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| 1 | Endoscopic extraction of large common bile duct stones:A review article显示文摘Since therapeutic endoscopic retrograde cholangiopancreatography replaced surgery as the first approach in cases of choledocolithiasis,a plethora of endoscopic techniques and devices appeared in order to facilitate rapid,safe and effective bile duct stones extraction.Nowadays,endoscopic sphincterotomy combined with balloon catheters and/or baskets is the routine endoscopic technique for stone extraction in the great majority of patients.Large common bile duct stones are treated conventionally with mechanical lithotripsy,while the most serious complication of the procedure is 'basket and stone impaction' that is predominately resolved surgically.In cases of difficult,impacted,multiple or intrahepatic stones,more sophisticated procedures have been used.Electrohydraulic lithotripsy and laser lithotripsy are performed using conventional mother-baby scope systems,ultra-thin cholangio-scopes,thin endoscopes and ultimately using the novel single use,single operator SpyGlass Direct Visualization System,in order to deliver intracorporeal shock wave energy to fragment the targeted stone,with very good outcomes.Recently,large balloon dilation after endoscopic sphincterotomy confirmed its effectiveness in the extraction of large stones in a plethora of trials.When compared with mechanical lithotripsy or with balloon dilation alone,it proved to be superior.Moreover,dilation is an ideal alternative in cases of altered anatomy where access to the papilla is problematic.Endoscopic sphincterotomy followed by large balloon dilation represents the onset of a new era in large bile duct stone extraction and the management of 'impaction' because it seems that is an effective,inexpensive,less traumatic,safe and easy method that does not require sophisticated apparatus and can be performed widely by skillful endoscopists.When complete extraction of large stones is unsuccessful,the drainage of the common bile duct is mandatory either for bridging to the final therapy or as a curative therapy for very elderly patients with short life expectancy.Placing of more than one plastic endoprostheses is better while the administration of Ursodiol is ineffective.The great majority of patients with large stones can be treated endoscopically.In cases of unsuccessful stone extraction using balloons,baskets,mechanical lithotripsy,electrohydraulic or laser lithotripsy and large balloon dilation,the patient should be referred for extracorporeal shock wave lithotripsy or a percutaneous approach and finally surgery. | Gerasimos Stefanidis Christos Christodoulou Spilios Manolakopoulos Ram Chuttani | 2012 | World Journal of Gastrointestinal Endoscopy2012,4,5: | 23 |
| 2 | Effectiveness of circumferential endoscopic mucosal resection with a novel tissue-anchoring device显示文摘AIM: To evaluate the efficacy of circumferential endoscopic mucosal resection (EMR) with a tissue-anchoring device in comparison to forceps precut EMR and conventional endoscopic submucosal dissection (ESD). METHODS: The study was designed as a prospective, randomized, ex vivo study. Fresh ex vivo specimens were harvested from adult white Yorkshire pigs weighing 30-50 kg. Seventy-five standardized, artificial lesions measuring 3 cm × 3 cm were created by methy- lene blue tattoo at the greater curvature in fresh ex vivo stomachs using the EASIE-R simulator platform (Endosim LLC, Berlin, MA, United States). The three advanced endoscopists performed the three resection techniques such as circumferential EMR using the tissue-anchoring device (TA-EMR), forceps precut EMR (FP-EMR), and endoscopic submucosal dissection. The endoscopists and the type of cutting methods were determined randomly by grouped randomized selection.The resection bed was grossly inspected to determine whether the lesion was resected 'en-bloc ' (defined as no remaining mucosal tattoo remaining on specimen). The resection bed was also probed for evidence of perforation. The procedural time of circumferential resection, submucosal dissection, and injection frequency were recorded by an independent observer.RESULTS: All 75 created lesions were successfully resected by three advanced endoscopists using the three techniques. The mean ± SD size of resected specimens (long axis) were 39.5 ± 5.6 mm, 36.5 ± 7.3 mm, and 44.6 ± 5.6 mm for TA-EMR, FP-EMR, and ESD respectively. The overall mean dissection time of both the TA- EMR and FP-EMR was significant shorter than ESD (TA- EMR: 5.1 ± 3.3 min, FP-EMR: 3.5 ± 2.0 min vs ESD: 15.8 ± 9.5 min, P < 0.001, P < 0.001). The overall mean total procedure time of both the tissue-anchoring and forceps circumferential EMR was significantly shorter than ESD (TA-EMR: 17.5 ± 6.0 min, FP-EMR: 16.6 ± 6.6 min vs ESD: 28.6 ± 13.9 min, P < 0.001, P < 0.001). The en-bloc resection rate of ESD was 100% (25/25) and the en-bloc resection rate of the TA-EMR (84.0%, 21/25) was higher than for the FP-EMR (60.0%, 15/25), yet not statistically significant (P = 0.18). The perforation rate of each technique was 8.0% (2/25). CONCLUSION: TA-EMR appears to be quicker than ESD, and there was a trend towards improved en bloc resection rate with the TA-EMR when compared to the FP-EMR. | Yunho Jung Masayuki Kato Jongchan Lee Mark A Gromski Ram Chuttani Kai Matthes | 2013 | World Journal of Gastrointestinal Endoscopy2013,5,6: | 3 |
| 3 | Covered Wallstents for palliation of malignant biliary obstruction: primary stent placement versus reintervention显示文摘 | Laura C. Ornellas Gerasimos Stefanidis Ram Chuttani Andres Gelrud T. Barry Kelleher Douglas K. Pleskow | 2009 | Gastrointestinal Endoscopy2009,,: | 2 |
| 4 | Development of virtual CT cholangiopancreatoscopy显示文摘 | Prassopoulos P Raptopoulos V Chuttani R | 1998 | Radiology1998,209,2: | 1 |
| 5 | ASGE Technology Status Evaluation Report: wireless capsule endoscopy 显示文摘 | Mishkin DS Chuttani ER Croffie | 2006 | Gastroinest Endo- sc2006,63,4: | 1 |
| 6 | Design and development of nanoemulsion drug delivery system of amlodipine besilate for im- provement of oral bioavailability 显示文摘 | Chhabra G Chuttani K Mishra AK | 2011 | Drug Development and Industri- al Pharmacy2011,37,8: | 1 |
| 7 | The learning curve for endoscopic submucosal dissection in an established experimental setting显示文摘 | Masayuki Kato Mark Gromski Yunho Jung Ram Chuttani Kai Matthes | 2013 | Surgical Endoscopy2013,,1: | 1 |
| 8 | The acute and long-term effect of balloon sphincteroplasty on papillary structure in pigs显示文摘 | Padraic Mac Mathuna David Siegenberg David Gibbons Daniel Gorin Michael O’Brien Nezem A. Afdhal Ram Chuttani | 1996 | Gastrointestinal Endoscopy1996,,6: | 1 |
| 9 | Evaluation of recombinant platelet-activating factor acetylhydrolase for reducing the incidence and severity of post-ERCP acute pancreatitis显示文摘 | Stuart Sherman Waleed M. Alazmi Glen A. Lehman Joseph E. Geenen Ram Chuttani Richard A. Kozarek William D. Welch Sonia Souza John Pribble | 2009 | Gastrointestinal Endoscopy2009,,3: | 1 |
| 10 | Gene expression, biodistribution, and pharmaeoscintigraphic evaluation of chondroitin sulfate-PEI nanoconstructs mediated tumor gene therapy 显示文摘 | PATHAK A KUMAR P CHUTTANI K | 2009 | ACS Nano2009,3,6: | 1 |
| 11 | ASGE technology status evaluation report:wireless capsule endoscopy显示文摘 | Mish kin DS Chuttani R Croffie J | 2006 | Gastrointest Endosc2006,63,4: | 1 |
| 12 | Influence of administration route on tumor uptake and bio- distribution of etoposide loaded solid lipid nanopartieles in Dal- ton' s lymphoma tumor bearing mice显示文摘 | HARIVARDHAN R L SHARMA R K CHUTTANI K | 2005 | J Controlled Release2005,105,3: | 1 |
| 13 | Covered Wallstents for palliation of maglignant billary obstruction:primary stent placement verrsus reintervention显示文摘 | Ornellas LC Stefanidis G Chuttani R | 2009 | Gastrointest endosc2009,70,4: | 1 |
| 14 | Biliary and pancreatic stents 显示文摘 | Somogyi L Chuttani R Croffie J | 2006 | Gastrointest Endosc2006,63,7: | 1 |
| 15 | MR cholangiopancreatography:efficacy of three-dimensional turbo spin-echo techqique显示文摘 | Yucel EK Soto JA Chuttani R Ferrucci JT | 1995 | AJR Am J Roentgenol1995,165,: | 1 |
| 16 | Comparison of carcinoembryonic antigen and molecular analysis in pancreatic cyst fluid显示文摘 | Mandeep S. Sawhney Shiva Devarajan Paul O'Farrel Marcelo S. Cury Rabi Kundu Charles M. Vollmer Alphonso Brown Ram Chuttani Douglas K. Pleskow | 2009 | Gastrointestinal Endoscopy2009,,6: | 1 |
| 17 | Inteslinal tuberculosis显示文摘 | Chuttani HK Sarin SK | 1985 | lnd JTub1985,32,3: | 1 |
| 18 | Anovel endoscopic full-thickness plicater for the treatment of GERD:A pilot study 显示文摘 | Chuttani R Sud R Sachdev G | 2003 | Gastrointest Endosic2003,58,5: | 1 |
| 19 | Biliary and pancreaticstents显示文摘 | Sornogyi L Chuttani R Croffie J | 2006 | Gastrointest Endosc2006,63,7: | 1 |
| 20 | Enteral stents 显示文摘 | TIERNEY W CHUTTANI R CROFFIE J | 2006 | Gastrointest Endosc2006,63,7: | 1 |