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| 1 | Giant cavernous liver hemangiomas: is it the time to change the size categories?显示文摘BACKGROUND: Four different sizes(4, 5, 8 and 10 cm in diameter) can be found in the literature to categorize a liver hemangioma as giant. The present review aims to clarify the appropriateness of the size category 'giant' for liver hemangioma.DATA SOURCES: We reviewed the reports on the categorization of hemangioma published between 1970 and 2014. The number of hemangiomas, size criteria, mean and range of hemangioma sizes, and number of asymptomatic and symptomatic patients were investigated in patients aged over 18 years. Liver hemangiomas were divided into four groups: <5.0 cm, 5.0-9.9 cm, 10.0-14.9 cm and ≥15.0 cm in diameter. Inclusion criteria were noted in 34 articles involving 1972(43.0%) hemangiomas(>4.0 cm).RESULTS: The patients were divided into the following groups: 154 patients(30.0%) with hemangiomas less than 5.0 cm in diameter(small), 182(35.5%) between 5.0 cm and 9.9 cm(large), 75(14.6%) between 10.0 and 14.9 cm(giant), and 102(19.9%) more than 15.0 cm(enormous). There were 786(39.9%) asymptomatic patients and 791(40.1%) symptomatic patients. Indications for surgery related to symptoms were reported in only 75(3.8%) patients. Operations including 137 non-anatomical resection(12.9%) and 469 enucleation(44.1%) were unclearly related to size and symptoms.CONCLUSIONS: The term 'giant' seems to be justified for liver hemangiomas with a diameter of 10 cm. Hemangiomas categorized as 'giant' are not indicated for surgery. Surgery should be performed only when other symptoms are apparent. | isidoro di carlo renol koshy saif al mudares annalisa ardiri gaetano bertino adriana toro | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，1： | 22 |
| 2 | Chronic hepatitis C:This and the new era of treatment显示文摘Over the last years it has started a real revolution in the treatment of chronic hepatitis C. This occurred for the availability of direct-acting antiviral agents that allow to reach sustained virologic response in approximately 90% of cases. In the near future further progress will be achieved with the use of pan-genotypic drugs with high efficacy but without side effects. | Gaetano Bertino Annalisa Ardiri Maria Proiti Giuseppe Rigano Evelise Frazzetto Shirin Demma MariaIrene Ruggeri Laura Scuderi Giulia Malaguarnera Nicoletta Bertino Venerando Rapisarda Isidoro Di Carlo Adriana Toro Federico Salomone Mariano Malaguarnera Emanuele Bertino Michele Malaguarnera | 2016 | World Journal of Hepatology2016，8，2： | 10 |
| 3 | Hepatocellular carcinoma and the risk of occupational exposure显示文摘Hepatocellular carcinoma(HCC)is the most common type of liver cancer.The main risk factors for HCC are alcoholism,hepatitis B virus,hepatitis C virus,nonalcoholic steatohepatitis,obesity,type 2 diabetes,cirrhosis,aflatoxin,hemochromatosis,Wilson’s disease and hemophilia.Occupational exposure to chemicals is another risk factor for HCC.Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent.This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. | Venerando Rapisarda Carla Loreto Michele Malaguarnera Annalisa Ardiri Maria Proiti Giuseppe Rigano Evelise Frazzetto Maria Irene Ruggeri Giulia Malaguarnera Nicoletta Bertino Mariano Malaguarnera Vito Emanuele Catania Isidoro Di Carlo Adriana Toro Emanuele Bertino Dario Mangano Gaetano Bertino | 2016 | World Journal of Hepatology2016，8，13： | 5 |
| 4 | Colorectal cancer and lymph nodes:The obsession with the number 12显示文摘Lymphadenectomy of colorectal cancer is a decisive factor for the prognostic and therapeutic staging of the patient.For over 15 years,we have asked ourselves if the minimum number of 12 examined lymph nodes(LNs)was sufficient for the prevention of understaging.The debate is certainly still open if we consider that a limit of 12 LNs is still not the gold standard mainly because the research methodology of the first studies has been criticized.Moreover many authors report that to date both in the United States and Europe the number'12'target is uncommon,not adequate,or accessible only in highly specialised centres.It should however be noted that both the pressing nature of the debate and the dissemination of guidelines have been responsible for a trend that has allowed for a general increase in the number of LNs examined.There are different variables that can affect the retrieval of LNs.Some,like the surgeon,the surgery,and the pathology exam,are without question modifiable;however,other both patient and disease-related variables are non-modifiable and pose the question of whether the minimum number of examined LNs must be individually assigned.The lymph nodal ratio,the sentinel LNs and the study of the biological aspects of the tumor could find valid application in this field in the near future. | Giovanni Li Destri Isidoro Di Carlo Roberto Scilletta Beniamino Scilletta Stefano Puleo | 2014 | World Journal of Gastroenterology2014，20，8： | 4 |
| 5 | Systemic therapies in hepatocellular carcinoma: present and future显示文摘 | Gaetano Bertino Isidoro Di Carlo Annalisa Ardiri Giuseppe Stefano Calvagno Shirin Demma Giulia Malaguarnera Nicoletta Bertino Mariano Malaguarnera Adriana Toro Michele Malaguarnera | 2013 | Future Oncol2013，，10： | 3 |
| 6 | Induced autophagy reduces virus output in dengue infected monocytic cells显示文摘 | Mingkwan Panyasrivanit Michael P. Greenwood David Murphy Ciro Isidoro Prasert Auewarakul Duncan R. Smith | 2011 | Virology2011，，1： | 2 |
| 7 | Evaluation of posttreatment response of hepatocellular carcinoma: comparison of ultrasonography with second-generation ultrasound contrast agent and multidetector CT显示文摘 | Giuseppe Salvaggio Antonella Campisi Vito Greco Isidoro Cannella Maria Franca Meloni Giuseppe Caruso | 2010 | Abdominal Imaging2010，，4： | 2 |
| 8 | Accumulation of Pb and Zn in Bidens triplinervia and Senecio sp. spontaneous species from mine spoils in Peru and their potential use in phytoremediation显示文摘 | Jaume Bech Paola Duran Núria Roca Wilfredo Poma Isidoro Sánchez Luis Roca-Pérez Rafael Boluda Juan Barceló Charlotte Poschenrieder | 2012 | Journal of Geochemical Exploration2012，，： | 2 |
| 9 | Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress显示文摘 | María C. Salgado Isidoro Metón Ida G. Anemaet Isabel V. Baanante | 2014 | BBA - Gene Regulatory Mechanisms2014，，4： | 1 |
| 10 | Evaluation of posttreatment response of hepatocellular carcinoma: comparison of ultrasonography with second-generation ultrasound contrast agent and multidetector CT显示文摘 | Giuseppe Salvaggio Antonella Campisi Vito Greco Isidoro Cannella Maria Franca Meloni Giuseppe Caruso | 2010 | Abdominal Imaging2010，，4： | 1 |
| 11 | Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer显示文摘 | Isidoro A Martinez M Femandez PL | 2004 | Biochem J2004，378，1： | 1 |
| 12 | Measuring efficiency and productivity in professional football teams: evidence from the English Premier League显示文摘 | Isidoro Guzmán Stephen Morrow | 2007 | Central European Journal of Operations Research2007，，4： | 1 |
| 13 | Measuring efficiency and productivity in professional football teams: evidence from the English Premier League显示文摘 | Isidoro Guzmán Stephen Morrow | 2007 | Central European Journal of Operations Research2007，，4： | 1 |
| 14 | 927T > C polymorphism of the cysteinyl - leukotriene type - 1 receptor (CYSLTR1) gene in children with asthma and atopic dermatitis显示文摘 | Arriba - Mendez S Sanz C Isidoro - Garcia M | 2006 | Pediatr Allergy Immunol2006，17，5： | 1 |
| 15 | Effect of size on performance of Spanish agricultural cooperatives显示文摘 | ARCAS N GARCíA D ISIDORO G | 2011 | Outlook on Agriculture2011，40，3： | 1 |
| 16 | Analysis of 927T >C CYSLTR1 and -444A > C LTC4S polymovphisms in children with asthma 显示文摘 | Arriba - M6ndez S Sanz C Isidoro - Garcia M | 2008 | AUergol Immunopathol (Madr)2008，36，5： | 1 |
| 17 | Altered intracelhdar processing and enhanced secrection of procathepsin D in a highly deviated rat hepatoma 显示文摘 | Isidoro C Demoz M | 1995 | Cancer1995，60，： | 1 |
| 18 | Biomechanical evaluation of surgical constructs for stabilization of cervical teardrop fractures显示文摘 | Allyson Ianuzzi Isidoro Zambrano Jigar Tataria Azeema Ameerally Marc Agulnick Jesse S. Little Goodwin Mark Stephen Partap S. Khalsa | 2006 | The Spine Journal2006，，5： | 1 |
| 19 | Stability and rheological behaviour of salad dressing obtained with whey and different combinations of stabilizers显示文摘 | DE C魣SSIA DA FONSECA V魦NIA HAMINIUK CHARLES WINDSON ISIDORO | 2009 | International Journal of Food Science and Technology2009，44，4： | 1 |
| 20 | Local Resection by Combined Laparoendoscopic Surgery for Duodenal Gastrointestinal Stromal Tumor显示文摘 | Motohiko Kato Kiyokazu Nakajima Toshirou Nishida Makoto Yamasaki Tsutomu Nishida Shusaku Tsutsui Hideharu Ogiyama Shunsuke Yamamoto Takuya Yamada Masaki Mori Yuichiro Doki Norio Hayashi Isidoro Di Carlo | 2011 | Diagnostic and Therapeutic Endoscopy2011，，： | 1 |
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