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| 1 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 2 | Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds,2014–2015显示文摘A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015.Based on the genetic and phylogenetic analyses,the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA,a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin.The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain(A/Alberta/01/2014).Further analysis showed that similar viruses have been circulating in wild birds in China,Russia,Dubai(Western Asia),Bulgaria and Romania(Europe),as well as domestic poultry in some regions of Africa.The affected areas include the Central Asian,East Asian-Australasian,West Asian-East African,and Black Sea/Mediterranean flyways.These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds,thus posing a serious threat to wild birds and potentially humans. | Yuhai Bi Jianjun Chen Zhenjie Zhang Mingxin Li Tianlong Cai Kirill Sharshov Ivan Susloparov Alexander Shestopalov Gary Wong Yubang He Zhi Xing Jianqing Sun Di Liu Yingxia Liu Lei Liu Wenjun Liu Fumin Lei Weifeng Shi George F. Gao | 2016 | Virologica Sinica2016，31，4： | 5 |
| 3 | Efficacy of calcium sulfate plus decompression bone in lumbar and lumbosacral spinal fusion:preliminary results in 40 patients显示文摘 | Alexander DI Manson NA Mitchell MJ | 2001 | Can J Surg2001，44，4： | 1 |
| 4 | The effect of 6-dimethylaminopurine (6-DMAP)and cycloheximide (CHX) on the development and chromosomal complement of sheep parthenogenetic and nuclear transfer embryos显示文摘 | ALEXANDER B COPPOLA G DI B D | 2006 | Mol Reprod Dev2006，73，1： | 1 |
| 5 | Optical Solitons Due to Qquadratic Nonlinearities:From Basic Physics to Futuristic Applications显示文摘 | Buryak Alexander V Trapani Paolo Di Skryabin Dmitry V | 2002 | Physics Reports2002，370，： | 1 |
| 6 | Ablation of osteoid osteomas with a percutaneously placed electrode:a new procedure显示文摘 | Rosenthal DI Alexander A Rosenberg AE | | 0，，01： | 1 |
| 7 | Traumatic basal ganglia hemorrhage: clinicopathologic features and outcome 显示文摘 | Katz DI Alexander MP seliger GM | 1989 | Neurdog1989，39，7： | 1 |
| 8 | Hemofiltration for cytokine-driven illnesses:the mediator delivery hypothesis显示文摘 | Di Carlo JV Alexander SR | 2005 | Int J Artif Organs2005，28，8： | 1 |
| 9 | Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone显示文摘Osteocytes are the most abundant cells in bone,which is a frequent site of breast cancer metastasis.Here,we focused on Wnt signaling and evaluated tumor-osteocyte interactions.In animal experiments,mammary tumor cells were inoculated into the mammary fat pad and tibia.The role of Lrp5-mediated Wnt signaling was examined by overexpressing and silencing Lrp5 in osteocytes and establishing a conditional knockout mouse model.The results revealed that administration of osteocytes or their conditioned medium(CM)inhibited tumor progression and osteolysis.Osteocytes overexpressing Lrp5 or β-catenin displayed strikingly elevated tumor-suppressive activity,accompanied by downregulation of tumor-promoting chemokines and upregulation of apoptosis-inducing and tumor-suppressing proteins such as p53.The antitumor effect was also observed with osteocyte-derived CM that was pretreated with a Wnt-activating compound.Notably,silencing Lrp5 in tumors inhibited tumor progression,while silencing Lrp5 in osteocytes in conditional knockout mice promoted tumor progression.Osteocytes exhibited elevated Lrp5 expression in response to tumor cells,implying that osteocytes protect bone through canonical Wnt signaling.Thus,our results suggest that the Lrp5/β-catenin axis activates tumor-promoting signaling in tumor cells but tumor-suppressive signaling in osteocytes.We envision that osteocytes with Wnt activation potentially offer a novel cell-based therapy for breast cancer and osteolytic bone metastasis. | Shengzhi Liu Di Wu Xun Sun Yao Fan Rongrong Zha Aydin Jalali Yan Feng Kexin Li Tomohiko Sano Nicole Vike Fangjia Li Joseph Rispoli Akihiro Sudo Jing Liu Alexander Robling Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota | 2021 | Bone Research2021，9，4： | 1 |
| 10 | Hemofiltration for cytokine-driven illness:the mediator delivery hypothesis显示文摘 | Di Carlo JV Alexander SR | 2005 | Int J Artif Organs2005，28，8： | 1 |
| 11 | Computational cytometer based on magnetically modulated coherent imaging and deep learning显示文摘Detecting rare cells within blood has numerous applications in disease diagnostics.Existing rare cell detection techniques are typically hindered by their high cost and low throughput.Here,we present a computational cytometer based on magnetically modulated lensless speckle imaging,which introduces oscillatory motion to the magneticbead-conjugated rare cells of interest through a periodic magnetic force and uses lensless time-resolved holographic speckle imaging to rapidly detect the target cells in three dimensions(3D).In addition to using cell-specific antibodies to magnetically label target cells,detection specificity is further enhanced through a deep-learning-based classifier that is based on a densely connected pseudo-3D convolutional neural network(P3D CNN),which automatically detects rare cells of interest based on their spatio-temporal features under a controlled magnetic force.To demonstrate the performance of this technique,we built a high-throughput,compact and cost-effective prototype for detecting MCF7 cancer cells spiked in whole blood samples.Through serial dilution experiments,we quantified the limit of detection(LoD)as 10 cells per millilitre of whole blood,which could be further improved through multiplexing parallel imaging channels within the same instrument.This compact,cost-effective and high-throughput computational cytometer can potentially be used for rare cell detection and quantification in bodily fluids for a variety of biomedical applications. | Yibo Zhang Mengxing Ouyang Aniruddha Ray Tairan Liu Janay Kong Bijie Bai Donghyuk Kim Alexander Guziak Yi Luo Alborz Feizi Katherine Tsai Zhuoran Duan Xuewei Liu Danny Kim Chloe Cheung Sener Yalcin Hatice Ceylan Koydemir Omai B.Garner Dino Di Carlo Aydogan Ozcan | 2019 | Light(Science & Applications)2019，8，1： | 1 |
| 12 | Efficacy of calcium sulfate plus decompression bone in lumbar and lumbosacral spinal fusion:preliminaryresults in 40 patients显示文摘 | Alexander DI Manson NA Mitchell MJ | 2001 | Can J Surg2001，44，4： | 1 |
| 13 | Efficacy of calcium sulfate plus decompression bone in lumbar and lumbosacral spinal fusion:preliminary results in 40 patients显示文摘 | Alexander DI Manson NA Mitchell MJ | 2001 | Can J Surg2001，44，4： | 1 |
| 14 | The effect of 6- dimethylaminopurine (6-DMAP) and cycloheximide (CHX) on the development and chromosomal complement of sheep par- thenogenetic and nuclear transfer embryos 显示文摘 | Alexander B Coppola G Di Berardino D etal | 2006 | Mol Reprod Dev2006，73，1： | 1 |
| 15 | Ablation of osteoid osteomas with a percutaneously placed electrode: a new procedure显示文摘 | Rosenthal DI Alexander A Rosenberg AE | 1992 | Radiology1992，183，： | 1 |
| 16 | Enhancing the graphene photocurrent using surface plasmons and a p-n junction显示文摘The recently proposed concept of graphene photodetectors offers remarkable properties such as unprecedented compactness,ultrabroadband detection,and an ultrafast response speed.However,owing to the low optical absorption of pristine monolayer graphene,the intrinsically low responsivity of graphene photodetectors significantly hinders the development of practical devices.To address this issue,numerous efforts have thus far been made to enhance the light–graphene interaction using plasmonic structures.These approaches,however,can be significantly advanced by leveraging the other critical aspect of graphene photoresponsivity enhancement-electrical junction control.It has been reported that the dominant photocarrier generation mechanism in graphene is the photothermoelectric(PTE)effect.Thus,the two energy conversion mechanisms involved in the graphene photodetection process are light-to-heat and heat-to-electricity conversions.In this work,we propose a meticulously designed device architecture to simultaneously enhance the two conversion efficiencies.Specifically,a gap plasmon structure is used to absorb a major portion of the incident light to induce localized heating,and a pair of split gates is used to produce a p-n junction in graphene to augment the PTE current generation.The gap plasmon structure and the split gates are designed to share common key components so that the proposed device architecture concurrently realizes both optical and electrical enhancements.We experimentally demonstrate the dominance of the PTE effect in graphene photocurrent generation and observe a 25-fold increase in the generated photocurrent compared to the un-enhanced cases.While further photocurrent enhancement can be achieved by applying a DC bias,the proposed device concept shows vast potential for practical applications. | Di Wang Andres E.Llacsahuanga Allcca Ting-Fung Chung Alexander V.Kildishev Yong P.Chen Alexandra Boltasseva Vladimir M.Shalaev | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 17 | Field-portable flow-injection analysers for monitoring of air and water pollution显示文摘 | Alexander P W Di Benedetto L T Telis Dimitrakopoulos D B | 1996 | Talanta1996，43，： | 1 |
| 18 | Efficacy of calcium sulfate plus decompression bone in lumbar and lumbosacaral spinal fusion: Preliminary results in ro panents显示文摘 | Alexander DI Manson NA 1 Vfitchetl MJ | 2001 | Can J Surg2001，44，4： | 1 |
| 19 | Flexion- distraction injuries of the lumbar spine associated with abdominal injuries显示文摘 | Le Gay DA Petrie DP Alexander DI | 1990 | J Spinal Disord1990，4，： | 1 |
| 20 | Hemofihration for cytokine-driven illnesses: the mediator delivery hypothesis显示文摘 | Di Carlo J V Alexander S R | 2005 | Int J Artif Organs2005，28，8： | 1 |
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