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| 1 | Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber显示文摘Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system1–4.Advances in wavefrontshaping methods and computational power have recently allowed for a novel approach to high-resolution imaging,utilizing deterministic light propagation through optically complex media and,of particular importance for this work,multimode optical fibers(MMFs)5–7.We report a compact and highly optimized approach for minimally invasive in vivo brain imaging applications.The volume of tissue lesion was reduced by more than 100-fold,while preserving diffraction-limited imaging performance utilizing wavefront control of light propagation through a single 50-μm-core MMF.Here,we demonstrated high-resolution fluorescence imaging of subcellular neuronal structures,dendrites and synaptic specializations,in deep-brain regions of living mice,as well as monitored stimulus-driven functional Ca2+responses.These results represent a major breakthrough in the compromise between high-resolution imaging and tissue damage,heralding new possibilities for deep-brain imaging in vivo. | Sebastian A.Vasquez-Lopez Raphaël Turcotte Vadim Koren Martin Plöschner Zahid Padamsey Martin J.Booth TomášČižmár Nigel J.Emptage | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 2 | Association of Nutrition Parameters Including Bioelectrical Impedance and Systemic Inflammatory Response With Quality of Life and Prognosis in Patients With Advanced Non-Small-Cell Lung Cancer: A Prospective Study显示文摘 | Karla Sánchez-Lara JennyG Turcott Eva Juárez Patricia Guevara Carolina Nú?ez-Valencia LuisF. O?ate-Oca?a Diana Flores Oscar Arrieta | 2012 | Nutrition and Cancer2012，，4： | 3 |
| 3 | The new liver allocation system: Moving toward evidence-based transplantation policy显示文摘 | Richard B. Freeman Russell H. Wiesner Ann Harper Sue V. McDiarmid Jack Lake Erick Edwards Robert Merion Robert Wolfe Jeremiah Turcotte Lewis Teperman | 2002 | Liver Transplantation2002，，9： | 2 |
| 4 | A rapid turbidometric microplate hioassay for accurate quantification of lactic acid bacteria bacteriocins 显示文摘 | Turcotte C Lacroixb C Kheadr E | 2004 | International Journal of Food Microbiology2004，901，： | 1 |
| 5 | Diallyl disulfide,a chemoproventive agent in garlic,induces multidrug resistance-associated protein 2 expression显示文摘 | Brossard M Turcotte S | 2004 | Biochem Biophys Res Common2004，324，： | 1 |
| 6 | Giant cell tumor of the sacrum显示文摘 | Turcotte RT Sim FH Unni KK | 1993 | Clin Orthop1993，291，： | 1 |
| 7 | Modulation of human GABAA and glycine receptor currents by menthol and related monoterpenoids显示文摘 | Hall AC Turcotte CM Betts BA | 2004 | Eur J Pharmocol2004，506，1： | 1 |
| 8 | Comparison of target registration errors for multiple image-guided techniques in accelerated partial breast irradiation显示文摘 | Gierga DP Riboldi M Turcotte JC | 2008 | Int J Radiat Oncol Biol Phys2008，70，： | 1 |
| 9 | Cough variant asthma:Lessons learned from deep inspirations显示文摘 | Lougheed MD Turcotte SE Fisher T | 2012 | Lung2012，190，1： | 1 |
| 10 | Cough variant asthma : lessons learned from deep inspirations 显示文摘 | Lougheed MD Turcotte SE Fisher T | 2012 | Lung2012，190，1： | 1 |
| 11 | Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression显示文摘 | Nam JS Turcotte TJ Smith PF | 2006 | J Biol Chem2006，281，13： | 1 |
| 12 | Fractals and fragmentation显示文摘 | Turcotte D L | 1986 | Geophysical Res1986，91，2： | 1 |
| 13 | A rapid turbidometric microplate bioassay for accurate quantification of lactic acid bacteria bacteriocins显示文摘 | Carl Turcotte Christophe Lacroix Ehad Kheadr | 2004 | International J of Food Microbiology2004，90，： | 1 |
| 14 | High yields in advanced lines of Pima cotton are associated with higher stomatal conductance, reduced leaf area and lower temperature显示文摘 | Lu Z Radin J Turcotte E Percy R Zeiger E | 1994 | Physiol Plant1994，92，： | 1 |
| 15 | Fractals and fragmentation显示文摘 | Turcotte D L | 1986 | Journal of Geophysics Research1986，91，132： | 1 |
| 16 | A comparative study between an endoglucanase Ⅳ and its fused protein complex Cel5CBM6显示文摘 | BAE H J TURCOTTE G CHAMBERLAND H | 2003 | FEMS Microbiol Lett2003，227，： | 1 |
| 17 | Determination of the drainage structure of a watershed using a digital elevation model and a digital river and lake network显示文摘 | Turcotte R Fortin J P Rousseau A N | 2001 | Journal of Hydrology2001，240，34： | 1 |
| 18 | Thermal hazard assessment of nitrobenzene/dinitrobenzene mixtures显示文摘 | Badeen C Turcotte R Hobenshield E | 2011 | J Hazard Mater2011，188，13： | 1 |
| 19 | Outcome after pelvic sarooma resection reconstructed with saddle prosthesis显示文摘 | Aljassir F Beadel GP Turcotte RE | | 0，，： | 1 |
| 20 | Fractals and fragmentation显示文摘 | TURCOTTE D L | 1986 | Journal of Geophysical Research: Solid Earth1986，91，2： | 1 |
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