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| 1 | The promises and challenges of patient-derived tumor organoids in drug development and precision oncology显示文摘In the era of precision medicine,cancer researchers and oncologists are eagerly searching for more realistic,cost effective,and timely tumor models to aid drug development and precision oncology.Tumor models that can faithfully recapitulate the histological and molecular characteristics of various human tumors will be extremely valuable in increasing the successful rate of oncology drug development and discovering the most efficacious treatment regimen for cancer patients.Two‐dimensional(2D)cultured cancer cell lines,genetically engineered mouse tumor(GEMT)models,and patient‐derived tumor xenograft(PDTX)models have been widely used to investigate the biology of various types of cancers and test the efficacy of oncology drug candidates.However,due to either the failure to faithfully recapitulate the complexity of patient tumors in the case of 2D cultured cancer cells,or high cost and untimely for drug screening and testing in the case of GEMT and PDTX,new tumor models are urgently needed.The recently developed patient‐derived tumor organoids(PDTO)offer great potentials in uncovering novel biology of cancer development,accelerating the discovery of oncology drugs,and individualizing the treatment of cancers.In this review,we will summarize the recent progress in utilizing PDTO for oncology drug discovery.In addition,we will discuss the potentials and limitations of the current PDTO tumor models. | Lauren M.Granat Ooha Kambhampati Stephanie Klosek Brian Niedzwecki Kian Parsa Dong Zhang | 2019 | Animal Models and Experimental Medicine2019，2，3： | 5 |
| 2 | Quantitative risk of positive family history in developing colorectal cancer: A meta-analysis显示文摘BACKGROUND Positive family history is a risk factor for development of colorectal cancer.Despite numerous studies on the topic,the absolute risk in patients with a positive family history remains unclear and therefore studies are lacking to validate non-invasive screening methods in individuals with positive family history.AIM To quantify the risk of colorectal cancer in individuals with a positive family history.METHODS A comprehensive electronic literature search was performed using PubMed from January 1955 until November 2017,EMBASE from 1947 until 2018,and Cochrane Library without date restrictions.Two independent reviewers conducted study selection,data extraction and quality assessment.A meta-analysis of Mantel-Haenzel relative risks was performed using the random effects model.Newcastle-Ottawa scale was used to score the quality of selected papers.Funnel plot and Egger’s regression test was performed to detect publication bias.Subgroup analysis was performed comparing Asian and non-Asian studies.Sensitivity analyses were performed to rule out the effect of the timing of the study,overall quality,the main outcome and the effect of each individual study in overall result.RESULTS Forty-six out of 3390 studies,including 906981 patients were included in the final analysis.41 of the included studies were case-control and 5 were cohort.A positive family history of colorectal cancer in first-degree relatives was associated with significantly increased risk of colorectal cancer with a relative risk of 1.87(95%CI:1.68-2.09;P<0.00001).Cochrane Q test was significant(P<0.00001,I2=90%).Egger’s regression test showed asymmetry in the funnel plot and therefore the Trim and Fill method was used which confirmed the validity of the results.There was no difference between Asian versus non-Asian studies.Results remained robust in sensitivity analyses.CONCLUSION Individuals with a positive family history of colorectal cancer are 1.87 times more likely to develop colorectal cancer.Screening guidelines should pay specific attention to individuals with positive family history and further studies need to be done on validating current screening methods or developing new modalities in this high-risk population. | Parsa Mehraban Far Abdulaziz Alshahrani Mohammad Yaghoobi | 2019 | World Journal of Gastroenterology2019，25，30： | 4 |
| 3 | Inforence: effective fault localization based on information-theoretic analysis and statistical causal inference显示文摘In this paper, a novel approach, Inforence, is proposed to isolate the suspicious codes that likely contain faults. Inforence employs a feature selection method, based on mutual information, to identify those bug-related statements that may cause the program to fail. Because the majority of a program faults may be revealed as undesired joint effect of the program statements on each other and on program termination state, unlike the state-of-the-art methods, Inforence tries to identify and select groups of interdependent statements which altogether may affect the program failure. The interdependence amongst the statements is measured according to their mutual effect on each other and on the program termination state. To provide the context of failure, the selected bug-related statements are chained to each other, considering the program static structure. Eventually, the resultant causeeffect chains are ranked according to their combined causal effect on program failure. To validate Inforence, the results of our experiments with seven sets of programs include Siemens suite, gzip, grep, sed, space, make and bash are presented. The experimental results are then compared with those provided by different fault localization techniques for the both single-fault and multi-fault programs. The experimental results prove the outperformance of the proposed method compared to the state-of-the-art techniques. | Farid FEYZI Saeed PARSA | 2019 | Frontiers of Computer Science2019，13，4： | 2 |
| 4 | Five-phase permanent-magnet mo- tor drives 显示文摘 | L Parsa H A Toliyat | 2005 | IEEE Transactions on Industry Applications2005，41，1： | 1 |
| 5 | Recent Advances in Modeling and Online Detection of Stator Interterm Faults in Electrical Motors 显示文摘 | Gandhi A Corrigan T Parsa L | 2011 | IEEE Trans Ind Electron2011，58，5： | 1 |
| 6 | Control of macro-micro manipulators revisited显示文摘 | PARSA K ANGELES J ARUN K M | 2005 | Journal of Dynamic Systems Measurement and Control Transactions of the ASME2005，127，4： | 1 |
| 7 | Real-time microfluidic system for studying mammalian cells in 3D microenvironments 显示文摘 | LII J HSU W J PARSA H | 2008 | Anal Chem2008，80，10： | 1 |
| 8 | Sensorless direct torque control of five-phase interior permanent-magnet motor drives 显示文摘 | Parsa L Toliyat H A | 2007 | IEEE Transactions on Industry Applications2007，43，4： | 1 |
| 9 | Association of p63 with proliferative potential in normal and neoplastic human keratinocytes显示文摘 | Yang A McKeon F | 1999 | J Investig Dermatol1999，113，6： | 1 |
| 10 | Anti-infectives-induced adverse drug reactions in hospitalized patients显示文摘 | Parsa S Shalviri G | 2005 | Pharmacoepidemiology and Drug Safety2005，14，： | 1 |
| 11 | Five-phase Permanent-magnet Motor Drives 显示文摘 | L Parsa H A Toliyat | 2005 | IEEE Transactions on industrial application2005，41，1： | 1 |
| 12 | Improvementof initial blank shape for intricate products using slipline method显示文摘 | PARSA M H MATIN P H MASHHADI M M | 2004 | Journal Materials Processing Technology2004，13，145： | 1 |
| 13 | Discrimination of pathologi- cal voices using a time-frequency approach显示文摘 | Umapathy K Krishnan S Parsa V | 2005 | IEEE Trans Biomed Eng2005，52，3： | 1 |
| 14 | Reliability and validity of Champion's Health Belief Model Scale for breast cancer screening among Malaysian women 显示文摘 | Parsa P Kandiah M Mohd N M | 2008 | Singapore Med J2008，49，11： | 1 |
| 15 | Two art museum programs for people with dementia显示文摘 | Parsa A Humble L Gerber C | 2010 | Museums Soc Issues2010，5，2： | 1 |
| 16 | Pulmonary surfactant protein - a regulates TLR expression and activity in human macrophages显示文摘 | Henning LN Azad AK Parsa KV | 2008 | J Immunol2008，180，12： | 1 |
| 17 | A novel protective effect of erythropoietin in the infarcted heart显示文摘 | Parsa CJ Matsumoto A Kim J | 2003 | J Clin Invest2003，112，7： | 1 |
| 18 | Mediastinal tuberculosis in Bradford, United Kingdom: the role of mediastinoscopy 显示文摘 | Jacob B Parsa R Frizzell R | 2011 | Int J Turberc Lung Dis2011，15，2： | 1 |
| 19 | A novel protective effect of erythropoietin in the infarcted heart 显示文摘 | PARSA C J MATSUMOTO A KIM J | 2003 | J Clin Invest2003，112，7： | 1 |
| 20 | Common variants in Mendelian kidney disease genes and their association with renal func- tion显示文摘 | Parsa A Fuchsberger C Kottgen A | 2013 | J Am Soc Ncphrol2013，24，12： | 1 |
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