|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Roles of Rap1 signaling in tumor cell migration and invasion显示文摘Ras-associated protein-1(Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions(e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Through its interaction with other proteins, Rap1 plays many roles during cell invasion and metastasis in different cancers. The basic function of Rap1 is straightforward; it acts as a switch during cellular signaling transduction and regulated by its binding to either guanosine triphosphate(GTP) or guanosine diphosphate(GDP). However, its remarkably diverse function is rendered by its interplay with a large number of distinct Rap guanine nucleotide exchange factors and Rap GTPase activating proteins. This review summarizes the mechanisms by which Rap1 signaling can regulate cell invasion and metastasis, focusing on its roles in integrin and cadherin regulation, Rho GTPase control, and matrix metalloproteinase expression. | Yi-Lei Zhang Ruo-Chen Wang Ken Cheng Brian Z.Ring Li Su | 2017 | Cancer Biology & Medicine2017，14，1： | 8 |
| 2 | Blastic Plasmacytoid Dendritic Cell Neoplasm:Progress in Cell Origin,Molecular Biology,Diagnostic Criteria and Therapeutic Approaches显示文摘Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare hematological malignancy characterized by recurrent skin nodules,an aggressive clinical course with rapid involvement of hematological organs,and a poor prognosis with poor overall survival.BPDCN is derived from plasmacytoid dendritic cells(pDCs)and its pathogenesis is unclear.The tumor cells show aberrant expression of CD4,CD56,interleukin-3 receptor alpha chain(CD 123),blood dendritic cell antigen 2(BDCA 2/CD303),blood dendritic cell antigen 4(BDCA4)and transcription factor(E protein)E2-2(TCF4).The best treatment drugs are based on experience by adopting those used for either leukemia or lymphoma.Relapse with drug resistance generally occurs quickly.Stem cell transplantation after the first complete remission is recommended and tagraxofusp is the first targeted therapy.In this review,we summarize the differentiation of BPDCN from its cell origin,its connection with normal pDCs,clinical characteristics,genetic mutations and advances in treatment of BPDCN.This review provides insights into the mechanisms of and new therapeutic approaches for BPDCN. | Wei CHENG Tian-tian YU Ai-ping TANG Ken HE YOUNG Li YUI | 2021 | Current Medical Science2021，41，3： | 4 |
| 3 | Absorption characteristics of highpower disc fiber laser by side pumping of laser diode显示文摘 | Nam Seong Kim Mahendra Prabhu Cheng Li Jie Song Deyuan Shen and Ken ichi Ueda | 1999 | Lasers and Electro Optics1999，3，9： | 1 |
| 4 | Estimation of lime stone particle mass from 2D images显示文摘 | Larry Banta Ken Cheng Zaniewski J | 2003 | Powder Technology2003，132，： | 1 |
| 5 | A novel, in vivo, indoor method topreserve RBSDV in SBPH using wheat seedling as a bridge host显示文摘 | Ken C Cheng Z Yang L | 2014 | Journal of Virological methods2014，208，： | 1 |
| 6 | Bimetallic Oxyhydroxide as a High-Performance Water Oxidation Electrocatalyst under Industry-Relevant Conditions显示文摘Developing high-performing oxygen evolution reaction(OER)electrocatalysts under high-current operation conditions is critical for future commercial applications of alkaline water electrolysis for clean energy generation.Herein,we prepared a three-dimensional(3D)bimetallic oxyhydroxide hybrid grown on a Ni foam(NiFeOOH/NF)prepared by immersing Ni foam(NF)into Fe(NO_(3))_(3) solution.In this unique 3D structure,the NiFeOOH/NF hybrid was composed of crystalline Ni(OH)_(2) and amorphous FeOOH evenly grown on the NF surface.As a bimetallic oxyhydroxide electrocatalyst,the NiFeOOH/NF hybrid exhibited excellent catalytic activity,surpassing not only the other reported Ni–Fe based electrocatalysts,but also the commercial Ir/C catalyst.In situ electrochemical Raman spectroscopy demonstrated the active FeOOH and NiOOH phases involved in the OER process.Profiting from the synergy of Fe and Ni catalytic sites,the NiFeOOH/NF hybrid delivered an outstanding OER performance under challenging industrial conditions in a 10.0 mol·L^(-1) KOH electrolyte at 80℃,requiring potentials as small as 1.47 and 1.51 V to achieve the super-high catalytic current densities of 100 and 500mA∙cm^(-2),respectively. | Jiaxin Yuan Xiaodi Cheng Chaojun Lei Bin Yang Zhongjian Li Kun Luo K.H.Koko Lam Lecheng Lei Yang Hou Kostya Ken Ostrikov | 2021 | Engineering2021，7，9： | 1 |
| 7 | The price adjustment and lead-lag relations between stock returns: microstructure evidence from the Taiwan stock market显示文摘 | Chaoshin Chiao Ken Hung Cheng F. Lee | 2004 | Journal of Empirical Finance2004，，5： | 1 |
| 8 | Estimation of limestone particle mass from 2D images显示文摘 | Larry Banta Ken Cheng John Zaniewski | 2003 | Powder Tech nology2003，132，23： | 1 |
| 9 | Estimation of limestone particle mass from 2-D images 显示文摘 | Larry Banta Ken Cheng Zaniewski J | 2003 | Powder Technology2003，132，： | 1 |
| 10 | Estimation of limestone particle mass from 2-D images 显示文摘 | Larry Banta Ken Cheng Zaniewski J | 2003 | Powder Technology2003，，： | 1 |
| 11 | Microwave rapid heating for the synthesis of gold nanorods显示文摘 | Fu Ken L Yu Cheng C Fu Hsiang K | 2004 | Materials Letters2004，58，： | 1 |
| 12 | Preparation and characterization of biodegradable poly(L-lactide)/chitosan blends显示文摘 | Cheng chen Lisong Dong Man Ken Cheung | 2005 | European Polymer Journal2005，41，5： | 1 |
| 13 | Rather than interleukin‐27, interleukin‐6 expresses positive correlation with liver severity in na?ve hepatitis B infection patients显示文摘 | Jung‐Ta Kao Hsueh‐Chou Lai Shu‐Mei Tsai Pei‐Chao Lin Po‐Heng Chuang Cheng‐Ju Yu Ken‐Sheng Cheng Wen‐Pang Su Ping‐Ning Hsu Cheng‐Yuan Peng Yi‐Ying Wu | 2012 | Liver Int2012，，6： | 1 |
| 14 | Improved design of remote wireless transmission terminal using GPRS/GSM integrated network 显示文摘 | LI Cheng DING Tian-huai CHEN Ken | 2006 | Computer Communications2006，29，8： | 1 |
| 15 | Improvements in self-control from financial monitoring显示文摘 | Megan Oaten Ken Cheng | 2006 | Journal of Economic Psychology2006，，4： | 1 |
| 16 | Improved Self-Control: The Benefits of a Regular Program of Academic Study显示文摘 | Megan Oaten Ken Cheng | 2006 | Basic and Applied Social Psychology2006，，1： | 1 |
| 17 | Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression显示文摘 | Wartman Lukas D Larson David E Xiang Zhifu Ding Li Chen Ken Lin Ling Cahan Patrick Klco Jeffery M Welch John S Li Cheng Payton Jacqueline E Uy Geoffrey L Varghese Nobish Ries Rhonda E Hoock Mieke Koboldt Daniel C McLellan Michael D Schmid | 2011 | Journal of Clinical Investigation2011，，： | 1 |
| 18 | Rather than interleukin‐27, interleukin‐6 expresses positive correlation with liver severity in na?ve hepatitis B infection patients显示文摘 | Jung‐Ta Kao Hsueh‐Chou Lai Shu‐Mei Tsai Pei‐Chao Lin Po‐Heng Chuang Cheng‐Ju Yu Ken‐Sheng Cheng Wen‐Pang Su Ping‐Ning Hsu Cheng‐Yuan Peng Yi‐Ying Wu | 2012 | Liver Int2012，，6： | 1 |
| 19 | Increased PD‐1 and decreased CD28 expression in chronic hepatitis B patients with advanced hepatocellular carcinoma显示文摘 | Ping‐NingHsu Tsuey‐ChingYang Jung‐TaKao Ken‐ShengCheng Yi‐JuLee Yuan‐MinWang Chin‐TungHsieh Cheng‐WenLin Yi‐YingWu | 2010 | Liver International2010，，9： | 1 |
| 20 | Improved Self-Control: The Benefits of a Regular Program of Academic Study显示文摘 | Oaten Megan & Cheng Ken | 2006 | Basic & Applied Social Psy- chology2006，28，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员