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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection显示文摘AIM:To study the association between Helicobacter pylori(H.pylori)infection and autoimmune type atrophic gastritis. METHODS:Twenty-three patients with different grades of atrophic gastritis were analysed using enzyme immunoassay-based serology,immunoblot-based serology,and histology to reveal a past or a present H.pylori infection.In addition,serum markers for gastric atrophy(pepsinogenⅠ,pepsinogenⅠ/Ⅱand gastrin)and autoimmunity[parietal cell antibodies(PCA), and intrinsic factor(IF),antibodies]were determined. RESULTS:Of the 14 patients with severe gastricatrophy,as demonstrated by histology and serum markers,and no evidence for an ongoing H.pylori infection,eight showed H.pylori antibodies by immunoblotting.All eight had elevated PCA and 4/8 also had IF antibodies.Of the six immunoblot-negative patients with severe corpus atrophy,PCA and IF antibodies were detected in four.Among the patients with low to moderate grade atrophic gastritis(all except one with an ongoing H.pylori infection),serum markers for gastric atrophy and autoimmunity were seldom detected.However,one H.pylori negative patient with mild atrophic gastritis had PCA and IF antibodies suggestive of a pre-atrophic autoimmune gastritis. CONCLUSION:Signs of H.pylori infection in autoimmune gastritis,and positive autoimmune serum markers in H.pylori gastritis suggest an etiological role for H.pylori in autoimmune gastritis. | Lea Irene Veijola Aino Mirjam Oksanen Pentti Ilmari Sipponen Hilpi Iris Kaarina Rautelin | 2010 | World Journal of Gastroenterology2010，16，1： | 10 |
| 3 | Immunogenetic characteristics of patients with autoimmune gastritis显示文摘AIM:To explore whether predisposition to autoimmune gastritis (AIG) is found in human leukocyte antigen (HLA), cytokine or killer cell immunoglobulin-like receptor (KIR) gene variations.METHODS: Twelve Finnish patients with autoimmunetype severe atrophy of the gastric corpus were included. The patients' serum was analyzed for pepsinogen-interleukin (IL)-1 gene cluster, IL-2, IL-4, IL-6, IL-10, IL-12, interferon γ, transforming growth factor β, and tumor necrosis factor α. Variation in KIR genes was also explored. The results were compared with prevalence of the polymorphisms in Finnish or European populations.RESULTS: All patients had pepsinogen-CONCLUSION: As explored with modern DNA-based methods, HLA-DRB1*04 and DQB1*03 alleles, but not HLA-B8-DRB1*03, may predispose to AIG. | Aino Mirjam Oksanen Katri Eerika Haimila Hilpi Iris Kaarina Rautelin Jukka Antero Partanen | 2010 | World Journal of Gastroenterology2010，16，3： | 8 |
| 4 | 提供免费眼镜对中国学龄儿童学习成绩的影响:整群随机对照试验显示文摘目的探讨免费眼镜对中国农村近视儿童学习成绩的影响。设计仅对研究者进行设盲的整群随机对照研究。地点2012-2013年,中国西部的两个市的252所学校。研究对象在19934名小学四、五年级儿童中的、任一眼裸眼视力〈6/12且戴镜视力可提高至〉6/12的3177名(平均龄10.5岁)儿童,其中的3052名(96.0%)儿童完成了整个研究。干预措施纳入研究的儿童在学年开始时,以学校为单位(平均每组84所学校)随机分为3组,分别接受以下干预:仅获得配镜处方(此组为本研究的对照组),获得项目指定眼镜店换取眼镜的凭证,或现场获取免费眼镜。主要结果指标末次检查(研究结束)时的戴镜率和研究结束时用专门设计的数学测试考核的成绩(用研究开始的成绩进行调整,以标准差的改变来度量)。结果3177名纳入的儿童被随机分配到对照组(1036名,占32.6%)、凭证组(988名,占31.1%)和免费眼镜组(1153名,占36.3%)。虽然所有儿童戴镜后视力均有提高,但在研究开始时,仅15%的儿童配戴了眼镜。研究结束时免费眼镜组观察到的戴镜率为41%,儿童自诉的戴镜率为68%;对照组观察到的戴镜率为26%,儿童自诉的戴镜率为37%。相对于对照组,免费眼镜组对学习成绩影响为0.11标准差(SD)[95%可信区间(CI)0.01—0.21,P=0.03]。调整后的免费眼镜的效应(0.10SD,95%CI0.002~0.19;P=0.04)也远远大于父母的受教育程度(0.03,95%CI-0.04~0.09)及家庭的富裕程度(0.01,95%CI-0.06~0.08)。虽然组间有统计学差异,但差异的幅度还是比用于样本量计算的幅度,即0.20SD小。结论尽管儿童的依从性并不是非常好,向儿童提供免费眼镜对于提高儿童的数学成绩有统计学意义,但各组间差异小于预期。本研究中,儿童的近视患病率较高但戴镜率却很低。 | 马晓晨 周钟强 易红梅 庞晓鹏 史耀疆 陈倩韵 Mirjam E. Meltzer Saskia le Cessie 何明光 Scott Rozelle 刘奕志 Nathan Congdon | 2014 | 英国医学杂志中文版2014，17，6： | 7 |
| 5 | Development of an internally braced prosthesis for total talus replacement显示文摘Total loss of talus due to trauma or avascular necrosis,for example,still remains to be a major challenge in foot and ankle surgery with severely limited treatment options.Implantation of a custom made total talar prosthesis has shown promising results so far.Most important factors for long time success are degree of congruence of articular surfaces and ligamentous stability of the ankle.Therefore,our aim was to develop an optimized custom made prosthesis for total talus replacement providing a high level of primary stability.A custom made hemiprosthesis was developed using computed tomography and magnetic resonance imaging data of the affected and contralateral talus considering the principles and technology for the development of the S.T.A.R.prosthesis(Stryker).Additionally,four eyelets for fixation of artificial ligaments were added at the correspondent footprints of the most important ligaments.Two modifications can be provided according to the clinical requirements:A tri-articular hemiprosthesis or a bi-articular hemiprosthesis combined with the tibial component of the S.T.A.R.total ankle replacement system.A feasibility study was performed using a fresh frozen human cadaver.Maximum range of motion of the ankle was measured and ligamentous stability was evaluated by use of standard X-rays after application of varus,valgus or sagittal stress with 150 N.Correct implantation of the prosthesis was technically possible via an anterior approach to the ankle and using standard instruments.Malleolar osteotomies were not required.Maximum ankle dorsiflexion and plantarflexion were measured as 22-0-28 degrees.Maximum anterior displacement of the talus was 6 mm,maximum varus tilt 3 degrees and maximum valgus tilt 2 degrees.Application of an internally braced prosthesis for total talus replacement in humans is technically feasible and might be a reasonable procedure in carefully selected cases with no better alternatives left. | Markus Regauer Mirjam Lange Kevin Soldan Steffen Peyerl Sebastian Baumbach Wolfgang Bocker Hans Polzer | 2017 | World Journal of Orthopedics2017，8，3： | 4 |
| 6 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 7 | 新光线下的艺术--谈博物馆与美术馆照明显示文摘博物馆和美术馆的照明是影响观众展览体验的重要因素。在使用LED等节能灯具的同时,合理有效的利用日光是当代博物馆照明的重要趋势,尽管日光的动态变化能给观众连接外部世界的体验并增加舒适度,但博物馆中日光的使用一直是充满挑战的任务,要关注照明节能,要提高观众的体验,同时保护展品免受光损伤。 | Emrah Baki Ulas Mirjam Roos | 2014 | 中国博物馆2014，，4： | 3 |
| 8 | Neutralizing antibodies in hepatitis C virus infection显示文摘Hepatitis C virus (HCV) is a major cause of hepatitis world-wide. The majority of infected individuals develop chronic hepatitis which can then progress to liver cirrhosis and hepatocellular carcinoma. Spontaneous viral clearance occurs in about 20%-30% of acutely infected individuals and results in resolution of infection without sequaelae. Both viral and host factors appear to play an important role for resolution of acute infection. A large body of evidence suggests that a strong, multispecific and long-lasting cellular immune response appears to be important for control of viral infection in acute hepatitis C. Due too the lack of convenient neutralization assays, the impact of neutralizing responses for control of viral infection had been less defined. In recent years, the development of robust tissue culture model systems for HCV entry and infection has finally allowed study of antibody-mediated neutralization and to gain further insights into viral targets of host neutralizing responses. In addition, detailed analysis of antibody-mediated neutralization in individual patients as well as cohorts with well defined viral isolates has enabled the study of neutralizing responses in the course of HCV infection and characterization of the impact of neutralizing antibodiesfor control of viral infection. This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis. | Mirjam B Zeisel Samira Fafi-Kremer Isabel Fofana Heidi Barth Franoise Stoll-Keller Michel Doffo■l Thomas F Baumert | 2007 | World Journal of Gastroenterology2007，13，36： | 3 |
| 9 | Importance of intellectual property generated by biomedical research at universities and academic hospitals显示文摘Biomedical research has many different facets.Researchers and clinicians study disease biology and biochemistry to discover novel therapeutic targets,unravel biochemical pathways and identify biomarkers to improve diagnosis,or devise new approaches to clinically manage diseases more effectively.In all instances,the overall goal of biomedical research is to ensure that results thereof(such as a therapy,a device,or a method which may be broadly referred to as“inventions”)are clinically implemented.Most of the researchers’efforts are centered on the advance of technical and scientific aspects of an invention.The development and implementation of an invention can be arduous and very costly.Historically,it has proven to be crucial to protect intellectual property rights(IPR)to an invention(i.e.,a patent)to ensure that companies can obtain a fair return on their investment that is needed to develop an academic invention into a product for the benefit of patients.However,the importance of IPR is not generally acknowledged among researchers at academic institutions active in biomedical research.Therefore this paper aims to(1)raise IP awareness amongst clinical and translational researchers;(2)provide a concise overview of what the patenting trajectory entails;and(3)highlight the importance of patenting for research and the researcher.Importance for patients:Adequate patent protection of inventions generated through biomedical research at academic institutions increases the probability that patients will benefit from these inventions,and indirectly enables the financing of clinical studies,mainly by opening up funding opportunities(e.g.specific grants aimed at start-ups,pre-seed and seed capital)that otherwise would not be accessible.As a consequence,patented inventions are more likely to become clinically tested and reach the market,providing patients with more treatment options. | Joris J.Heus Elmar S.de Pauw Mirjam Leloux Margherita Morpurgo Michael R Hamblin Michal Heger | 2017 | Journal of Clinical & Translational Research2017，3，2： | 3 |
| 10 | Laparoscopy in Combination with Fast Track Multimodal Management is the Best Perioperative Strategy in Patients Undergoing Colonic Surgery: A Randomized Clinical Trial (LAFA-study)显示文摘 | Malaika S. Vlug Jan Wind Markus W. Hollmann Dirk T. Ubbink Huib A. Cense Alexander F. Engel Michael F. Gerhards Bart A. van Wagensveld Edwin S. van der Zaag Anna A.W. van Geloven Mirjam A.G. Sprangers Miguel A. Cuesta Willem A. Bemelman | 2011 | Annals of Surgery2011，，6： | 3 |
| 11 | Towards the Tipping Point for FAIR Implementation显示文摘This article explores the global implementation of the FAIR Guiding Principles for scientific management and data stewardship,which provide that data should be findable,accessible,interoperable and reusable.The implementation of these principles is designed to lead to the stewardship of data as FAIR digital objects and the establishment of the Internet of FAIR Data and Services(IFDS).If implementation reaches a tipping point,IFDS has the potential to revolutionize how data is managed by making machine and human readable data discoverable for reuse.Accordingly,this article examines the expansion of the implementation of FAIR Guiding Principles,especially how and in which geographies(locations)and areas(topic domains)implementation is taking place.A literature review of academic articles published between 2016 and 2019 on the use of FAIR Guiding Principles is presented.The investigation also includes an analysis of the domains in the IFDS Implementation Networks(INs).Its uptake has been mainly in the Western hemisphere.The investigation found that implementation of FAIR Guiding Principles has taken firm hold in the domain of bio and natural sciences.To achieve a tipping point for FAIR implementation,it is now time to ensure the inclusion of non-European ascendants and of other scientific domains.Apart from equal opportunity and genuine global partnership issues,a permanent European bias poses challenges with regard to the representativeness and validity of data and could limit the potential of IFDS to reach across continental boundaries.The article concludes that,despite efforts to be inclusive,acceptance of the FAIR Guiding Principles and IFDS in different scientific communities is limited and there is a need to act now to prevent dampening of the momentum in the development and implementation of the IFDS.It is further concluded that policy entrepreneurs and the GO FAIR INs may contribute to making the FAIR Guiding Principles more flexible in including different research epistemologies,especially through its GO CHANGE pillar. | Mirjam van Reisen Mia Stokmans Mariam Basajja Antony Otieno Ong’ayo Christine Kirkpatrick Barend Mons | 2020 | Data Intelligence2020，2，1： | 3 |
| 12 | 地理信息系统在四川省麻风防治中的应用显示文摘目的:探索四川省新发麻风病例的空间时间集群分布及GIS技术在麻风防治中的应用。方法:采用回顾性描述性研究方法,应用GIS技术对麻风流行病学数据,包括病例发现率、患病率、新发病例数和新发病例中2级畸残率等进行分析。结果:2002-2008年发现3个统计学意义的短时限新发病例空间时间群集分布,最大可能的集群分布于凉山彝族自治州;部分相对低流行地区新发病例2级畸残率显著高于全省水平。结论:GIS技术作为一种先进应用工具,为麻风流行状况分析、合理资源分配、项目管理评估等提供新的手段。 | 刘杨英 宁湧 Mirjam Bakker 熊俊浩 | 2011 | 中国麻风皮肤病杂志2011，27，4： | 2 |
| 13 | Budesonide Is Effective in Adolescent and Adult Patients With Active Eosinophilic Esophagitis显示文摘 | Alex Straumann Sebastien Conus Lukas Degen Stephanie Felder Mirjam Kummer Hansjürg Engel Christian Bussmann Christoph Beglinger Alain Schoepfer Hans–Uwe Simon | 2010 | Gastroenterology2010，，： | 2 |
| 14 | 水泵水轮机尾水管中涡带的研究显示文摘在部分负荷条件下,水泵水轮机尾水管的非稳定流态(即所谓的尾水管涡带)和它对转轮轴的影响已经通过雷诺应力紊流模型利用非稳态雷诺Navier-Stokes法进行了数值模拟。为了寻求尾水管涡带对转轮轴的瞬变力和扭矩的作用,计算域包含了全部转轮和尾水管。模拟流场的结果与转轮轴上的力、扭矩还有尾水管壁的壁而脉动的实验数据完全一致。尾水管中涡带引起的力、压力脉动的频率和幅值是设计水轮机转轮的重要信息,而这蝼可以通过CFD方法得到珲想的预测。 | Mirjam Sick 金东杰(译) 吴新润(校) | 2006 | 国外大电机2006，，1： | 2 |
| 15 | Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury显示文摘 | Fatih Arslan Ruenn Chai Lai Mirjam B. Smeets Lars Akeroyd Andre Choo Eissa N.E. Aguor Leo Timmers Harold V. van Rijen Pieter A. Doevendans Gerard Pasterkamp Sai Kiang Lim Dominique P. de Kleijn | 2013 | Stem Cell Research2013，，3： | 2 |
| 16 | FAIR Practices in Africa显示文摘This article investigates expansion of the Internet of FAIR Data and Services(IFDS)to Africa,through the three GO FAIR pillars:GO CHANGE,GO BUILD and GO TRAIN.Introduction of the IFDS in Africa has a focus on digital health.Two examples of introducing FAIR are compared:a regional initiative for digital health by governments in the East Africa Community(EAC)and an initiative by a local health provider(Solidarmed)in collaboration with Great Zimbabwe University in Zimbabwe.The obstacles to introducing FAIR are identified as underrepresentation of data from Africa in IFDS at this moment,the lack of explicit recognition of situational context of research in FAIR at present and the lack of acceptability of FAIR as a foreign and European invention which affects acceptance.It is envisaged that FAIR has an important contribution to solve fragmentation in digital health in Africa,and that any obstacles concerning African participation,context relevance and acceptance of IFDS need to be removed.This will require involvement of African researchers and ICT-developers so that it is driven by local ownership.Assessment of ecological validity in FAIR principles would ensure that the context specificity of research is reflected in the FAIR principles.This will help enhance the acceptance of the FAIR Guidelines in Africa and will help strengthen digital health research and services. | Mirjam van Reisen Mia Stokmans Munyaradzi Mawere Mariam Basajja Antony Otieno Ong’ayo Primrose Nakazibwe Christine Kirkpatrick Kudakwashe Chindoza | 2020 | Data Intelligence2020，2，1： | 2 |
| 17 | Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial显示文摘 | Mirjam Christ-Crain Daiana Jaccard-Stolz Roland Bingisser Mikael M Gencay Peter R Huber Michael Tamm Beat Müller | 2004 | 2004 (9409)2004，，9409： | 2 |
| 18 | 鲁内哈马隧道大型火灾试验综述显示文摘对于重型货运车辆在隧道中起火和蔓延的了解非常有限,需要详细了解隧道衬砌受到的高热。本文论述了2003年9月在挪威鲁内哈马隧道进行的大型火灾试验。 | Mirjam Nelisse J. Brekelmans A. Lemaire Dr. H. Ingason A. Lonnermark | 2005 | 隧道(中文版)2005，，1： | 2 |
| 19 | Characterization of Hepatitis C Virus Particle Subpopulations Reveals Multiple Usage of the Scavenger Receptor BI for Entry Steps显示文摘 | Viet Loan Dao Thi Christelle Granier Mirjam B. Zeisel Maryse Guérin Jimmy Mancip Ophélia Granio Fran?ois Penin Dimitri Lavillette Ralf Bartenschlager Thomas F. Baumert Fran?ois-Lo?c Cosset Marlène Dreux | 2012 | Journal of Biological Chemistry2012，，37： | 2 |
| 20 | 气候变化对挪威托夫达尔河流域至邻近海域氮通量的影响显示文摘假定4种气候变化情景,利用质量运输模型(TEOTIL)可预测挪威最南部的托夫达尔河流域的硝酸盐(NO_3)通量。目前,森林、高地和开阔水体占NO_3通量的90%。2071~2100年的气候情景显示,温度将增加2~4℃,降水会增加3%~11%。利用气候实验和长期监测来估算未来的氮(N)淋溶率。冬季将有更多的水流经陆地流域,而春季则较少。预计从托夫达尔河到邻近的托普达尔峡湾,年NO_3通量保持不变,但是,冬季运送的NO_3要多,春季要少。可以预计,沿海水域藻类大量繁殖会发生在当年的更早时候。主要的不确定来源是储存在土壤有机物中的氮的长期命运及森林管理的影响。 | Richard F.Wright Φyvind Kaste Heleen A.de Wit Torulv Tjomsland Mirjam Bloemerts Jarle Molvr John Rune Selvik 高战朝 | 2008 | AMBIO-人类环境杂志2008，37，1： | 2 |
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