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| 1 | Importance of bifurcation angle in bifurcation stenting显示文摘Bifurcation coronary lesions are relatively frequent in today's interventional cardiology practice,averaging between 10%-15% of all percutaneous coronary interventions(PCIs).1 Several problems inherent in the treatment of bifurcation lesions are periprocedural side branch(SB)compromise(composite of SB closure or appearance of significant ostial stenosis after main vessel(MV)stenting causing ischemia)frequently related to periprocedural myonecrosis,relatively higher restenosis rates especially in two-stent techniques,and higher rates of stent thrombosis in different time frames.1-4 The lead author and other investigators demonstrated that both periprocedural result and long-term results could be influenced by bifurcation angulations.The purpose of this study is to show why and how bifurcation angulations are important for bifurcation stenting. | Dobrin Vassilev Alexander Alexandrov Dan Le Katrina Nguyen James Nguyen Hung Phan Robert J. Gil | 2012 | Chinese Medical Journal2012，，22： | 7 |
| 2 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 3 | Cohort-based long-term ozone exposure-associated mortality risks with adjusted metrics:A systematic review and meta-analysis显示文摘Long-term ozone(O_(3))exposure may lead to non-communicable diseases and increase mortality risk.However,cohort-based studies are relatively rare,and inconsistent exposure metrics impair the credibility of epidemiological evidence synthetization.To provide more accurate meta-estimations,this study updates existing systematic reviews by including recent studies and summarizing the quantitative associations between O_(3) exposure and cause-specific mortality risks,based on unified exposure metrics.Cross-metric conversion factors were estimated linearly by decadal observations during 1990-2019. | Haitong Zhe Sun Pei Yu Changxin Lan Michelle WLWan Sebastian Hickman Jayaprakash Murulitharan Huizhong Shen Le Yuan Yuming Guo Alexander T.Archibald | 2022 | The Innovation2022，3，3： | 2 |
| 4 | The Metallic Nature of Epitaxial Silicene Monolayers on Ag(111)显示文摘 | Neil W. Johnson Patrick Vogt Andrea Resta Paola De Padova Israel Perez David Muir Ernst Z. Kurmaev Guy Le Lay Alexander Moewes | 2014 | Adv. Funct. Mater2014，，： | 2 |
| 5 | Melanoma:Molecular genetics,metastasis,targeted therapies,immunotherapies,and therapeutic resistance显示文摘Cutaneous melanoma is a common cancer and cases have steadily increased since the mid 70s.For some patients,early diagnosis and surgical removal of melanomas is lifesaving,while other patients typically turn to molecular targeted therapies and immunotherapies as treatment options.Easy sampling of melanomas allows the scientific community to identify the most prevalent mutations that initiate melanoma such as the BRAF,NRAS,and TERT genes,some of which can be therapeutically targeted.Though initially effective,many tumors acquire resistance to the targeted therapies demonstrating the need to investigate compensatory pathways.Immunotherapies represent an alternative to molecular targeted therapies.However,inter-tumoral immune cell populations dictate initial therapeutic response and even tumors that responded to treatment develop resistance in the long term.As the protocol for combination therapies develop,so will our scientific understanding of the many pathways at play in the progression of melanoma.The future direction of the field may be to find a molecule that connects all of the pathways.Meanwhile,noncoding RNAs have been shown to play important roles in melanoma development and progression.Studying noncoding RNAs may help us to understand how resistance e both primary and acquired e develops;ultimately allow us to harness the true potential of current therapies.This review will cover the basic structure of the skin,the mutations and pathways responsible for transforming melanocytes into melanomas,the process by which melanomas metastasize,targeted therapeutics,and the potential that noncoding RNAs have as a prognostic and treatment tool. | William Wagstaff Rimel N.Mwamba Karina Grullon Mikhayla Armstrong Piao Zhao Bryce Hendren-Santiago Kevin H.Qin Alexander J.Li Daniel A.Hu Andrew Youssef Russell R.Reid Hue H.Luu Le Shen Tong-Chuan He Rex C.Haydon | 2022 | Genes & Diseases2022，9，6： | 2 |
| 6 | Roads and their major ecological effects 显示文摘 | Fo man RTT Alexander LE | 1998 | Annual Review of Ecology and Systematics1998，29，： | 1 |
| 7 | Preventing and treating maternal hypothy- roidism during pregnancy 显示文摘 | Dichtel LE Alexander EK | 2011 | Current Opinion in Endocrinology Dia- betes & Obesity2011，18，6： | 1 |
| 8 | Reduction in Mortality as a Result of Direct Transport From the Field to a Receiving Center for Primary Percutaneous Coronary Intervention显示文摘 | Michel R. Le May George A. Wells Derek Y. So Chris A. Glover Michael Froeschl Justin Maloney Richard Dionne Jean-Fran?ois Marquis Edward R. O’Brien Alexander Dick Heather L. Sherrard John Trickett Pierre Poirier Melissa Blondeau Jordan Bernick Marino Labi | 2012 | Journal of the American College of Cardiology2012，，14： | 1 |
| 9 | Roads and their major ecological effects 显示文摘 | Forman RTT Alexander LE | 1995 | Annual Review of Ecology and Systematics1995，29，： | 1 |
| 10 | Statin Therapy and Saphenous Vein Graft Disease After Coronary Bypass Surgery: Analysis From the CASCADE Randomized Trial显示文摘 | Alexander Kulik Pierre Voisine Patrick Mathieu Roy G. Masters Thierry G. Mesana Michel R. Le May Marc Ruel | 2011 | The Annals of Thoracic Surgery2011，，4： | 1 |
| 11 | Ultraviolet light and ozone stimulate accumulation of salicylic acid, pathogenesis-related proteins and virus resistance in tobacco显示文摘 | Nasser Yalpani Alexander J. Enyedi Jose León Ilya Raskin | 1994 | Planta1994，，3： | 1 |
| 12 | Slow injection does not prevent midazolam induced ventilatory depression显示文摘 | Alexander CM Teller LE Gross JB | 1992 | Anesth Analg1992，74，： | 1 |
| 13 | Roads and their major ecological effects显示文摘 | Forman RT T Alexander LE | 1998 | Annual Rev Ecol System1998，，29： | 1 |
| 14 | Roads and their major ecological effects显示文摘 | Forman RT Alexander LE | | 0，，： | 1 |
| 15 | IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement显示文摘 | Schmidt-Weber CB Alexander SI Henault LE | 1999 | J Immunol1999，162，1： | 1 |
| 16 | Flexion- distraction injuries of the lumbar spine associated with abdominal injuries显示文摘 | Le Gay DA Petrie DP Alexander DI | 1990 | J Spinal Disord1990，4，： | 1 |
| 17 | Implanted adipose progenitor cells as physicochemical regulators of breast cancer显示文摘 | Emily M. Chandler Bo Ri Seo Joseph P. Califano Roberto C. Andresen Eguiluz Jason S. Lee Christine J. Yoon David T. Tims James X. Wang Le Cheng Sunish Mohanan Mark R. Buckley Itai Cohen Alexander Yu Nikitin Rebecca M. Williams Delphine Gourdon Cynthia A. R | 2012 | Proceedings of the National Academy of Sciences2012，，25： | 1 |
| 18 | Hy- poxia inducible factor(HIF)α subunits modulate eosinophil migration,oxidative burst, and degranulation 显示文摘 | Crotty Alexander LE Nicatia S McEachern E | 2013 | J Allergy Clin Immunol2013，131，2： | 1 |
| 19 | Clinical performance of serum prostate‐specific antigen isoform [‐2] proPSA ( p2PSA ) and its derivatives, % p2PSA and the prostate health index ( PHI ), in men with a family history of prostate cancer: results from a multicentre E uropean study, the PROM显示文摘 | Massimo Lazzeri Alexander Haese Alberto Abrate Alexandre Taille Joan Palou Redorta Thomas McNicholas Giovanni Lughezzani Giuliana Lista Alessandro Larcher Vittorio Bini Andrea Cestari Nicolòmaria Buffi Markus Graefen Olivier Bosset Philippe Le Corvoisier | 2013 | BJU Int2013，，3： | 1 |
| 20 | Prevalence of Disordered-Eating Behaviors in Undergraduate Female Collegiate Athletes and Nonathletes显示文摘 | Reinking MF Alexander LE | 2005 | J Athl Train2005，40，： | 1 |
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