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| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | Positive Surgical Margins After Radical Prostatectomy: A Systematic Review and Contemporary Update显示文摘 | Ofer Yossepowitch Alberto Briganti James A. Eastham Jonathan Epstein Markus Graefen Rodolfo Montironi Karim Touijer | 2014 | European Urology2014，，： | 2 |
| 3 | Nephron-sparing Surgery Is Equally Effective to Radical Nephrectomy for T1BN0M0 Renal Cell Carcinoma: A Population-based Assessment显示文摘 | Maxime Crépel Claudio Jeldres Paul Perrotte Umberto Capitanio Hendrik Isbarn Shahrokh F. Shariat Daniel Liberman Maxine Sun Giovanni Lughezzani Philippe Arjane Hugues Widmer Markus Graefen Francesco Montorsi Jean-Jacques Patard Pierre I. Karakiewicz | 2010 | Urology2010，，： | 2 |
| 4 | Open retropubic nerve-sparing radical prostatectomy 显示文摘 | Graefen M Walz J Huland H | 2006 | Eur Urol2006，49，1： | 1 |
| 5 | The relationship between Prostate Cancer gene 3 (PCA3) and prostate cancer significance显示文摘 | VAN POPPEL H HAESE A GRAEFEN M | 2012 | BJU Int2012，109，3： | 1 |
| 6 | Systematic Review and Meta-analysis of Studies Reporting Oncologic Outcome After Robot-assisted Radical Prostatectomy 显示文摘 | Giacomo Novara Vincenzo Ficarra Simone Mocellin Thomas E. Ahlering Peter R. Carroll Markus Graefen Giorgio Guazzoni Mani Menon Vipul R. Patel Shahrokh F. Shariat Ashutosh K. Tewari Hendrik Van Poppel Filiberto Zattoni Francesco Montorsi Alexandre Mottrie | 2012 | European Urology2012，，： | 1 |
| 7 | The value of the ratio offree-to-total prostate specific antigen for staging purposes in previously untreated prostate cancer显示文摘 | NOLDUS J GRAEFEN M HULANDE | 1998 | J Urol1998，159，6： | 1 |
| 8 | A critical analysis of the long-term impact of radical prostatectomy on cancer control and function outcomes 显示文摘 | Boorjian SA Eastham JA Graefen M | 2012 | Eur Urol2012，61，4： | 1 |
| 9 | Surgical anatomy of the pros- tate in the era of radical robotic prostatectomy 显示文摘 | Walz JJ Graefen MM Huland HH | 2011 | Curr Opin Urol2011，21，： | 1 |
| 10 | Depression,anxiety,post- traumatic stress disorder and health-related quality of life and its asso- ciation with social support in ambulatory prostate cancer patients显示文摘 | Mehnert A Lehmann C Graefen M | 2009 | Eur J Cancer Gare2009，19，6： | 1 |
| 11 | Assessment of clinical and pathologiccharacteristics predisposing to disease recurrence following radical prostatectomy in menwith pathologically organ-confined prostate cancer显示文摘 | Palisaar RJ Graefen M Karakiewicz PI | 2002 | Euro Urol2002，41，2： | 1 |
| 12 | Prediction of postoperative sexual function after nerve sparing radical retropubic prostatectomy显示文摘 | Michl UH Friedrich MG Graefen M | 2006 | J Uro12006，176，： | 1 |
| 13 | Intraoperative and perioperative morbidity of contemporary radical retropubic prostatectomy in a consecutive series of 1243 patients: results of a single center between 1999 and 2002 显示文摘 | Augustin H Hammerer P Graefen M | 2003 | Eur Urol2003，43，2： | 1 |
| 14 | Intraoperative and perioperative morbidity of contemporary radical retropubic prostatectomy in a consecutive series of 1243 patients: Results of a single centre between 1999 and 2002显示文摘 | Augustin H Hammerer P Graefen M | 2003 | Eur Urol2003，43，2： | 1 |
| 15 | Analysis of molecular isoforms of PSA and their ratios in men with PSA-relapse after radical prostatectomy显示文摘 | Hammerer P Graefen M Henke RP | | 0，，6： | 1 |
| 16 | Basic principles of anatomy for optimal surgical treatment of prostate cancer 显示文摘 | Walz J Graefen M Huland H | 2007 | World J Urol2007，25，1： | 1 |
| 17 | Reporting and grading of complications after urologic surgical procedures:an ad hoc EAU guidelines panel assessment and recommendations显示文摘 | MITROPOULOS D ARTIBANI W GRAEFEN M | 2012 | Eur Urol2012，61，9： | 1 |
| 18 | The novel nomogram of Gleason sum upgrade: Possible application for the eligible criteria of low dose rate brachytherapy显示文摘 | Budaus L Graefen M Salomon G | 2012 | International Journal of Urology2012，17，： | 1 |
| 19 | Prognostic impact of positive surgical margins in surgi- cally treated prostate cancer: Multi-institutional assess- ment of 5831 patients显示文摘 | Karakiewicz P I Eastham J A Graefen M | 2005 | Urology2005，66，6： | 1 |
| 20 | Prognostic impact of positive surgical margins in surgically treated prostate cancer:nmhi - institutional assessment of 5831 patients 显示文摘 | Karakiewicz PI Eastham JA Graefen M | 2005 | Urology2005，66，6： | 1 |
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