵敏度低至40%。使用基于人工智能(artificial intelligence,AI)计算机辅助诊断(computer aided diagnostic,CAD)技术的自动显微镜系统对结核病进行自动诊断,提供了一个有效解决当前痰涂片诊断结核病所存在的缺陷。胸部X射线片也是世界卫生组织认定的非常有效的快速分流和转诊检测方法。但是,在不发达地区,因放射医生缺乏,它无法为大量的感染人群提供服务。为解决这一需要,将先进的数字化医学影像精准诊断应用于肺结核(pulmonary tuberculosis,PTB)检测,基于人工智能的CAD自动化智能系统,为肺结核的数字化医学影像精准诊断开辟了一条新路。 | Fleming Y.M.Lure Stefan Jaeger Sameer Antani Shenwen Quan | 2017 | 新发传染病电子杂志2017，2，1： | 11 |
| 4 | 汽车风挡玻璃用密封胶的结构与性能研究显示文摘研究了三种汽车风挡玻璃用单组分PU(聚氨酯)密封胶和SPU(硅烷改性聚氨酯)密封胶。采用红外光谱(FT-IR)、凝胶渗透色谱(GPC)法分析了三种密封胶的结构和相对分子质量,并对其固化行为、粘接性能和力学性能等进行了研究。结果表明:相对湿度越大(或固化温度越高),则三种密封胶的表干时间越短且固化速率越大;在三种密封胶的储存过程中,其表干时间和固化速率变化不大,稳定性较好;SPU密封胶与基材的粘接性能优于PU密封胶;PU密封胶的拉伸强度(≥8.2 MPa)和撕裂强度(19 N/mm)均优于SPU密封胶的拉伸强度(5.8 MPa)和撕裂强度(13 N/mm)。 | 曹春莉 张军营 王瑞 程珏 QU JUN JAEGER URS | 2010 | 中国胶粘剂2010，19，6： | 10 |
| 5 | 独立于RANKL/RANK系统的调控根吸收机制:TNFα的可溶性受体抑制根吸收显示文摘目的 :深入探知TNFα ,IL - 1在根吸收过程中的作用及两种骨吸收调控机制 ,即RANKL/RANK调控系统 ,炎症因子IL - 1,TNFα调控系统相互间的关系。方法 :18只雄Wistar大鼠 ,4周龄 ,随机分为 3组 ,正常对照组 ,IL - 1组 ,TNFα组 ,每组 6只。根据Nakane方法建立大鼠根吸收模型。研究 3组大鼠标本中RANKL ,RANK ,mRNA各自表达程度的差别及相应的ED1(单核巨噬细胞标记物 )阳性细胞在根吸收组织中的分布情况。结果 :T检验证实 :正常组与TNFα组间有显著性差别 ,P <0 .0 1;正常组与IL - 1组无显著性差别。在下列细胞内可以检测到RANKLmRNA的阳性信号 :成骨细胞 ,骨内膜细胞 ,基质细胞 ,近根吸收陷窝处的纺锤状成纤维细胞。3组间的信号表达水平比较无显著差别。结论 :本研究采用ED1作为免疫组化标记物 。 | 张栋梁 欧阳喈 汪玲丽 Werner Goetz Andreas Jaeger | 2004 | 口腔医学研究2004，20，1： | 8 |
| 6 | 用混合弹性模型解决图象变形匹配问题显示文摘由于用传统的刚体匹配方法难以解决待匹配图象之间的结构差异 ,因此需要引入变形模型来进行图象的非刚体匹配 .为此提出了一种利用混合弹性模型 (HEM)来解决图象变形匹配问题的新方法 .该方法不需要预先提取图象的特征 ,而是直接利用匹配图象之间的灰度信息来实现图象之间的匹配 .匹配时 ,首先通过基于主轴的方法来实现两幅图象之间的全局仿射匹配 ;然后利用线性弹簧网模型来求取两幅图象之间的相关性 ,并进一步利用薄板样条模型来实现两幅图象的变形匹配 .该方法在匹配过程中还采取了多分辨率匹配策略 ,合成图象和医学脑图象的实验结果表明 。 | 蔡志锋 卢汉清 Marc Jaeger | 2003 | 中国图象图形学报(A辑)2003，8，7： | 7 |
| 7 | STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer显示文摘 | Dimitrios Iliopoulos Savina A. Jaeger Heather A. Hirsch Martha L. Bulyk Kevin Struhl | 2010 | Molecular Cell2010，，4： | 5 |
| 8 | Parameters affecting different acoustic radiation force impulse applications in the diagnosis of fibrotic liver changes显示文摘AIM: To analyze the virtual touch tissue quantification(VTTQ) and virtual touch imaging quantification(VTIQ) techniques, and identify possible factors that may influence VTTQ and VTIQ measurements.METHODS: One hundred and eighty-six(104 women/82 men) of 323 subjects met the inclusion criteria(age > 18 years, no history of chronic or gastrointestinal disease, body-mass index(BMI) < 30 kg/m2, a fasting period of at least three hours, no history of hepatotoxic pharmaceuticals, alcohol consumption < 24 g/d in men and < 12 g/d in women, and normal findings upon ultrasound examination of the abdomen). Measurements were taken at depths of 50 mm with VTTQ, 15 mm and 25 mm with VTIQ in the right hepatic lobe, and at 15 mm with only VTIQ in the left hepatic lobe. The examiner acquired six measurements per position, thereby giving 24 measurements in total.RESULTS: The 95% confidence intervals of mean were1.23-1.29 m/s for VTTQ and 1.29-1.37 m/s, 1.17-1.23 m/s, and 1.48-1.57 m/s for VTIQ in a depth of 15 mm and 25 mm in the right hepatic lobe and 15 mm in the left hepatic lobe. Only superficial measurements in the right hepatic lobe with the VTIQ method exhibited an effect of age on shear wave velocity. Measurements acquired using the 6C1 probe with the VTTQ method showed no dependence on BMI. By comparison, BMI influenced measurements taken with the VTIQ method using the 9L4 probe in the superficial and deep areas of the right hepatic lobe, as well as in the left hepatic lobe(P = 0.0160, P = 0.0019, P = 0.0173, respectively). Gender influenced measurements at depths of 50 mm with VTTQ and 25 mm with VTIQ in the right hepatic lobe(P = 0.0001, P = 0.0269). Significant differences were found between measurements with the 6C1(VTTQ) and 9L4 probes(VTIQ)(P = 0.0067), between superficial and deep measurements(P < 0.0001), and between the right and left lobes of the liver(P < 0.0001). CONCLUSION: Measurements in the right lobe and deep regions are preferable. Gender differences must be considered. BMI must be considered when assessing VTIQ technology. | Sabrina Galgenmueller Heike Jaeger Wolfgang Kratzer Stefan A Schmidt Suemeyra Oeztuerk Mark M Haenle Richard A Mason Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，27： | 5 |
| 9 | Towards Quantitatively Understanding the Complexity of Social-Ecological Systems——From Connection to Consilience显示文摘The complexity of social-ecological systems(SES) is rooted in the outcomes of node activities connected by network topology. Thus far, in network dynamics research, the connectivity degree(CND), indicating how many nodes are connected to a given node, has been the dominant concept. However, connectivity focuses only on network topology, neglecting the crucial relation to node activities, and thereby leaving system outcomes largely unexplained. Inspired by the phenomenon of ‘‘consensus of wills and coordination of activities' ' often observed in disaster risk management, we propose a new concept of network characteristic, the consilience degree(CSD),aiming to measure the way in which network topology and node activities together contribute to system outcomes. The CSD captures the fact that nodes may assume different states that make their activities more or less compatible.Connecting two nodes with in/compatible states will lead to outcomes that are un/desirable from the perspective of the SES in question. We mathematically prove that the CSD is a generalized CND, and the CND is a special case of CSD. As a general, fundamental concept, the CSD can facilitate the development of a new framework of network properties, models, and theories that allows us to understand patterns of network behavior that cannot be explained in terms of connectivity alone. We further demonstrate that a co-evolutionary mechanism can naturally improve the CSD. Given the generality of co-evolution in SES, we argue that the CSD is an inherent attribute rather than an artificial concept, which underpins the fundamental importance of the CSD to the study of SES. | Xiao-Bing Hu Peijun Shi Ming Wang Tao Ye Mark S.Leeson Sander E.van der Leeuw Jianguo Wu Ortwin Renn Carlo Jaeger | 2017 | International Journal of Disaster Risk Science2017，8，4： | 4 |
| 10 | Disaster Risk Science:A Geographical Perspective and a Research Framework显示文摘In this article,we recall the United Nations’30-year journey in disaster risk reduction strategy and framework,review the latest progress and key scientific and technological questions related to the United Nations disaster risk reduction initiatives,and summarize the framework and contents of disaster risk science research.The object of disaster risk science research is the'disaster system'consisting of hazard,the geographical environment,and exposed units,with features of regionality,interconnectedness,coupling,and complexity.Environmental stability,hazard threat,and socioeconomic vulnerability together determine the way that disasters are formed,establish the spatial extent of disaster impact,and generate the scale of losses.In the formation of a disaster,a conducive environment is the prerequisite,a hazard is the necessary condition,and socioeconomic exposure is the sufficient condition.The geographical environment affects local hazard intensity and therefore can change the pattern of loss distribution.Regional multi-hazard,disaster chain,and disaster compound could induce complex impacts,amplifying or attenuating hazard intensity and changing the scope of affected areas.In the light of research progress,particularly in the context of China,we propose a threelayer disaster risk science disciplinary structure,which contains three pillars(disaster science,disaster technology,and disaster governance),nine core areas,and 27 research fields.Based on these elements,we discuss the frontiers in disaster risk science research. | Peijun Shi Tao Ye Ying Wang Tao Zhou Wei Xu Juan Du Jing'ai Wang Ning Li Chongfu Huang Lianyou Liu Bo Chen Yun Su Weihua Fang Ming Wang Xiaobin Hu Jidong Wu Chunyang He Qiang Zhang Qian Ye Carlo Jaeger Norio Okada | 2020 | International Journal of Disaster Risk Science2020，11，4： | 4 |
| 11 | Investigating soil moisture–climate interactions in a changing climate: A review显示文摘 | Sonia I. Seneviratne Thierry Corti Edouard L. Davin Martin Hirschi Eric B. Jaeger Irene Lehner Boris Orlowsky Adriaan J. Teuling | 2010 | Earth Science Reviews2010，，3： | 3 |
| 12 | Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis显示文摘BackgroundTranscatheter 大动脉的阀门培植(TAVI ) 与严重征兆的大动脉的狭窄为病人成为了标准治疗(作为) 为外科的大动脉的阀门代替在很高的风险考虑了。这亚学习的目的是评估长期的(> 4 年) 在 octogenarians 的生活(QoL ) 的健康相关的质量经历了 TAVI.MethodsA 单个中心在在 TAVI 以后经历了框架分析评价 4 年的二十个病人的观察登记。健康相关的 QoL 被评估,用短 Form-36 ( SF-36 ),吗 EuroQoL-5D ( EQ-5D )和 questionnaires.ResultsThe 平均数 SF-36 subscale 在后续获得的视觉类似物分数(EQ管)是物理的工作 40.8 ????????????????????????????搠?潮潶???吗?湡楧灯慬瑳?????????愠杮潩牧灡票?€ 敦潭潲潰汰瑩慥???????????????愠桴牥'啼蠹溃浚? | Marjo JAG De Ronde-Tillmans Tom AJ de Jager Jeannette A Goudzwaard Nahid El Faquir Nicolas M van Mieghem Felix Zijlstra Elisabeth MWJ. Utens Francesco US Mattace-Raso MaRie J Lenzen Peter PT de Jaegere | 2018 | Journal of Geriatric Cardiology2018，15，4： | 3 |
| 13 | 固始鸡无抗养殖技术研究显示文摘根据消费市场对优质安全肉品日益增长的发展需求,进行了固始鸡无抗养殖技术研究,设计配套出无抗养殖综合技术,涉及场选址与布局、鸡品种选择、饲料配方、免疫程序、饲养管理制度等方面.固始鸡雏鸡从1日龄进入养殖场,严格执行免疫程序,饲喂自行配制的符合不同阶段生长需要的饲料,通过循序渐进的方式从室内至室外,适应放养的环境.养殖场内鸡全部出栏后,对养殖场实施休耕180 d,给予环境充分的生态恢复期,以保证养殖场环境的生态平衡.整个饲养过程实现了无抗生素养殖,并未发生重大疫情.该技术模式养殖的肉鸡肉质鲜美,氨基酸及风味物等与有抗养殖比较更佳,不存在由于抗生素残留可能导致的对消费者健康的不利影响,更符合区域消费市场需求. | 吉莉莉 王卫 Friedhelm Jaeger 陈林 张佳敏 邹强 唐仁勇 | 2017 | 成都大学学报(自然科学版)2017，36，2： | 3 |
| 14 | Simulation and Visualisation of Functional Landscapes:Effects of the Water Resource Competition Between Plants显示文摘Vegetation ecosystem simulation and visualisation are challenging topics involving multidisciplinary aspects. In this paper,we present a new generic frame for the simulation of natural phenomena through manageable and interacting models.It focuses on the functional growth of large vegetal ecosystems,showing coherence for scales ranging from the individual plant to communities and with a particular attention to the effects of water resource competition between plants.The proposed approach is based on a model of plant growth in interaction with the environmental conditions. These are deduced from the climatic data (light,temperature,rainfall) and a model of soil hydrological budget.A set of layers is used to store the water resources and to build the interfaces between the environmental data and landscape components:temperature,rain,light,altitude,lakes,plant positions,biomass,cycles,etc.At the plant level,the simulation is performed for each individual by a structural-functional growth model,interacting with the plant's environment.Temperature is spatialised,changing according to altitude,and thus locally controls plant growth speed.The competition for water is based on a soil hydrological model taking into account rainfalls,water runoff, absorption,diffusion,percolation in soil.So far,the incoming light radiation is not studied in detail and is supposed constant.However,competition for light between plants is directly taken into account in the plant growth model.In our implementation,we propose a simple architecture for such a simulator and a simulation scheme to synchronise the water resource updating (on a temporal basis) and the plant growth cycles (determined by the sum of daily temperatures). The visualisation techniques are based on sets of layers,allowing both morphological and functional landscape views and providing interesting tools for ecosystem management.The implementation of the proposed frame leads to encouraging results that are presented and illustrate simple academic cases. | Vincent Le Chevalier Marc Jaeger 梅兴 Paul-Henry Cournède | 2007 | Journal of Computer Science & Technology2007，22，6： | 2 |
| 15 | Regional differences in lung radiosensitivity after radiotherapy for non–small-cell lung cancer显示文摘 | Yvette Seppenwoolde Katrien De Jaeger Liesbeth J. Boersma José S.A. Belderbos Joos V. Lebesque | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 2 |
| 16 | Choice for China:What Role for Vocational Education in Green Growth?显示文摘Green growth cannot succeed without significant changes in the education system and the closely related social division of labor.This paper combines historical evidence and a game-theoretic analysis to study the relation between vocational education and green growth.It is found that a low-vocation and a high-vocation equilibrium can be distinguished in the interplay between education and labor markets,and that a high-vocation equilibrium is better suited for green growth.At the present stage of development,there are tendencies in both directions in China.Therefore,China has the possibility to successfully implement a green growth strategy by developing a strong vocational education with Chinese characteristics. | Carlo Jaeger | 2014 | China & World Economy2014，22，5： | 2 |
| 17 | Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma显示文摘 | Bonertz Andreas Weitz Jürgen Pietsch Dong-Ho Kim Rahbari Nuh N Schlude Christoph Ge Yingzi Juenger Simone Vlodavsky Israel Khazaie Khashayarsha Jaeger Dirk Reissfelder Christoph Antolovic Dalibor Aigner Maximilian Koch Moritz Beckhove Phili | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
| 18 | Level of detail technique for plant models显示文摘Realistic modelling and interactive rendering of forestry and landscape is a challenge in computer graphics and virtual reality.Recent new developments in plant growth modelling and simulation lead to plant models faithful to botanical structure and development,not only representing the complex architecture of a real plant but also its functioning in interaction with its environment.Complex geometry and material of a large group of plants is a big burden even for high performances computers,and they often overwhelm the numerical calculation power and graphic rendering power.Thus,in order to accelerate the rendering speed of a group of plants,software techniques are often developed.In this paper,we focus on plant organs,i.e.leaves,flowers,fruits and inter-nodes.Our approach is a simplification process of all sparse organs at the same time,i.e.,Level of Detail(LOD),and multi-resolution models for plants.We do explain here the principle and construction of plant simplification.They are used to construct LOD and multi-resolution models of sparse organs and branches of big trees.These approaches take benefit from basic knowledge of plant architecture,clustering tree organs according to biological structures.We illustrate the potential of our approach on several big virtual plants for geometrical compression or LOD model definition.Finally we prove the efficiency of the proposed LOD models for realistic rendering with a virtual scene composed by 184 mature trees. | Xiaopeng ZHANG Qingqiong DENG~ Marc JAEGER | 2006 | 中国体视学与图像分析2006，11，4： | 2 |
| 19 | Lessons from the Mainland of China’s Epidemic Experience in the First Phase about the Growth Rules of Infected and Recovered Cases of COVID-19 Worldwide显示文摘The first phase of the novel coronavirus disease(COVID-19)that emerged at the end of 2019 has been brought under control in the mainland of China in March,while it is still spreading globally.When the pandemic will end is a question of great concern.A logistic model that depicts the growth rules of infected and recovered cases in China’s mainland may shed some light on this question.This model well explained the data by 13 April from 31 countries that have been experiencing serious COVID-2019 outbreaks(R2≥0.95).Based on this model,the semi-saturation period(SSP)of infected cases in those countries ranges from 3 March to 18 June.According to the linear relationship between the growth rules for infected and for recovered cases identified from the Chinese data,we predicted that the SSP of the recovered cases outside China ranges from 22 March to 8 July.More importantly,we found a strong positive correlation between the SSP of infected cases and the timing of a government’s response.Finally,this model was also applied to four regions that went through other coronavirus or Ebola virus epidemics(R2≥0.95).There is a negative correlation between the death rate and the logistic growth rate.These findings provide strong evidence for the effectiveness of rapid epidemic control measures in various countries. | Chuanliang Han Yimeng Liu Jiting Tang Yuyao Zhu Carlo Jaeger Saini Yang | 2020 | International Journal of Disaster Risk Science2020，11，4： | 2 |
| 20 | Rapid generation of recombinant Pseudomonas putida secondary metabolite producers using yTREX显示文摘Microbial secondary metabolites represent a rich source of valuable compounds with a variety of applications in medicine or agriculture.Effective exploitation of this wealth of chemicals requires the functional expression of the respective biosynthetic genes in amenable heterologous hosts.We have previously established the TREX system which facilitates the transfer,integration and expression of biosynthetic gene clusters in various bacterial hosts.Here,we describe the yTREX system,a new tool adapted for one-step yeast recombinational cloning of gene clusters.We show that with yTREX,Pseudomonas putida secondary metabolite production strains can rapidly be constructed by random targeting of chromosomal promoters by Tn5 transposition.Feasibility of this approach was corroborated by prodigiosin production after yTREX cloning,transfer and expression of the respective biosynthesis genes from Serratia marcescens.Furthermore,the applicability of the system for effective pathway rerouting by gene cluster adaptation was demonstrated using the violacein biosynthesis gene cluster from Chromobacterium violaceum,producing pathway metabolites violacein,deoxyviolacein,prodeoxyviolacein,and deoxychromoviridans.Clones producing both prodigiosin and violaceins could be readily identified among clones obtained after random chromosomal integration by their strong color-phenotype.Finally,the addition of a promoter-less reporter gene enabled facile detection also of phenazine-producing clones after transfer of the respective phenazine-1-carboxylic acid biosynthesis genes from Pseudomonas aeruginosa.All compounds accumulated to substantial titers in the mg range.We thus corroborate here the suitability of P.putida for the biosynthesis of diverse natural products,and demonstrate that the yTREX system effectively enables the rapid generation of secondary metabolite producing bacteria by activation of heterologous gene clusters,applicable for natural compound discovery and combinatorial biosynthesis. | Andreas Domrose Robin Weihmann Stephan Thies Karl-Erich Jaeger Thomas Drepper Anita Loeschcke | 2017 | Synthetic and Systems Biotechnology2017，2，4： | 2 |
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