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| 1 | HVEM,a cosignaling molecular switch,and its interactions with BTLA,CD160 and LIGHT显示文摘Temporal and spatial expression of cosignaling receptors and their ligands regulates the early stages of T-cell activation(signal 1,T-cell receptor(TCR)signaling and signal 2,costimulation/coinhibition),clonal expansion and T-cell survival during their differentiation towards effector T cells.Once the inflammatory stimulus is eliminated,effector T cells return to homeostasis after undergoing a contraction phase by activation-induced cell death and the intervention of ligands for coinhibitory receptors,leaving a population of long-term memory T cells.The expression of ligands for coinhibitory receptors on hematopoietic cells and,more importantly,on non-hematopoietic cells of peripheral tissues is a key process in tuning the functional activity of effector T cells to prevent excess tissue inflammation that may lead to immunopathology and subsequent tissue dysfunction. | Jose Ignacio Rodriguez-Barbosa Pascal Schneider Andreas Weigert Kyung-Mi Lee Tae-Jin Kim Jose-Antonio Perez-Simon Maria-Luisa del Rio | 2019 | Cellular & Molecular Immunology2019，16，7： | 4 |
| 2 | Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis. | Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 3 | 氮氧化物吸附催化器与选择性催化还原装置组合排放控制系统用的先进催化剂显示文摘与仅采用一种技术的系统相比,由氮氧化物(NO_x)吸附催化器(NAC)和选择性催化还原(SCR)装置组合的排放控制系统能够对稀燃条件下的NO_x控制提供更大的优势。然而,组合系统也对新的催化剂设计提出了挑战。与仅采用NAC的系统相比,NO_x再生时,NAC+SCR组合系统中NAC生成的氨(NH_3)是所需的特性。组合系统中的SCR需要与单独的SCR技术一样耐热,同时必须能抵抗上游的NAC周期性脱硫时出现的高温稀/浓状态反复变化。研究中,特别为组合系统研发了先进的NAC和SCR催化剂。改进的NAC催化剂展示出更宽广的运行温度窗口,并在减少铂族金属涂敷量的情况下获得了更高的NH_3生成活性。先进的SCR具有优异的低温NO_x还原效率,即便在高温稀/浓状态反复交替后依然具有极好的耐久性。采用改进的NAC和SCR催化剂后,系统性能显著提高。新研发的催化剂的优势也在车辆上得到了验证。 | Chen H Y Weigert E C Fedeyko J M Cox J P Andersen P J 许蕾 | 2012 | 国外内燃机2012，44，2： | 3 |
| 4 | Trust as a social reality显示文摘 | Lewis J D Weigert A | 1985 | Social Forces1985，63，4： | 1 |
| 5 | Trust as a Social Reality 显示文摘 | Lewis J D Weigert A | 1985 | Social Force1985，63，4： | 1 |
| 6 | AP-1 proteins mediate hyperglycemia - induced activation of the human TGF- betal promoter in mesangial cells显示文摘 | Weigert C Sauer U Brodbeck K | 2000 | J Am Soc Nephrol2000，11，11： | 1 |
| 7 | Interplay and effects of temporal changes in the phosphorylation state of serine-302,-307, and-318 of insulin receptor substrate-1 on insulin action in skeletal muscle ceils 显示文摘 | Weigert C Kron M Kalbacher H | 2008 | Mol Endocrinol2008，22，12： | 1 |
| 8 | Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes显示文摘 | Weigert J Neumeier M Wanninger J | 2010 | Clin Endecrinol2010，72，： | 1 |
| 9 | All mutually unbiased bases in dimension two to five显示文摘 | Brierley S Weigert S Bengtsson I | 2010 | Quantum In{orm Comput2010，10，： | 1 |
| 10 | Trust as A Social Reality 显示文摘 | LEWIS JD WEIGERT A | 1985 | Social Force1985，63，4： | 1 |
| 11 | Immunopathogenesis and role of T cells in psoriasis显示文摘 | Ghoreschi K Weigert C Rocken M | 2007 | Clin Dermatol2007，25，6： | 1 |
| 12 | Comparison of stimulation with clomiphene citrate in combination with recombinant follicle-stimulating hormone and recombinant luteinizing hormone to stimulation with a gonadotropin-releasing hormone agonist protocol: a prospective randomized study 显示文摘 | Weigert M Krischker U Pohl M | 2002 | Fertil Steril2002，78，1： | 1 |
| 13 | Construction of a functional S-layer fusion protein comprising an immunoglobulin G-binding domain for development of specific adsorbents for extracorporeal blood purification显示文摘 | Vollenkle C Weigert S Ilk N | 2004 | Appl Environ Microbiol2004，70，3： | 1 |
| 14 | Methylprednisolone enhances contraction of porcine femoral head epiphyseal arteries显示文摘 | Drescher W Būnger MH Weigert K | 2004 | Clin Orthop Relat Res2004，423，： | 1 |
| 15 | Angiotensin II induces human TGF-beta 1 promoter activation:similarity to hyperglycaemia显示文摘 | Weigert C Brodbeck K Klopfer K | 2002 | Diabetologia2002，45，6： | 1 |
| 16 | Systemic chemerin is related to inflammation rath- er than obesity in type 2 diabetes显示文摘 | WEIGERT J NEUMEIER M WANNINGER J | 2010 | Clin Endocri- nol2010，72，： | 1 |
| 17 | Multiple activities for Arfl at the Golgi complex显示文摘 | Donaldson JG Honda A Weigert R | 2005 | Biochim Biophys Acta2005，1744，3： | 1 |
| 18 | Painfulness of transvaginal follicle aspiration for oocyte retrieval in in-vitro-fertilization 显示文摘 | Wicke V Weigert M Danninger B | 2000 | Zenlralbl Gynakol2000，122，3： | 1 |
| 19 | Role of the hexosamine biosynthet- ic pathway in diabetic nephropathy显示文摘 | Schleicher ED Weigert C | 2000 | Kidney Int2000，77，： | 1 |
| 20 | A targeted mutational landscape of angioimmunoblastic T-cell lymphoma 显示文摘 | Odejide O Weigert O Lane AA | 2014 | Blood2014，123，9： | 1 |
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