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| 1 | Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar cholangiocarcinoma.METHODS: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between 1995-2005.RESULTS: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology).CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings. | Andreas Weber Claus von Weyhern Falko Fend Jochen Schneider Bruno Neu Alexander Meining Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，7： | 17 |
| 2 | Argon Plasma Coagulation of Cervical Heterotopic Gastric Mucosa as an Alternative Treatment for Globus Sensations显示文摘 | Monther Bajbouj Valentin Becker Florian Eckel Stephan Miehlke Oliver Pech Christian Prinz Roland M. Schmid Alexander Meining | 2009 | Gastroenterology2009，，2： | 2 |
| 3 | Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors显示文摘 | Sarah Schwitalla Paul K. Ziegler David Horst Valentin Becker Irina Kerle Yvonne Begus-Nahrmann André Lechel K. Lenhard Rudolph Rupert Langer Julia Slotta-Huspenina Franz G. Bader Olivia Prazeres da Costa Markus F. Neurath Alexander Meining Thomas Kirchner | 2013 | Cancer Cell2013，，： | 2 |
| 4 | ERCP or EUS for tissue diagnosis of biliary strictures? a prospective comparative study显示文摘 | Thomas R?sch Kim Hofrichter Eckart Frimberger Alexander Meining Peter Born Norbert Weigert Hans-Dieter Allescher Meinhard Classen Marius Barbur Ulrich Schenck Martin Werner | 2004 | Gastrointestinal Endoscopy2004，，3： | 1 |
| 5 | A prospective comparison of the diagnostic accuracy of ERCP, MRCP, CT, and EUS in biliary strictures显示文摘 | Thomas R?sch Alexander Meining Silke Frühmorgen Christian Zillinger Volker Schusdziarra Karin Hellerhoff Meinhard Classen Hermann Helmberger | 2002 | Gastrointestinal Endoscopy2002，，7： | 1 |
| 6 | Long-term outcome of endoscopic and/or percutaneous transhepatic therapy in patients with biliary stricture after orthotopic liver transplantation显示文摘 | Andreas Weber Christian Prinz Carlos Gerngro? Leopold Ludwig Wolfgang Huber Bruno Neu Matthias P. Ebert Alexander Meining Hans Weidenbach Roland M. Schmid Ewert Schulte-Frohlinde | 2009 | Journal of Gastroenterology2009，，12： | 1 |
| 7 | Incidence, predictors, and outcomes of high-degree atrioventricular block complicating acute myocardial infarction treated with thrombolytic therapy显示文摘 | Meine TJ Al-Khatib SM Alexander JH | 2005 | Am Heart J2005，149，4： | 1 |
| 8 | Gastric carcinoma risk index in patients infected with Helicobacter pylori显示文摘 | Alexander Meining Ekkehard Bayerd?rffer Petra Müller Stephan Miehlke Norbert Lehn Dieter H?lzel Rudolf Hatz M. Stolte | 1998 | Virchows Archiv1998，，4： | 1 |
| 9 | Differing degree and distribution of gastritis in Helicobacter pylori-associated diseases显示文摘 | Alexander Meining M. Stolte Rudolf Hatz Norbert Lehn Stephan Miehlke Andrea Morgner Ekkehard Bayerd?rffer | 1997 | Virchows Archiv1997，，1： | 1 |
| 10 | Real-time increased detection of neoplastic tissue in Barrett’s esophagus with probe-based confocal laser endomicroscopy: final results of an international multicenter, prospective, randomized, controlled trial显示文摘 | Prateek Sharma Alexander R. Meining Emmanuel Coron Charles J. Lightdale Herbert C. Wolfsen Ajay Bansal Monther Bajbouj Jean-Paul Galmiche Julian A. Abrams Amit Rastogi Neil Gupta Joel E. Michalek Gregory Y. Lauwers Michael B. Wallace | 2011 | Gastrointestinal Endoscopy2011，，3： | 1 |
| 11 | Positive predictors for gastroesophageal reflux disease and the therapeutic response to proton-pump inhibitors显示文摘AIM:To identify objective and subjective predictors for the reliable diagnosis of gastroesophageal reflux disease(GERD)and the response to proton pump inhibitor(PPI)therapy.METHODS:Retrospectively,683 consecutive patients suspected for GERD who underwent pH-metry/impedance measurement(pH/MII)were analyzed.All patients had previously undergone standard PPI treatment(e.g.,pantoprazole 40 mg/d or comparable).Four hundred sixty patients were at least 10 d off PPIs(group A),whereas 223 patients were analyzed during their ongoing PPI therapy(group B).In addition,all patients completed a standardized symptom-and lifestyle-based questionnaire,including the therapeutic response to previous PPI trials on a 10-point scale.Uniand multivariance analyses were performed to identify criteria associated with positive therapeutic response to PPIs.RESULTS:In group A,positive predictors(PPs)for response in empirical PPI trials were typical GERD symptoms(heartburn and regurgitation),a positive symptom index(SI)and pathological results in pH/MII,along with atypical symptoms,including hoarseness and fullness.In group B,regular alcohol consumption was associated with the therapeutic response.The PPs for pathological results in pH/MII in group A included positive SI,male gender,obesity,heartburn and regurgitation.In group B,the PPs were positive SI and vomiting.Analyzing for positive SI,the PPs were pathological pH and/or MII,heartburn regurgitation,fullness,nausea and vomiting in group A and pathological pH and/or MII in group B.CONCLUSION:Anamnestic parameters(gender,obesity,alcohol)can predict PPI responses.In non-obese,female patients with non-typical reflux symptoms,pH/MII should be considered instead of empirical PPIs. | Valentin Becker Stefan Grotz Christoph Schlag Simon Nennstiel Analena Beitz Bernhard Haller Roland M Schmid Alexander Meining Monther Bajbouj | 2014 | World Journal of Gastroenterology2014，20，14： | 1 |
| 12 | Direct visualization of indeterminate pancreaticobiliary strictures with probe-based confocal laser endomicroscopy: a multicenter experience显示文摘 | Alexander Meining Yang K. Chen Douglas Pleskow Peter Stevens Raj J. Shah Ram Chuttani Joel Michalek Adam Slivka | 2011 | Gastrointestinal Endoscopy2011，，5： | 1 |
| 13 | Detection of Cholangiocarcinoma In Vivo Using Miniprobe-Based Confocal Fluorescence Microscopy显示文摘 | Alexander Meining Eckart Frimberger Valentin Becker Stefan Von Delius Claus Hann Von Weyhern Roland M. Schmid Christian Prinz | 2008 | Clinical Gastroenterology and Hepatology2008，，9： | 1 |
| 14 | Endoscopic stent therapy in patients with chronic pancreatitis:A 5-year follow-up study显示文摘AIM:This study analyzed clinical long-term outcomes after endoscopic therapy,including the incidence and treatment of relapse. METHODS:This study included 19 consecutive patients(12 male,7 female,median age 54 years)with obstructive chronic pancreatitis who were admitted to the 2nd Medical Department of the Technical University of Munich.All patients presented severe chronic pancreatitis(stageⅢ°)according to the Cambridge classification.The majority of the patients suffered intermittent pain attacks.6 of 19 patients had strictures of the pancreatic duct;13 of 19 patients had strictures and stones.The first endoscopic retrograde pancreatography(ERP)included an endoscopic sphincterotomy, dilatation of the pancreatic duct,and stent placement.The first control ERP was performed 4 wk after the initial intervention,and the subsequent control ERP was performed after 3 mo to re-evaluate the clinical and morphological conditions.Clinical follow-up was performed annually to document the course of pain and the management of relapse.The course of pain was assessed by a pain scale from 0 to 10.The date and choice of the therapeutic procedure were documented in case of relapse. RESULTS:Initial endoscopic intervention was successfully completed in 17 of 19 patients.All 17 patients reported partial or complete pain relief after endoscopic intervention.Endoscopic therapy failed in 2 patients. Both patients were excluded from further analysis.One failed patient underwent surgery,and the other patient was treated conservatively with pain medication.Seventeen of 19 patients were followed after the successful completion of endoscopic stent therapy.Three of 17 patients were lost to follow-up.One patient was not avail-able for interviews after the 1st year of follow-up.Two patients died during the 3rd year of follow-up.In both patients chronic pancreatitis was excluded as the cause of death.One patient died of myocardial infarction, and one patient succumbed to pneumonia.All three patients were excluded from follow-up analysis.Followup was successfully completed in 14 of 17 patients.4 patients at time point 3,2 patients at time point 4,3 patients at time point 5 and 2 patients at time point 6 and time point 7 used continuous pain medication after endoscopic therapy.No relapse occurred in 57%(8/14) of patients.All 8 patients exhibited significantly reduced or no pain complaints during the 5-year follow-up.Seven of 8 patients were completely pain free 5 years after endoscopic therapy.Only 1 patient reported continuous moderate pain.In contrast,7 relapses occurred in 6 of the 14 patients.Two relapses were observed during the 1st year,2 relapses occurred during the 2nd year,one relapse was observed during the 3rd year,one relapse occurred during the 4th year,and one relapse occurred during the 5th follow-up year.Four of these six patients received conservative treatment with endoscopic therapy or analgesics.Relapse was conservatively treated using repeated stent therapy in 2 patients.Analgesic treatment was successful in the other 2 patients. CONCLUSION:57%of patients exhibited long-term benefits after endoscopic therapy.Therefore,endoscopic therapy should be the treatment of choice in patients being inoperable or refusing surgical treatment. | Andreas Weber Jochen Schneider Bruno Neu Alexander Meining Peter Born Stefan von Delius Monther Bajbouj Roland M Schmid Hana Algül Christian Prinz | 2013 | World Journal of Gastroenterology2013，19，5： | 1 |
| 15 | Cardiac resynchronisation therapy optimisation strategies: Systematic classification, detailed analysis, minimum standards and a roadmap for development and testing显示文摘 | S.M. Afzal Sohaib Zachary I. Whinnett Kenneth A. Ellenbogen Christoph Stellbrink T. Alexander Quinn Margot D. Bogaard Pierre Bordachar Berry M. van Gelder Irene E. van Geldorp Cecilia Linde Mathias Meine Frits W. Prinzen Robert G. Turcott Henry M. Spotnit | 2013 | International Journal of Cardiology2013，，2： | 1 |
| 16 | Real-time increased detection of neoplastic tissue in Barrett’s esophagus with probe-based confocal laser endomicroscopy: final results of an international multicenter, prospective, randomized, controlled trial显示文摘 | Prateek Sharma Alexander R. Meining Emmanuel Coron Charles J. Lightdale Herbert C. Wolfsen Ajay Bansal Monther Bajbouj Jean-Paul Galmiche Julian A. Abrams Amit Rastogi Neil Gupta Joel E. Michalek Gregory Y. Lauwers Michael B. Wallace | 2011 | Gastrointestinal Endoscopy2011，，3： | 1 |
| 17 | Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors显示文摘 | Sarah Schwitalla Paul K. Ziegler David Horst Valentin Becker Irina Kerle Yvonne Begus-Nahrmann André Lechel K. Lenhard Rudolph Rupert Langer Julia Slotta-Huspenina Franz G. Bader Olivia Prazeres da Costa Markus F. Neurath Alexander Meining Thomas Kirchner | 2013 | Cancer Cell2013，，： | 1 |
| 18 | Needle-based confocal endomicroscopy for in vivo histology of intra-abdominal organs: first results in a porcine model (with videos )显示文摘 | Valentin Becker Michael B. Wallace Paul Fockens Stefan von Delius Timothy A. Woodward Massimo Raimondo Rogier P. Voermans Alexander Meining | 2010 | Gastrointestinal Endoscopy2010，，7： | 1 |
| 19 | Incidence, predic- tors, and outcomes of high-degree atrioventricular block complica- ting acute myocardial infarction treated with thrombolytic therapy 显示文摘 | Meine TJ AI-Khatib SM Alexander JH | 2005 | Am Heart J2005，149，4： | 1 |
| 20 | Gastric carcinoma risk index in patients infected with Helicobacter pylori显示文摘 | Alexander Meining Ekkehard Bayerd?rffer Petra Müller Stephan Miehlke Norbert Lehn Dieter H?lzel Rudolf Hatz M. Stolte | 1998 | Virchows Archiv1998，，4： | 1 |
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