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| 1 | 苦参素、膦甲酸钠和阿德福韦酯联合治疗乙型肝炎的体外研究显示文摘目的研究苦参素(OMTR)、膦甲酸钠(PFA)和阿德福韦酯(ADV)体外联合用药抑制HBV DNA的作用。方法采用Dot Blot分析法,将不同浓度的OMTR、ADV、PFA以及三种药物间任意矩阵组合,分别作用于2215细胞,一周后,采用同位素杂交测定HBV DNA的表达量,凝胶扫描分析软件对其进行半定量分析,比较联合用药与单独用药的抗病毒效果。结果结果表明,与单种药物作用相比,不同浓度OMTR、PFA和ADV合理联合作用,显著抑制了HBV DNA复制,对HBV DNA的抑制效果显示较强的相加作用。结论本实验通过比较三种药物联合与单独用药体外抗病毒效果研究,证实了不同作用机制的药物联合作用,相比单种药物,可以显著增强抗病毒效果,为临床联合用药治疗乙型肝炎提供了重要的理论基础。 | 王宇萍 韩燕星 蒋建东 | 2016 | 中华临床医师杂志(电子版)2016，10，15： | 4 |
| 2 | New horizon for radical cure of chronic hepatitis B virus infection显示文摘About 250 to 350 million people worldwide are chronically infected with hepatitis B virus(HBV), and about 700000 patients per year die of HBV-related cirrhosis or hepatocellular carcinoma(HCC). Several anti-viral agents, such as interferon and nucleos(t)ide analogues(NAs), have been used to treat this disease. NAs especially have been shown to strongly suppress HBV replication, slowing the progression to cirrhosis and the development of HCC. However, reactivation of HBV replication often occurs after cessation of treatment, because NAs alone cannot completely remove covalentlyclosed circular DNA(ccc DNA), the template of HBV replication, from the nuclei of hepatocytes. Anti-HBV immune responses, in conjunction with interferon-γ and tumor necrosis factor-α, were found to eliminate ccc DNA, but complete eradication of ccc DNA by immune response alone is difficult, as shown in patients who recover from acute HBV infection but often show long-term persistence of small amounts of HBV-DNA in the blood. Several new drugs interfering with the life cycle of HBV in hepatocytes have been developed, with drugs targeting ccc DNA theoretically the most effective for radical cure of chronic HBV infection. However, the safety of these drugs should be extensively examined before application to patients, and combinations of several approaches may be necessary for radical cure of chronic HBV infection. | Kazuto Tajiri Yukihiro Shimizu | 2016 | World Journal of Hepatology2016，8，21： | 1 |
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