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| 1 | Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images显示文摘Super-resolution structured illumination microscopy(SR-SIM) provides an up to twofold enhanced spatial resolution of fluorescently labeled samples. The reconstruction of high-quality SR-SIM images critically depends on patterned illumination with high modulation contrast. Noisy raw image data(e.g., as a result of low excitation power or low exposure time), result in reconstruction artifacts. Here, we demonstrate deep-learning based SR-SIM image denoising that results in high-quality reconstructed images. A residual encoding–decoding convolutional neural network(RED-Net) was used to successfully denoise computationally reconstructed noisy SR-SIM images.We also demonstrate the end-to-end deep-learning based denoising and reconstruction of raw SIM images into high-resolution SR-SIM images. Both image reconstruction methods prove to be very robust against image reconstruction artifacts and generalize very well across various noise levels. The combination of computational image reconstruction and subsequent denoising via RED-Net shows very robust performance during inference after training even if the microscope settings change. | ZAFRAN HUSSAIN SHAH MARCEL MÜLLER TUNG-CHENG WANG PHILIP MAURICE SCHEIDIG AXEL SCHNEIDER MARK SCHÜTTPELZ THOMAS HUSER WOLFRAM SCHENCK | 2021 | Photonics Research2021，9，5： | 11 |
| 2 | A comparison of Kneipp hydrotherapy with conventional physiotherapy in the treatment of osteoarthritis: a pilot trial显示文摘BACKGROUND: An increasingly aging population implies an increasing prevalence of osteoarthritis (OA) of hip or knee. It has been ascertained that unspecific hydrotherapy of OA according to Sebastian Kneipp not only improves the range of mobility but also reduces pain significantly and increases the quality of life of the patients affected. OBJECTIVE: The main aim of this pilot study was to determine the effects of hydrotherapy in comparison to conventional physiotherapy, and to analyze the feasibility of the study design under clinical circumstances. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: The study design is a prospective randomized controlled three-arm clinical pilot trial, carried out at a specialist clinic for integrative medicine. Thirty patients diagnosed with symptomatic OA of hip or knee and radiologic findings were randomly assigned to one of two intervention groups and a control group: hydrotherapy (group 1), physiotherapy (group 2), and both physiotherapy and hydrotherapy (group 3, control group) of the affected joint. MAIN OUTCOME MEASURES: Primary outcome: pain intensity of the affected joint in the course of inpatient treatment; secondary outcome: health-related quality of life, joint-specific pain and mobility in the course of the study. RESULTS: Concerning the main outcome, intervention group 1 showed most beneficial effects in the course of inpatient treatment, followed by groups 3 and 2, and also the indirect flexion ability of hip or knee together with the general patient mobility through the 'timed up and go' test were mainly improved within group 1 followed by groups 3 and 2. CONCLUSION: The results of this pilot study demonstrate beneficial effects of hydrotherapy. The study design is feasible. For statistically significant evidence and a robust conclusion of efficacy of Kneipp's hydrotherapy, a larger sample size is necessary. | Martin Schencking Stefan Wilm Marcus Redaelli | 2013 | Journal of Integrative Medicine2013，11，1： | 4 |
| 3 | A new nematode-trapping hyphomycete and a reevaluation of Dactylaria and Arthrobotrys显示文摘 | Schenck S Kendrick W B Pramer D | 1977 | Can J Bot1977，55，： | 2 |
| 4 | The oral commensal Streptococcus mitis activates the aryl hydrocarbon receptor in human oral epithelial cells显示文摘Streptococcus mitis(S. mitis) is a pioneer commensal bacterial species colonizing many of the surfaces of the oral cavity in healthy individuals. Yet, not much information is available regarding its interaction with the host. We used examination of its transcriptional regulation in oral keratinocytes to elucidate some of its potential roles in the oral cavity. Transcription factor analysis of oral keratinocytes predicted S. mitis-mediated activation of aryl hydrocarbon receptor(Ah R). Activation and functionality of Ah R was confirmed through nuclear translocation determined by immunofluorescence microscopy and real-time polymerase chain reaction with reverse transcription analysis of CYP1A1, the hallmark gene for Ah R activation. Addition of Streptococcus mutans or Streptococcus gordonii did not induce CYP1A1 transcription in the keratinocyte cultures. Introduction of an Ah R-specific inhibitor revealed that S. mitis-mediated transcription of CXCL2 and CXCL8 was regulated by Ah R. Elevated levels of prostaglandin E2(enzyme-linked immunosorbent assay) in supernatants from S. mitis-treated oral epithelial cells were also attenuated by inhibition of Ah R activity. The observed Ah R-regulated activities point to a contribution of S. mitis in the regulation of inflammatory responses and thereby to wound healing in the oral cavity. The concept that the oral commensal microbiota can induce Ah R activation is important, also in view of the role that Ah R has in modulation of T-cell differentiation and as an anti-inflammatory factor in macrophages. | stian a engen gro h rørvik olav schreurs inger js blix karl schenck | 2017 | International Journal of Oral Science2017，9，3： | 2 |
| 5 | 巨獭(Pteronura brasiliensis)处境危险吗?秘鲁鱼体和水獭粪便中总汞和甲基汞水平显示文摘本文对秘鲁马努国家公园(Manu National Park)及其邻近的一个金矿区内的鱼的肌肉和巨獭(Pteronura brasiliensis)粪便中的汞和甲基汞水平进行了分析。68%的鱼肌肉中,总汞水平超过了规定的欧洲水獭(Lutra lutra)最大忍受水平(0.1mg/kg鱼鲜重),17.6%超过了最一般的人类消费标准0.5mg/kg鱼鲜重。鱼肌肉中甲基汞与总汞的比值在61.3%~96.9%之间。水獭粪便中没有检出甲基汞而只有微量的无机汞。目前还没有巨獭组织汞浓度的有关数据,但鱼体汞水平大比例超过欧洲水獭的可忍受值,根据过去对欧洲和北美自由生活的水獭的汞中毒的描述,可以设想巨獭体内汞中毒的危险可能存在。 | Arno Christian Gutleb Christof Schenck Elke Staib 张国梁 | 1997 | 人类环境杂志1997，26，8： | 2 |
| 6 | NEJM:治疗性低温不能改善惊厥性癫痫持续状态的预后显示文摘惊厥性癫痫持续状态是最具挑战的威胁生命的神经系统急症,应迅速给予抗癫痫药物治疗,并根据对临床和脑电图的反应调整治疗方案。其住院死亡率大约为20%,难治性癫痫持续状态死亡率高达40%。癫痫持续状态的功能缺损可能是由其对皮质神经元的作用或原发病对大脑的损害造成的。在前瞻性多中心研究中,90 d时50%收住ICU的惊厥性癫痫持续状态幸存者残留功能缺损。不良预后独立危险因素包括老年、运动性痫性发作的持续时间、 | 杨中华 Legriel S Lemiale V Schenck M | 2017 | 中国卒中杂志2017，12，4： | 2 |
| 7 | 显示文摘 | Green M L Schenck P K | 2009 | Microeleetronic Engi- neering2009，86，： | 1 |
| 8 | Antibodies against lipopolysaccharide from bacteroides gingivalis before and after periodontal treatment显示文摘 | Schenck K Helgeland K Tollefsen T | 1987 | Scand J Dent Res1987，95，2： | 1 |
| 9 | New race of sugarcane smut on Maul 显示文摘 | SCHENCK S | 2003 | Hawaii Agriculture Research Center Pathology Report2003，69，6： | 1 |
| 10 | Intravenous administration of vitamin C in the treatment of herpetic neuralgia:two case reports显示文摘 | Schencking M Sandholzer H Frese T | | 0，，： | 1 |
| 11 | Insights from studying human sleep disorders显示文摘 | MAHOWALD M W SCHENCK C H | 2005 | Nature2005，437，： | 1 |
| 12 | Evaluation of the quick,easy,cheap,effective,rugged and safe (QuEChERS) approach to pesticide residue analysis显示文摘 | F Schenck J hobbs | 2004 | Bull Environ Contain Toxicol2004，73，： | 1 |
| 13 | Improved integral formulation for acoustic radiation problems显示文摘 | Schenck H A | 1968 | J Acous Soc Am1968，，44： | 1 |
| 14 | A Transistor Method for Measuring Changes in Double Layer Potentials 显示文摘 | Schenck J F | 2003 | Journal of Colloid and Interface Science2003，61，： | 1 |
| 15 | A comparison of Kneipp hydrotherapy with conventional physiotherapy in the treatment of osteoarthritis of the hip or knee:protocol of a prospective randomised controlled clinical trial显示文摘 | Schencking M Otto A Deutsch T | | 0，，： | 1 |
| 16 | Imaging of brain iron by magnetic resonance:T2 relaxation at different field strengths显示文摘 | Schenck JF | 1995 | J Neurol Sci1995，，： | 1 |
| 17 | Does further clean-up reduce the matrix enhancement effect in gas chromatographic analysis of pesticide residues in food显示文摘 | SCHENCK F J LEHOTAY S J | 2000 | J Chrornatogr A2000，868，1： | 1 |
| 18 | Improved integral formulation for acoustic radiation problems显示文摘 | Schenck H A | 1968 | J Acoust Soc Am1968，44，1： | 1 |
| 19 | Improved integral formulation for acoustic radiation problems显示文摘 | Schenck H | 1968 | The Journal of the Acoustical Society of America1968，44，1： | 1 |
| 20 | Volatile organic compounds and micro- organisms显示文摘 | Stotzky G Schenck S | 1976 | CRC Critical Reviews in Microbiology1976，4，4： | 1 |
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