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| 1 | New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p H metry in extraesophageal gastroesophageal reflux disease显示文摘AIM:To determine the laryngeal H+K+-ATPase and pharyngeal p H in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI therapy.METHODS:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human H+K+-ATPase.Quantitative real-time RT-PCR for each of the H+K+-ATPase subunits was performed.The p H values were assessed in the aerosolized environment of the oropharynx(Dxp H Catheter) and compared to a subsequently applied combined p H/MII measurement.RESULTS:Twenty patients with LPR symptoms were included.In only one patient,the laryngeal H+K+-ATPase was verified by immunohistochemical staining.In another patient,real-time RT-PCR for each H+K+-ATPase subunit was positive.Fourteen out of twenty patients had pathological results in Dxp H,and 6/20 patients had pathological results in p H/MII.Four patients had pathological results in both functional tests.Nine out of twenty patients responded to PPIs.CONCLUSION:The laryngeal H+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR symptoms.Alternative hypotheses for the pathomechanism are needed.The role of pharyngeal p H-metry remains unclearand its use can only be recommended for patients in a research study setting. | Valentin Becker Romina Drabner Simone Graf Christoph Schlag Simon Nennstiel Anna Maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj | 2015 | World Journal of Gastroenterology2015，21，3： | 14 |
| 2 | IK versus 2K monitor:a clinical alternative free-response receiver operating characteristic study of observer performance using pulmonary nodules显示文摘 | Graf B U Simon F Eickmeyer | 2000 | AJR2000，174，4： | 1 |
| 3 | Structural and doping effects in the half-metallic double perovskite A2CrWO6 (A=Sr, Ba, and Ca)显示文摘 | PHILIPP J B MAJEWSKI P ALFF L ERB A GROSS R GRAF T BRANDT M S SIMON J WHATHER T MADER W TOPWAL D SARMA D D | 2003 | Phys Rev B2003，68，14： | 1 |
| 4 | 1K versus 2K monitor:a clinical alternative free-response receiver operating characteristic study of observer performance using pulmonary nodules显示文摘 | Graf B Simon U Eickmeyer F | 2000 | AJR2000，174，4： | 1 |
| 5 | First Agreement Analysis and Day-to-Day Comparison of Pharyngeal pH Monitoring with pH/Impedance Monitoring in Patients with Suspected Laryngopharyngeal Reflux显示文摘 | Valentin Becker Simone Graf Christoph Schlag Tibor Schuster Hubertus Feussner Roland Schmid Monther Bajbouj | 2012 | Journal of Gastrointestinal Surgery2012，，6： | 1 |
| 6 | Experimental and clinical validation of arterial diameter waveform and intimal media thickness obtained from B-mode ultrasound image processing显示文摘 | Sebastian Graf Jerome Gariepy Marc Massonneau Ricardo L Armentano Souheil Mansour Juan G Barra Alain Simon Jaime Levenson | 1999 | Ultrasound in Medicine & Biology1999，，9： | 1 |
| 7 | lk versus 2k monitor:a clinical alternative free-response receiver operating characteristic study of observer performance using pulmonary nodules显示文摘 | Graf B Simon V Eickmeyer F | 2000 | AJR2000，174，4： | 1 |
| 8 | IKversus 2K monitor a clinical alternative flee-response receiver operating characteristic study of observer performance using pulmonary nodules显示文摘 | Graf B Simon U Eickmeyer F | 2000 | AJR2000，174，： | 1 |
| 9 | IK versus 2K monitor: a clinical alternative free-response receiver operating characteristic study of observer performance using pulmonary nodules 显示文摘 | Graf B Simon U Eickmeyer F | 2000 | AJR2000，174，： | 1 |
| 10 | lk versus 2k monitor:a clinical alternative free-response receiver operating characteristic study of observer performance using pulmonary nodules显示文摘 | Graf B Simon V Eickmeyer F | 2000 | AJR2000，174，4： | 1 |
| 11 | Regulation of genetically modified foods in Australia and New Zealand显示文摘 | Paul Brent Dennis Bittisnich Simon Brooke-Taylor Nora Galway Lynda Graf Marion Healy Lisa Kelly | 2003 | Food Control2003，，6： | 1 |
| 12 | Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis显示文摘BACKGROUND The expression of amino acid transporters is known to vary during acute pancreatitis(AP)except for LAT1(slc7a5),the expression of which remains stable.LAT1 supports cell growth by importing leucine and thereby stimulates mammalian target of rapamycin(mTOR)activity,a phenomenon often observed in cancer cells.The mechanisms by which LAT1 influences physiological and pathophysiological processes and affects disease progression in the pancreas are not yet known.AIM To evaluate the role of LAT1 in the development of and recovery from AP.METHODS AP was induced with caerulein(cae)injections in female and male mice expressing LAT1 or after its knockout(LAT1 Cre/LoxP).The development of the initial AP injury and its recovery were followed for seven days after cae injections by daily measuring body weight,assessing microscopical tissue architecture,mRNA and protein expression,protein synthesis,and enzyme activity levels,as well as by testing the recruitment of immune cells by FACS and ELISA.RESULTS The initial injury,evaluated by measurements of plasma amylase,lipase,and trypsin activity,as well as the gene expression of dedifferentiation markers,did not differ between the groups.However,early metabolic adaptations that support regeneration at later stages were blunted in LAT1 knockout mice.Especially in females,we observed less mTOR reactivation and dysfunctional autophagy.The later regeneration phase was clearly delayed in female LAT1 knockout mice,which did not regain normal expression of the pancreas-specific differentiation markers recombining binding protein suppressor of hairless-like protein(rbpjl)and basic helixloop-helix family member A15(mist1).Amylase mRNA and protein levels remained lower,and,strikingly,female LAT1 knockout mice presented signs of fibrosis lasting until day seven.In contrast,pancreas morphology had returned to normal in wild-type littermates.CONCLUSION LAT1 supports the regeneration of acinar cells after AP.Female mice lacking LAT1 exhibited more pronounced alterations than male mice,indicating a sexual dimorphism of amino acid metabolism. | Cristina M Hagen Eva Roth Theresia Reding Graf François Verrey Rolf Graf Anurag Gupta Giovanni Pellegrini Nadège Poncet Simone Mafalda Rodrigues Camargo | 2022 | World Journal of Gastroenterology2022，28，10： | 0 |
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