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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Spatial pattern of grassland aboveground biomass and its environmental controls in the Eurasian steppe显示文摘Vegetation biomass is an important component of terrestrial ecosystem carbon stocks. Grasslands are one of the most widespread biomes worldwideplaying an important role in global carbon cycling. Thereforestudying spatial patterns of biomass and their correlations to environment in grasslands is fundamental to quantifying terrestrial carbon budgets. The Eurasian steppean important part of global grasslandsis the largest and relatively well preserved grassland in the world. In this studywe analyzed the spatial pattern of aboveground biomass(AGB)and correlations of AGB to its environment in the Eurasian steppe by meta-analysis. AGB data used in this study were derived from the harvesting method and were obtained from three data sources(literatureglobal NPP database at the Oak Ridge National Laboratory Distributed Active Archive Center(ORNL)some data provided by other researchers). Our results demonstrated that:(1) as for the Eurasian steppe overallthe spatial variation in AGB exhibited significant horizontal and vertical zonality. In detailAGB showed an inverted parabola curve with the latitude and with the elevationwhile a parabola curve with the longitude. In additionthe spatial pattern of AGB had marked horizontal zonality in the Black Sea-Kazakhstan steppe subregion and the Mongolian Plateau steppe subregionwhile horizontal and vertical zonality in the Tibetan Plateau alpine steppe subregion.(2) Of the examined environmental variablesthe spatial variation of AGB was related to mean annual precipitation(MAP)mean annual temperature(MAT)mean annual solar radiation(MAR)soil Gravel contentsoil p H and soil organic content(SOC) at the depth of 0–30 cm. NeverthelessMAP dominated spatial patterns of AGB in the Eurasian steppe and its three subregions.(3) A Gaussian function was found between AGB and MAP in the Eurasian steppe overallwhich was primarily determined by unique patterns of grasslands and environment in the Tibetan Plateau. AGB was significantly positively related to MAP in the Black Sea-Kazakhstan steppe subregion(elevation < 3000 m)the Mongolian Plateau steppe subregion(elevation < 3000 m) and the surface(elevation ≥ 4800 m) of the Tibetan Plateau. Neverthelessthe spatial variation in AGB exhibited a Gaussian function curve with the increasing MAP in the east and southeast margins(elevation < 4800 m) of the Tibetan Plateau. This study provided more knowledge of spatial patterns of AGB and their environmental controls in grasslands than previous studies only conducted in local regions like the Inner Mongolian temperate grasslandthe Tibetan Plateau alpine grasslandetc. | JIAO Cuicui YU Guirui HE Nianpeng MA Anna GE Jianping HU Zhongmin | 2017 | Journal of Geographical Sciences2017，27，1： | 7 |
| 3 | Glucose-responsive oral insulin delivery for postprandial glycemic regulation显示文摘Controlling postprandial glucose levels for diabetic patients is critical to achieve the tight glycemic control that decreases the risk for developing long-term micro- and macrovascular complications.Herein,we report a glucose-responsive oral insulin delivery system based on Fc receptor (FcRn)-targeted liposomes with glucose-sensitive hyaluronic acid (HA) shell for postprandial glycemic regulation.After oral administration,the HA shell can quickly detach in the presence of increasing intestinal glucose concentration due to the competitive binding of glucose with the phenylboronic acid groups conjugated with HA.The exposed Fc groups on the surface of liposomes then facilitate enhanced intestinal absorption in an FcRn-mediated transport pathway.In vivo studies on chemically-induced type 1 diabetic mice show this oral glucose-responsive delivery approach can effectively reduce postprandial blood glucose excursions.This work is the first demonstration of an oral insulin delivery system directly triggered by increasing postprandial glucose concentrations in the intestine to provide an on-demand insulin release with ease of administration. | Jicheng Yu Yuqi Zhang Jinqiang Wang Di Wen Anna R. Kahkoska John B. Buse Zhen Gu | 2019 | Nano Research2019，12，7： | 6 |
| 4 | New approaches for evaluation of soil health, sensitivity and resistance to degradation显示文摘Assessment of soil health requires complexevaluation of properties and functions responsible for abroad range of ecosystem services. Numerous soil qualityindices (SQI) have been suggested for the evaluation ofspecific groups of soil functions, but comparison of variousSQI is impossible because they are based on a combinationof specific soil properties. To avoid this problem, wesuggest an SQI-area approach based on the comparison ofthe areas on a radar diagram of a combination of chemical,biological and physical properties. The new approach isindependent of the SQI principle and allows rapid andsimple comparison of parameter groups and soils. Anotherapproach analyzing the resistance and sensitivity ofproperties to degradation is suggested for a detailedevaluation of soil health. The resistance and sensitivityof soil properties are determined through comparison withthe decrease of soil organic carbon (SOC) as a universalparameter responsible for many functions. The SQI-areaand resistance/sensitivity approaches were tested based on quences after the ab and on ment of agricultural soils. Both the SQI-area and the resistance/sensitivity approaches areuseful for basic and applied research, and for decisionmakersto evaluate land-use practices and measure thedegree of soil degradation. | Yakov KUZYAKOV Anna GUNINA Kazem ZAMANIAN Jing TIAN Yu LUO Xingliang XU Anna YUDINA Humberto APONTE Hattan ALHARBI Lilit OVSEPYAN Irina KURGANOVA Tida GE Thomas GUILLAUME | 2020 | Frontiers of Agricultural Science and Engineering2020，7，3： | 6 |
| 5 | Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis显示文摘Immunomodulatory signaling imposes tight regulations on metabolic programs within immune cells and consequentially determines immune response outcomes.Although the glucocorticoid receptor(GR)has been recently implicated in regulating the function of myeloid-derived suppressor cells(MDSCs),whether the dysregulation of GR in MDSCs is involved in immune-mediated hepatic diseases and how GR regulates the function of MDSCs in such a context remains unknown.Here,we revealed the dysregulation of GR expression in MDSCs during innate immunological hepatic injury(IMH)and found that GR regulates the function of MDSCs through modulating HIF1α-dependent glycolysis.Pharmacological modulation of GR by its agonist(dexamethasone,Dex)protects IMH mice against inflammatory injury.Mechanistically,GR signaling suppresses HIF1αand HIF1α-dependent glycolysis in MDSCs and thus promotes the immune suppressive activity of MDSCs.Our studies reveal a role of GR-HIF1αin regulating the metabolism and function of MDSCs and further implicate MDSC GR signaling as a potential therapeutic target in hepatic diseases that are driven by innate immune cell-mediated systemic inflammation. | Yun Lu Huanrong Liu Yujing Bi Hui Yang Yan Li Jian Wang Zhengguo Zhang Yu Wang Chunxiao Li Anna Jia Linian Han Ying Hu Yong Zhao Ruoning Wang Guangwei Liu | 2018 | Cellular & Molecular Immunology2018，15，6： | 4 |
| 6 | Effects of a check dam system on the runoff generation and concentration processes of a catchment on the Loess Plateau显示文摘As an important soil and water conservation engineering measure,more than 100,000 check dams are constructed across the Loess Plateau;these dams play a vital role in reducing floods and sediment in the region.However,the effects of check dams on hydrologic process are still unclear,particularly when they are deployed as a system for watershed soil and water management.This study examined the watershed hydrologic process modulated by the check dam system in a typical Loess Plateau catchment.By simulating scenarios with various numbers of check dams using a distributed physically-based hydro-logical model,the effects of the number of check dams on runoff generation and concentration were analyzed for the study catchment.The results showed that the presence of check dams reduced the peak discharge and the flood volume and extended the flood duration;the reduction effect on peak discharge was most significant among the three factors.The system of check dams substantially decreased the runoff coefficient,and the runoff coefficient reduction rate was greater for rainstorms with shorter return periods than for rainstorms with longer return periods.The check dams increased the capacity of the catchment regulating and storing floods and extended the average runoff concentration time in the catchment that flattened the instantaneous unit hydrograph.This study reveals the influencing mech-anism of check dam system on the watershed hydrological process under heavy rainstorm conditions and provides a theoretical basis for evaluating the effects of numerous check dams on regional hydrology and water resources on the Loess Plateau. | Shuilong Yuan Zhanbin Li Li Chen Peng Li Zeyu Zhang Junzheng Zhang Anna Wang kunxia Yu | 2022 | International Soil and Water Conservation Research2022，10，1： | 3 |
| 7 | The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor显示文摘 | Anne E. Powell Yang Wang Yina Li Emily J. Poulin Anna L. Means Mary K. Washington James N. Higginbotham Alwin Juchheim Nripesh Prasad Shawn E. Levy Yan Guo Yu Shyr Bruce J. Aronow Kevin M. Haigis Jeffrey L. Franklin Robert J. Coffey | 2012 | Cell2012，，1： | 2 |
| 8 | Direct competitive ELISA based on a monoclonal antibody for detection of aflatoxin B1. Stabilization of ELISA kit components and application to grain samples显示文摘 | Anna Yu Kolosova Won-Bo Shim Zheng-You Yang Sergei A. Eremin Duck-Hwa Chung | 2006 | Analytical and Bioanalytical Chemistry2006，，1： | 2 |
| 9 | Notch2‐induced COX‐2 expression enhancing gastric cancer progression显示文摘 | Yun‐Chien Tseng Yu‐Hui Tsai Min‐Jen Tseng Kai‐Wen Hsu Min‐Chieh Yang Kuo‐Hung Huang Anna Fen‐Yau Li Chin‐Wen Chi Rong‐Hong Hsieh Hung‐Hai Ku Tien‐Shun Yeh | 2011 | Mol Carcinog2011，，12： | 2 |
| 10 | Competitive food supply chain networks with application to fresh produce显示文摘 | Min Yu Anna Nagurney | 2013 | European Journal of Operational Research2013，，2： | 1 |
| 11 | 显示文摘 | Anna Frydrychewicz Sergey Yu Vassiliev Galina A Tsirlina | 2005 | Eleetrochimica Acta2005，50，： | 1 |
| 12 | Direct competitive ELISA based on a monoclonal antibody for detection of aflatoxin B1. Stabilization of ELISA kit components and application to grain samples显示文摘 | Anna Yu Kolosova Won-Bo Shim Zheng-You Yang Sergei A. Eremin Duck-Hwa Chung | 2006 | Analytical and Bioanalytical Chemistry2006，，1： | 1 |
| 13 | Direct competitive ELISA based on a monoclonal antibody for detection of aflatoxin B 1 . Stabilization of ELISA kit components and application to grain samples显示文摘 | Anna Yu Kolosova Won-Bo Shim Zheng-You Yang Sergei A. Eremin Duck-Hwa Chung | 2005 | Analytical and Bioanalytical Chemistry2005，，1： | 1 |
| 14 | Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression显示文摘 | Maria Genander Michael M. Halford Nan-Jie Xu Malin Eriksson Zuoren Yu Zhaozhu Qiu Anna Martling Gedas Greicius Sonal Thakar Timothy Catchpole Michael J. Chumley Sofia Zdunek Chenguang Wang Torbj?rn Holm Stephen P. Goff Sven Pettersson Richard G. Pestell M | 2009 | Cell2009，，4： | 1 |
| 15 | Green and black tea intake in relation to prostate cancer risk among Singapore Chinese显示文摘 | Julia Montague Lesley Butler Anna Wu Jeanine Genkinger Woon-Puay Koh Alvin Wong Renwei Wang Jian-Min Yuan Mimi Yu | 2012 | Cancer Causes & Control2012，，10： | 1 |
| 16 | Aldosterone Receptor Antagonism Induces Reverse Remodeling When Added to Angiotensin Receptor Blockade in Chronic Heart Failure显示文摘 | Anna K.Y. Chan John E. Sanderson Tian Wang Wynnie Lam Gabriel Yip Mei Wang Yat-Yin Lam Yan Zhang Leata Yeung Eugene B. Wu Wilson W.M. Chan John T.H. Wong Nina So Cheuk-Man Yu | 2007 | Journal of the American College of Cardiology2007，，7： | 1 |
| 17 | Competitive food supply chain networks with application to fresh produce显示文摘 | Min Yu Anna Nagurney | 2013 | European Journal of Operational Research2013，，2： | 1 |
| 18 | Galectin-3 – A jack-of-all-trades in cancer显示文摘 | Anna U. Newlaczyl Lu-Gang Yu | 2011 | Cancer Letters2011，，2： | 1 |
| 19 | Express detection of nonylphenol in water samples by fluorescence polarization immunoassay 显示文摘 | Julia N Yakovleva Anna Yu | 2004 | Anal Bioanal Chem2004，378，3： | 1 |
| 20 | Numerical investigation on the dynamic behavior of advanced ceramics显示文摘 | Rena C. Yu Gonzalo Ruiz Anna Pandolfi | 2003 | Engineering Fracture Mechanics2003，，4： | 1 |
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