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| 1 | 2015年全国细菌耐药监测报告显示文摘为贯彻落实《抗菌药物临床应用指导原则》,加强医疗机构抗菌药物临床应用的监督和管理,国家卫生计生委合理用药专家委员会和全国细菌耐药监测网日前发布了《2015年全国细菌耐药监测报告》,现予全文刊登,以促进合理用药,提高抗菌药物临床应用水平。 | Committee of Experts on Rational Drug Use, National Health and Family Planning Commission of the P.R.China | 2016 | 中国执业药师2016，0，3： | 206 |
| 2 | 临床研究协调员(CRC)行业指南(试行)显示文摘随着中国药物临床研究事业的发展,临床研究协调员(CRC)作为新兴的行业,扮演着越来越重要的角色。目前国内尚无统一的行业管理标准与指南,严重影响了CRC行业的健康发展。基于此,中关村玖泰药物临床试验技术创新联盟/中国药物临床试验机构联盟起草制定了《临床研究协调员行业管理指南》,从CRC职业基本要求、培训、等级评估、工作要求、监督管理等方面规范了行业行为。 | Zhongguancun Jiutai Drug Clinical Trial Technology Innovation Association/Chinese GCP Association,China | 2015 | 药物评价研究2015，38，3： | 42 |
| 3 | 统一认识 正确定位 加速临床药师制的建立——临床药师培训试点基地工作调研报告显示文摘从试点基地及专业培训分布情况、学员基本情况、培训组织工作、试点基地的培训管理制度、培训师资情况、专业培训方向设计、培训计划的制定、带教模式、临床药师在职培训工作的定位等方面介绍了第一批临床药师培训试点工作基本情况,指出必须坚持《卫生部临床药师培训试点方案》的基本原则,坚持招收学员的标准,调整专科化临床药师的培训方向,制订《专科临床药师培训标准》,强化培训计划的制定与实施,加强培训的带教工作,规范培训用技术性文件,加强法律法规教育。 | Drug Management Committee, Clinical Pharmacist Training Committee of Chinese Hospital Association Drug Management Committee, Clinical Pharmacist Training Committee of Chinese Hospital Association, No, 2, South Xizhimen Street, Beijing, 100044, PRC | 2007 | 中国医院2007，11，1： | 21 |
| 4 | Metabonomic phenotype and identification of “heart blood stasis obstruction pattern” and “qi and yin deficiency pattern” of myocardial ischemia rat models显示文摘The traditional Chinese medicine concepts of 'Xinxueyuzuzheng (heart blood stasis obstruction pattern)' and 'Qiyinliangxuzheng (qi and yin deficiency pattern)' for myocardial ischemia rat models were constructed in the present study. Endogenous metabolites in rat plasma were analyzed using the GC/TOF-MS-based metabonomic method. Significant metabolic differences were observed between the control and two model groups, and the three groups were distinguished clearly by pattern recognition. Compared with those of the control, the levels of hydroxyproline, threonic acid, glutamine and citric acid were strikingly up or down-regulated in model rats. The metabolites contributing most to the classification between the two 'pattern' rats were identified, such as valine, serine, threonine, ornithine, hydroxyproline, lysine, 2-hydroxybutanoic acid, 3-hydroxybutanoic acid, galactofuranose and inositol. These compounds were indicated as the potential biomarkers. The results suggested that the two 'patterns' are involved in dysfunction in oxidative stress, energy metabolism and amino acid metabolism. These findings also provided the substantial foundation for exploring the scientific connotation of these two 'Zhengxing (pattern types)' of myocardial ischemia, and 'Bianzheng (pattern identification)'. | YAN Bei1, A JiYe1, HAO HaiPing1, WANG GuangJi1, ZHU XuanXuan2, 3, ZHA WeiBin1, LIU LinSheng1, GUAN EnZe3, ZHANG Ying1, GU ShengHua1, HUANG Qing1 & ZHENG YuanTing1 1Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China 2Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, China 3College of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China | 2009 | Science China(Life Sciences)2009，52，11： | 19 |
| 5 | 国内外药品GMP对比调研报告(一)显示文摘根据国家食品药品监督管理局部署,局药品安全监管司组织药品认证管理中心及有关单位和专家,翻译查阅了世界卫生组织(WHO)、美国食品药品管理局(US-FDA)、欧盟(EU)、日本(JAP)、人用药品注册技术要求国际协调会(ICH)、药品检查条约/合作计划组织(PIC/S)等国家和组织的药品GMP管理法规及相关资料,以我国药品GMP为背景,在管理体系和药品GMP具体内容上进行了对比调研。对比调研过程中,座谈听取了国内药品生产企业和有关专家关于实施药品GMP、接受国外药品GMP认证检查的经验和体会。从而使对比调研工作获得了较全面、系统和有价值的资料。由于整个对比调研工作只限于翻译查阅资料及座谈研讨,缺乏对国外药品GMP管理和认证检查的实地考察,以及搜索信息量所限,可能存在不确之处;报告中所提建议也未经论证和征求有关方面的意见,不妥之处,敬请谅解。 | State Food And Drug Administration Center For Certification Of Drug(Beijing 100061) | 2008 | 中国药事2008，22，10： | 19 |
| 6 | Effect of areca on contraction of colonic muscle strips in rats显示文摘AIM: To investigate the effects of areca on the contractileactivity of isolated colonic muscle strips in rats andmechanism involved.METHODS: Each strip (LMPC, longitudinal muscle ofproximal colon; CMPC, circular muscle of proximal colon;LMDC, longitudinal muscle of distal colon; CMlC, circularmuscle of distal colon. ) was suspended in a tissue chambercontaining 5 mL Krebs solution (37 ℃), bubbledcontinuously with 950 mL@ L-1 O2 and 50 mL@ L-1 CO2 . Themean contractile amplitude (A), the resting tension (T),and the contractile frequency (F) were simultaneouslyrecorded on recorders.RESULTS: Arsca dose dependently increased the meancontractile amplitude, the resting tension of proximal anddistal colonic smooth muscle strips in rats ( P < 0.05). Italso partly increased the contractile frequency of colonicsmooth muscle strips in rats ( P < 0.05). The effects werepartly inhibited by atropine (the resting tension of LMPCdecreased from 0. 44 ± 0. 12 to 0. 17 ± 0.03; the restingtension of LMDC decreased from 0.71 ± 0.14 to 0.03 ± 0.01;the mean contractile amplitude of LMPC increased from -45.8 ± 7.2 to -30.5 ± 2.9; the motility index of CMDC decreasedfrom 86.6± 17.3 to 32.8 ± 9.3; P< 0.05 vs areca), but theeffects were not inhibited by hexamethonium (P> 0.05).CONCLUSION: Areca stimulated the motility of isolatedcolonic smooth muscle strips in rats. The stimulation ofareca might be relevant with M reoeptor partly. | Dong-Ping Xie Lian-Bi Chen,Department of Physiology,Medical College,Shandong University,Jinan 250012,Shandong Province,China Wei Li Song-Yi Qu Tian-Zhen Zheng,Department of Physiology,Lanzhou Medical College,Lanzhou 730000,Gansu Province,China Ying-Li Yang,Northwest Normal University,Lanzhou 730070,Gansu Province,China Yong-Hui Ding Yu-Ling Wei,Drug Control Institute of Gansu Province,Lanzhou 730000,Gansu Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 18 |
| 7 | New Collection of Crude Drugs in Chinese Pharmacopoeia 2010 Ⅰ.Callicarpa Linn. and Related Items显示文摘Callicarpa Linn. (beautyberry) is one of the major genera in Verbenaceae, about 20 of which are medicinal plants. Beautyberry, called Zizhu in China, is a generic name of those species and largely used as hemostatic medicine. The Chinese Pharmacopoeia 2010 has admitted three new crude drugs from the genus of Callicarpa Linn. including Callicarpae Macrophyllae Folium, Callicarpae Caulis et Folium, and Callicarpae Formosanae Folium for the first time since the 1977 version of the Chinese Pharmacopoeia. In order to better understand these new crude drugs, we systematically described their bibliography, admission reasons, botanical identification, chemistry, and pharmacology. Several other species, out of national regulations but intensively studied and widely used, are also covered in this review. | DAN Yang1, QIAN Zhong-zhi2, LIU Yan-ze1, ZHOU Guo-ping3, PENG Yong1, XIAO Pei-gen1 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Beijing 100193, China 2. China Pharmacopoeia Committee, Beijing 100061, China 3. Jiangxi Provincial Institute for Food and Drug Control, Nanchang 330046, China | 2010 | Chinese Herbal Medicines2010，2，4： | 18 |
| 8 | Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10A^(CE)显示文摘ERα36,a variant of estrogen receptor-α,acts as a dominant-negative factor in both estrogen-dependent and estrogen-independent transactivation signaling pathways,and is a key factor in the promotion,progression and prognosis of breast cancers.Caveolin-1,a 22-to 24-kD integral membrane protein,may function as a tumor suppressor in inhibiting of many growth-promoting signaling pathways.It was shown that downregulation of Caveolin-1 strengthens the interaction of ERα and Caveolin-1.In conclusion,Caveolin-1 gene silencing activated the PI3K/AKT signaling pathway in an ERα36-dependent way.Our finding may provide a promising therapeutic target of breast cancer. | FENG Shuang1,WANG Yang1,WANG Xi1,WANG ZhaoYi3,CUI YuYing1,LIU Jing4,ZHAO ChunHui1,JIN Mei1,2 & ZOU Wei1,2 1 College of Life Science,Liaoning Normal University,Dalian 116029,China 2 Liaoning Key Laboratory of Biotechnology and Molecular Drug R&D,Dalian 116029,China 3 Cancer Center,Creighton University,2500 California Plaza,Omaha,NE 68178,USA 4 First Clinical Hospital of Dalian Medical University,Dalian 116011,China | 2010 | Science China(Life Sciences)2010，53，5： | 16 |
| 9 | Effects of Astragaloside Ⅳ Derivative on Heart Failure in Rats显示文摘Objective Astragaloside Ⅳ derivative(ASId) is one of Astragaloside Ⅳ(ASI) derivatives with higher water-solubility and may have more druggability than ASI.The present study aims at observing the effects of ASId on cardiovascular parameters in chronic heart failure in rats.Methods Using echocardiographic and haemodynamic measurements,the effects of ASId on congestive heart failure(CHF) induced by ligation of the left coronary artery in rats were investigated.Results ASId iv 0.5,1.0,and 2.0 mg/(kg·d) attenuated the decline of ejection fraction.The peak derivatives of the left ventricle(LV) pressure(dp/dt) in ASId treated groups were significantly increased.Both LV volumes in diastole and in systole were decreased significantly after ASId treatment,accompanied with a trend towards normalization of relative wall thickness at end-systole.ASId 0.5,1.0,and 2.0 mg/(kg·d) attenuated the increase of LV systolic and diastolic wall stress.ASId treatment also inhibited compensatory hypertrophy of depressed heart.Conclusion ASId could improve cardiac functions and inhibite compensatory hypertrophy and LV remodelling,which suggests the possibility of ASId as a new therapeutic drug for the treatment of CHF. | WANG Wei-ting1,ZHAO Zhuan-you1,HAN Ying-mei2,XU Wei-ren2,TANG Li-da1 1.State Key Laboratory of Pharmacokinetics and Pharmacodynamics,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China 2.Tianjin Key Laboratory of Molecular Design & Drug Discovery,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China | 2010 | Chinese Herbal Medicines2010，2，1： | 13 |
| 10 | Fingerprinting Analysis of Four Variants of Chrysanthemi Morifoli Flos by RP-HPLC显示文摘Objective To establish a RP-HPLC fingerprinting analysis method for quality evaluation and control of the four variants of Chrysanthemi Morifoli Flos.Methods RP-HPLC was used to establish the fingerprinting method.Results Despite of the similarity in terms of holistic HPLC chromatograms,the four variants of Chrysanthemi Morifoli Flos exhibit characteristic fingerprints and can be readily recognized by similarity clusters.Conclusion A simple and reliable HPLC fingerprinting method has been developed and validated to authenticate the four variants of Chrysanthemi Morifoli Flos,providing a scientific basis for quality control of Chrysanthemi Morifoli Flos. | SHEN Zhi1,ZHANG Wen-ting2,HUA Yun-fei1,ZHAO Wei-liang2 1.College of Pharmacy,Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China 2.Zhejiang Institute for Food and Drug Control,Hangzhou 310004,China | 2010 | Chinese Herbal Medicines2010，2，2： | 12 |
| 11 | Development of a complex scintillation proximity assay for highthroughput screening of PPAR7 modulators显示文摘Aim: To develop a complex high-throughput screening (HTS) assay based on scintillation proximity assay (SPA) technology for identification of novel peroxisome proliferator-activated receptor gamma (PPARγ) modulators. Methods: Fulllength PPARγand retinoid X receptor alpha (RXRα), biotinylated PPAR response element (PPRE), [^3H]BRL49653 and streptavidin-coated FlashPlate or microbead were used to develop an HTS assay based on SPA technology. This ‘ABCDE' method was validated against conventional hydroxyapatite (HA) assay and applied to large-scale screening of 16 000 synthetic compounds and natural product extracts. Results: (1) IC50 values of positive control compounds (BRL49653 and troglitazone) obtained from the ‘ABCDE' method and HA assay were comparable and consistent with those reported elsewhere; (2) Approximately 178 compounds, showing more than 70% competitive inhibition on BRL49653 binding to PPARγ, were identified initially by the ‘ABCDE' method (microbead); (3) Secondary screening using FlashPlate and cross-reactivity studies with RARα, β,γand RXRα,β,γconfirmed that 12 compounds possessed specific PPARγbinding properties including 2 with IC50 values less than 0.5μmol/L and novel chemical structures. Conclusions: The ‘ABCDE' method using either FlashPlate or microbead, is a highly efficient, automatable, and robust tool to screen potential PPARγmodulators in HTS setting. Its application may be expanded to other nuclear receptors that form heterodimers upon activation. | Bin WU Jie GAO Ming-wei WANG~2 The National Center for Drug Screening,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences Graduate School of Chinese Academy of Sciences,Shanghai 201203,China | 2005 | Acta Pharmacologica Sinica2005，26，3： | 12 |
| 12 | Isolation and Purification of Isoaloeresin D and Aloin from Aloe vera by High-speed Counter-current Chromatography显示文摘Objective To develop an efficient method to isolate and purify the main components isoaloeresin D and aloin from Aloe vera for its industrial production.Methods High-speed counter-current chromatography was used to isolate isoaloeresin D and aloin in a one-step separation from dried crude extract of A.vera.The biphasic solvent system composed of hexane-ethyl acetate-acetone-water(0.2:5:1.5:5) was used at a flow rate of 1.0 mL/min,while the lipophilic phase was selected as the mobile phase and the apparatus was rotated at 840 r/min.The effluent was detected at 254 nm.Results Isoaloeresin D(53.1 mg) and aloin(106.9 mg) were separated from the crude extract(384.7 mg) with the purities of 98.6% and 99.5%,respectively.Conclusion HSCCC is a powerful technique for isolation and separation of chemical composition from aloe. | WAN Jin-zhi1,CHEN Xin-xia1,QIU Chun-mei1,LIN Xiang-cheng2 1.Laboratory for Pharmaceutical Analysis and Quality Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China 2.Institute of Fine Chemicals and Synthetic Drugs,Sun Yat-sen University,Guangzhou 510006,China | 2010 | Chinese Herbal Medicines2010，2，2： | 12 |
| 13 | Ginsenoside-Rg_6, a Novel Triterpenoid Saponin from the Stem-Leaves of Panax ginseng C. A. Mey.显示文摘A novel dammarane-type triterpene oligoglycoside, named ginsenoside-Rg6 3, was isolated from the stem-leaves of Panax ginseng C. A. Mey., together with two known ones, 20(S)-ginsenoside-Rg2 1 and 20(R)-ginsenoside-Rg2 2. On the basis of chemical and physicochemical evidence , the structure of ginsenoside-Rg6 have been elucidated as 6-O-(-L-rhamnosyl-(1?2)-(-D-glucopyranosyl-dammarane-(E)-20(22), 24-diene-3(, 6(, 12(-triol. | Xiu Wei YANG, Long Yun LI, Jian Ming TIAN, Zhi Wei ZHANG, Jin Mei YE, Wei Fang Gu (National Research Laboratory of Natural & Biomimetic Drugs, Peking University, Beijing 100083) (Academy of Chinese Traditional Medicine and Materia Medica of Jilin Provinc | 2000 | Chinese Chemical Letters2000，11，10： | 12 |
| 14 | FOXP3 expression and clinical characteristics of hepatocellular carcinoma显示文摘AIM: To study the biological and clinical characteristics of transcription factor forkhead box protein 3 (FOXP3) in hepatocellular carcinoma (HCC). METHODS: We analyzed the expression and localization of FOXP3 in HCC tissues and cell lines to evaluate its biological features. The relationship between FOXP3 staining and clinical risk factors of HCC was assessedto identify the clinical characteristics of FOXP3 in HCC. RESULTS: The mRNA and protein expression of FOXP3 were found in some hepatoma cell lines. Immunohistochemical (IHC) analysis of HCC sections revealed that 48% of HCC displayed FOXP3 staining, but we did not find any FOXP3 staining in normal liver tissues and para-tumor tissues. IHC and Confocal analysis showed that the expressions of FOXP3 were mainly present in the nucleus and cytoplasm of tumor cells in tissues or cell lines. In HCC, the distribution of FOXP3 was similar to that of the cirrhosis, but not to the hepatitis B virus. Those findings implicate that FOXP3 staining seems to be associated with the high risk of HCC. CONCLUSION: The clinical characteristics of FOXP3 in HCC warrants further studies to explore its functions and roles in the cirrhosis and development of HCC. | Wei-Hua Wang, Jun-Zhi Wang, National Center for Safety Evaluation of Drugs, National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China Wei-Hua Wang, Chang-Li Jiang, Cun Zhang, Bo Yan, Wei Zhang, Wei Han, Ying-Qi Zhang, Biotechnology Center, School of Pharmacy, the Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China Wei-Hua Wang, Chang-Li Jiang, Cun Zhang, Bo Yan, Wei Zhang, Wei Han, Ying-Qi Zhang, State Key Laboratory of Cancer Biology, Xi’an 710032, Shaanxi Province, China Wei Yan, Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China Yu-Hai Zhang, Department of Health Statistics, The Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China Jiang-Tao Yang, Department of Pathology, Xi’an Gaoxin Hospital, Xi’an 710032, Shaanxi Province, China | 2010 | World Journal of Gastroenterology2010，16，43： | 10 |
| 15 | 国外合理用药概述显示文摘本文收集检索了关于国外药物使用与合理用药的概况,并对合理使用药物的重要性和迫切性进行了阐述。对国外促进合理用药的重要措施进行了归纳和分析,目的是为提高我国药物合理使用水平提供参考和思路。 | The Office of Chinese Monitoring System for Rational Use of Drugs (The Office of Chinese Monitoring System for Rational Use of Drugs,Beijing 100027,China) | 2011 | 中国执业药师2011，8，2： | 10 |
| 16 | Studies on Absorption and Tansport of Limoninoids from Fructus Evodiae in Caco-2 Cell Monolayer Model显示文摘Objective To study the intestinal absorption and transepithelial transport of three limoninoids: evodol (EVO), limonin (LIM), and shihulimonin A (SHIA), isolated from Fructus Evodiae [the unripe fruit of Evodia rutaecarpa and Evodia rutaecarpa var. bodinieri] in the human intestine. Methods The in vitro cultured human colon carcinoma cell line, Caco-2 cell monolayer model, was applied to studying the absorption and transepithelial transport of the three limoninoids from apical (AP) to basolateral (BL) side and from BL to AP side. The three limoninoids were measured by reversed-phase high performance liquid chromatography coupled with ultraviolet absorption detector. Transport parameters and apparent permeability coefficients (Papp) were then calculated and compared with those of Propranolol as a control substance of high permeability and Atenolol as a control substance of poor permeability. Results The Papp value of EVO and LIM from AP to BL side for absorption and transport were 1.78 × 10-5 cm/s and 1.16 × 10-5 cm/s, respectively, which was comparable to that of Propranolol with Papp 2.18 × 10-5 cm/s. Conclusion The absorption and transport of both EVO and LIM are main passive diffusion as the dominating process in Caco-2 cell monolayer model, and they were estimated to be high absorbed compounds. SHIA in Caco-2 cell monolayer model may be involved in metabolism in the transport processes. | YANG Xiu-wei1*, TENG Jie1, ZHAO Bo2, ZHANG Lian-xue2 1. State Key Laboratory of Natural and Biomimetic Drugs (Peking University), School of Pharmaceutical Sciences, Peking University, Beijing 100191, China 2. College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China | 2009 | Chinese Herbal Medicines2009，1，1： | 10 |
| 17 | Cloning of cytochrome P-450 2C9 cDNA from human liver and its expression in CHL cells显示文摘AIM: Using bacterial, yeast, or mammalian cell expressing a human drug metabolism enzyme would seem good way to study drug metabolism-related problems. Human cytochrome P-450 2C9 ( CYP2 C9) is a polymorphic enzyme responsible for the metabolism of a large number of clinically important drugs. It ranks among the most important drug metabolizing enzymes in humans. In order to provide a sufficient amount of the enzyme for drug metabolic research, the CYP2 C9 eDNA was cloned and expressed stably in CHL cellsMETHODS: After extraction of total RNA from human livertissue, the human CYP2C9 eDNA was amplified withreverse transcription-polymerase chain reaction (RT-PCR),and cloned into cloning vector pGEM-T. The cDNA fragmentwas identified by DNA sequencing and subcloned into amammalian expression vector pREP9. A transgenic cell linewas established by transfecting the recombinant vector ofpREP9-CYP2C9 into CHL cells. The enzyme activity ofCYP2C9 catalyzing oxidation of tolbutamide to hydroxytolbutamide in S9 fraction of the cell was determined by highperformance liquid chromatography(HPLC).RESULTS: The amino acid sequence predicted from theeDNA segment was identical to that of CYP2 C9 * 1, the wildtype CYP2 C9. However, there were two base differences, i.e. 21T > C, 1146C > T, but the encoding amino acidsequence was the same, L7, P382. The S9 fraction of theestablished cell line metabolizes tolbutamide to hydroxytolbutamide; tolbutamide hydroxylass activity was found to be0.465 ± 0.109 μmol@ min-1 . g1 S9 protein or 8.62 ± 2.02 mol@ min 1 ~mol-1 CYP, but was undetectable in parental CHL cell.CONCLUSION: The cDNA of human CYP2C9 was successfullycloned and a cell line of CHL- CYP2C9, efficiently expressingthe protein of CYP2C9, was established. | Ge-Jian Zhu Ying-Nian Yu,Department of Pathophysiology and Laboratory of Medical Molecular Biology,Zhejiang University School of Medicine,Hangzhou 310031,Zhejiang Province,China Xin Li,Department of pharmaceutical analysis & drug metabolism,College of Pharmacology Science,Zhejiang University,Hangzhou 310031,Zhejiang Province,China Yu-Li Qian, Present address:Center of laboratory,Women’s hospital,School of Medicine,Zhejiang University,Hangzhou 310031,Zhejiang Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 9 |
| 18 | 国内外药品GMP对比调研报告(二)显示文摘在回顾我国实施GMP的基本情况基础上,分析了国际药品GMP的现状与特点,为实现我国药品GMP与国际先进水平接轨提供参考。 | State Food and Drug Administration Center for Certification of Drug(Beijing 100061) | 2008 | 中国药事2008，22，11： | 9 |
| 19 | 国内外药品GMP对比调研报告(三)显示文摘在回顾了我国实施GMP的基本情况,分析了国际药品GMP的现状与特点的基础上,进一步研究对比我国与欧盟、WHO、美国GMP通则之间存在的具体差异,为实现我国药品GMP与国际先进水平接轨提供参考。 | State Food and Drug Administration Center for Certification of Drug(Beijing 100061) | 2008 | 中国药事2008，22，12： | 7 |
| 20 | 建立全国合理用药监测系统的重大意义与作用显示文摘公共卫生事业关系国计民生。合理用药保障人民生命健康,是医药卫生工作永恒的主题,也是一项艰巨而责任重大的任务。为加强医疗机构药物临床应用的管理,建立统一、规范的药物使用管理机制,推进临床合理用药,保障医疗质量和医疗安全,卫生部先后10次下发文件,部领导作了3次重要批示,组织构建了全国合理用药监测系统。本刊特开设由全国合理用药监测办公室主持的'合理用药监测'专栏,及时地总结和报告全国合理用药监测工作的进展与分析评估情况,为各级医疗机构和医药工作者提供合理用药的临床用药建议,为政府制定合理用药政策提供依据。相信通过这个专业交流平台,可以与广大医药工作者携手努力,提高疾病治疗水平,促进临床用药'安全、有效、经济、适宜'。 | The Office of Chinese Monitoring System for Rational Use of Drugs, Beijing 100027, China | 2011 | 中国执业药师2011，8，1： | 7 |
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