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| 1 | Clinical outcomes of isolated renal failure compared to other forms of organ failure in patients with severe acute pancreatitis显示文摘AIM To assess differences in clinical outcomes of isolated renal failure(RF) compared to other forms of organ failure(OF) in patients with severe acute pancreatitis(SAP).METHODS Using a prospectively maintained database of patients with acute pancreatitis admitted to a tertiary medical center between 2003 and 2016, those with evidence of persistent OF were classified to renal, respiratory, cardiovascular, or multi-organ(2 or more organs). Data regarding demographics, comorbidities, etiology of acute pancreatitis, and clinical outcomes were prospectively recorded. Differences in clinical outcomes after development of isolated RF in comparison to other forms of OF were determined using independent t and Mann-Whitney U tests for continues variables, and χ~2 test for discrete variables.RESULTS Among 500 patients with acute pancreatitis, 111 patients developed persistent OF: mean age was 54 years, and 75(67.6%) were male. Forty-three patients had isolated OF: 17(15.3%) renal, 25(21.6%) respiratory, and 1(0.9%) patient with cardiovascular failure. No differences in demographics, etiology of acute pancreatitis, systemic inflammatory response syndrome scores, or development of pancreatic necrosis were seen between patients with isolated RF vs isolated respiratory failure. Patients with isolated RF were less likely to require nutritional support(76.5% vs 96%, P = 0.001), ICU admission(58.8% vs 100%, P = 0.001), and had shorter mean ICU stay(2.4 d vs 15.7 d, P < 0.001), compared to isolated respiratory failure. None of the patients with isolated RF or isolated respiratory failure died.CONCLUSION Among patients with SAP per the Revised Atlanta Classification, approximately 15% develop isolated RF. This subgroup seems to have a less protracted clinical course compared to other forms of OF. Isolated RF might be weighed less than isolated respiratory failure in risk predictive modeling of acute pancreatitis. | Amir Gougol Mohannad Dugum Anwar Dudekula Phil Greer Adam Slivka David C Whitcomb Dhiraj Yadav Georgios I Papachristou | 2017 | World Journal of Gastroenterology2017，23，29： | 20 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | The effect of endoscopic sphincterotomy on acute and chronic complications of biliary endoprostheses显示文摘 | Craig Margulies Eduardo Sampaio Siqueira William Bruce Silverman Xue Sen Lin John Anthony Martin Mordechai Rabinovitz Adam Slivka | 1999 | Gastrointestinal Endoscopy1999，，6： | 2 |
| 4 | Comparison of Existing Clinical Scoring Systems to Predict Persistent Organ Failure in Patients With Acute Pancreatitis显示文摘 | Rawad Mounzer Christopher J. Langmead Bechien U. Wu Anna C. Evans Faraz Bishehsari Venkata Muddana Vikesh K. Singh Adam Slivka David C. Whitcomb Dhiraj Yadav Peter A. Banks Georgios I. Papachristou | 2012 | Gastroenterology2012，，7： | 2 |
| 5 | Postcholecystemy pain syn-drome: Pathogypsiology of abdominal pain in sphincter of Oddi type Ⅲ显示文摘 | Desautel SG Slivka A Hutson WR | 1999 | Gasrtroenterology1999，116，4： | 1 |
| 6 | Local heat application enhances glycogenesis显示文摘 | Slivka D Tucker T Cuddy J | 2012 | Appl Physiol Nutr Metab2012，37，2： | 1 |
| 7 | Wireless capsule endoscopyAugust 2002显示文摘 | Gregory G. Ginsberg Alan N. Barkun John J. Bosco Gerard A. Isenberg Cuong Cao Nguyen Bret T. Petersen William B. Silverman Adam Slivka Greta Taitelbaum | 2002 | Gastrointestinal Endoscopy2002，，5： | 1 |
| 8 | Intra-arterial carboplatin and intravenous etoposide for the treatment of metastatic brain tumors显示文摘 | Newton HB Slivka MA Volpi C | 2003 | J Neurooncol2003，61，1： | 1 |
| 9 | Pain in chronic pancreatitis and pancreatic cancer 显示文摘 | Fasanella K E Davis B Lyons J Chen Z Lee K K Slivka A | 2007 | Gastroenterol Clin North Am2007，36，： | 1 |
| 10 | Pain in Chronic Pancreatitis and Pancreatic Cancer显示文摘 | Kenneth E. Fasanella Brian Davis John Lyons Zongfu Chen Kenneth K. Lee Adam Slivka David C. Whitcomb | 2007 | Gastroenterology Clinics of North America2007，，2： | 1 |
| 11 | Is the Monocyte Chemotactic Protein-1 ?2518 G Allele a Risk Factor for Severe Acute Pancreatitis?显示文摘 | Georgios I. Papachristou David A. Sass Haritha Avula Janette Lamb Anna Lokshin M. Michael Barmada Adam Slivka David C. Whitcomb | 2005 | Clinical Gastroenterology and Hepatology2005，，5： | 1 |
| 12 | The effect of cadence on cycling efficiency and local tissue oxygenation显示文摘 | D Jacobs R E Berg K Slivka DR | 2013 | J Strength Cond Res2013，27，3： | 1 |
| 13 | High rate of fusion in sheep cervical spines following anterior interbody surgery with absorbable and non- absorbable implant devices显示文摘 | Slivka M A Speneiner D B Seim H B 3rd Welch W C Serhan H A Turner A S | 2006 | Spine2006，31，： | 1 |
| 14 | Safety of ERCP during pregnancy显示文摘 | T.C.K Tham J Vandervoort R.C.K Wong H Montes A.D Roston A Slivka A.P Ferrari D.R Lichtenstein J Van Dam R.D Nawfel R Soetikno D.L Carr-Locke | 2003 | The American Journal of Gastroenterology2003，，2： | 1 |
| 15 | Hyperoxia and glucocorticoid modify retinal vessel growth and interleukin-1 receptor antagonist in newborn rabbits显示文摘 | Lawas-Alejo PA Slivka S Hernandez H Bry K Hallman M | 1999 | Pediatr Res1999，45，： | 1 |
| 16 | Intraarterial thrombolytic therapy within 3 hours of the onset of stoke显示文摘 | Bourekas E Slivka A | 2004 | Neurosurgery2004，54，： | 1 |
| 17 | Impact of extreme exercise at high altitude on oxidative stress in humans 显示文摘 | Quindry J Dumke C Slivka D | 2015 | J Physiol2015，10，10： | 1 |
| 18 | Cerebral edema after temporary and permanent middle cerebral artery occlusion in the rat显示文摘 | Slivka A Murphy E Horrocks L | | 0，，6： | 1 |
| 19 | Postcholecystemy pain syn - drome: pathogypsiology of abdominal pain in sphincter of Oddi type Ⅲ 显示文摘 | DESAUTEL S G SLIVKA A HUTSON W R | 1999 | Gasrtroenterology1999，116，4： | 1 |
| 20 | Diagnostic yield and clinical outcomes of capsule endoscopy显示文摘 | Rastogi A Schoen RE Slivka A | | 0，，06： | 1 |
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