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| 1 | Third-line rescue therapy for Helicobacter pylori infection显示文摘H pylori 胃的感染是世界范围的最流行的传染病之一。很上面的胃肠的疾病与 H pylori 感染有关能因此与抗菌素被对待的发现是重要医药进展。当前,首要的三倍的治疗被所有一致会议和指南基于质子泵禁止者(PPI ) 或加二抗菌素(clarithromycin 和 amoxicillin 或 nitroimidazole ) 的 ranitidine 枸橼酸铋(RBC ) 推荐。甚至与这药联合的正确使用,感染不能在多达 23% 病人被根除。因此,几第二线治疗被推荐了。7 d 四倍的治疗基于 PPI,铋,四圜素和灭滴灵,更多经常被接受。与第二线的治疗,然而,细菌的根除可以在多达 40% 盒子失败。当 H pylori 根除严格地被显示时,进一步的治疗的选择是争论的。当前,标准第三线的治疗正在缺乏,各种各样的协议被建议了。甚至在二连续失败以后,最近的文学数据证明了 H pylori 根除能在几乎所有病人被完成,甚至当抗菌素危险性没被测试时。实验治疗的不同可能性存在,可得到的第三线的策略此处被考察。 | Rossella Cianci Massimo Montalto Franco Pandolfi Giovan Battista Gasbarrini Giovanni Cammarota | 2006 | World Journal of Gastroenterology2006，12，15： | 31 |
| 2 | Virus against virus:a potential treatment for 2019-nCov(SARS-CoV-2)and other RNA viruses显示文摘The novel coronavirus,2019-nCov(named as SARS-CoV-2 by ICTV Coronaviridae Study Group on February 12,2020),causes severe respiratory illness1 and has been spreading around the world rapidly.2 As of February 14,2020,there are over 64,000 confirmed cases with 1,384 deaths.This raises an urgent need for an effective treatment of the deadly disease.However,current antiviral drugs have limited effects on 2019-nCov(SARS-CoV-2). | Tuan M.Nguyen Yang Zhang Pier Paolo Pandolfi | 2020 | Cell Research2020，30，3： | 30 |
| 3 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 4 | A circular twist on microRNA regulation显示文摘 | Marco Bezzi Jlenia Guarnerio Pier Paolo Pandolfi | 2017 | Cell Research2017，27，12： | 7 |
| 5 | Aberrant ceRNA activity drives lung cancer显示文摘 | Yvonne Tay Florian A Karreth Pier Paolo Pandolfi | 2014 | Cell Research2014，24，3： | 5 |
| 6 | Osteogenic differentiation of amniotic fluid mesenchymal stromal cells and their bone regeneration potential显示文摘In orthopedics, tissue engineering approach using stem cells is a valid line of treatment for patients with bone defects. In this context, mesenchymal stromal cells of various origins have been extensively studied and continue to be a matter of debate. Although mesenchymal stromal cells from bone marrow are already clinically applied, recent evidence suggests that one may use mesenchymal stromal cells from extra-embryonic tissues, such as amniotic fluid, as an innovative andadvantageous resource for bone regeneration. The use of cells from amniotic fluid does not raise ethical problems and provides a sufficient number of cells without invasive procedures. Furthermore, they do not develop into teratomas when transplanted, a consequence observed with pluripotent stem cells. In addition, their multipotent differentiation ability, low immunogenicity, and anti-inflammatory properties make them ideal candidates for bone regenerative medicine. We here present an overview of the features of amniotic fluid mesenchymal stromal cells and their potential in the osteogenic differentiation process. We have examined the papers actually available on this regard, with particular interest in the strategies applied to improve in vitro osteogenesis. Importantly, a detailed understanding of the behavior of amniotic fluid mesenchymal stromal cells and their osteogenic ability is desirable considering a feasible application in bone regenerative medicine. | Caterina Pipino Assunta Pandolfi | 2015 | World Journal of Stem Cells2015，7，4： | 4 |
| 7 | Intravenous vs intraperitoneal mesenchymal stem cells administration:What is the best route for treating experimental colitis?显示文摘AIM:To investigate the therapeutic effects of mesenchymal stem cells(MSCs)transplanted intraperitoneally andintravenously in a murine model of colitis.METHODS:MSCs were isolated from C57BL/6 mouse adipose tissue.MSC cultures were analyzed according to morphology,cellular differentiation potential,and surface molecular markers.Experimental acute colitis was induced in C57BL/6 mice by oral administration of2%dextran sulfate sodium(DSS)in drinking water ad libitum from days 0 to 7.Colitis mice were treated with1×106 MSCs via intraperitoneal or intravenous injection on days 2 and 5.The disease activity index was determined daily based on the following parameters:weight loss,stool consistency and presence of blood in the feces and anus.To compare morphological and functional differences in tissue regeneration between different MSC injection modalities,mice were euthanized on day 8,and their colons were examined for length,weight,and histopathological changes.Inflammatory responses were determined by measuring the levels of different serum cytokines using a CBA Th1/Th2/Th17 kit.Apoptotic rates were evaluated by terminal deoxynucleotidyl transferase-mediated d UDPbiotin nick end labeling assay.RESULTS:Intravenous infusion of MSCs was more effective than intraperitoneal treatment(P<0.001)in reducing the clinical and histopathologic severity of colitis,which includes weight loss,diarrhea and inflammation.An histological evaluation demonstrated decreased colonic inflammation based on reduced crypt loss and reduced infiltration of inflammatory cells.This therapeutic effect was most likely mediated by the down-regulation of pro-inflammatory cytokines[interleukin(IL)-6 and tumor necrosis factor(TNF)];and by the up-regulation of anti-inflammatory cytokines(IL-10 and IL-4).Intravenous transplantation alsoinduced high levels of IFN that lead to activation of the immunosuppressive activity of the MSCs,which did not occur with intraperitoneal transplantation(P=0.006).An increase in apoptotic T cells was observed after intravenous,but not intraperitoneal,MSC infusion,suggesting that MSCs can induce apoptosis in resistant T cells in colonic inflammation(P=0.027).CONCLUSION:Our results demonstrate that intravenous treatment is a superior method for reducing colon inflammation compared with intraperitoneal therapy. | Fabiany da Costa Goncalves Natália Schneider Fernanda Otesbelgue Pinto Fabíola Schons Meyer Fernanda Visioli Bianca Pfaffenseller Patrícia Luciana da Costa Lopez Eduardo Pandolfi Passos Elizabeth Obino Cirne-Lima Luíse Meurer Ana Helena Paz | 2014 | World Journal of Gastroenterology2014，20，48： | 4 |
| 8 | Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner显示文摘 | Min Sup Song Arkaitz Carracedo Leonardo Salmena Su Jung Song Ainara Egia Marcos Malumbres Pier Paolo Pandolfi | 2011 | Cell2011，，2： | 3 |
| 9 | Tenets of PTEN Tumor Suppression显示文摘 | Leonardo Salmena Arkaitz Carracedo Pier Paolo Pandolfi | 2008 | Cell2008，，： | 3 |
| 10 | The Multiple Roles of PTEN in Tumor Suppression显示文摘 | Antonio Di Cristofano Pier Paolo Pandolfi | 2000 | Cell2000，，4： | 2 |
| 11 | A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?显示文摘 | Leonardo Salmena Laura Poliseno Yvonne Tay Lev Kats Pier Paolo Pandolfi | 2011 | Cell2011，，3： | 2 |
| 12 | 动态文化为骨头工程作为脚手架在 freeze-dried 骨头上改进 MSC 粘附显示文摘 AIM:To investigate the interaction between mesenchymal stem cells(MSCs) and bone grafts using two different cultivation methods:static and dynamic.METHODS:MSCs were isolated from rat bone marrow.MSC culture was analyzed according to the morphology,cell differentiation potential,and surface molecular markers.Before cell culture,freeze-dried bone(FDB) was maintained in culture for 3 d in order to verify culture medium pH.MSCs were co-cultured with FDB using two different cultivation methods:static co-culture(two-dimensional) and dynamic co-culture(threedimensional).After 24 h of cultivation by dynamic or static methods,histological analysis of Cell adhesion on FDB was performed.Cell viability was assessed by the Trypan Blue exclusion method on days 0,3 and 6 after dynamic or static culture.Adherent cells were detached from FDB surface,stained with Trypan Blue,and quantified to determine whether the cells remained on the graft surface in prolonged non-dynamic culture.Statistical analyses were performed with SPSS and a P < 0.05 was considered significant.RESULTS:The results showed a clear potential for adipogenic and osteogenic differentiation of MSC cultures.Rat MSCs were positive for CD44,CD90 and CD29 and negative for CD34,CD45 and CD11bc.FDBs were maintained in culture for 3 d and the results showed there was no significant variation in the culture medium pH with FDB compared to pure medium pH(P > 0.05).In histological analysis,there was a significant difference in the amount of adhered cells on FDB between the two cultivation methods(P < 0.05).The MSCs in the dynamic co-culture method demonstrated greater adhesion on the bone surface than in static co-culture method.On day 0,the cell viability in the dynamic system was significantly higher than in the static system(P < 0.05).There was a statistical difference in cell viability between days 0,3 and 6 after dynamic culture(P < 0.05).In static culture,cell viability on day 6 was significantly lower than on day 3 and 0(P < 0.05).CONCLUSION:An alternative cultivation method was developed to improve the MSCs adhesion on FDB,demonstrating that dynamic co-culture provides a superior environment over static conditions. | Fabiany da Costa Gonalves Ana Helena da Rosa Paz Priscila Schmidt Lora Eduardo Pandolfi Passos Elizabeth Obino Cirne-Lima | 2012 | World Journal of Stem Cells2012，4，2： | 2 |
| 13 | Long-term results of endoscopic management of postoperative bile duct strictures with increasing numbers of stents显示文摘 | Guido Costamagna Monica Pandolfi Massimiliano Mutignani Cristiano Spada Vincenzo Perri | 2001 | Gastrointestinal Endoscopy2001，，2： | 2 |
| 14 | 用于三维裂纹扩展分析的有限变形不可逆内聚元显示文摘为了能准确和高效的跟踪动态裂纹扩展,我们发展了三维有限变形的内聚元和一系列不可逆内聚力关系.该内聚元通过采用不可逆内聚力关系来控制裂纹两侧物质的逐渐分离和形成自由表面,这一点可类比于传统有限元对块体材料的离散化.为了展示该方法的预测能力及便于灵活使用的特点,我们模拟了Zehnder和Rosakis所做的重物落下动态断裂实验,值得注意的是该方法可以近似模拟出裂尖的轨迹. | M. Ortiz A. Pandolfi 申胜平(译) 刘彬(译) 胡更开(校) | 2008 | 力学进展2008，38，5： | 2 |
| 15 | Numerical Instabilities in Upwind Methods: Analysis and Cures for the “Carbuncle” Phenomenon显示文摘 | Maurizio Pandolfi Domenic D’Ambrosio | 2001 | Journal of Computational Physics2001，，2： | 1 |
| 16 | MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling显示文摘 | Su Jung Song Laura Poliseno Min Sup Song Ugo Ala Kaitlyn Webster Christopher Ng Gary Beringer Nicolai J. Brikbak Xin Yuan Lewis C. Cantley Andrea L. Richardson Pier Paolo Pandolfi | 2013 | Cell2013，，： | 1 |
| 17 | The multiple roles of PTEN in tumor suppression显示文摘 | Di Cristofano A Pandolfi PP | 2000 | Cell2000，387，： | 1 |
| 18 | The multiple roles of PTEN in tumor suppression显示文摘 | Di Cristofano A Pandolfi PP | 2000 | Cell2000，100，： | 1 |
| 19 | Analysis of the molecular genetics of acute promyelocytic leukemia in mouse models 显示文摘 | Rego EM Pandolfi PP | 2001 | Semin Hematol2001，38，： | 1 |
| 20 | Plasminogen activator inhibitor type 1 is increased in the arterial wall of type II diabetic subjects 显示文摘 | Pandolfi A Cetrullo D Polishuck R | 2001 | Arterioscler Thromb Vasc Biol2001，21，8： | 1 |
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