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| 1 | Treatment technologies for aqueous perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA)显示文摘Fluorochemicals(FCs)are oxidatively recalcitrant,environmentally persistent,and resistant to most conventional treatment technologies.FCs have unique physiochemical properties derived from fluorine which is the most electronegative element.Perfluorooctanesulfonate(PFOS),and perfluorooctanoate(PFOA)have been detected globally in the hydrosphere,atmosphere and biosphere.Reducing treatment technologies such as reverses osmosis,nano-filtration and activated carbon can remove FCs from water.However,incineration of the concentrated waste is required for complete FC destruction.Recently,a number of alternative technologies for FC decomposition have been reported.The FC degradation technologies span a wide range of chemical processes including direct photolysis,photocatalytic oxidation,photochemical oxidation,photochemical reduction,thermally-induced reduction,and sonochemical pyrolysis.This paper reviews these FC degradation technologies in terms of kinetics,mechanism,energetic cost,and applicability.The optimal PFOS/PFOA treatment method is strongly dependent upon the FC concentration,background organic and metal concentration,and available degradation time. | Chad D.VECITIS Hyunwoong PARK Jie CHENG Brian T.MADER Michael R.HOFFMANN | 2009 | Frontiers of Environmental Science & Engineering2009，3，2： | 26 |
| 2 | Connexin 43 hemichannels protect bone loss during estrogen deficiency显示文摘Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone fracture.Connexin 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and remodeling.We showed here that estrogen deficiency reduced Cx43 expression and HC function.To determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were investigated.Our results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty lacunae.Moreover,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 mice.These data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency. | Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang | 2019 | Bone Research2019，7，2： | 11 |
| 3 | Roles of Rap1 signaling in tumor cell migration and invasion显示文摘Ras-associated protein-1(Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions(e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Through its interaction with other proteins, Rap1 plays many roles during cell invasion and metastasis in different cancers. The basic function of Rap1 is straightforward; it acts as a switch during cellular signaling transduction and regulated by its binding to either guanosine triphosphate(GTP) or guanosine diphosphate(GDP). However, its remarkably diverse function is rendered by its interplay with a large number of distinct Rap guanine nucleotide exchange factors and Rap GTPase activating proteins. This review summarizes the mechanisms by which Rap1 signaling can regulate cell invasion and metastasis, focusing on its roles in integrin and cadherin regulation, Rho GTPase control, and matrix metalloproteinase expression. | Yi-Lei Zhang Ruo-Chen Wang Ken Cheng Brian Z.Ring Li Su | 2017 | Cancer Biology & Medicine2017，14，1： | 8 |
| 4 | Impact Factor:1.90 Total flavonoids from Saussurea involucrata attenuate inflammation in lipopolysaccharide-stimulated RAW264.7 macrophages via modulating p65,c-Jun,and IRF3 signaling pathways显示文摘Objective:To investigate the anti-inflammatory effects of the total flavonoids from Saussurea involucrata on lipopolysaccharides(LPS)-stimulated murine RAW264.7 macrophages and explore its underlying mechanism of action.Methods:Total flavonoids from Saussurea involucrata were extracted using chromatographic column method.Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay.The production of nitric oxide was detected by Griess assay and the release of cytokines(IL-10 and TNF-α)and chemokines(MCP-1,MIP-1α,and CCL5/RANTES)was determined by ELISA to evaluate the anti-inflammatory activity of total flavonoids from Saussurea involucrata.Moreover,nuclear translocation of p65,c-Jun,and IRF3 was detected by immunofluorescence microscopy and Western blotting analysis was performed to determine the expression of related proteins.Results:Total flavonoids extracted from Saussurea involucrata were 751.5 mg/g and the content of rutin was 506.5 mg/g.The production of inflammatory mediators including nitric oxide,cytokines,and chemokines was effectively inhibited by total flavonoids from Saussurea involucrata.Meanwhile,total flavonoids also suppressed the nuclear translocation of p65,c-Jun,and IRF3 in LPS-stimulated RAW264.7 cells.The LPS-induced expression of iNOS and COX-2 was remarkably reduced by treatment with total flavonoids from Saussurea involucrata.Moreover,total flavonoids decreased the expression levels of p-IKKα/β,p-TBK1,p-p38,p-ERK,p-JNK,p-p65,p-c-Jun,and p-IRF3 in LPS-exposed RAW264.7 macrophages.Conclusions:Total flavonoids from Saussurea involucrata potentially inhibit the secretion of pro-inflammatory mediators,which may be related to inhibition of p65,c-Jun,and IRF3 signaling pathways in LPS-stimulated RAW264.7 cells. | Li-Shan Yan Li Wang Brian Chi-Yan Cheng Yu Ding Jing Kong Qing Gao Wang Xiu-Qiong Fu Shuo-Feng Zhang Gan Luo Yi Zhang | 2021 | Asian Pacific Journal of Tropical Biomedicine2021，11，6： | 3 |
| 5 | Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria:a meta-analysis of 18,421 patients显示文摘Background:Outcomes after liver resection(LR)and liver transplantation(LT)for hepatocellular carcinoma(HCC)are heterogenous and may vary by region,over time periods and disease burden.We aimed to compare overall survival(OS)and disease-free survival(DFS)between LT versus LR for HCC within the Milan criteria.Methods:Two authors independently searched Medline and Embase databases for studies comparing survival after LT and LR for patients with HCC meeting the Milan criteria.Meta-analyses and meta-regression were conducted using random-effects models.Results:We screened 2,278 studies and included 35 studies with 18,421 patients.LR was associated with poorer OS[hazard ratio(HR)=1.44;95%confidence interval(CI):1.14-1.81;P<0.01]and DFS(HR=2.71;95%CI:2.23-3.28;P<0.01)compared to LT,with similar findings among intention-to-treat(ITT)studies.In uninodular disease,OS in LR was comparable to LT(P=0.13)but DFS remained poorer(HR=2.95;95%CI:2.30-3.79;P<0.01).By region,LR had poorer OS versus LT in North America and Europe(P≤0.01),but not Asia(P=0.25).LR had inferior survival versus LT in studies completed before 2010(P=0.01),but not after 2010(P=0.12).Cohorts that underwent enhanced surveillance had comparable OS after LT and LR(P=0.33),but cohorts undergoing usual surveillance had worse OS after LR(HR=1.95;95%CI:1.24-3.07;P<0.01).Conclusions:Mortality after LR for HCC is nearly 50%higher compared to LT.Survival between LR and LT were similar in uninodular disease.The risk of recurrence after LR is threefold that of LT. | Jin Hean Koh Darren Jun Hao Tan Yuki Ong Wen Hui Lim Cheng Han Ng Phoebe Wen Lin Tay Jie Ning Yong Mark D.Muthiah Eunice X.Tan Ning Qi Pang Beom Kyung Kim Nicholas Syn Alfred Kow Brian K.P.Goh Daniel Q.Huang | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 3 |
| 6 | Historical Evolution of Mariculture in China During Past 40 Years and Its Impacts on Eco-environment显示文摘The rapid development of mariculture in China in recent decades has satisfied people's demand of seafood, and has made a great contribution to economic development. However, mariculture has also caused some negative impacts on the eco-environment. By statistically analyzing national data(as well as data for four main provinces) regarding the mariculture area and cultivation species in China since reform and opening up, the historical evolution of mariculture during the past 40 years was analyzed, the driving factors related to policy, market and technology innovation were discussed, and the potential impacts of mariculture on the coastal eco-environment were also illustrated. The statistical results indicated that the maricultural area increased radically during the past 40 years, from 1979(116.47 × 10~3 ha) to 2012(2205.65 × 10~3 ha), with an increase of nearly 20-fold. Shandong Province represented the fastest-growing region, with an increase of 31-fold. Moreover, the cultivated species had gradually become diversified. Initially, shellfish and algae were major species, and then it developed to various species including fish, and currently shellfish and crustaceans were the major species. The development of mariculture was driven by government policies, market economy and technology innovation. Rapid development of mariculture also caused significantly adverse impacts on the eco-environment of the coastal regions. For example, the sea reclamation for mariculture decreased the area and function of coastal wetlands and the contaminants originating from mariculture destroyed the coastal aquatic environment. Fortunately, the implementation of ‘13 th Five-Year Fisheries Planning' is expected to help both improve the seafood quality and reduce the contamination in coastal aquatic environment. This current study will provide reference for management and structure adjustment of mariculture in the future. | LIANG Yinxiu CHENG Xianwei ZHU Hui Brian SHUTES YAN Baixing ZHOU Qingwei YU Xiangfei | 2018 | Chinese Geographical Science2018，28，3： | 3 |
| 7 | Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor显示文摘Dear Editor,Dopamine acts as an essential neurotransmitter whose signaling is conducted through five G protein-coupled receptors(GPCRs),dopamine D1 to D5 receptors(DRD1–DRD5).1 The D1-like receptors,comprising DRD1 and DRD5,primarily couple to the Gs family of G proteins to activate adenylyl cyclase and induce cAMP production.DRD1 is the most abundantly expressed dopamine receptor in the CNS.1 It is the central receptor mediating excitatory dopamine signaling in multiple dopaminergic pathways.Dysregulation of DRD1 signaling has been directly linked to Parkinson’s disease(PD),schizophrenia,and drug abuse. | Youwen Zhuang Brian Krumm Huibing Zhang X.Edward Zhou Yue Wang Xi-Ping Huang Yongfeng Liu Xi Cheng Yi Jiang Hualiang Jiang Cheng Zhang Wei Yi Bryan L.Roth Yan Zhang H.Eric Xu | 2021 | Cell Research2021，31，5： | 2 |
| 8 | Targeted hepatitis C screening among ex‐injection drug users in the community显示文摘 | Vincent Wai‐Sun Wong Grace Lai‐Hung Wong Angel Mei‐Ling Chim Tsz‐Fai Cheng Shirley Wing‐Yan Cheung Carol Man‐Sze Lai Kylie Joan‐Yi Szeto Sharon Tsang Stephen Ho‐Chun Wu Kenneth Kar‐Lung Yan Alex Yui Hui Desmond Chi‐Him Yiu Brian Bing‐Ying Wu David Cheung | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 9 | Detection of JC virus DNA sequences in colorectal cancers in Japan显示文摘 | Ryouta Hori Yoshihiro Murai Kouichi Tsuneyama Hekmat Osman Abdel-Aziz Kazuhiro Nomoto Hiroyuki Takahashi Chun-mei Cheng Tomohiko Kuchina Brian V. Harman Yasuo Takano | 2005 | Virchows Archiv2005，，4： | 1 |
| 10 | Velamentous cord insertion: is it associated with adverse perinatal outcomes?*显示文摘 | Tania F. Esakoff Yvonne W. Cheng Jonathan M. Snowden Susan H. Tran Brian L. Shaffer Aaron B. Caughey | 2014 | The Journal of Maternal-Fetal & Neonatal Medicine2014，，： | 1 |
| 11 | Taking an innovative approach to quality practices: exploring the importance of a company’s innovativeness on the success of TQM practices显示文摘 | Frank Wiengarten Brian Fynes EdwinT.C. Cheng Roberto Chavez | 2013 | International Journal of Production Research2013，，10： | 1 |
| 12 | Nutrient removal in a pilot and full scale constructed wetland, Putrajaya city, Malaysia显示文摘 | Cheng Hua Sim Mohd Kamil Yusoff Brian Shutes Sinn Chye Ho Mashhor Mansor | 2007 | Journal of Environmental Management2007，，2： | 1 |
| 13 | Energy and B-spline interapproximation显示文摘 | WANG Xue-fu CHENG Fu-hua BRIAN A Barsky | 1997 | Computer Aided Design1997，29，7： | 1 |
| 14 | TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation显示文摘 | Xiping Cheng Jie Jin Lily Hu Dongbiao Shen Xian-ping Dong Mohammad A. Samie Jayne Knoff Brian Eisinger Mei-ling Liu Susan M. Huang Michael J. Caterina Peter Dempsey Lowell Evan Michael Andrzej A. Dlugosz Nancy C. Andrews David E. Clapham Haoxing Xu | 2010 | Cell2010，，2： | 1 |
| 15 | Changes in mycobacterium spp population structure and pyrene mineralization in polycyclic aromatic hydrocarbon-amended soils显示文摘 | Cheng Puiyi Brian K Kinkle | 2005 | Soil Biology & Biochemistry2005，37，10： | 1 |
| 16 | knowledge governance 显示文摘 | Chong Ju Choi Philip Cheng Brian Hilton and Edward Russell | 2005 | Journal of Knowledge management2005，，46： | 1 |
| 17 | Knowledge Governance显示文摘 | Chong Ju Choi Philip Cheng Brian Hilton | 2005 | Journal of Knowledge Management2005，9，6： | 1 |
| 18 | Management of recurrent intracranial hemangiopericytoma显示文摘 | Martin J. Rutkowski Orin Bloch Brian J. Jian Cheng Chen Michael E. Sughrue Tarik Tihan Igor J. Barani Mitchel S. Berger Michael W. McDermott Andrew T. Parsa | 2011 | Journal of Clinical Neuroscience2011，，11： | 1 |
| 19 | Preliminary evidence of delayed spawning and suppressed larval growth and condition of the major carps in the Yangtze River below the Three Gorges Dam显示文摘 | Guo Zhang Lang Wu Hongtao Li Ming Liu Fei Cheng Brian R. Murphy Songguang Xie | 2012 | Environmental Biology of Fishes2012，，3： | 1 |
| 20 | SHI- RAZ: an automated histology image annotation system for ze- brafish phenomics显示文摘 | Brian A Canada Georgia K Thomas Keith C Cheng | 2011 | Muhimed Tools Appl2011，51，： | 1 |
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