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| 1 | Helping the Consumers and Producers of Standards,Repositories and Policies to Enable FAIR Data显示文摘Thousands of community-developed(meta)data guidelines,models,ontologies,schemas and formats have been created and implemented by several thousand data repositories and knowledge-bases,across all disciplines.These resources are necessary to meet government,funder and publisher expectations of greater transparency and access to and preservation of data related to research publications.This obligates researchers to ensure their data is FAIR,share their data using the appropriate standards,store their data in sustainable and community-adopted repositories,and to conform to funder and publisher data policies.FAIR data sharing also plays a key role in enabling researchers to evaluate,re-analyse and reproduce each other’s work.We can map the landscape of relationships between community-adopted standards and repositories,and the journal publisher and funder data policies that recommend their use.In this paper,we show how the work of the GO-FAIR FAIR Standards,Repositories and Policies(StRePo)Implementation Network serves as a central integration and cross-fertilisation point for the reuse of FAIR standards,repositories and data policies in general.Pivotal to this effort,the FAIRsharing,an endorsed flagship resource of the Research Data Alliance that maps the landscape of relationships between community-adopted standards and repositories,and the journal publisher and funder data policies that recommend their use.Lastly,we highlight a number of activities around FAIR tools,services and educational efforts to raise awareness and encourage participation. | Peter McQuilton Dominique Batista Oya Beyan Ramon Granell Simon Coles Massimiliano Izzo Allyson L.Lister Robert Pergl Philippe Rocca-Serra Ben Schaap Hugh Shanahan Milo Thurston Susanna-Assunta Sansone | 2020 | Data Intelligence2020，2，1： | 5 |
| 2 | Clinical laboratory and imaging evidence for effectiveness of agarose-agarose macrobeads containing stem-like cells derived from a mouse renal adenocarcinoma cell population (RMBs) in treatment-resistant, advanced metastatic colorectal cancer:Evaluation of显示文摘Objective: The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merited. Testing this hypothesis, the tumor marker, metabolic activity, and overall survival(OS) responses, to the use of one such system, implantable macrobeads [RENCA macrobeads(RMBs)], in phase I and IIa clinical trials in advanced,treatment-resistant metastatic colorectal cancer(m CRC) are described here.Methods: Forty-eight m CRC patients(30 females; 18 males), who had failed all available, approved treatments,underwent RMB implantation(8 RMB/kg body weight) up to 4 times in phase I and phase IIa open-label trials.Physicals, labs [tumor and inflammation markers, lactate dehydrogenase(LDH)] and positron emission tomography-computed tomography(PET-CT) imaging to measure number/volume and metabolic activity of the tumors were performed pre-and 3-month-post-implantation to evaluate safety and initial efficacy(as defined by biological responses). PET-CT maximum standard uptake value(SUVmax)(baseline and d 90; SUVmax ≥2.5), LDH,and carcinoembryonic antigen(CEA) and/or cancer antigen 19-9(CA 19-9) response(baseline, d 30 and/or d 60)were assessed and compared to OS.Results: Responses after implantation were characterized by an at least 20% decrease in CEA and/or CA 19-9 in75% of patients. Fluorodeoxyglucose(FDG)-positive lesions(phase I, 39; 2 a, 82) were detected in 37/48 evaluable patients, with 35% stable volume and stable or decreased SUV(10) plus four with necrosis; 10, increased tumor volume, SUV. LDH levels remained stable and low in Responders(R)(d 0–60, 290.4–333.9), but increased steadily in Non-responders(NR)(d 0–60, 382.8–1,278.5)(d 60, P=0.050). Responders to RMBs, indicated by the changes in the above markers, correlated with OS(R mean OS=10.76 months; NR mean OS=4.9 months; P=0.0006).Conclusions: The correlations of the tumor marker, tumor volume and SUV changes on PET-CT, and LDH levels themselves, and with OS, support the concept of a biological response to RMB implantation and the validity of the biological-systems approach to m CRC. A phase III clinical trial is planned. | Barry H.Smith Lawrence S.Gazda Thomas J.Fahey Angelica Nazarian Melissa A.Laramore Prithy Martis Zoe P.Andrada Joanne Thomas Tapan Parikh Sudipta Sureshbabu Nathaniel Berman Allyson J.Ocean Richard D.Hall David J.Wolf | 2018 | Chinese Journal of Cancer Research2018，30，1： | 2 |
| 3 | PFI is bad for your health 显示文摘 | ALLYSON P | 2000 | Journal of Public Finance2000，，2： | 1 |
| 4 | Dopamine D2 Receptor Antagonism Suppresses Tau Aggregation and Neurotoxicity 显示文摘 | Allyson V McCormick | 2013 | Biolpsychiatry2013，28，73： | 1 |
| 5 | Synthesis and evalu- ation of heparin immobilized 'side-on' to polystyrene micro- spheres coated with end-group activated polyethylene oxide 显示文摘 | PRANAV J KARL F S ALLYSON F | 2010 | International Journal of Biological Macromolecules2010，47，： | 1 |
| 6 | Ethanol via biomass-generated syngas 显示文摘 | Lewis R S Frankman R S Allyson T | 2008 | International Sugar Jour- nal2008，110，1311： | 1 |
| 7 | Biomechanical evaluation of surgical constructs for stabilization of cervical teardrop fractures显示文摘 | Allyson Ianuzzi Isidoro Zambrano Jigar Tataria Azeema Ameerally Marc Agulnick Jesse S. Little Goodwin Mark Stephen Partap S. Khalsa | 2006 | The Spine Journal2006，，5： | 1 |
| 8 | Best practices for elderly hip fracture patients显示文摘 | Lauren A. Beaupre C. Allyson Jones L. Duncan Saunders D. William C. Johnston Jeanette Buckingham Sumit R. Majumdar | 2005 | Journal of General Internal Medicine2005，，： | 1 |
| 9 | Correction of the Mutation Responsible for Sickle Cell Anemia by an RNA DNAOligonucleotide显示文摘 | Kyonggeun Yoon Yufei Xiang | 1996 | Science1996，273，： | 1 |
| 10 | Spinal cord injury and neural repair:focus on neuroregenerative approaches for spinal cord injury显示文摘 | Drug C Baptiste Allyson Tighe Michael G Fehlings | | 0，，05： | 1 |
| 11 | Assessing surveillance using sensitivity, specificity and timeliness 显示文摘 | Ken PK Allyson MA | 2006 | Stat Methods Med Res2006，15，： | 1 |
| 12 | Ni-olivine Catalysts Prepared by Thermal Impregnation:Structure,Steam Reforming Activity,and Stability显示文摘 | Kuhn J N Zhao Z K Allyson S N | | 0，，： | 1 |
| 13 | Cytomegaloviral enterocolitis显示文摘 | Dr. Howard S. Kaufman M.D. Allyson C. Kahn M.S. Christine Iacobuzio-Donahue M.D. Ph.D. Mark A. Talamini M.D. Keith D. Lillemoe M.D. Stanley R. Hamilton M.D | 1999 | Diseases of the Colon & Rectum1999，，1： | 1 |
| 14 | SJES14110700184569显示文摘 | Di?go P. Bezerra Francisco W.M. da Silva Pedro A.S. de Moura Allyson G.S. Sousa Rodrigo S. Vieira Enrique Rodriguez-Castellon Diana C.S. Azevedo | 2014 | Applied Surface Science2014，，： | 1 |
| 15 | Characterization and surface treatment effects on topography of a glass-infiltrated alumina/zirconia-reinforced ceramic显示文摘 | Alvaro Della Bona Tiago A. Donassollo Flávio F. Demarco Allyson A. Barrett John J. Mecholsky | 2006 | Dental Materials2006，，6： | 1 |
| 16 | Absent voices compromise the effectiveness of nursing home regulation:A critique of regulatory reform in the UK nursing home industry显示文摘 | Susan H Kerrison M Allyson M | | 0，，06： | 1 |
| 17 | Cyanoacrylate as a microbial sealant: Examining the evidence显示文摘 | Allyson Lipp Cheryl Phillips Paul Harris | 2011 | The Journal of Perioperative Practice2011，21，1： | 1 |
| 18 | The association between chronic disease and physical disability among female Medicaid beneficiaries 18–64 years of age显示文摘 | Amal J. Khoury Allyson Hall Elena Andresen Jianyi Zhang Rachel Ward Chad Jarjoura | 2012 | Disability and Health Journal2012，，： | 1 |
| 19 | Chronic disease self-management for individuals with stroke, multiple sclerosis and spinal cord injury显示文摘 | Robert C. Hirsche Beverly Williams Allyson Jones Patricia Manns | 2011 | 2011 (13-1)2011，，13： | 1 |
| 20 | Influence of tab and disk design on shade matching of dental porcelain 显示文摘 | Allyson AB Nicholoas JG Denneth JA | 2002 | J Prosthet Dent2002，88，6： | 1 |
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